L-arginine for the treatment of centrally obese subjects: A pilot study

Journal of Dietary Supplements

Volumn 11, Issue 1, 2014, Pages 40-52

  Hurt, Ryan T ^a,b,c   Ebbert, Jon O ^a   Schroeder, Darrell R ^a   Croghan, Ivana T ^a   Bauer, Brent A ^a   McClave, Stephen A ^b   Miles, John M ^a   McClain, Craig J ^c  

^a MAYO CLINIC   (United States)

^b University of Louisville School of Medicine   (United States)

^c Department of Medicine   (United States)

Author keywords

L arginine; Obesity; Supplement; Weight loss

Indexed keywords

ARGININE;

ABDOMINAL OBESITY; ADULT; ARTICLE; BLOOD; BODY MASS; BODY WEIGHT; CLINICAL TRIAL; DRUG EFFECT; FEMALE; HUMAN; INTRAABDOMINAL FAT; METABOLISM; OBESITY; PILOT STUDY; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

ADIPOSITY; ADULT; ARGININE; BODY MASS INDEX; BODY WEIGHT; FEMALE; HUMANS; INTRA-ABDOMINAL FAT; OBESITY, ABDOMINAL; PILOT PROJECTS; WAIST CIRCUMFERENCE; WAIST-HIP RATIO;

EID: 84894600647     PISSN: 19390211     EISSN: 1939022X     Source Type: Journal    
DOI: 10.3109/19390211.2013.859216     Document Type: Article

References (33)

