Aspirin reduces lung cancer metastasis to regional lymph nodes

Biomedicine and Pharmacotherapy

Volumn 68, Issue 1, 2014, Pages 79-86

  Ogawa, Fumihiro ^a   Amano, Hideki ^a   Ito, Yoshiya ^a   Matsui, Yoshio ^a   Hosono, Kanako ^a   Kitasato, Hidero ^b   Satoh, Yukitoshi ^a   Majima, Masataka ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

Aspirin; Lung cancer; Lymph node metastasis

Indexed keywords

ASPIRIN; LUNG CANCER; LYMPH NODE METASTASIS;

ANIMALS; ASPIRIN; CARCINOMA, LEWIS LUNG; CYCLOOXYGENASE INHIBITORS; GREEN FLUORESCENT PROTEINS; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MEDIASTINUM; MICE; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; SURVIVAL RATE; TIME FACTORS;

EID: 84895075463     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2013.11.006     Document Type: Article

References (33)

1. Jemal A., Siegel R., Xu J., Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010, 60:277-300.
2. Siegel R., Naishadham D., Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012, 62:10-29.
3. SEER Cancer Statistics Review 1975-2010 2013, Cancer Statistics. N.N.A. Howlader, M. Krapcho, J. Garshell, N. Neyman, S.F. Altekruse, C.L. Kosary, M. Yu, J. Ruhl, Z. Tatalovich, H. Cho, A. Mariotto, D.R. Lewis, H.S. Chen, E.J. Feuer, K.A. Cronin (Eds.).
4. Sandler A., Gray R., Perry M.C., et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006, 355:2542-2550.
5. Chaffer C.L., Weinberg R.A. A perspective on cancer cell metastasis. Science 2011, 331:1559-1564.
6. Fidler I.J. The pathogenesis of cancer metastasis: the "seed and soil" hypothesis revisited. Nat Rev Cancer 2003, 3:453-458.
7. Joyce J.A., Pollard J.W. Microenvironmental regulation of metastasis. Nat Rev Cancer 2009, 9:239-252.
8. Dannenberg A.J., Subbaramaiah K. Targeting cyclooxygenase-2 in human neoplasia: rationale and promise. Cancer Cell 2003, 4:431-436.
9. Amano H., Hayashi I., Endo H., et al. Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. J Exp Med 2003, 197:221-232.
10. Hosono K., Suzuki T., Tamaki H., et al. Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation. Arterioscler Thromb Vasc Biol 2011, 31:1049-1058.
11. Kashiwagi S.H.K., Suzuki T., Takeda A., Uchinuma E., Majima M. Role of COX-2 in lymphangiogenesis and restorationof lymphatic flow in secondary lymphedema. Lab Invest 2011, 91:12.
12. Katoh H., Hosono K., Ito Y., et al. COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems. Am J Pathol 2010, 176:1469-1483.
13. Kubo H., Hosono K., Suzuki T., et al. Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis. Biomed Pharmacother 2010, 64:101-106.
14. Majima M., Amano H., Hayashi I. Prostanoid receptor signaling relevant to tumor growth and angiogenesis. Trends Pharmacol Sci 2003, 24:524-529.
15. Oshima M., Dinchuk J.E., Kargman S.L., et al. Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 1996, 87:803-809.
16. Thun M.J.H.S., Patrono C. Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J Natl Cancer Inst 2002, 94:252-266.
17. Doki Y., Murakami K., Yamaura T., Sugiyama S., Misaki T., Saiki I. Mediastinal lymph node metastasis model by orthotopic intrapulmonary implantation of Lewis lung carcinoma cells in mice. Brit J Cancer 1999, 79:1121-1126.
18. McLemore T.L., Eggleston J.C., Shoemaker R.H., et al. Comparison of intrapulmonary, percutaneous intrathoracic, and subcutaneous models for the propagation of human pulmonary and non-pulmonary cancer cell lines in athymic nude mice. Cancer Res 1988, 48:2880-2886.
19. McLemore T.L., Liu M.C., Blacker P.C., et al. Novel intrapulmonary model for orthotopic propagation of human lung cancers in athymic nude mice. Cancer Res 1987, 47:5132-5140.
20. Wang X., Fu X., Kubota T., Hoffman R.M. A new patient-like metastatic model of human small-cell lung cancer constructed orthotopically with intact tissue via thoracotomy in nude mice. Anticancer Res 1992, 12:1403-1406.
21. Brodt P. Characterization of two highly metastatic variants of Lewis lung carcinoma with different organ specificities. Cancer Res 1986, 46:2442-2448.
22. Talmadge J.E., Fidler I.J. Enhanced metastatic potential of tumor cells harvested from spontaneous metastases of heterogeneous murine tumors. J Natl Cancer Inst 1982, 69:975-980.
23. Fridman R., Giaccone G., Kanemoto T., Martin G.R., Gazdar A.F., Mulshine J.L. Reconstituted basement-membrane (matrigel) and laminin can enhance the tumorigenicity and the drug-resistance of small-cell lung-cancer cell-lines. Proc Natl Acad Sci U S A 1990, 87:6698-6702.
24. Fridman R., Kibbey M.C., Royce L.S., et al. Enhanced tumor-growth of both primary and established human and murine tumor-cells in athymic mice after coinjection with matrigel. J Natl Cancer I 1991, 83:769-774.
25. Bonfil R.D., Vinyals A., Bustuoabad O.D., et al. Stimulation of angiogenesis as an explanation of matrigel-enhanced tumorigenicity. Int J Cancer 1994, 58:233-239.
26. Ito Y., Iwamoto Y., Tanaka K., Okuyama K., Sugioka Y. A quantitative assay using basement membrane extracts to study tumor angiogenesis in vivo. Int J Cancer 1996, 67:148-152.
27. Yamamura K., Kibbey M.C., Jun S.H., Kleinman H.K. Effect of Matrigel and laminin peptide YIGSR on tumor growth and metastasis. Semin Cancer Biol 1993, 4:259-265.
28. Greenhough A., Smartt H.J., Moore A.E., et al. The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis 2009, 30:377-386.
29. Flossmann E., Rothwell P.M. Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet 2007, 369:1603-1613.
30. Holmes M.D., Chen W.Y., Li L., Hertzmark E., Spiegelman D., Hankinson S.E. Aspirin intake and survival after breast cancer. J Clin Oncol 2010, 28:1467-1472.
31. Liu J.F., Jamieson G.G., Wu T.C., Zhu G.J., Drew P.A. A preliminary study on the postoperative survival of patients given aspirin after resection for squamous cell carcinoma of the esophagus or adenocarcinoma of the cardia. Ann Surg Oncol 2009, 16:1397-1402.
32. Rothwell P.M., Wilson M., Elwin C.E., et al. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet 2010, 376:1741-1750.
33. Zaorsky N.G., Buyyounouski M.K., Li T., Horwitz E.M. Aspirin and statin nonuse associated with early biochemical failure after prostate radiation therapy. Int J Radiat Oncol Biol Phys 2012, 84:e13-e17.