A new method for the production of gelatin microparticles for controlled protein release from porous polymeric scaffolds

Journal of Tissue Engineering and Regenerative Medicine

Volumn 8, Issue 3, 2014, Pages 242-247

  Ozkizilcik, Asya ^a   Tuzlakoglu, Kadriye ^a,b  

^a HACETTEPE UNIVERSITY   (Turkey)

^b YALOVA UNIVERSITY   (Turkey)

Author keywords

Bone tissue engineering; Controlled release; Gelatin; Microparticle; Porous scaffolds

Indexed keywords

BODY FLUIDS; BONE; PORE SIZE; PROTEINS; SCAFFOLDS (BIOLOGY); TISSUE REGENERATION;

BONE TISSUE ENGINEERING; BOVINE SERUM ALBUMINS; CONTROLLED RELEASE; GELATIN; GELATIN MICROPARTICLES; LOADING PROCESS; MICRO PARTICLES; POROUS SCAFFOLD; PROTEIN LOSS; PROTEIN RELEASE;

POLYCAPROLACTONE;

BOVINE SERUM ALBUMIN; CARBON DIOXIDE; GELATIN; POLYCAPROLACTONE; POLYMER; SODIUM CHLORIDE; SURFACTANT; TISSUE SCAFFOLD;

ANIMAL TISSUE; ARTICLE; BONE TISSUE; FREEZE DRYING; GRINDING; IN VITRO STUDY; LEACHING; MICROSCOPY; NONHUMAN; POLYMERIZATION; POROSITY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN SECRETION; TISSUE ENGINEERING;

BONE TISSUE ENGINEERING; CONTROLLED RELEASE; GELATIN; MICROPARTICLE; POROUS SCAFFOLDS;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE AND BONES; CATTLE; DRUG DELIVERY SYSTEMS; GELATIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; POLYESTERS; POLYMERS; POROSITY; PROTEINS; SERUM ALBUMIN, BOVINE; SURFACE-ACTIVE AGENTS; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84895556822     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.1524     Document Type: Article

References (45)