1. Abedini S, Meinitzer A, Holme I, Marz W, Weihrauch G, Fellstrom B, Jardine A, Holdaas H. Asymmetrical dimethylarginine is associated with renal and cardiovascular outcomes and allcause mortality in renal transplant recipients. Kidney Int. 2010;77(1):44-50.
2. Cave MC, Hurt RT, Frazier TH, Matheson PJ, Garrison RN, McClain CJ, McClave SA. Obesity, inflammation, and the potential application of pharmaconutrition. Nutr Clin Pract. 2008;23(1):16-34.
3. Colao A, Di Somma C, Savastano S, Rota F, Savanelli MC, Aimaretti G, Lombardi G. A reappraisal of diagnosing GH deficiency in adults: role of gender, age, waist circumference, and body mass index. J Clin Endocrinol Metab. 2009;94(11):4414-4422.
4. Curioni CC, Lourenco PM. Long-term weight loss after diet and exercise: a systematic review. Int J Obes (Lond). 2005;29(10):1168-1174.
5. Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. Dec 14 2006;444(7121):881-887.
6. Dhaliwal SS, Welborn TA. Central obesity and multivariable cardiovascular risk as assessed by the Framingham prediction scores. Am J Cardiol. 2009;103(10):1403-1407.
7. Fidler MC, Sanchez M, Raether B, Weissman NJ, Smith SR, Shanahan WR, Anderson CM. A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial. J Clin Endocrinol Metab. 2011;96(10):3067-3077.
8. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA. 2012;307(5):491-497.
9. Fu WJ, Haynes TE, Kohli R, Hu J, Shi W, Spencer TE, Carroll RJ, Meininger CJ, Wu G. Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats. J Nutr. 2005;135(4):714-721.
10. Han TS, Richmond P, Avenell A, Lean ME. Waist circumference reduction and cardiovascular benefits during weight loss in women. Int J Obes Relat Metab Disord. 1997;21(2):127-134.
11. Hurt RT, Frazier TH, Matheson PJ, Cave MC, Garrison RN, McClain CJ, McClave SA. Obesity and inflammation: should the principles of immunonutrition be applied to this disease process? Curr Gastroenterol Rep. 2007;9(4):305-306.
12. Hurt RT, Frazier TH, McClave SA, Cave MC. Pharmaconutrition for the obese, critically ill patient. JPEN J Parenter Enteral Nutr. 2011;35(5 Suppl):60S-72S.
13. Hurt RT, Frazier TH, McClave SA, Kaplan LM. Obesity epidemic: overview, pathophysiology, and the intensive care unit conundrum. JPEN J Parenter Enteral Nutr. 2011;35(5 Suppl):4S-13S.
14. Ioannides-Demos LL, Piccenna L, McNeil JJ. Pharmacotherapies for obesity: past, current, and future therapies. J Obes. 2011;2011:179674.
15. Jobgen W, Fu WJ, Gao H, Li P, Meininger CJ, Smith SB, Spencer TE, Wu G. High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue. Amino Acids. 2009;37(1):187-198.
16. Jobgen W, Meininger CJ, Jobgen SC, Li P, Lee MJ, Smith SB, Spencer TE, Fried SK, Wu G. Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats. J Nutr. 2009;139(2):230-237.
17. Kielstein JT, Zoccali C. Asymmetric dimethylarginine: a novel marker of risk and a potential target for therapy in chronic kidney disease. Curr Opin Nephrol Hypertens. 2008;17(6):609-615.
18. Kolotkin RL, Crosby RD, Kosloski KD,Williams GR. Development of a brief measure to assess quality of life in obesity. Obes Res. 2001;9(2):102-111.
19. Kreitschmann-Andermahr I, Suarez P, Jennings R, Evers N, Brabant G. GH/IGF-I regulation in obesity-mechanisms and practical consequences in children and adults. Horm Res Paediatr. 2010;73(3):153-160.
20. Kurz K, Teerlink T, Sarcletti M, Weiss G, Zangerle R, Fuchs D. Plasma concentrations of the cardiovascular risk factor asymmetric dimethylarginine (ADMA) are increased in patients with HIV-1 infection and correlate with immune activation markers. Pharmacol Res. 2009;60(6):508-514.
21. Lucotti P, Setola E, Monti LD, Galluccio E, Costa S, Sandoli EP, Fermo I, Rabaiotti G, Gatti R, Piatti P. Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients. Am J Physiol Endocrinol Metab. 2006;291(5):E906-E912.
22. Lu WM, Lei ST, Zhang Q, Zhang YJ, Wang SM, Shi HP. Effect of L-arginine on diabetic rats [article in Chinese]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2006;26(10):1434-1435, 1445.
23. McClave SA, Kushner R, Van Way CW, 3rd, Cave M, DeLegge M, Dibaise J, Dickerson R, Drover J, Frazier TH, Fujioka K, Gallagher D, Hurt RT, Kaplan L, Kiraly L, Martindale R, McClain C, Ochoa J. Nutrition therapy of the severely obese, critically ill patient: summation of conclusions and recommendations. JPEN J Parenter Enteral Nutr. 2011;35(5 Suppl):88S-96S.
24. McKnight JR, SatterfieldMC, Jobgen WS, Smith SB, Spencer TE,Meininger CJ, McNeal CJ,Wu G. Beneficial effects of L-arginine on reducing obesity: potential mechanisms and important implications for human health. Amino Acids. 0000;39(2):349-357.
25. McLaughlin T, Stuhlinger M, Lamendola C, Abbasi F, Bialek J, Reaven GM, Tsao PS. Plasma asymmetric dimethylarginine concentrations are elevated in obese insulin-resistant women and fall with weight loss. J Clin Endocrinol Metab. 2006;91(5):1896-1900.
26. Onat A, Hergenc G. Reduced asymmetric dimethylarginine (ADMA) levels mediate in the protection from metabolic syndrome by smoking. Atherosclerosis. 2008;196(1):479-480.
27. Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1:385-401.
28. Stern L, Iqbal N, Seshadri P, Chicano KL, Daily DA, McGrory J, Williams M, Gracely EJ, Samaha FF. The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Ann Intern Med. 2004;140(10):778-785.
29. Tan B, Yin Y, Liu Z, Li X, Xu H, Kong X, Huang R, Tang W, Shinzato I, Smith SB, Wu G. Dietary L-arginine supplementation increases muscle gain and reduces body fatmass in growingfinishing pigs. Amino Acids. 2009;37(1):169-175.
30. Ukropec J, Penesova A, Skopkova M, Pura M, Vlcek M, Radikova Z, Imrich R, Ukropcova B, Tajtakova M, Koska J, Zorad S, Belan V, Vanuga P, Payer J, Eckel J, Klimes I, Gasperikova D. Adipokine protein expression pattern in growth hormone deficiency predisposes to the increased fat cell size and the whole body metabolic derangements. J Clin Endocrinol Metab. 2008;93(6):2255-2262.
31. Wu G, Bazer FW, Cudd TA, Jobgen WS, Kim SW, Lassala A, Li P, Matis JH, Meininger CJ, Spencer TE. Pharmacokinetics and safety of arginine supplementation in animals. J. Nutr. 2007;137(6 Suppl 2):1673S-1680S.
32. Wu G, Bazer FW, Davis TA, Kim SW, Li P, Marc Rhoads J, Carey Satterfield M, Smith SB, Spencer TE, Yin Y. Arginine metabolism and nutrition in growth, health and disease. Amino Acids. 2009;37(1):153-168.
33. Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi MG, Commerford P, Lang CC, Rumboldt Z, Onen CL, Lisheng L, Tanomsup S, Wangai P, Razak F, Sharma AM, Anand SS. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet. 2005;366(9497):1640-1649.