Confocal laser endomicroscopy for prediction of disease relapse in ulcerative colitis: A pilot study

Journal of Crohn's and Colitis

Volumn 8, Issue 4, 2014, Pages 304-311

  Buda, Andrea ^a   Hatem, Giorgia ^a   Neumann, Helmut ^a   D' Incà, Renata ^a   Mescoli, Claudia ^b   Piselli, Pierluca ^a   Jackson, John ^c   Bruno, Marco ^d   Sturniolo, Giacomo Carlo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Confocal laser endomicroscopy; Microvasculature; Mucosal healing; Relapse; Ulcerative colitis

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL EVALUATION; COHORT ANALYSIS; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DISEASE EXACERBATION; FEMALE; FLUORESCENCE; FOLLOW UP; HISTOLOGY; HUMAN; IMAGE PROCESSING; MALE; MIDDLE AGED; OUTCOME ASSESSMENT; PILOT STUDY; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RELAPSE; REMISSION; ULCERATIVE COLITIS; CLINICAL TRIAL; COLITIS, ULCERATIVE; COLON; COLONOSCOPY; CONFOCAL MICROSCOPY; INTESTINE MUCOSA; MICROVASCULATURE; PATHOLOGY; PROCEDURES; RECURRENT DISEASE; VASCULARIZATION;

COLITIS, ULCERATIVE; COLON; COLONOSCOPY; FEMALE; HUMANS; INTESTINAL MUCOSA; MALE; MICROSCOPY, CONFOCAL; MICROVESSELS; MIDDLE AGED; PILOT PROJECTS; RECURRENCE;

EID: 84895422000     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1016/j.crohns.2013.09.005     Document Type: Article

References (34)

