A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

Nature Methods

Volumn 11, Issue 1, 2014, Pages 79-85

  Wang, Chu ^a   Weerapana, Eranthie ^a   Blewett, Megan M ^a   Cravatt, Benjamin F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; CYSTEINE; ELECTROPHILE; HISTIDINE; LIPID; LIPID DERIVED ELECTROPHILE; LYSINE; PHOSPHOTRANSFERASE; PROTEOME; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ZAK KINASE; 15-DEOXYPROSTAGLANDIN J2; PROSTAGLANDIN D2; PROTEIN KINASE; ZAK PROTEIN, HUMAN; 15 DEOXYPROSTAGLANDIN J2; DRUG DERIVATIVE;

ARTICLE; CANCER CELL CULTURE; CHEMICAL MODIFICATION; CHEMOPROTEOMIC; ELECTROPHILICITY; ENZYME INHIBITION; ENZYME REPRESSION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; NEGATIVE FEEDBACK; NUCLEOPHILICITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TARGETING; PROTEOMICS; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANALOGS AND DERIVATIVES; BREAST TUMOR; CHEMISTRY; DOSE RESPONSE; ELECTROCHEMISTRY; ENZYME ACTIVE SITE; FEMALE; GENE EXPRESSION REGULATION; HEK293 CELL LINE; IC50; METABOLISM; MOLECULAR GENETICS; PROCEDURES; PROTEIN PROCESSING; SEQUENCE HOMOLOGY; TUMOR CELL LINE; CELL STRAIN HEK293; IC 50; METHODOLOGY;

AMINO ACID SEQUENCE; BREAST NEOPLASMS; CATALYTIC DOMAIN; CELL LINE, TUMOR; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCHEMISTRY; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LIPIDS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; OXIDATIVE STRESS; PROSTAGLANDIN D2; PROTEIN KINASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOME; PROTEOMICS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84894619225     PISSN: 15487091     EISSN: 15487105     Source Type: Journal    
DOI: 10.1038/nmeth.2759     Document Type: Article

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