메뉴 건너뛰기




Volumn 9, Issue 2, 2014, Pages

Androgen receptor status is a prognostic marker in non-basal triple negative breast cancers and determines novel therapeutic options

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; MESSENGER RNA; TUMOR MARKER;

EID: 84895525356     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0088525     Document Type: Article
Times cited : (82)

References (47)
  • 1
    • 34248148215 scopus 로고    scopus 로고
    • Androgens and androgen receptors: A clinically neglected sector in breast cancer biology
    • DOI 10.1002/jso.20722
    • Moe RE, Anderson BO (2007) Androgens and androgen receptors: a clinically neglected sector in breast cancer biology. J Surg Oncol 95: 437-439. (Pubitemid 46709384)
    • (2007) Journal of Surgical Oncology , vol.95 , Issue.6 , pp. 437-439
    • Moe, R.E.1    Anderson, B.O.2
  • 2
    • 78649321904 scopus 로고    scopus 로고
    • The androgen receptor in breast cancer: Learning from the past
    • Higgins MJ, Wolff AC (2010) The androgen receptor in breast cancer: learning from the past. Breast Cancer Res Treat 124: 619-621.
    • (2010) Breast Cancer Res Treat , vol.124 , pp. 619-621
    • Higgins, M.J.1    Wolff, A.C.2
  • 3
    • 77649188673 scopus 로고    scopus 로고
    • Expression of androgen receptors in primary breast cancer
    • Park S, Koo J, Park HS, Kim JH, Choi SY, et al. (2010) Expression of androgen receptors in primary breast cancer. Ann Oncol 21: 488-492.
    • (2010) Ann Oncol , vol.21 , pp. 488-492
    • Park, S.1    Koo, J.2    Park, H.S.3    Kim, J.H.4    Choi, S.Y.5
  • 4
    • 84903276848 scopus 로고    scopus 로고
    • Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver
    • Chang C, Lee SO, Yeh S, Chang TM (2013) Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver. Oncogene.
    • (2013) Oncogene
    • Chang, C.1    Lee, S.O.2    Yeh, S.3    Chang, T.M.4
  • 5
    • 84864447342 scopus 로고    scopus 로고
    • Minireview: The androgen receptor in breast tissues: Growth inhibitor, tumor suppressor, oncogene?
    • Hickey TE, Robinson JL, Carroll JS, Tilley WD (2012) Minireview: The androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene? Mol Endocrinol 26: 1252-1267.
    • (2012) Mol Endocrinol , vol.26 , pp. 1252-1267
    • Hickey, T.E.1    Robinson, J.L.2    Carroll, J.S.3    Tilley, W.D.4
  • 6
    • 83655167086 scopus 로고    scopus 로고
    • Androgens and breast cancer
    • Kotsopoulos J, Narod SA (2012) Androgens and breast cancer. Steroids 77: 1-9.
    • (2012) Steroids , vol.77 , pp. 1-9
    • Kotsopoulos, J.1    Narod, S.A.2
  • 8
    • 84859208512 scopus 로고    scopus 로고
    • Androgen receptor expression predicts breast cancer survival: The role of genetic and epigenetic events
    • Peters KM, Edwards SL, Nair SS, French JD, Bailey PJ, et al. (2012) Androgen receptor expression predicts breast cancer survival: the role of genetic and epigenetic events. BMC Cancer 12: 132.
    • (2012) BMC Cancer , vol.12 , pp. 132
    • Peters, K.M.1    Edwards, S.L.2    Nair, S.S.3    French, J.D.4    Bailey, P.J.5
  • 9
    • 84865677341 scopus 로고    scopus 로고
    • Role of androgen excess in the development of estrogen receptor-positive and estrogen receptor-negative breast cancer
    • Secreto G, Zumoff B (2012) Role of androgen excess in the development of estrogen receptor-positive and estrogen receptor-negative breast cancer. Anticancer Res 32: 3223-3228.
