Do margins matter? the influence of positive surgical margins on prostate cancer-specific mortality

European Urology

Volumn 65, Issue 4, 2014, Pages 675-680

  Stephenson, Andrew J ^a   Eggener, Scott E ^b   Hernandez, Adrian V ^a   Klein, Eric A ^a   Kattan, Michael W ^a   Wood, David P ^c   Rabah, Danny M ^d   Eastham, James A ^e   Scardino, Peter T ^e  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Models; Prostatectomy; Prostatic neoplasms; Statistical; Surgical margins; Treatment outcome

Indexed keywords

PROSTATE SPECIFIC ANTIGEN;

ADULT; AGED; ANDROGEN DEPRIVATION THERAPY; ARTICLE; CANCER MORTALITY; CANCER RADIOTHERAPY; FOLLOW UP; GLEASON SCORE; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; POSTOPERATIVE CARE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATECTOMY; SEMINAL VESICLE; TREATMENT OUTCOME;

MODELS; PROSTATECTOMY; PROSTATIC NEOPLASMS; STATISTICAL; SURGICAL MARGINS; TREATMENT OUTCOME;

AGED; HUMANS; MALE; MIDDLE AGED; PROSTATE; PROSTATECTOMY; PROSTATIC NEOPLASMS;

EID: 84894497044     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2013.08.036     Document Type: Article

References (34)

