Investigation of endogenous corticosteroids profiles in human urine based on liquid chromatography tandem mass spectrometry

Analytica Chimica Acta

Volumn 812, Issue , 2014, Pages 92-104

  Marcos, Josep ^a,b   Renau, Nuria ^a   Casals, Gregori ^c   Segura, Jordi ^a,b   Ventura, Rosa ^a,b   Pozo, Oscar J ^a  

^a HOSPITAL DEL MAR   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c HOSPITAL CLÍNIC   (Spain)

Author keywords

Glucocorticosteroids; Mass spectrometry; Metabolites; Quantitative method; Urine

Indexed keywords

GLUCOCORTICOSTEROIDS; MASS SPECTROMETRY; METABOLITES; QUANTITATIVE METHOD; URINE;

ADRENAL CORTEX HORMONES; CHROMATOGRAPHY, LIQUID; HUMANS; LIMIT OF DETECTION; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84894902085     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2013.12.030     Document Type: Article

References (33)

1. Krone N., Hughes B.A., Lavery G.G., Stewart P.M., Arlt W., Shackleton C.H. Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS). J. Steroid Biochem. Mol. Biol. 2010, 121:496-504.
2. Soldin S.J., Soldin O.P. Steroid hormone analysis by tandem mass spectrometry. Clin. Chem. 2009, 55:1061-1066.
3. Kushnir M.M., Rockwood A.L., Roberts W.L., Yue B., Bergquist J., Meikle A.W. Liquid chromatography tandem mass spectrometry for analysis of steroids in clinical laboratories. Clin. Biochem. 2011, 44:77-88.
4. McEwen B.S. Allostasis and allostatic load: implications for neuropsychopharmacology. Neuropsychopharmacology 2000, 22:108-124.
5. Hryhorczuk C., Sharma S., Fulton S.E. Metabolic disturbances connecting obesity and depression. Front. Neurosci. 2013, 7:1-14.
6. Shackleton C.H.L., Marcos P. GC-MS steroid Profiling: Diagnosis of disorders affecting steroid synthesis and metabolism. The Encyclopedia of Mass Spectrometry 2006, 789-813. Elsevier, Amsterdam. M. Gross, R. Caprioli (Eds.).
7. Caulfield M.P., Lynn T., Gottschalk M.E., Jones K.L., Taylor N.F., Malunowicz E.M., Shackleton C.H.L., Reitz R.E., Fisher D.A. The diagnosis of congenital adrenal hyperplasia in the newborn by gas chromatography/mass spectrometry analysis of random urine specimens. J. Clin. Endocrinol. Metab. 2002, 87:3682-3690.
8. Miller W.L., Auchus R.J. The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr. Rev. 2011, 32:81-151.
9. Falany C.N. Enzymology of human cytosolic sulfotransferases. FASEB J. 1997, 11:206-216.
10. Fabregat A., Kotronoulas A., Marcos J., Joglar J., Alfonso I., Segura J., Ventura R., Pozo O.J. Detection, synynthesis and characterization of metabolites of steroid hormones conjugated with cysteine. Steroids 2013, 78:327-336.
11. Meng L.J., Griffiths W.J., Sjövall J. The identification of novel steroid N-acetylglucosaminides in the urine of pregnant women. J. Steroid Biochem. Mol. Biol. 1996, 58:585-598.
12. Shackleton C.H.L. Mass spectrometry in the diagnosis of steroid-related disorders and in hypertension research. J. Steroid Biochem. Mol. Biol. 1993, 45:127-140.
13. Taylor N.F. Urinary steroid profiling. Methods Mol. Biol. 2006, 324:159-175.
14. Shackleton C.H. Profiling steroid hormones and urinary steroids. J. Chromatogr. 1986, 379:91-156.
15. Kushnir M.M., Rockwood A.L., Bergquist J. Liquid chromatography-tandem mass spectrometry applications in endocrinology. Mass Spectrom. Rev. 2010, 29:480-502.
16. Jerjes W.K., Cleare A.J., Peters T.J., Taylor N.F. Circadian rhythm of urinary steroid metabolites. Ann. Clin. Biochem. 2006, 43:287-294.
17. Deventer K., Delbeke F.T. Validation of a screening method for corticosteroids in doping analysis by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2003, 17:2107-2114.
