Pathophysiology and risk factors of cervical artery dissection: What have we learnt from large hospital-based cohorts?

Current Opinion in Neurology

Volumn 27, Issue 1, 2014, Pages 20-28

  Debette, Stéphanie ^a,b,c,d  

^a HÔPITAL LARIBOISIÈRE   (France)

^b INSERM   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cervical artery dissection; pathophysiology; risk factors; stroke

Indexed keywords

COHORT STUDIES; ENVIRONMENT; HOSPITALS; HUMANS; HYPERTENSION; MIGRAINE DISORDERS; RISK FACTORS; STROKE; VERTEBRAL ARTERY DISSECTION;

EID: 84895059536     PISSN: 13507540     EISSN: 14736551     Source Type: Journal    
DOI: 10.1097/WCO.0000000000000056     Document Type: Review

References (87)

1. Debette S, Leys D. Cervical-artery dissections: Predisposing factors, diagnosis, and outcome. Lancet Neurol 2009; 8:668-678
2. Leys D, Bandu L, Henon H, et al. Clinical outcome in 287 consecutive young adults (15 to 45 years) with ischemic stroke. Neurology 2002; 59:26-33
3. Putaala J, Metso AJ, Metso TM, et al. Analysis of 1008 consecutive patients aged 15 to 49 with first-ever ischemic stroke: The Helsinki young stroke registry. Stroke 2009; 40:1195-1203
4. Lee VH, Brown RD Jr, Mandrekar JN, Mokri B. Incidence and outcome of cervical artery dissection: A population-based study. Neurology 2006; 67:1809-1812
5. Bé jot Y, Daubail B, Debette S, et al. Incidence and outcome of cerebrovascular events related to cervical artery dissection: The Dijon Stroke Registry. Int J Stroke 2013; doi: 10.1111/ijs.12154. [Epub ahead of print]
6. Debette S, Grond-Ginsbach C, Bodenant M, et al. Differential features of carotid and vertebral artery dissections: The CADISP study. Neurology 2011; 77:1174-1181
7. Arnold M, Kappeler L, Georgiadis D, et al. Gender differences in spontaneous cervical artery dissection. Neurology 2006; 67:1050-1052
8. Huang YC, Chen YF, Wang YH, et al. Cervicocranial arterial dissection: Experience of 73 patients in a single center. Surg Neurol 2009; 72 (Suppl 2): S20-S27
9. Nakajima S, Tsukahara T, Minematsu K. A study of vertebrobasilar artery dissection with subarachnoid hemorrhage. Acta Neurochir Suppl 2010; 107:45-49
10. Metso AJ, Metso TM, Debette S, et al. Gender and cervical artery dissection. Eur J Neurol 2012; 19:594-602
11. Arnold M, Fischer U, Bousser MG. Treatment issues in spontaneous cervicocephalic artery dissections. Int J Stroke 2011; 6:213-218
12. Engelter ST, Brandt T, Debette S, et al. Antiplatelets versus anticoagulation in cervical artery dissection. Stroke 2007; 38:2605-2611
13. Lyrer P, Engelter S. Antithrombotic drugs for carotid artery dissection. Cochrane Database Syst Rev 2010; 10:CD000255
14. Kennedy F, Lanfranconi S, Hicks C, et al. Antiplatelets vs anticoagulation for dissection: CADISS nonrandomized arm and meta-analysis. Neurology 2012; 79:686-689
15. Zinkstok SM, Vergouwen MD, Engelter ST, et al. Safety and functional outcome of thrombolysis in dissection-related ischemic stroke: A meta-analysis of individual patient data. Stroke 2011; 42:2515-2520
16. Qureshi AI, Chaudhry SA, Hassan AE, et al. Thrombolytic treatment of patients with acute ischemic stroke related to underlying arterial dissection in the United States. Arch Neurol 2011; 68:1536-1542
17. Engelter ST, Dallongeville J, Kloss M, et al. Thrombolysis in cervical artery dissection: Data from the Cervical Artery Dissection and Ischaemic Stroke Patients (CADISP) database. Eur J Neurol 2012; 19:1199-1206
18. Arauz A, Ruiz A, Pacheco G, et al. Aspirin versus anticoagulation in intra- and extracranial vertebral artery dissection. Eur J Neurol 2013; 20:167-172
19. Schievink WI, Mokri B, O'Fallon WM. Recurrent spontaneous cervical-artery dissection. N Engl J Med 1994; 330:393-397
