Vitamin D deficiency is associated with greater tumor size and poorer outcome in Merkel cell carcinoma patients

Journal of the European Academy of Dermatology and Venereology

Volumn 28, Issue 3, 2014, Pages 298-308

  Samimi, M ^a,b,c   Touze A ^a,b   Laude, H ^d,e   Le Bidre, E ^c,f   Arnold, F ^a,b   Carpentier, A ^a,b   Gardair, C ^b,c   Carlotti, A ^d,e   Maubec, E ^g   Dupin, N ^d,e   Aubin, F ^h   Avril, M F ^d,e   Rozenberg, F ^d,e   Avenel Audran, M ⁱ   Guyetant, S ^b,c   Lorette, G ^a,b,c   MacHet, L ^b,c   Coursaget, P ^a,b  

^a CNRS   (France)

^b UNIVERSITÉ DE TOURS   (France)

^c UNIVERSITY HOSPITAL OF TOURS   (France)

^d Service de Dermatologie Hôpital Cochin ^*  (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f CENTRE HOSPITALIER RÉGIONAL D ORLÉANS   (France)

^g BICHAT HOSPITAL   (France)

^h UNIVERSITÉ DE FRANCHE COMTÉ   (France)

ⁱ ANGERS UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, MERKEL CELL; COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; RECEPTORS, CALCITRIOL; SKIN NEOPLASMS; TREATMENT OUTCOME; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84894502162     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/jdv.12101     Document Type: Article

References (55)

