Coeliac disease screening in first-degree relatives on the basis of biopsy and genetic risk

European Journal of Gastroenterology and Hepatology

Volumn 26, Issue 3, 2014, Pages 263-267

  Vaquero, Luis ^a   Caminero, Alberto ^b   Nuñez, Alejandro ^a   Hernando, Mercedes ^a   Iglesias, Cristina ^a   Casqueiro, Javier ^b   Vivas, Santiago ^a,b  

^a Hospital of Leon   (Spain)

^b UNIVERSITY OF LEÓN   (Spain)

Author keywords

Coeliac disease; Gluten free diet; Human leukocyte antigen typing; Lymphocytic enteritis; Screening

Indexed keywords

ADOLESCENT; ADULT; AGED; AUTOANTIBODIES; BIOLOGICAL MARKERS; BIOPSY; CELIAC DISEASE; DUODENUM; DYSPEPSIA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GTP-BINDING PROTEINS; HISTOCOMPATIBILITY TESTING; HLA-DQ ANTIGENS; HUMANS; MALE; MASS SCREENING; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; TRANSGLUTAMINASES; YOUNG ADULT;

EID: 84895075517     PISSN: 0954691X     EISSN: 14735687     Source Type: Journal    
DOI: 10.1097/MEG.0000000000000020     Document Type: Article

References (26)

1. Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA. American College of Gastroenterology. ACG clinical guidelines: diagnosis and management of celiac disease. Am J Gastroenterol 2013; 108:656-676, quiz 677.
2. Dube C, Rostom A, Sy R, Cranney A, Saloojee N, Garritty C, et al. The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review. Gastroenterology 2005; 128:S57-S67.
3. Vivas S, Ruiz de Morales JM, Fernandez M, Hernando M, Herrero B, Casqueiro J, et al. Age-related clinical, serological, and histopathological features of celiac disease. Am J Gastroenterol 2008; 103:2360-2365, quiz 2366.
4. Vivas S, Ruiz de Morales JG, Riestra S, Arias L, Fuentes D, Alvarez N, et al. Duodenal biopsy may be avoided when high transglutaminase antibody titers are present. World J Gastroenterol 2009; 15: 4775-4780.
5. Esteve M, Rosinach M, Fernandez-Banares F, Farre C, Salas A, Alsina M, et al. Spectrum of gluten-sensitive enteropathy in first-degree relatives of patients with coeliac disease: clinical relevance of lymphocytic enteritis. Gut 2006; 55: 1739-1745.
6. Walker-Smith JA, Guandalini S, Schmitz J, Shmerling DH, Visakorpi JK. Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child 1990; 65: 909-911.
7. Fernandez ML, Vivas S, Ruiz de Morales JM, Marugan JM. Usefulness of anti-transglutaminase antibodies in the diagnosis of celiac disease. Gastroenterol Hepatol 2005; 28: 437-440.
8. Vivas S, Ruiz de Morales JM, Martinez J, Gonzalez MC, Martin S, Martin J, et al. Human recombinant anti-transglutaminase antibody testing is useful in the diagnosis of silent coeliac disease in a selected group of at-risk patients. Eur J Gastroenterol Hepatol 2003; 15: 479-483.
9. Olerup O, Aldener A, Fogdell A. HLA-DQB1 and -DQA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours. Tissue Antigens 1993; 41: 119-134.
10. Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol 1999; 11: 1185-1194.
11. Farre C, Humbert P, Vilar P, Varea V, Aldeguer X, Carnicer J, et al. Serological markers and HLA-DQ2 haplotype among first-degree relatives of celiac patients. Catalonian Coeliac Disease Study Group. Dig Dis Sci 1999; 44: 2344-2349.
12. Dogan Y, Yildirmaz S, Ozercan IH. Prevalence of celiac disease among firstdegree relatives of patients with celiac disease. J Pediatr Gastroenterol Nutr 2012; 55: 205-208.
13. Vitoria JC, Arrieta A, Astigarraga I, Garcia-Masdevall D, Rodriguez-Soriano J. Use of serological markers as a screening test in family members of patients with celiac disease. J Pediatr Gastroenterol Nutr 1994; 19: 304-309.
14. Book L, Zone JJ, Neuhausen SL. Prevalence of celiac disease among relatives of sib pairs with celiac disease in U.S. families. Am J Gastroenterol 2003; 98: 377-381.
15. Biagi F, Campanella J, Bianchi PI, Zanellati G, Capriglione I, Klersy C, et al. The incidence of coeliac disease in adult first degree relatives. Dig Liver Dis 2008; 40: 97-100.
16. Rostom A, Dube C, Cranney A, Saloojee N, Sy R, Garritty C, et al. The diagnostic accuracy of serologic tests for celiac disease: a systematic review. Gastroenterology 2005; 128:S38-S46.
17. Bonamico M, Ferri M, Mariani P, Nenna R, Thanasi E, Luparia RP, et al. Serologic and genetic markers of celiac disease: a sequential study in the screening of first degree relatives. J Pediatr Gastroenterol Nutr 2006; 42: 150-154.
18. Biagi F, Corazza GR. First-degree relatives of celiac patients: are they at an increased risk of developing celiac disease? J Clin Gastroenterol 2009; 43: 3-4.
19. Chang M, Green PH. Genetic testing before serologic screening in relatives of patients with celiac disease as a cost containment method. J Clin Gastroenterol 2009; 43: 43-50.
20. Santolaria Piedrafita S, Fernandez Banares F. Gluten-sensitive enteropathy and functional dyspepsia. Gastroenterol Hepatol 2012; 35: 78-88.
21. Biagi F, Bianchi PI, Vattiato C, Marchese A, Trotta L, Badulli C, et al. Influence of HLA-DQ2 and DQ8 on severity in celiac disease. J Clin Gastroenterol 2012; 46: 46-50.
22. Megiorni F, Mora B, Bonamico M, Barbato M, Nenna R, Maiella G, et al. HLA-DQ and risk gradient for celiac disease. Hum Immunol 2009; 70: 55-59.
23. Fabiani E, Taccari LM, Ratsch IM, Di Giuseppe S, Coppa GV, Catassi C. Compliance with gluten-free diet in adolescents with screening-detected celiac disease: a 5-year follow-up study. J Pediatr 2000; 136: 841-843.
24. Ciacci C, Cirillo M, Cavallaro R, Mazzacca G. Long-term follow-up of celiac adults on gluten-free diet: prevalence and correlates of intestinal damage. Digestion 2002; 66: 178-185.
25. Lebwohl B, Granath F, Ekbom A, Smedby KE, Murray JA, Neugut AI, et al. Mucosal healing and risk for lymphoproliferative malignancy in celiac disease: a population-based cohort study. Ann Intern Med 2013; 159: 169-175.
26. Rosinach M, Esteve M, Gonzalez C, Temino R, Marine M, Monzon H, et al. Lymphocytic duodenosis: aetiology and long-term response to specific treatment. Dig Liver Dis 2012; 44:643-648.