    • (2012) Anticancer Res , vol.32 , pp. 3223-3228
    • Secreto, G.1    Zumoff, B.2
  • 10
    • 79960050587 scopus 로고    scopus 로고
    • Targeting androgen receptor in estrogen receptor-negative breast cancer
    • Ni M, Chen Y, Lim E, Wimberly H, Bailey ST, et al. (2011) Targeting androgen receptor in estrogen receptor-negative breast cancer. Cancer Cell 20: 119-131.
    • (2011) Cancer Cell , vol.20 , pp. 119-131
    • Ni, M.1    Chen, Y.2    Lim, E.3    Wimberly, H.4    Bailey, S.T.5
  • 11
    • 65249139954 scopus 로고    scopus 로고
    • Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer
    • Gonzalez-Angulo AM, Stemke-Hale K, Palla SL, Carey M, Agarwal R, et al. (2009) Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer. Clin Cancer Res 15: 2472-2478.
    • (2009) Clin Cancer Res , vol.15 , pp. 2472-2478
    • Gonzalez-Angulo, A.M.1    Stemke-Hale, K.2    Palla, S.L.3    Carey, M.4    Agarwal, R.5
  • 13
    • 77149129286 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Role of the androgen receptor
    • Gucalp A, Traina TA (2010) Triple-negative breast cancer: role of the androgen receptor. Cancer J 16: 62-65.
    • (2010) Cancer J , vol.16 , pp. 62-65
    • Gucalp, A.1    Traina, T.A.2
  • 14
    • 33745603978 scopus 로고    scopus 로고
    • An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen
    • DOI 10.1038/sj.onc.1209415, PII 1209415
    • Doane AS, Danso M, Lal P, Donaton M, Zhang L, et al. (2006) An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene 25: 3994-4008. (Pubitemid 43990755)
    • (2006) Oncogene , vol.25 , Issue.28 , pp. 3994-4008
    • Doane, A.S.1    Danso, M.2    Lal, P.3    Donaton, M.4    Zhang, L.5    Hudis, C.6    Gerald, W.L.7
  • 16
    • 79960989401 scopus 로고    scopus 로고
    • Androgen receptor expression is significantly associated with better outcomes in estrogen receptor-positive breast cancers
    • Park S, Koo JS, Kim MS, Park HS, Lee JS, et al. (2011) Androgen receptor expression is significantly associated with better outcomes in estrogen receptor-positive breast cancers. Ann Oncol 22: 1755-1762.
    • (2011) Ann Oncol , vol.22 , pp. 1755-1762
    • Park, S.1    Koo, J.S.2    Kim, M.S.3    Park, H.S.4    Lee, J.S.5
  • 17
    • 84867024734 scopus 로고    scopus 로고
    • Decreased androgen receptor expression is associated with distant metastases in patients with androgen receptor-expressing triple-negative breast carcinoma
    • Sutton LM, Cao D, Sarode V, Molberg KH, Torgbe K, et al. (2012) Decreased androgen receptor expression is associated with distant metastases in patients with androgen receptor-expressing triple-negative breast carcinoma. Am J Clin Pathol 138: 511-516.
    • (2012) Am J Clin Pathol , vol.138 , pp. 511-516
    • Sutton, L.M.1    Cao, D.2    Sarode, V.3    Molberg, K.H.4    Torgbe, K.5
  • 19
    • 84873551499 scopus 로고    scopus 로고
    • Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer
    • Cascione L, Gasparini P, Lovat F, Carasi S, Pulvirenti A, et al. (2013) Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer. PLoS One 8: e55910.
    • (2013) PLoS One , vol.8
    • Cascione, L.1    Gasparini, P.2    Lovat, F.3    Carasi, S.4    Pulvirenti, A.5
  • 20
    • 80052608676 scopus 로고    scopus 로고
    • Aberrant expression of DNA damage response proteins is associated with breast cancer subtype and clinical features
    • Guler G, Himmetoglu C, Jimenez RE, Geyer SM, Wang WP, et al. (2011) Aberrant expression of DNA damage response proteins is associated with breast cancer subtype and clinical features. Breast Cancer Res Treat 129: 421-432.
