FGF19: How gut talks to brain to keep your sugar down

Molecular Metabolism

Volumn 3, Issue 1, 2014, Pages 3-4

  Stanley, Sarah ^a   Buettner, Christoph ^b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84895095805     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2013.10.008     Document Type: Note

References (11)

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2. Pournaras D.J., Glicksman C., Vincent R.P., Kuganolipava S., Alaghband-Zadeh J., Mahon D., et al. The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control. Endocrinology 2012, 153(8):3613-3619.
3. Marcelin G., Jo Y.-H., Li X., Schwartz G., Zhang Y., Dun N.J., et al. Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism. Molecular Metabolism 2013, 3. 10.1016/j.molmet.2013.10.002.
4. Ryan K.K., Kohli R., Gutierrez-Aguilar R., Gaitonde S.G., Woods S.C., Seeley R.J. Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats. Endocrinology 2013, 154(1):9-15.
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7. Obici S., Feng Z., Arduini A., Conti R., Rossetti L. Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nature Medicine 2003, 9(6):756-761.
8. Scherer T., O'Hare J., Diggs-Andrews K., Schweiger M., Cheng B., Lindtner C., et al. Brain insulin controls adipose tissue lipolysis and lipogenesis. Cell Metabolism 2011, 13(2):183-194.
9. Mighiu P.I., Yue J.T., Filippi B.M., Abraham M.A., Chari M., Lam C.K., et al. Hypothalamic glucagon signaling inhibits hepatic glucose production. Nature Medicine 2013, 19(6):766-772.
10. Batterham R.L., Cowley M.A., Small C.J., Herzog H., Cohen M.A., Dakin C.L., et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 2002, 418(6898):650-654.
11. Fu T., Choi S.E., Kim D.H., Seok S., Suino-Powell K.M., Xu H.E., et al. Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor beta-Klotho. Proceedings of the National Academy of Sciences of the United States of America 2012, 109(40):16137-16142.