1. Rockville Merkel Cell Carcinoma Group. Merkel cell carcinoma: recent progress and current priorities on etiology, pathogenesis, and clinical management. J Clin Oncol 2009; 27: 4021-4026.
2. Feng H, Shuda M, Chang Y, Moore PS,. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008; 319: 1096-1100.
3. Becker JC, Houben R, Ugurel S, Trefzer U, Pföhler C, Schrama D., MC polyomavirus is frequently present in Merkel cell carcinoma of European patients. J Invest Dermatol 2009; 129: 248-250.
4. Sastre-Garau X, Peter M, Avril M-F, et al,. Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis. J Pathol 2009; 218: 48-56.
5. Touzé A, Gaitan J, Maruani A, et al,. Merkel cell polyomavirus strains in patients with merkel cell carcinoma. Emerg Infect Dis 2009; 15: 960-962.
6. Bhatia K, Goedert JJ, Modali R, Preiss L, Ayers LW., Merkel cell carcinoma subgroups by Merkel cell polyomavirus DNA relative abundance and oncogene expression. Int J Cancer 2010; 126: 2240-2246.
7. Sihto H, Kukko H, Koljonen V, Sankila R, Böhling T, Joensuu H., Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma. J Natl Cancer Inst 2009; 101: 938-945.
8. Bhatia K, Goedert JJ, Modali R, Preiss L, Ayers LW., Immunological detection of viral large T antigen identifies a subset of Merkel cell carcinoma tumors with higher viral abundance and better clinical outcome. Int J Cancer 2010; 127: 1493-1496.
9. Sihto H, Kukko H, Koljonen V, Sankila R, Böhling T, Joensuu H., Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma. Clin Cancer Res 2011; 17: 4806-4813.
10. Touzé A, Le Bidre E, Laude H, et al,. High levels of antibodies against merkel cell polyomavirus identify a subset of patients with merkel cell carcinoma with better clinical outcome. J Clin Oncol 2011; 29: 1612-1619.
11. Tolstov YL, Pastrana DV, Feng H, et al,. Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. Int J Cancer 2009; 125: 1250-1256.
12. Carter JJ, Paulson KG, Wipf GC, et al,. Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma. J Natl Cancer Inst 2009; 101: 1510-1522.
13. Kean JM, Rao S, Wang M, Garcea RL,. Seroepidemiology of human polyomaviruses. PLoS Pathog 2009; 5: e1000363.
14. Touzé A, Gaitan J, Arnold F, et al,. Generation of Merkel cell polyomavirus (MCV)-like particles and their application to detection of MCV antibodies. J Clin Microbiol 2010; 48: 1767-1770.
15. Zerwekh JE,. Blood biomarkers of vitamin D status. Am J Clin Nutr 2008; 87: 1087S-1091S.
16. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al,. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011; 96: 1911-1930.
17. Gandini S, Boniol M, Haukka J, et al,. Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma. Int J Cancer 2011; 128: 1414-1424.
18. Buttigliero C, Monagheddu C, Petroni P, et al,. Prognostic role of vitamin d status and efficacy of vitamin D supplementation in cancer patients: a systematic review. Oncologist 2011; 16: 1215-1227.
19. Major JM, Kiruthu C, Weinstein SJ, et al,. Pre-diagnostic circulating vitamin D and risk of melanoma in men. PLoS ONE 2012; 7: e35112.
20. Gambichler T, Bindsteiner M, Höxtermann S, Kreuter A., Serum 25-hydroxyvitamin D serum levels in a large German cohort of melanoma patients. Br J Dermatol 2012; Aug 9. doi: 10.1111/j.1365-2133.2012.11212.x. [Epub ahead of print].
21. Giovannucci E, Liu Y, Rimm EB, et al,. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst 2006; 98: 451-459.
22. Liang G, Nan H, Qureshi AA, Han J,. Pre-diagnostic plasma 25-hydroxyvitamin D levels and risk of non-melanoma skin cancer in women. PLoS ONE 2012; 7: e35211.
23. Tang JY, Parimi N, Wu A, et al,. Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men. Cancer Causes Control 2010; 21: 387-391.
24. Asgari MM, Tang J, Margaret Warton E, et al,. Association of Prediagnostic Serum Vitamin D levels with the Development of Basal Cell Carcinoma. J Invest Dermatol 2010; 130: 1438-1443.
25. Eide MJ, Johnson DA, Jacobsen GR, et al,. Vitamin D and nonmelanoma skin cancer in a health maintenance organization cohort. Arch Dermatol 2011; 147: 1379-1384.
26. Nürnberg B, Gräber S, Gärtner B, et al,. Reduced serum 25-hydroxyvitamin D levels in stage IV melanoma patients. Anticancer Res 2009; 29: 3669-3674.
27. Randerson-Moor JA, Taylor JC, Elliott F, et al,. Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data. Eur J Cancer 2009; 45: 3271-3281.
28. Newton-Bishop JA, Beswick S, Randerson-Moor J, et al,. Serum 25-Hydroxyvitamin D3 Levels Are Associated With Breslow Thickness at Presentation and Survival From Melanoma. J Clin Oncol 2009; 27: 5439-5444.