20. Tzourio C, Cohen A, Lamisse N, et al. Aortic root dilatation in patients with spontaneous cervical artery dissection. Circulation 1997; 95:2351-2353
21. Calvet D, Boutouyrie P, Touze E, et al. Increased stiffness of the carotid wall material in patients with spontaneous cervical artery dissection. Stroke 2004; 35:2078-2082
22. Baracchini C, Tonello S, Vitaliani R, et al. Vasomotion in multiple spontaneous cervical artery dissections. Stroke 2008; 39:1148-1151
23. Barbour PJ, Castaldo JE, Rae-Grant AD, et al. Internal carotid artery redundancy is significantly associated with dissection. Stroke 1994; 25:1201-1206
24. Volker W, Dittrich R, Grewe S, et al. The outer arterial wall layers are primarily affected in spontaneous cervical artery dissection. Neurology 2011; 76:1463-1471
25. Grond-Ginsbach C, Debette S. The association of connective tissue disorders with cervical artery dissections. Curr Mol Med 2009; 9:210-214
26. Germain DP. Ehlers-Danlos syndrome type IV. Orphanet J Rare Dis 2007; 2:32
27. Rodrigues VJ, Elsayed S, Loeys BL, et al. Neuroradiologic manifestations of Loeys-Dietz syndrome type 1. AJNR Am J Neuroradiol 2009; 30:1614-1619
28. Brandt T, Orberk E, Weber R, et al. Pathogenesis of cervical artery dissections: Association with connective tissue abnormalities. Neurology 2001; 57:24-30
29. Wiest T, Hyrenbach S, Bambul P, et al. Genetic analysis of familial connective tissue alterations associated with cervical artery dissections suggests locus heterogeneity. Stroke 2006; 37:1697-1702
30. Rubinstein SM, Peerdeman SM, van Tulder MW, et al. A systematic review of the risk factors for cervical artery dissection. Stroke 2005; 36:1575-1580
31. Dittrich R, Rohsbach D, Heidbreder A, et al. Mild mechanical traumas are possible risk factors for cervical artery dissection. Cerebrovasc Dis 2007; 23:275-281
32. Engelter ST, Grond-Ginsbach C, Metso TM, et al. Cervical artery dissection: Trauma and other potential mechanical trigger events. Neurology 2013; 80:1950-1957
33. Grau AJ, Brandt T, Buggle F, et al. Association of cervical artery dissection with recent infection. Arch Neurol 1999; 56:851-856
34. Guillon B, Berthet K, Benslamia L, et al. Infection and the risk of spontaneous cervical artery dissection: A case-control study. Stroke 2003; 34:e79-e81
35. Genius J, Dong-Si T, Grau AP, Lichy C. Postacute C-reactive protein levels are elevated in cervical artery dissection. Stroke 2005; 36:e42-e44
36. Grond-Ginsbach C, Giossi A, Aksay SS, et al. Elevated peripheral leukocyte counts in acute cervical artery dissection. Eur J Neurol 2013; 20:1405-1410
37. Naggara O, Touze E, Marsico R, et al. High-resolution MR imaging of periarterial edema associated with biological inflammation in spontaneous carotid dissection. Eur Radiol 2009; 19:2255-2260
38. Lucas C, Lecroart JL, Gautier C, et al. Impairment of endothelial function in patients with spontaneous cervical artery dissection: Evidence for a general arterial wall disease. Cerebrovasc Dis 2004; 17:170-174
39. Pezzini A, Caso V, Zanferrari C, et al. Arterial hypertension as risk factor for spontaneous cervical artery dissection. A case-control study. J Neurol Neurosurg Psychiatry 2006; 77:95-97
40. Arnold M, Pannier B, Chabriat H, et al. Vascular risk factors and morphometric data in cervical artery dissection: A case-control study. J Neurol Neurosurg Psychiatry 2009; 80:232-234
41. Debette S, Metso T, Pezzini A, et al. Association of vascular risk factors with cervical artery dissection and ischemic stroke in young adults. Circulation2011; 123:1537-1544
42. Golledge J, Eagle KA. Acute aortic dissection. Lancet 2008; 372:55-66