    • (2011) Breast Cancer Res Treat , vol.129 , pp. 421-432
    • Guler, G.1    Himmetoglu, C.2    Jimenez, R.E.3    Geyer, S.M.4    Wang, W.P.5
  • 22
    • 39549088717 scopus 로고    scopus 로고
    • Androgen receptor as a target for the treatment of hormone receptor-negative breast cancer: An unchartered territory
    • Nahleh Z (2008) Androgen receptor as a target for the treatment of hormone receptor-negative breast cancer: an unchartered territory. Future Oncol 4: 15-21.
    • (2008) Future Oncol , vol.4 , pp. 15-21
    • Nahleh, Z.1
  • 23
    • 79959503213 scopus 로고    scopus 로고
    • Triple-negative breast cancer: An unmet medical need
    • Hudis CA, Gianni L (2011) Triple-negative breast cancer: an unmet medical need. Oncologist 16 Suppl 1: 1-11.
    • (2011) Oncologist , vol.16 , Issue.SUPPL. 1 , pp. 1-11
    • Hudis, C.A.1    Gianni, L.2
  • 24
    • 84895486557 scopus 로고    scopus 로고
    • Loss of androgen receptor expression predicts early recurrence in triple-negative and basal-like breast cancer
    • Thike AA, Yong-Zheng Chong L, Cheok PY, Li HH, Wai-Cheong Yip G, et al. (2013) Loss of androgen receptor expression predicts early recurrence in triple-negative and basal-like breast cancer. Mod Pathol.
    • (2013) Mod Pathol
    • Thike, A.A.1    Yong-Zheng Chong, L.2    Cheok, P.Y.3    Li, H.H.4    Wai-Cheong Yip, G.5
  • 25
    • 84876420770 scopus 로고    scopus 로고
    • Androgenic pathway in triple negative invasive ductal tumors: Its correlation with tumor cell proliferation
    • McNamara KM, Yoda T, Miki Y, Chanplakorn N, Wongwaisayawan S, et al. (2013) Androgenic pathway in triple negative invasive ductal tumors: its correlation with tumor cell proliferation. Cancer Sci 104: 639-646.
    • (2013) Cancer Sci , vol.104 , pp. 639-646
    • McNamara, K.M.1    Yoda, T.2    Miki, Y.3    Chanplakorn, N.4    Wongwaisayawan, S.5
  • 26
    • 84864472736 scopus 로고    scopus 로고
    • The expression and clinical significance of the androgen receptor and E-cadherin in triple-negative breast cancer
    • Tang D, Xu S, Zhang Q, Zhao W (2012) The expression and clinical significance of the androgen receptor and E-cadherin in triple-negative breast cancer. Med Oncol 29: 526-533.
    • (2012) Med Oncol , vol.29 , pp. 526-533
    • Tang, D.1    Xu, S.2    Zhang, Q.3    Zhao, W.4
  • 27
    • 84864446191 scopus 로고    scopus 로고
    • Prognostic value of androgen receptor expression in operable triple-negative breast cancer: A retrospective analysis based on a tissue microarray
    • He J, Peng R, Yuan Z, Wang S, Peng J, et al. (2012) Prognostic value of androgen receptor expression in operable triple-negative breast cancer: a retrospective analysis based on a tissue microarray. Med Oncol 29: 406-410.
    • (2012) Med Oncol , vol.29 , pp. 406-410
    • He, J.1    Peng, R.2    Yuan, Z.3    Wang, S.4    Peng, J.5
  • 30
    • 84886412350 scopus 로고    scopus 로고
    • Differential Response to Neoadjuvant Chemotherapy Among 7 Triple-Negative Breast Cancer Molecular Subtypes
    • Masuda H, Baggerly KA, Wang Y, Zhang Y, Gonzalez-Angulo AM, et al. (2013) Differential Response to Neoadjuvant Chemotherapy Among 7 Triple-Negative Breast Cancer Molecular Subtypes. Clin Cancer Res 19: 5533-5540.
    • (2013) Clin Cancer Res , vol.19 , pp. 5533-5540
    • Masuda, H.1    Baggerly, K.A.2    Wang, Y.3    Zhang, Y.4    Gonzalez-Angulo, A.M.5
  • 31
    • 33847246805 scopus 로고    scopus 로고
    • Oncomine 3.0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles
    • Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Varambally R, Yu J, et al. (2007) Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia 9: 166-180.