29. Welsh J,. Cellular and molecular effects of vitamin D on carcinogenesis. Arch Biochem Biophys 2012; 523: 107-114.
30. Field S, Newton-Bishop JA,. Melanoma and vitamin D. Mol Oncol 2011; 5: 197-214.
31. Brożyna AA, Jozwicki W, Janjetovic Z, Slominski AT,. Expression of vitamin D receptor decreases during progression of pigmented skin lesions. Hum Pathol 2011; 42: 618-631.
32. Mitschele T, Diesel B, Friedrich M, et al,. Analysis of the vitamin D system in basal cell carcinomas (BCCs). Lab Invest 2004; 84: 693-702.
33. Reichrath J, Rafi L, Rech M, et al,. Analysis of the vitamin D system in cutaneous squamous cell carcinomas. J Cutan Pathol 2004; 31: 224-231.
34. Gedlicka C, Hager G, Weissenböck M, et al,. 1,25(OH)2Vitamin D3 induces elevated expression of the cell cycle inhibitor p18 in a squamous cell carcinoma cell line of the head and neck. J Oral Pathol Med 2006; 35: 472-478.
35. Teichert AE, Elalieh H, Elias PM, Welsh J, Bikle DD., Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice. J Invest Dermatol 2011; 131: 2289-2297.
36. Ellison TI, Smith MK, Gilliam AC, MacDonald PN,. Inactivation of the vitamin D receptor enhances susceptibility of murine skin to UV-induced tumorigenesis. J Invest Dermatol 2008; 128: 2508-2517.
37. Boccara O, Girard C, Mortier L, et al,. Guidelines for the diagnosis and treatment of Merkel cell carcinoma-Cutaneous Oncology Group of the French Society of Dermatology. Eur J Dermatol 2012; 22: 375-379.
38. Ray-Coquard I, Cropet C, Van Glabbeke M, et al,. Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas. Cancer Res 2009; 69: 5383-5391.
39. Laude HC, Jonchère B, Maubec E, et al,. Distinct merkel cell polyomavirus molecular features in tumour and non tumour specimens from patients with merkel cell carcinoma. PLoS Pathog 2010; 6: e1001076.
40. Platz EA, Leitzmann MF, Hollis BW, Willett WC, Giovannucci E., Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D and subsequent risk of prostate cancer. Cancer Causes Control 2004; 15: 255-265.
41. Hofmann JN, Yu K, Horst RL, Hayes RB, Purdue MP., Long-term variation in serum 25-hydroxyvitamin D concentration among participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Cancer Epidemiol Biomarkers Prev 2010; 19: 927-931.
42. Sonderman JS, Munro HM, Blot WJ, Signorello LB,. Reproducibility of Serum 25-Hydroxyvitamin D and Vitamin D-Binding Protein Levels Over Time in a Prospective Cohort Study of Black and White Adults. Am J Epidemiol 2012; 176: 615-621.
43. Jorde R, Sneve M, Hutchinson M, Emaus N, Figenschau Y, Grimnes G., Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study. Am J Epidemiol 2010; 171: 903-908.
44. Goodwin PJ, Ennis M, Pritchard KI, Koo J, Hood N., Prognostic effects of 25-hydroxyvitamin D levels in early breast cancer. J Clin Oncol 2009; 27: 3757-3763.
45. Kim HJ, Lee YM, Ko BS, et al,. Vitamin D deficiency is correlated with poor outcomes in patients with luminal-type breast cancer. Ann Surg Oncol 2011; 18: 1830-1836.
46. Tretli S, Hernes E, Berg JP, Hestvik UE, Robsahm TE., Association between serum 25(OH)D and death from prostate cancer. Br J Cancer 2009; 100: 450-454.
47. Ng AC, Kumar SK, Rajkumar SV, Drake MT,. Impact of vitamin D deficiency on the clinical presentation and prognosis of patients with newly diagnosed multiple myeloma. Am J Hematol 2009; 84: 397-400.
48. Thomas X, Chelghoum Y, Fanari N, Cannas G,. Serum 25-hydroxyvitamin D levels are associated with prognosis in hematological malignancies. Hematology 2011; 16: 278-283.
49. Goldray D, Mizrahi-Sasson E, Merdler C, et al,. Vitamin D deficiency in elderly patients in a general hospital. J Am Geriatr Soc 1989; 37: 589-592.
50. Ramel A, Jonsson PV, Bjornsson S, Thorsdottir I,. Vitamin D deficiency and nutritional status in elderly hospitalized subjects in Iceland. Public Health Nutr 2009; 12: 1001-1005.
51. Linnebur SA, Vondracek SF, Vande Griend JP, Ruscin JM, McDermott MT., Prevalence of vitamin D insufficiency in elderly ambulatory outpatients in Denver, Colorado. Am J Geriatr Pharmacother 2007; 5: 1-8.
52. Güler-Nizam E, Leiter U, Metzler G, Breuninger H, Garbe C, Eigentler TK., Clinical course and prognostic factors of Merkel cell carcinoma of the skin. Br J Dermatol 2009; 161: 90-94.
53. Engels EA, Frisch M, Goedert JJ, Biggar RJ, Miller RW., Merkel cell carcinoma and HIV infection. Lancet 2002; 359: 497-498.
54. Shuda M, Kwun HJ, Feng H, Chang Y, Moore PS., Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator. J Clin Invest 2011; 121: 3623-3634.
55. Lisse TS, Hewison M,. Vitamin D: a new player in the world of mTOR signaling. Cell Cycle 2011; 10: 1888-1889.