Suboptimal adherence to doxycycline and treatment outcomes among men with non-gonococcal urethritis: A prospective cohort study

Sexually Transmitted Infections

Volumn 90, Issue 1, 2014, Pages 3-7

  Khosropour, Christine M ^a   Manhart, Lisa E ^a   Colombara, Danny V ^a   Gillespie, Catherine W ^a,c   Lowens, M Sylvan ^b   Totten, Patricia A ^a   Golden, Matthew R ^a,b   Simoni, Jane ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b PUBLIC HEALTH SEATTLE AND KING COUNTY   (United States)

^c CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; DOXYCYCLINE; PLACEBO;

ADOLESCENT; ADULT; ANTIBIOTIC THERAPY; ARTICLE; BIOTYPE; CHLAMYDIA TRACHOMATIS; COHORT ANALYSIS; CONDOM USE; CONTROLLED STUDY; DIARRHEA; DISEASE ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICATION COMPLIANCE; MIDDLE AGED; MYCOPLASMA GENITALIUM; NAUSEA; NONSPECIFIC URETHRITIS; NUCLEIC ACID AMPLIFICATION; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PERSISTENT INFECTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RASH; SEXUAL BEHAVIOR; SINGLE DRUG DOSE; UREAPLASMA UREALYTICUM; URINALYSIS; VOMITING; YOUNG ADULT;

ADHERENCE; ANTIBIOTICS; CHLAMYDIA INFECTION; URETHRITIS;

ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CHLAMYDIA INFECTIONS; COHORT STUDIES; DOXYCYCLINE; HUMANS; MALE; MEDICATION ADHERENCE; MIDDLE AGED; MYCOPLASMA INFECTIONS; NUCLEIC ACID AMPLIFICATION TECHNIQUES; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; TREATMENT FAILURE; UREAPLASMA INFECTIONS; URETHRITIS; URINE;

EID: 84895517399     PISSN: 13684973     EISSN: 14723263     Source Type: Journal    
DOI: 10.1136/sextrans-2013-051174     Document Type: Article

References (20)

1. Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep 2010;59(RR-12): 1-110.
2. Lau CY, Qureshi AK. Azithromycin versus doxycycline for genital chlamydial infections: a meta-analysis of randomized clinical trials. Sex Transm Dis 2002;29: 497-502.
3. Stamm WE, Hicks CB, Martin DH, et al. Azithromycin for empirical treatment of the nongonococcal urethritis syndrome in men. A randomized double-blind study. JAMA 1995;274: 545-9.
4. Schwebke JR, Rompalo A, Taylor S, et al. Re-evaluating the treatment of nongonococcal urethritis: emphasizing emerging pathogens-a randomized clinical trial. Clin Infect Dis 2011;52: 163-70.
5. Manhart LE, Gillespie CW, Lowens MS, et al. Standard treatment regimens for nongonococcal urethritis have similar but declining cure rates: a randomized controlled trial. Clin Infect Dis 2013;56: 934-42.
6. Mena LA, Mroczkowski TF, Nsuami M, et al. A randomized comparison of azithromycin and doxycycline for the treatment of Mycoplasma genitalium-positive urethritis in men. Clin Infect Dis 2009;48: 1649-54.
7. Falk L, Fredlund H, Jensen JS. Tetracycline treatment does not eradicate Mycoplasma genitalium. Sex Transm Infect 2003;79: 318-19.
8. Katz BP, Caine VA, Batteiger BE, et al. A randomized trial to compare 7- and 21-day tetracycline regimens in the prevention of recurrence of infection with Chlamydia trachomatis. Sex Transm Dis 1991;18: 36-40.
9. Katz BP, Zwickl BW, Caine VA, et al. Compliance with antibiotic therapy for Chlamydia trachomatis and Neisseria gonorrhoeae. Sex Transm Dis 1992; 19: 351-4.
10. Augenbraun M, Bachmann L, Wallace T, et al. Compliance with doxycycline therapy in sexually transmitted diseases clinics. Sex Transm Dis 1998;25: 1-4.
11. Bachmann LH, Stephens J, Richey CM, et al. Measured versus self-reported compliance with doxycycline therapy for chlamydia-associated syndromes: high therapeutic success rates despite poor compliance. Sex Transm Dis 1999;26: 272-8.
12. Dutro SM, Hebb JK, Garin CA, et al. Development and performance of a microwell-plate-based polymerase chain reaction assay for Mycoplasma genitalium. Sex Transm Dis 2003;30: 756-63.
13. Kenny GE. Mycoplasmata. In: Lenette E, Balows A, Hausler WJ, et al. eds. Manual of Clinical Microbiology. Washington, DC: American Society for Microbiology, 1980: 365-70.
14. Ondondo RO, Whittington WL, Astete SG, et al. Differential association of ureaplasma species with non-gonococcal urethritis in heterosexual men. Sex Transm Infect 2010;86: 271-5.
15. Liu H, Golin CE, Miller LG, et al. A comparison study of multiple measures of adherence to HIV protease inhibitors. Ann Intern Med 2001;134: 968-77.
16. Simoni JM, Kurth AE, Pearson CR, et al. Self-report measures of antiretroviral therapy adherence: a review with recommendations for HIV research and clinical management. AIDS Behav 2006;10: 227-45.
17. Bangsberg DR, Hecht FM, Clague H, et al. Provider assessment of adherence to HIV antiretroviral therapy. J Acquir Immune Defic Syndr 2001;26: 435-42.
18. Zou G. A modified poisson regression approach to prospective studies with binary data. Am J Epidemiol 2004;159: 702-6.
19. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005;353: 487-97.
20. Centers for Disease Control and Prevention. Guidelines for the laboratory diagnosis of gonorrhea, chlamydia and syphilis. http://www.aphl.org