    • (2007) Neoplasia , vol.9 , pp. 166-180
    • Rhodes, D.R.1    Kalyana-Sundaram, S.2    Mahavisno, V.3    Varambally, R.4    Yu, J.5
  • 32
    • 84893694960 scopus 로고    scopus 로고
    • Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Update
    • Wolff AC, Hammond ME, Hicks DG, Dowsett M, McShane LM, et al. (2013) Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Update. Arch Pathol Lab Med.
    • (2013) Arch Pathol Lab Med
    • Wolff, A.C.1    Hammond, M.E.2    Hicks, D.G.3    Dowsett, M.4    McShane, L.M.5
  • 33
    • 84890254448 scopus 로고    scopus 로고
    • Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update
    • Wolff AC, Hammond ME, Hicks DG, Dowsett M, McShane LM, et al. (2013) Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update. J Clin Oncol 31: 3997-4013.
    • (2013) J Clin Oncol , vol.31 , pp. 3997-4013
    • Wolff, A.C.1    Hammond, M.E.2    Hicks, D.G.3    Dowsett, M.4    McShane, L.M.5
  • 34
    • 84872336069 scopus 로고    scopus 로고
    • Heterogeneity of triple-negative breast cancer: Histologic subtyping to inform the outcome
    • Montagna E, Maisonneuve P, Rotmensz N, Cancello G, Iorfida M, et al. (2013) Heterogeneity of triple-negative breast cancer: histologic subtyping to inform the outcome. Clin Breast Cancer 13: 31-39.
    • (2013) Clin Breast Cancer , vol.13 , pp. 31-39
    • Montagna, E.1    Maisonneuve, P.2    Rotmensz, N.3    Cancello, G.4    Iorfida, M.5
  • 35
    • 84867859783 scopus 로고    scopus 로고
    • Clinicopathologic features, patterns of recurrence, and survival among women with triple-negative breast cancer in the National Comprehensive Cancer Network
    • Lin NU, Vanderplas A, Hughes ME, Theriault RL, Edge SB, et al. (2012) Clinicopathologic features, patterns of recurrence, and survival among women with triple-negative breast cancer in the National Comprehensive Cancer Network. Cancer 118: 5463-5472.
    • (2012) Cancer , vol.118 , pp. 5463-5472
    • Lin, N.U.1    Vanderplas, A.2    Hughes, M.E.3    Theriault, R.L.4    Edge, S.B.5
  • 36
    • 60849092546 scopus 로고    scopus 로고
    • Fragile histidine triad protein, WW domain-containing oxidoreductase protein Wwox, and activator protein 2gamma expression levels correlate with basal phenotype in breast cancer
    • Guler G, Huebner K, Himmetoglu C, Jimenez RE, Costinean S, et al. (2009) Fragile histidine triad protein, WW domain-containing oxidoreductase protein Wwox, and activator protein 2gamma expression levels correlate with basal phenotype in breast cancer. Cancer 115: 899-908.
    • (2009) Cancer , vol.115 , pp. 899-908
    • Guler, G.1    Huebner, K.2    Himmetoglu, C.3    Jimenez, R.E.4    Costinean, S.5
  • 37
    • 0242300581 scopus 로고    scopus 로고
    • Androgen Receptor Expression in Estrogen Receptor-Negative Breast Cancer: Immunohistochemical, Clinical, and Prognostic Associations
    • DOI 10.1309/42F0-0D0D-JD0J-5EDT
    • Agoff SN, Swanson PE, Linden H, Hawes SE, Lawton TJ (2003) Androgen receptor expression in estrogen receptor-negative breast cancer. Immunohistochemical, clinical, and prognostic associations. Am J Clin Pathol 120: 725-731. (Pubitemid 37339680)
    • (2003) American Journal of Clinical Pathology , vol.120 , Issue.5 , pp. 725-731
    • Agoff, S.N.1    Swanson, P.E.2    Linden, H.3    Hawes, S.E.4    Lawton, T.J.5
  • 38
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Network CGA
    • Network CGA (2012) Comprehensive molecular portraits of human breast tumours. Nature 490: 61-70.
