From gut to brain: Bioencapsulated therapeutic protein reduces amyloid load upon oral delivery

Molecular Therapy

Volumn 22, Issue 3, 2014, Pages 485-486

  Mäger, Imre ^a,b   Roberts, Thomas C ^a,c   Wood, Matthew J A ^a   El Andaloussi, Samir ^a,d  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF TARTU   (Estonia)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; CHOLERA TOXIN B SUBUNIT; CHOLERA TOXIN B SUBUNIT MYELIN BASIC PROTEIN FUSION PROTEIN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MYELIN BASIC PROTEIN; OLIGOMER; SMALL INTERFERING RNA; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOID PLAQUE; BIOENCAPSULATION; BLOOD BRAIN BARRIER; BLOOD RETINA BARRIER; BRAIN CORTEX; ENCAPSULATION; ENZYME ACTIVITY; HIPPOCAMPUS; INTESTINE FLORA; MOLECULAR WEIGHT; NEUROFIBRILLARY TANGLE; NONHUMAN; NOTE; PATHOPHYSIOLOGY; PLANT CELL; PROTEIN DEGRADATION; RETINA; STOMACH; TRANSCYTOSIS;

ALZHEIMER DISEASE; AMINOPEPTIDASES; ANIMALS; APOLIPOPROTEINS E; BLOOD-BRAIN BARRIER; BLOOD-RETINAL BARRIER; CHLOROPLASTS; CHOLERA TOXIN; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; FEMALE; HUMANS; MALE; MYELIN BASIC PROTEIN; NEURONAL CEROID-LIPOFUSCINOSES; PEPTIDES; PLAQUE, AMYLOID; SERINE PROTEASES;

EID: 84895425924     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2014.13     Document Type: Note

References (9)

1. Kohli, N, Westerveld, DR, Ayache, AC, Verma, A, Shil, P, Prasad, T et al. (2014). Oral delivery of bioencapsulated proteins across blood-brain and blood-retinal barriers. Mol Ther 22: 535-546.
2. Pardridge, WM (2012). Drug transport across the blood-brain barrier. J Cereb Blood Flow Metab 32: 1959-1972.
3. Alvarez-Erviti, L, Seow, Y, Yin, H, Betts, C, Lakhal, S and Wood, MJA (2011). Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol 29: 341-345.
4. Meng, Y, Sohar, I, Sleat, DE, Richardson, JR, Reuhl, KR, Jenkins, RB et al. (2014). Effective intravenous therapy for neurodegenerative disease with a therapeutic enzyme and a peptide that mediates delivery to the brain. Mol Ther 22: 547-553.
5. Kwon, K-C, Verma, D, Singh, ND, Herzog, R and Daniell, H (2013). Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cells. Adv Drug Deliv Rev 65: 782-799.
6. Liao, MC, Ahmed, M, Smith, SO, Van Nostrand, WE (2009). Degradation of amyloid beta protein by purified myelin basic protein. J Biol Chem 284: 28917-28925.
7. Limaye, A, Koya, V, Samsam, M and Daniell, H (2006). Receptor-mediated oral delivery of a bioencapsulated green fluorescent protein expressed in transgenic chloroplasts into the mouse circulatory system. FASEB J 20: 959-961.
8. Zimran, A, Brill-Almon, E, Chertkoff, R, Petakov, M, Blanco-Favela, F, Muñoz, ET et al. (2011). Pivotal trial with plant cell-expressed recombinant glucocerebrosidase, taliglucerase alfa, a novel enzyme replacement therapy for Gaucher disease. Blood 118: 5767-5773.
9. Hill, DR, Ford, L and Lalloo, DG (2006). Oral cholera vaccines: use in clinical practice. Lancet Infect Dis 6: 361-373.