Molecular umbrella conjugate for the ocular delivery of siRNA

Bioconjugate Chemistry

Volumn 25, Issue 2, 2014, Pages 197-201

  Janout, Vaclav ^a   Cline, Lauren L ^a   Feuston, Bradley P ^b   Klein, Lee ^b   O'Brien, Ann ^b   Tucker, Tom ^b   Yuan, Yu ^b   O'Neill Davis, Lynn A ^b   Peiffer, Robert L ^b   Nerurkar, Sandhya S ^b   Jadhav, Vasant ^b   Tellers, David M ^b   Regen, Steven L ^a  

^a LEHIGH UNIVERSITY   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEIC ACIDS;

COMPUTER MODELS; IN-VITRO; IN-VIVO; INTRAVITREAL INJECTION; OCULAR DELIVERY; RNA CONJUGATE; TRANSFECTION REAGENTS; UMBRELLA CONJUGATES;

BIOACTIVITY;

DRUG CARRIER; HYBRID PROTEIN; MESSENGER RNA; OCTAWALLED MOLECULAR UMBRELLA SHORT INTERFACING RNA CONJUGATE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; COMPUTER MODEL; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; NONHUMAN; RAT; RETINA; RNA SEQUENCE;

DRUG ADMINISTRATION ROUTES; DRUG CARRIERS; EYE; HEK293 CELLS; HUMANS; MOLECULAR DYNAMICS SIMULATION; RNA, SMALL INTERFERING;

EID: 84894485826     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc400506m     Document Type: Article

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