1. A.J. Stephenson, D.P. Wood, and M.W. Kattan et al. Location, extent and number of positive surgical margins do not improve accuracy of predicting prostate cancer recurrence after radical prostatectomy J Urol 182 2009 1357 1363
2. J.A. Eastham, K. Kuroiwa, and M. Ohori et al. Prognostic significance of location of positive margins in radical prostatectomy specimens Urology 70 2007 965 969
3. P. Swindle, J.A. Eastham, and M. Ohori et al. Do margins matter? The prognostic significance of positive surgical margins in radical prostatectomy specimens J Urol 174 2005 903 907
4. M.A. Simon, S. Kim, and M.S. Soloway Prostate specific antigen recurrence rates are low after radical retropubic prostatectomy and positive margins J Urol 175 2006 140 144 discussion 144-5
5. A.J. Vickers, F.J. Bianco, and A.M. Serio et al. The surgical learning curve for prostate cancer control after radical prostatectomy J Natl Cancer Inst 99 2007 1171 1177
6. J.A. Eastham, M.W. Kattan, and E. Riedel et al. Variations among individual surgeons in the rate of positive surgical margins in radical prostatectomy specimens J Urol 170 2003 2292 2295
7. I.M. Thompson, C.M. Tangen, and J. Paradelo et al. Adjuvant radiotherapy for pathological T3N0M0 prostate cancer significantly reduces risk of metastases and improves survival: long-term followup of a randomized clinical trial J Urol 181 2009 956 962
8. M. Bolla, H. van Poppel, and B. Tombal et al. Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911) Lancet 380 2012 2018 2027
9. T. Wiegel, D. Bottke, and U. Steiner et al. Phase III postoperative adjuvant radiotherapy after radical prostatectomy compared with radical prostatectomy alone in pT3 prostate cancer with postoperative undetectable prostate-specific antigen: ARO 96-02/AUO AP 09/95 J Clin Oncol 27 2009 2924 2930
10. I.M. Thompson, C.M. Tangen, and E.A. Klein Is there a standard of care for pathologic stage T3 prostate cancer? J Clin Oncol 27 2009 2898 2899
11. R.K. Valicenti, I. Thompson Jr., and P. Albertsen et al. Adjuvant and salvage radiation therapy after prostatectomy: American Society for Radiation Oncology/American Urological Association Guidelines Int J Radiat Oncol Biol Phys 86 2013 822 828
12. T.H. Van der Kwast, M. Bolla, and H. Van Poppel et al. Identification of patients with prostate cancer who benefit from immediate postoperative radiotherapy: EORTC 22911 J Clin Oncol 25 2007 4178 4186
13. A.J. Stephenson, S.F. Shariat, and M.J. Zelefsky et al. Salvage radiotherapy for recurrent prostate cancer after radical prostatectomy JAMA 291 2004 1325 1332
14. M.G. Sanda, R.L. Dunn, and J. Michalski et al. Quality of life and satisfaction with outcome among prostate-cancer survivors N Engl J Med 358 2008 1250 1261
15. M.S. Litwin, J.L. Gore, and L. Kwan et al. Quality of life after surgery, external beam irradiation, or brachytherapy for early-stage prostate cancer Cancer 109 2007 2239 2247
16. Y. Pardo, F. Guedea, and F. Aguilo et al. Quality-of-life impact of primary treatments for localized prostate cancer in patients without hormonal treatment J Clin Oncol 28 2010 4687 4696
17. D.J. Brenner, R.E. Curtis, and E.J. Hall et al. Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery Cancer 88 2000 398 406
18. K. Moon, G.J. Stukenborg, and J. Keim et al. Cancer incidence after localized therapy for prostate cancer Cancer 107 2006 991 998
19. A.J. Stephenson, P.T. Scardino, and M.W. Kattan et al. Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy J Clin Oncol 25 2007 2035 2041
20. A.J. Stephenson, M. Bolla, and A. Briganti et al. Postoperative radiation therapy for pathologically advanced prostate cancer after radical prostatectomy Eur Urol 61 2012 443 451
21. S.E. Eggener, P.T. Scardino, and P.C. Walsh et al. Predicting 15-year prostate cancer specific mortality after radical prostatectomy J Urol 185 2011 869 875
22. F.J. Bianco Jr., P.T. Scardino, and J.A. Eastham Radical prostatectomy: long-term cancer control and recovery of sexual and urinary function ("trifecta") Urology 66 2005 83 94
23. F.L. Greene, D.L. Page, and I.D. Fleming et al. American Joint Committee on Cancer: AJCC Cancer Staging Manual ed. 6. 2002 Springer-Verlag New York
24. J.P. Fine, and R.J. Gray A proportional hazards model for the subdistribution of a competing risk J Am Stat Assoc 94 1999 496 509
25. B.J. Trock, M. Han, and S.J. Freedland et al. Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy JAMA 299 2008 2760 2769
26. R.B. Geskus Cause-specific cumulative incidence estimation and the fine and gray model under both left truncation and right censoring Biometrics 67 2011 39 49
27. T.M. Therneau, and P.M. Grambsch Modeling survival data: extending the Cox model 2000 Springer Verlag New York
28. A.J. Evans, P.C. Henry, and T.H. Van der Kwast et al. Interobserver variability between expert urologic pathologists for extraprostatic extension and surgical margin status in radical prostatectomy specimens Am J Surg Pathol 32 2008 1503 1512
29. S.J. Freedland, E.B. Humphreys, and L.A. Mangold et al. Death in patients with recurrent prostate cancer after radical prostatectomy: prostate-specific antigen doubling time subgroups and their associated contributions to all-cause mortality J Clin Oncol 25 2007 1765 1771
30. D.F. Paulson Impact of radical prostatectomy in the management of clinically localized disease J Urol 152 1994 1826 1830
31. J. Mauermann, V. Fradet, and L. Lacombe et al. The impact of solitary and multiple positive surgical margins on hard clinical end points in 1712 adjuvant treatment-naive pT2-4 N0 radical prostatectomy patients Eur Urol 64 2013 19 25
32. J.L. Wright, B.L. Dalkin, and L.D. True et al. Positive surgical margins at radical prostatectomy predict prostate cancer specific mortality J Urol 183 2010 2213 2218
33. S.K. Shah, T.M. Fleet, and V. Williams et al. SEER coding standards result in underestimation of positive surgical margin incidence at radical prostatectomy: results of a systematic audit J Urol 186 2011 855 859
34. A. Vickers, F. Bianco, and A. Cronin et al. The learning curve for surgical margins after open radical prostatectomy: implications for margin status as an oncological end point J Urol 183 2010 1360 1365