Measured versus self-reported compliance with doxycycline therapy for chlamydia-associated syndromes: High therapeutic success rates despite poor compliance

Sexually Transmitted Diseases

Volumn 26, Issue 5, 1999, Pages 272-280

  Bachmann, Laura H ^a   Stephens, Joan ^b   Richey, Charity M ^a   Hook III, Edward W ^a,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b Jefferson County Department of Health   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE;

ADOLESCENT; ADULT; ARTICLE; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; DRUG MONITORING; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PATIENT COMPLIANCE; POLYMERASE CHAIN REACTION; SELF REPORT; TREATMENT OUTCOME;

EID: 0032897682     PISSN: 01485717     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007435-199905000-00006     Document Type: Article

References (26)

1. Whatley JD, Thin RN, Mumtaz G, Ridgway GL. Azithromycin vs doxycycline in the treatment of non-gonococcal urethritis. Int J STD AIDS 1991; 2:248-251.
2. Stamm WE, Hicks CB, Martin DH, et al. Azithromycin for empirical treatment of the nongonococcal urethritis syndrome in men: a randomized double-blind study. JAMA 1995; 274:545-549.
3. Thorpe EM, Stamm WE, Hook EW, et al. Chlamydial cervicitis and urethritis: single dose treatment compared with doxycycline for seven days in community based practices. Genitourin Med 1996; 72:93-97.
4. Martin DH, Mroczkowski TF, Dalu ZA, et al. Controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. N Engl J Med 1992; 327:921-925.
5. Augenbraun M, Bachmann L, Wallace T, DuBouchet L, McCormack W, Hook EW III. Compliance with doxycycline therapy in sexually transmitted diseases clinics. Sex Trans Dis 1998; 25:1-4.
6. The Gallup Organization. Consumer attitudes toward antibiotic use. Conducted for the American Lung Association. February 1995.
7. Katz B, Caine V, Batteiger B, Jones R. A randomized trial to compare 7- and 21-day tetracycline regimens in the prevention of recurrence of infection with Chlamydia trachomatis. Sex Trans Dis 1991; 18:36-40.
8. Katz B, Zwickl B, Caine V, Jones R. Compliance with antibiotic therapy for Chlamydia trachomatis and Neisseria gonorrhoeae. Sex Trans Dis 1992; 19:351-354.
9. Brookoff D. Compliance with doxycycline therapy for outpatient treatment of pelvic inflammatory disease. South Med J 1994; 87: 1088-1091.
10. Cramer J. Microelectronic systems for monitoring and enhancing patient compliance with medication regimens. Drugs 1995; 49:321-327.
11. Brunham R, Paavonen J, Stevens C, et al. Mucopurulent cervicitis -the ignored counterpart in women of urethritis in men. N Engl J Med 1984; 311:1-6.
12. Hook EW III, Ching SF, Stephens J. Diagnosis of Neisseria gonorrhoeae infections in women by using the ligase chain reaction on patient-obtained vaginal swabs. J Clin Micro 1997; 35:2129-2132.
13. Parks KS, Dixon PB, Richey CM, Hook EW III. Spontaneous clearance of Chlamydia trachomatis infection in untreated patients. Sex Trans Dis 1997; 24:229-235.
14. SAS Institute Inc. SAS/STAT User's Guide, Version 6, Fourth Edition, Volume 1. Cary, NC: SAS Institute Inc., 1989.
15. Dean AG, Dean JA, Coubombier D, et al. Epi Info, Version 6: A word processing, database and statistics program for epidemiology on microcomputers. Atlanta: Centers for Disease Control and Prevention, 1994.
16. Anastasio GD, Little TM, Robinson MD, Pettice YL, Leitch BB, Norton JH. Impact of compliance and side effects on the clinical outcome of patients treated with oral erythromycin. Pharmacotherapy 1994; 14:229-234.
17. Matsui D, Hermann C, Klein J. Critical comparison of novel and existing methods of compliance assessment during a clinical trial of an oral iron chelator. J Clin Pharmacol 1994; 34:944-949.
18. Kruse W, Weber E. Dynamics of drug regimen compliance - its assessment by microprocessor-based monitoring. Eur J Clin Pharmacol 1990; 38:561-565.
19. Kruse W, Eggert-Kruse W, Rampmaier J, Runnebaum B, Weber E. Compliance and adverse drug reactions: a prospective study with ethinylestradiol using continuous compliance monitoring. Clin Invest 1993; 71:483-487.
20. Pullar T, Kumar S, Tindall H, Feely M. Time to stop counting the tablets? Clin Pharmacol Ther 1989; 46:163-168.
21. Tetracyclines. In: Cada D, et al. Drug Facts and Comparisons. St. Louis, MO: Facts and Comparisons, 1992:1818-1819.
22. Silverman N, Sullivan M, Hochman M, Womack M, Jungkind D. A randomized prospective trial comparing amoxicillin and erythromycin for the treatment of Chlamydia trachomatis in pregnancy. Am J Obstet Gynecol 1994; 170:829-832.
23. Handsfield HH, Stamm WE. Treating chlamydial infection: compliance versus cost. Sex Trans Dis 1998; 25:12-13.
24. Workowski K, Lampe M, Wong K, Watts M, Stamm W. Long-term eradication of Chlamydia trachomatis genital infection after antimicrobial therapy: evidence against persistent infection. JAMA 1993; 270:2071-2075.
25. Hillis SD, Coles FB, Litchfield B, et al. Doxycycline and azithromycin for prevention of chlamydial persistence or recurrence one month after treatment in women: a use-effectiveness study in public health settings. Sex Trans Dis 1998; 25:5-11.
26. Division of STD Prevention. Sexually Transmitted Disease Surveillance, 1996 US Department of Health and Human Services, Public Health Service. Atlanta: Centers for Disease Control and Prevention, 1997.