    • (2012) Nature , vol.490 , pp. 61-70
  • 39
    • 76349117455 scopus 로고    scopus 로고
    • Androgen receptor in breast cancer: Expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation
    • Niemeier LA, Dabbs DJ, Beriwal S, Striebel JM, Bhargava R (2010) Androgen receptor in breast cancer: expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation. Mod Pathol 23: 205-212.
    • (2010) Mod Pathol , vol.23 , pp. 205-212
    • Niemeier, L.A.1    Dabbs, D.J.2    Beriwal, S.3    Striebel, J.M.4    Bhargava, R.5
  • 41
    • 84884165276 scopus 로고    scopus 로고
    • Biological subtypes of triple-negative breast cancer are associated with distinct morphological changes and clinical behaviour
    • Elsawaf Z, Sinn HP, Rom J, Bermejo JL, Schneeweiss A, et al. (2013) Biological subtypes of triple-negative breast cancer are associated with distinct morphological changes and clinical behaviour. Breast 22: 986-992.
    • (2013) Breast , vol.22 , pp. 986-992
    • Elsawaf, Z.1    Sinn, H.P.2    Rom, J.3    Bermejo, J.L.4    Schneeweiss, A.5
  • 42
    • 78049496236 scopus 로고    scopus 로고
    • Intratumoral expression level of epidermal growth factor receptor and cytokeratin 5/6 is significantly associated with nodal and distant metastases in patients with basal-like triple-negative breast carcinoma
    • Sutton LM, Han JS, Molberg KH, Sarode VR, Cao D, et al. (2010) Intratumoral expression level of epidermal growth factor receptor and cytokeratin 5/6 is significantly associated with nodal and distant metastases in patients with basal-like triple-negative breast carcinoma. Am J Clin Pathol 134: 782-787.
    • (2010) Am J Clin Pathol , vol.134 , pp. 782-787
    • Sutton, L.M.1    Han, J.S.2    Molberg, K.H.3    Sarode, V.R.4    Cao, D.5
  • 43
    • 84864387137 scopus 로고    scopus 로고
    • Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors
    • Dean JL, McClendon AK, Hickey TE, Butler LM, Tilley WD, et al. (2012) Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors. Cell Cycle 11: 2756-2761.
    • (2012) Cell Cycle , vol.11 , pp. 2756-2761
    • Dean, J.L.1    McClendon, A.K.2    Hickey, T.E.3    Butler, L.M.4    Tilley, W.D.5
  • 44
    • 84865759481 scopus 로고    scopus 로고
    • Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6
    • Tang LH, Contractor T, Clausen R, Klimstra DS, Du YC, et al. (2012) Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6. Clin Cancer Res 18: 4612-4620.
    • (2012) Clin Cancer Res , vol.18 , pp. 4612-4620
    • Tang, L.H.1    Contractor, T.2    Clausen, R.3    Klimstra, D.S.4    Du, Y.C.5
  • 45
    • 84878067407 scopus 로고    scopus 로고
    • Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases
    • Schonbrunn E, Betzi S, Alam R, Martin MP, Becker A, et al. (2013) Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J Med Chem 56: 3768-3782.
    • (2013) J Med Chem , vol.56 , pp. 3768-3782
    • Schonbrunn, E.1    Betzi, S.2    Alam, R.3    Martin, M.P.4    Becker, A.5
  • 46
    • 84865254684 scopus 로고    scopus 로고
    • Modification of the DNA damage response by therapeutic CDK4/6 inhibition
    • Dean JL, McClendon AK, Knudsen ES (2012) Modification of the DNA damage response by therapeutic CDK4/6 inhibition. J Biol Chem 287: 29075-29087.
    • (2012) J Biol Chem , vol.287 , pp. 29075-29087
    • Dean, J.L.1    McClendon, A.K.2    Knudsen, E.S.3
  • 47
    • 84864378859 scopus 로고    scopus 로고
    • CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy
    • McClendon AK, Dean JL, Rivadeneira DB, Yu JE, Reed CA, et al. (2012) CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy. Cell Cycle 11: 2747-2755.
    • (2012) Cell Cycle , vol.11 , pp. 2747-2755
    • McClendon, A.K.1    Dean, J.L.2    Rivadeneira, D.B.3    Yu, J.E.4    Reed, C.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.