Is progesterone a neutral or protective factor for breast cancer?

Nature Reviews Cancer

Volumn 14, Issue 2, 2014, Pages 146-

  Muti, Paola ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; BREAST NEOPLASMS; FEMALE; HUMANS; PROGESTERONE;

EID: 84894568668     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3518-c1     Document Type: Letter

References (9)

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4. Alkhalaf, M. & El-Mowafy, A. M. Overexpression of wild-type p53 gene renders MCF-7 breast cancer cells more sensitive to the antiproliferative effect of progesterone. J. Endocrinol. 179, 55-62 (2003).
5. Lin, V. C., Eng, A. S., Hen, N. E., Ng, E. H. & Chowdhury, S. H. Effect of progesterone on the invasive properties and tumor growth of progesterone receptor-transfected breast cancer cells MDA-MB-231. Clin. Cancer Res. 7, 2880-2886 (2001).
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7. Micheli, A. et al. Endogenous sex hormones and subsequent breast cancer in premenopausal women. Int. J. Cancer 112, 312-318 (2004).
8. Schernhammer, E. S. et al. Endogenous sex steroids in premenopausal women and risk of breast cancer: the ORDET cohort. Breast Cancer Res. 15, R46 (2013).
9. Endogenous Hormones and Breast Cancer Collaborative Group. Sex hormones and risk of breast cancer in premenopausal women: a collaborative reanalysis of individual participant data from seven prospective studies. Lancet Oncol. 14, 1009-1019 (2013).