1. Geboes K. Histopathology of Crohn's disease and ulcerative colitis. Inflammatory bowel disease 2003, 255-276. Churchill Livingstone, Edinburgh, London, Melbourne. J. Satsangi, L.R. Sutherland, J.F. Colombel, C. Fiocci, R. Lofberg, J. Pemberton, P. Rutgeerts (Eds.).
2. Geboes K., Riddell R., Ost A., Jensfelt B., Persson T., Löfberg R. A reproducible grading scale for histological assessment of inflammation in ulcerative colitis. Gut Sep 2000, 47(3):404-409.
3. Geboes K., Ectors N., D'Haens G., Rutgeerts P. Is ileoscopy with biopsy worthwhile in patients presenting with symptoms of inflammatory bowel disease?. Am J Gastroenterol 1998, 93:201-206.
4. Powell-Tuck J., Day D.W., Buckell N.A., Wadsworth J., Lennard-Jones J.E. Correlations between defined sigmoidoscopic appearances and other measures of disease activity in ulcerative colitis. Dig Dis Sci 1982, 27:533-537.
5. Yantiss R.K., Odze R.D. Pitfalls in the interpretation of nonneoplastic mucosal biopsies in inflammatory bowel disease. Am J Gastroenterol 2007, 102:890-904.
6. Neurath M.F., Travis S.P. Mucosal healing in inflammatory bowel diseases: a systematic review. Gut 2012, 61:1619-1635.
7. Deban L., Correale C., Vetrano S., Malesci A., Danese S. Multiple pathogenic roles of microvasculature in inflammatory bowel disease: a jack of all trades. Am J Pathol 2008, 172(6):1457-1466.
8. Cines D.B., Pollak E.S., Buck C.A., Loscalzo J., Zimmerman G.A., McEver R.P., et al. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood May 15 1998, 91(10):3527-3561.
9. Danese S., Sans M., Scaldaferri F., Sgambato A., Rutella S., Cittadini A., et al. TNF-alpha blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation: a novel anti-inflammatory mechanism of infliximab in Crohn's disease. J Immunol 2006, 176:2617-2624.
10. Neumann H., Kiesslich R. Endomicroscopy and endocytoscopy in IBD. Gastrointest Endosc Clin N Am Jul 2013, 23(3):695-705.
11. Murthy S.K., Kiesslich R. Evolving endoscopic strategies for detection and treatment of neoplastic lesions in inflammatory bowel disease. Gastrointest Endosc Mar 2013, 77(3):351-359.
12. Li C.Q., Xie X.J., Yu T., Gu X.M., Zuo X.L., Zhou C.J., et al. Classification of inflammation activity in ulcerative colitis by confocal laser endomicroscopy. Am J Gastroenterol Jun 2010, 105(6):1391-1396.
13. Wallace M., Lauwers G.Y., Chen Y., Dekker E., Fockens P., Sharma P., et al. Miami classification for probe-based confocal laser endomicroscopy. Endoscopy Oct 2011, 43(10):882-891.
14. Neumann H., Vieth M., Atreya R., Grauer M., Siebler J., Bernatik T., et al. Assessment of Crohn's disease activity by confocal laser endomicroscopy. Inflamm Bowel Dis Dec 2012, 18(12):2261-2269.
15. D'Haens G., Sandborn W.J., Feagan B.G., Geboes K., Hanauer S.B., Irvine E.J., et al. A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology Feb 2007, 132(2):763-786.
16. Goetz M., Kiesslich R. Advances of endomicroscopy for gastrointestinal physiology and diseases. Am J Physiol Gastrointest Liver Physiol Jun 2010, 298(6):G797-G806.
17. Gheonea D.I., Saftoiu A., Ciurea T., Popescu C., Georgescu C.V., Malos A. Confocal laser endomicroscopy of the colon. J Gastrointestin Liver Dis Jun 2010, 19(2):207-211.
18. De Palma G.D. Confocal laser endomicroscopy in the "in vivo" histological diagnosis of the gastrointestinal tract. World J Gastroenterol Dec 14 2009, 15(46):5770-5775.
19. Salvatori F., Siciliano S., Maione F., Esposito D., Masone S., Persico M., et al. Confocal laser endomicroscopy in the study of colonic mucosa in IBD patients: a review. Gastroenterol Res Pract 2012, 2012:525098.
20. Becker V., Vercauteren T., von Weyhern C.H., Prinz C., Schmid R.M., Meining A. High-resolution miniprobe-based confocal microscopy in combination with video mosaicing (with video). Gastrointest Endosc Nov 2007, 66(5):1001.
21. van den Broek F.J., van Es J.A., van Eeden S., Stokkers P.C., Ponsioen C.Y., Reitsma J.B., et al. Pilot study of probe-based confocal laser endomicroscopy during colonoscopic surveillance of patients with longstanding ulcerative colitis. Endoscopy Feb 2011, 43(2):116-122.
22. Becker V., von Delius S., Bajbouj M., Karagianni A., Schmid R.M., Meining A. Intravenous application of fluorescein for confocal laser scanning microscopy: evaluation of contrast dynamics and image quality with increasing injection-to-imaging time. Gastrointest Endosc 2008, 68:319-323.
23. Mottet N.K. Intestinal histopathology of ulcerative colitis. Histopathologic spectrum of regional enteritis and ulcerative colitis 1971, W.B. Saunders, Philadelphia. J.L. Bennington (Ed.).
24. Wallace M.B., Meining A., Canto M.I., Fockens P., Miehlke S., Roesch T., et al. The safety of intravenous fluorescein for confocal laser endomicroscopy in the gastrointestinal tract. Aliment Pharmacol Ther Mar 2010, 31(5):548-552.
25. Nguyen N.Q., Leong R.W. Current application of confocal endomicroscopy in gastrointestinal disorders. J Gastroenterol Hepatol Oct 2008, 23(10):1483-1491.
26. Neumann H., Kiesslich R., Wallace M.B., Neurath M.F. Confocal laser endomicroscopy: technical advances and clinical applications. Gastroenterology Aug 2010, 139(2):388-392.
27. De Cruz P., Kamm M.A., Prideaux L., Allen P.B., Moore G. Mucosal healing in Crohn's disease: a systematic review. Inflamm Bowel Dis Feb 2013, 19(2):429-444.
28. Tibble J.A., Sigthorsson G., Bridger S., Fagerhol M.K., Bjarnason I. Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease. Gastroenterology Jul 2000, 119(1):15-22.
29. Rutter M., Saunders B., Wilkinson K., Rumbles S., Schofield G., Kamm M., et al. Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology Feb 2004, 126(2):451-459.
30. Riley S.A., Mani V., Goodman M.J., Dutt S., Herd M.E. Microscopic activity in ulcerative colitis: what does it mean?. Gut Feb 1991, 32(2):174-178.
31. Watanabe O., Ando T., Maeda O., Hasegawa M., Ishikawa D., Ishiguro K., et al. Confocal endomicroscopy in patients with ulcerative colitis. J Gastroenterol Hepatol Dec 2008, 23(Suppl. 2):S286-S290.
32. Kiesslich R., Duckworth C.A., Moussata D., Gloeckner A., Lim L.G., Goetz M., et al. Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. Gut Aug 2012, 61(8):1146-1153.
33. Paggi S., Rondonotti E., Amato A., Terruzzi V., Imperiali G., Mandelli G., et al. Resect and discard strategy in clinical practice: a prospective cohort study. Endoscopy Oct 2012, 44(10):899-904.
34. Rutgeerts P., Vermeire S., Van Assche G. Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target?. Gut Apr 2007, 56(4):453-455.