43. Norman PE, Davis TM, Le MT, Golledge J. Matrix biology of abdominal aortic aneurysms in diabetes: Mechanisms underlying the negative association. Connect Tissue Res 2007; 48:125-131
44. Shantikumar S, Ajjan R, Porter KE, Scott DJ. Diabetes and the abdominal aortic aneurysm. Eur J Vasc Endovasc Surg 2010; 39:200-207
45. Kloss M, Metso A, Pezzini A, et al. Towards understanding seasonal variability in cervical artery dissection (CeAD). J Neurol 2012; 259:1662-1667
46. Tzourio C, Benslamia L, Guillon B, et al. Migraine and the risk of cervical artery dissection: A case-control study. Neurology 2002; 59:435-437
47. Pezzini A, Granella F, Grassi M, et al. History of migraine and the risk of spontaneous cervical artery dissection. Cephalalgia 2005; 25:575-580
48. Rist PM, Diener HC, Kurth T, Schurks M. Migraine, migraine aura, and cervical artery dissection: A systematic review and meta-analysis. Cephalalgia 2011; 31:886-896
49. Schurks M, Rist PM, Bigal ME, et al. Migraine and cardiovascular disease: Systematic review and meta-analysis. BMJ 2009; 339:b3914
50. Metso TM, Tatlisumak T, Debette S, et al. Migraine in cervical artery dissection and ischemic stroke patients. Neurology 2012; 78:1221-1228
51. Kurth T, Mohamed S, Maillard P, et al. Headache, migraine, and structural brain lesions and function: Population based Epidemiology of Vascular Ageing-MRI study. BMJ 2011; 342:c7357
52. Lee ST, Chu K, Jung KH, et al. Decreased number and function of endothelial progenitor cells in patients with migraine. Neurology 2008; 70:1510-1517
53. Etchevers HC, Vincent C, Le Douarin NM, Couly GF. The cephalic neural crest provides pericytes and smooth muscle cells to all blood vessels of the face and forebrain. Development 2001; 128:1059-1068
54. Martin JJ, Hausser I, Lyrer P, et al. Familial cervical artery dissections: Clinical, morphologic, and genetic studies. Stroke 2006; 37:2924-2929
55. Beighton P, De Paepe A, Steinmann B, et al. Ehlers-Danlos syndromes: Revised nosology, Villefranche, 1997. Ehlers-Danlos National Foundation (USA) and Ehlers-Danlos Support Group (UK). Am J Med Genet 1998; 77:31-37
56. Ong KT, Perdu J, De Backer J, et al. Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: A prospective randomised, open, blinded-endpoints trial. Lancet 2010; 376:1476-1484
57. Debette S, Markus HS. The genetics of cervical artery dissection: A systematic review. Stroke 2009; 40:e459-e466
58. Schievink WI, Mokri B, Piepgras DG, Kuiper JD. Recurrent spontaneous arterial dissections: Risk in familial versus nonfamilial disease. Stroke 1996; 27:622-624
59. Kuivaniemi H, Prockop DJ, Wu Y, et al. Exclusion of mutations in the gene for type III collagen (COL3A1) as a common cause of intracranial aneurysms or cervical artery dissections: Results from sequence analysis of the coding sequences of type III collagen from 55 unrelated patients. Neurology 1993; 43:2652-2658
60. van den Berg JS, Limburg M, Kappelle LJ, et al. The role of type III collagen in spontaneous cervical arterial dissections. Ann Neurol 1998; 43:494-498
61. von Pein F, Valkkila M, Schwarz R, et al. Analysis of the COL3A1 gene in patients with spontaneous cervical artery dissections. J Neurol 2002; 249:862-866
62. Pezzini A, Drera B, Del Zotto E, et al. Mutations in TGFBR2 gene cause spontaneous cervical artery dissection. J Neurol Neurosurg Psychiatry 2011; 82:1372-1374
63. Buss A, Pech K, Roelver S, et al. Functional polymorphisms in matrix metalloproteinases-1, -3, -9 and -12 in relation to cervical artery dissection. BMC Neurol 2009; 9:40