1. Adhirajan N, Shanmugasundaram N, Shanmuganathan S et al. 2009; Functionally modified gelatin microspheres impregnated collagen scaffold as novel wound dressing to attenuate the proteases and bacterial growth. Eur J Pharm Sci 36: 235-245.
2. Atyabi F, Vahabzadeh R, Dinarvand R. 2004; Preparation of ethylcellulose coated gelatin microspheres as a multiparticulate colonic delivery system for 5-aminosalicilic acid. Iranian J Pharm Res 2: 81-88.
3. Aydin HM, Yang Y, Kohler T et al. 2009; Interaction of osteoblasts with macroporous scaffolds made of plla/pcl blends modified with collagen and hydroxyapatite. Adv Eng Mater 11B: 83-88.
4. Balmayor ER, Feichtinger GA, Azevedo HS et al. 2009; Starch-poly-epsilon-caprolactone microparticles reduce the needed amount of BMP-2. Clin Orthop Relat Res 467: 3138-48.
5. Bessa PC, Balmayor ER, Azevedo HS et al. 2010; Silk fibroin microparticles as carriers for delivery of human recombinant BMPs. Physical characterization and drug release. J Tissue Eng Regen Med 4: 349-355.
6. Bigi A, Cojazzi G, Panzavolta S et al. 2002; Stabilization of gelatin films by crosslinking with genipin. Biomaterials 23: 4827-4832.
7. Bigi A, Cojazzi G, Panzavolta S et al. 2001; Mechanical and thermal properties of gelatin films at different degrees of glutaraldehyde crosslinking. Biomaterials 22: 763-768.
8. Bigi A, Panzavolta S, Rubini K. 2004; Relationship between triple-helix content and mechanical properties of gelatin films. Biomaterials 25: 5675-5680.
9. Bruschi ML, Cardoso ML, Lucchesi MB et al. 2003; Gelatin microparticles containing propolis obtained by spray-drying technique: preparation and characterization. Int J Pharm 264: 45-55.
10. So KF, Chan BP. 2008; Fabrication of nano-fibrous collagen microspheres for protein delivery and effects of photochemical crosslinking on release kinetics. J Control Release 129: 135-143.
11. Chen FM, Wu ZF, Wang QT et al. 2005; Preparation of recombinant human bone morphogenetic protein-2 loaded dextran-based microspheres and their characteristics. Acta Pharmacol Sin 26: 1093-1103.
12. Chen FM, Zhao YM, Sun HH et al. 2007; Novel glycidyl methacrylated dextran (Dex-GMA)/gelatin hydrogel scaffolds containing microspheres loaded with bone morphogenetic proteins: formulation and characteristics. J Control Release 118: 65-77.
13. Chung HJ, Park TG. 2007; Surface engineered and drug releasing pre-fabricated scaffolds for tissue engineering. Adv Drug Deliv Rev 59: 249-262.
14. Dinarvand R, Rahmani E, Farbod E. 2003; Gelatin microspheres for the controlled release of all-trans-retinoic acid topical formulation and drug delivery evaluation. Iranian J Pharm Res 1: 47-50.
15. Forni F, Vandelli MA, Cameroni R. 1992a; Influence of drug loading level on drug release and dynamic swelling of crosslinked gelatin microspheres. J Microencapsul 9: 29-39.
16. Forni FC, Furiosi G, Pifferi G. 1992b; Italian patent application.
17. Fundueanu G, Nastruzzi C, Carpov A et al. 1999; Physico-chemical characterization of Ca-alginate microparticles produced with different methods. Biomaterials 20: 1427-1435.
18. Gomes ME, Godinho JS, Tchalamov D et al. 2002; Alternative tissue engineering scaffolds based on starch: processing methodologies, morphology, degradation and mechanical properties. Mater Sci Eng C 20: 19-26.
19. Hermanson GT 1996; Bioconjugate Techniques. California, Academic. In Press, Academic Press Inc.: California
20. Huang S, Wang Y, Liang T et al. 2009; Fabrication and characterization of a novel microparticle with gyrus-patterned surface and growth factor delivery for cartilage tissue engineering. Mater Sci Eng C 29: 1351-1356.
21. Jeyanthi R, Panduranga RK. 1987; Preparation of gelatin microspheres of bleomycin. Int J Pharm 35: 177-179.
22. Jiang T, Abdel-Fattah WI, Laurencin CT. 2006; In vitro evaluation of chitosan/poly(lactic acid-glycolic acid) sintered microsphere scaffolds for bone tissue engineering. Biomaterials 27: 4894-4903.
23. Kang SW, Kim JS, Park KS et al. 2011; Surface modification with fibrin/hyaluronic acid hydrogel on solid-free form-based scaffolds followed by BMP-2 loading to enhance bone regeneration. Bone 48: 298-306.
24. Kempen DH, Lu L, Hefferan TE et al. 2008; Retention of in vitro and in vivo BMP-2 bioactivities in sustained delivery vehicles for bone tissue engineering. Biomaterials 29: 3245-52.
25. Kempen DH, Lu L, Heijink A et al. 2009; Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration. Biomaterials 30: 2816-2825.
26. Leucuta SE. 1986; Magnetic microspheres and microcapsules for intravenous administration of metranidozole. Drug Dev Ind Pharm 12: 2281-2288.
27. Leucuta SE, Ponchel G, Duchene D. 1997; Oxprenolol release from bioadhesive gelatin/poly(acrylic acid) microspheres. J Microencapsul 14: 511-522.
28. Liu X, Ma PX. 2004; Polymeric scaffolds for bone tissue engineering. Ann Biomed Eng 32: 477-486.
29. Matsumoto G, Omi Y, Kubota E et al. 2009; Enhanced regeneration of critical bone defects using a biodegradable gelatin sponge and beta-tricalcium phosphate with bone morphogenetic protein-2. J Biomater Appl 24: 327-342.
30. Mladenovska K, Kumbaradzi E, Dodov G et al. 2002; Biodegradation and drug release studies of BSA loaded gelatin microspheres. Int J Pharm 242: 247-249.
31. Niu X, Feng Q, Wang M et al. 2009; Porous nano-HA/collagen/PLLA scaffold containing chitosan microspheres for controlled delivery of synthetic peptide derived from BMP-2. J Control Release 134: 111-117.
32. Franssen OO, Hennick WE. 1998; A novel preparation method for polymeric microparticles without the use of organic solvents. Int J Pharma Sci 168: 1-7.
33. Patel ZS, Yamamoto M, Ueda H et al. 2008; Biodegradable gelatin microparticles as delivery systems for the controlled release of bone morphogenetic protein-2. Acta Biomater 4: 1126-1138.
34. Tabata Y, Ikada Y. 1989; Synthesis of gelatin microspheres containing interferon. Pharm Res 6: 422-427.
35. Talebian A, Kordestani SS, Dadashian F et al. 2007; Study of properties of cross linked gelatin films with glutaraldehyde. World Appl Sci J 2: 575-581.
36. Tan H, Huang D, Lao L et al. 2009; RGD modified PLGA/gelatin microspheres as microcarriers for chondrocyte delivery. J Biomed Mater Res B Appl Biomater 91: 228-238.
37. Tanaka N, Takino S, Utsumi I. 1963; A new oral gelatinized sustained-release dosage form. J Pharm Sci 52: 664-667.
38. Tuzlakoglu K, Bolgen N, Salgado AJ et al. 2005; Nano- and micro-fiber combined scaffolds: A new architecture for bone tissue engineering. J Mater Sci Mater Med 16: 1099-1104.
39. Tuzlakoglu K, Santos MI, Neves N et al. 2011; Design of nano- and microfiber combined scaffolds by electrospinning of collagen onto starch-based fiber meshes: a man-made equivalent of natural extracellular matrix. Tissue Eng Part A 17: 463-473.
40. Vandelli MA, Rivasi F, Guerra P et al. 2001; Gelatin microspheres crosslinked with D, L-glyceraldehyde as a potential drug delivery system: preparation, characterisation, in vitro and in vivo studies. Int J Pharm 215: 175-184.
41. Wang H, Li Y, Zuo Y et al. 2007; Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering. Biomaterials 28: 3338-3348.
42. Weiner AA, Moore MC, Walker AH et al. 2008; Modulation of protein release from photocrosslinked networks by gelatin microparticles. Int J Pharm 360: 107-114.
43. Yamamoto M, Ikada Y, Tabata Y. 2001; Controlled release of growth factors based on biodegradation of gelatin hydrogel. J Biomater Sci Polym Ed 12: 77-88.
44. Yamamoto M, Tabata Y, Ikada Y. 1998; Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein. J Biomater Sci Polym Ed 9: 439-458.
45. Yu H, Xiao C. 2008; Synthesis and properties of novel hydrogels from oxidized konjac glucomannan crosslinked gelatin for in vitro drug delivery. Carbohydr Polym 72: 479-489.