18. Mazzarino M., Turi S., Botrè F. A screening method for the detection of synthetic glucocorticosteroids in human urine by liquid chromatography-mass spectrometry based on class-characteristic fragmentation pathways. Anal. Bioanal. Chem. 2008, 390:1389-1402.
19. Matabosch X., Pozo O.J., Pérez-Mañá C., Farré M., Marcos J., Segura J., Ventura R. Identification of budesonide metabolites in human urine after oral administration. Anal. Bioanal. Chem. 2012, 404:325-340.
20. Matabosch X., Pozo O.J., Monfort N., Pérez-Mañá C., Farré M., Marcos J., Segura J., Ventura R. Urinary profile of methylprednisolone and its metabolites after oral and topical administrations. J. Steroid Biochem. Mol. Biol. 2013, 138:214-221.
21. Yamashita K., Nakagawa R., Okuyama M., Honma S., Takahashi M., Numazawa M. Simultaneous determination of tetrahydrocortisol, allotetrahydrocortisol and tetrahydrocortisone in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry. Steroids 2008, 73:727-737.
22. Cho H.J., Kim J.D., Lee W.Y., Chung B.C., Cho M.H. Quantitative metabolic profiling of 21 endogenous corticosteroids in urine by liquid chromatography-triple quadrupole-mass spectrometry. Anal. Chim. Acta 2009, 632:101-108.
23. Brooks T., Keevil C.W. A simple artificial urine for the growth of urinary pathogens. Lett. Appl. Microbiol. 1997, 24:203-206.
24. Weykamp C.W., Penders T.J., Schmidt N.A., Borburgh A.J., van de Calseyde J.F., Wolthers B.J. Steroid profile for urine: reference values. Clin. Chem. 1989, 35:2281-2284.
25. The Quest Diagnostic Manual, Endocrinology. Test selection and interpretation 2007, 105. Quest Diagnostics Incorporated. D.A. Fischer (Ed.).
26. Pozo O.J., Van Eenoo P., Deventer K., Delbeke F.T. Ionization of anabolic steroids by adduct formation in liquid chromatography electrospray mass spectrometry. J. Mass Spectrom. 2007, 42:497-516.
27. Pozo O.J., Ventura R., Monfort N., Segura J., Delbeke F.T. Evaluation of different scan methods for the urinary detection of corticosteroid metabolites by liquid chromatography tandem mass spectrometry. J. Mass Spectrom. 2009, 44:929-944.
28. Pozo O.J., Van Eenoo P., Deventer K., Grimalt S., Sancho J.V., Hernández F., Delbeke F.T. Collision-induced dissociation of 3-keto anabolic steroids and related compounds after electrospray ionization. Considerations for structural elucidation. Rapid Commun. Mass Spectrom. 2008, 22:4009-4024.
29. Pozo O.J., Deventer K., Van Eenoo P., Delbeke F.T. Presence of endogenous interferences in the urinary detection of selected anabolic steroids by liquid chromatography/electrospray tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2007, 21:2785-2796.
30. McCarver D.G., Hines R.N. The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms. J. Pharmacol. Exp. Ther. 2002, 300:361-366.
31. Christakoudi S., Cowan D.A., Taylor N.F. Steroids excreted in urine by neonates with 21-hydroxylase deficiency: characterization, using GC-MS and GC-MS/MS, of the D-ring and side chain structure of pregnanes and pregnenes. Steroids 2010, 75:34-52.
32. Christakoudi S., Cowan D.A., Taylor N.F. Steroids excreted in urine by neonates with 21-hydroxylase deficiency. 2. Characterization, using GC-MS and GC-MS/MS, of pregnanes and pregnenes with an oxo- group on the A- or B-ring. Steroids 2012, 77:382-393.
33. Christakoudi S., Cowan D.A., Taylor N.F. Steroids excreted in urine by neonates with 21-hydroxylase deficiency. 4. Characterization, using GC-MS and GC-MS/MS, of 11oxo-pregnanes and 11oxo-pregnenes. Steroids 2013, 78:468-475.