64. Jara-Prado A, Alonso ME, Martinez Ruano L, et al. MTHFR C677T, FII G20210A, FV Leiden G1691A, NOS3 intron 4 VNTR, and APOE epsilon4gene polymorphisms are not associated with spontaneous cervical artery dissection. Int J Stroke 2010; 5:80-85
65. Longoni M, Grond-Ginsbach C, Grau AJ, et al. The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection. Neurology 2006; 66:1273-1275
66. Pezzini A, Grassi M, Del Zotto E, et al. Migraine mediates the influence of C677T MTHFR genotypes on ischemic stroke risk with a stroke-subtype effect. Stroke 2007; 38:3145-3151
67. Pezzini A, Del Zotto E, Archetti S, et al. Plasma homocysteine concentration, C677T MTHFR genotype, and 844ins68 bp CBS genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke. Stroke 2002; 33:664-669
68. Arauz A, Hoyos L, Cantu C, et al. Mild hyperhomocysteinemia and low folate concentrations as risk factors for cervical arterial dissection. Cerebrovasc Dis2007; 24:210-214
69. Zondervan KT, Cardon LR. Designing candidate gene and genome-wide case-control association studies. Nat Protoc 2007; 2:2492-2501
70. Dichgans M, Markus HS. Genetic association studies in stroke: Methodological issues and proposed standard criteria. Stroke 2005; 36:2027-2031
71. Traylor M, Farrall M, Holliday EG, et al. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): A meta-analysis of genome-wide association studies. Lancet Neurol 2012; 11:951-962
72. Ikram MA, Seshadri S, Bis JC, et al. Genome wide association studies of stroke. N Engl J Med 2009; 360:1718-1728
73. Holliday EG, Maguire JM, Evans TJ, et al. Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Nat Genet 2012; 44:1147-1151
74. Southerland AM, Meschia JF, Worrall BB. Shared associations of nonatherosclerotic, large-vessel, cerebrovascular arteriopathies: Considering intracranial aneurysms, cervical artery dissection, moyamoya disease and fibromuscular dysplasia. Curr Opin Neurol 2013; 26:13-28
75. Ducros A. Reversible cerebral vasoconstriction syndrome. Lancet Neurol2012; 11:906-917
76. Mawet J, Boukobza M, Franc J, et al. Reversible cerebral vasoconstriction syndrome and cervical artery dissection in 20 patients. Neurology 2013; 81:821-824
77. Calabrese LH, Dodick DW, Schwedt TJ, Singhal AB. Narrative review: Reversible cerebral vasoconstriction syndromes. Ann Intern Med 2007; 146:34-44
78. Touze E, Oppenheim C, Trystram D, et al. Fibromuscular dysplasia of cervical and intracranial arteries. Int J Stroke 2010; 5:296-305
79. Persu A, Touze E, Mousseaux E, et al. Diagnosis and management of fibromuscular dysplasia: An expert consensus. Eur J Clin Invest 2012; 42:338-347
80. Olin JW, Sealove BA. Diagnosis, management, and future developments of fibromuscular dysplasia. J Vasc Surg 2011; 53:826.e1-836.e1
81. Olin JW, Froehlich J, Gu X, et al. The United States Registry for Fibromuscular Dysplasia: Results in the first 447 patients. Circulation 2012; 125:3182-3190
82. Blondin D, Lanzman R, Schellhammer F, et al. Fibromuscular dysplasia in living renal donors: Still a challenge to computed tomographic angiography. Eur J Radiol 2010; 75:67-71
83. Bé jot Y, Aboa-Eboulé C, Debette S, et al. Characteristics and outcomes of patients with multiple cervical artery dissection. Stroke 2013
84. de Bray JM, Marc G, Pautot V, et al. Fibromuscular dysplasia may herald symptomatic recurrence of cervical artery dissection. Cerebrovasc Dis 2007; 23:448-452
85. D'anglejan Chatillon J, Ribeiro V, Mas JL, et al. Dissection of the extracranial internal carotid artery. 62 cases. Presse Med 1990; 19:661-667
86. Perdu J, Boutouyrie P, Bourgain C, et al. Inheritance of arterial lesions in renal fibromuscular dysplasia. J Hum Hypertens 2007; 21:393-400
87. Slovut DP, Olin JW. Fibromuscular dysplasia. N Engl J Med 2004; 350:1862-1871