Potential involvement of μ-opioid receptor dysregulation on the reduced antinociception of morphine in the inflammatory pain state in mice

Journal of Pharmacological Sciences

Volumn 124, Issue 2, 2014, Pages 258-266

  Aoki, Yuta ^a   Mizoguchi, Hirokazu ^a   Watanabe, Chizuko ^a   Takeda, Kumiko ^a   Sakurada, Tsukasa ^b   Sakurada, Shinobu ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b DAIICHI UNIVERSITY OF PHARMACY   (Japan)

Author keywords

Antinociception; Inflammatory pain; Morphine; Protein kinase C; opioid receptor

Indexed keywords

3 [8 [(DIMETHYLAMINO)METHYL] 6,7,8,9 TETRAHYDROPYRIDO[1,2 A]INDOL 10 YL] 4 (1 METHYL 1H INDOL 3 YL) 1H PYRROLE 2,5 DIONE; FREUND ADJUVANT; MESSENGER RNA; MORPHINE; MU OPIATE RECEPTOR; PROTEIN KINASE C ALPHA;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG RESPONSE; ENZYME PHOSPHORYLATION; GENE EXPRESSION; INFLAMMATORY PAIN; LUMBAR SPINAL CORD; MALE; MECHANICAL ALLODYNIA; MECHANICAL STRESS; MOUSE; NONHUMAN; RECEPTOR DOWN REGULATION; SPINAL GANGLION; VON FREY TEST;

ANALGESICS, OPIOID; ANIMALS; DISEASE MODELS, ANIMAL; FREUND'S ADJUVANT; GANGLIA, SPINAL; HYPERALGESIA; INDOLES; INFLAMMATION; INJECTIONS, SUBCUTANEOUS; MALE; MICE; MICE, INBRED STRAINS; MORPHINE; PAIN; PHOSPHORYLATION; PROTEIN KINASE C-ALPHA; PYRROLES; RECEPTORS, OPIOID, MU; SPINAL CORD;

EID: 84895521038     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.13242FP     Document Type: Article

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