Use of methylnaltrexone to induce laxation in acutely injured patients with burns and necrotizing soft-tissue infections

Journal of Burn Care and Research

Volumn 35, Issue 2, 2014, Pages

  Hewitt, Kelly ^a   Lin, Hsin ^a   Faraklas, Iris ^a   Morris, Stephen ^a   Cochran, Amalia ^a   Saffle, Jeffrey ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AGED, 80 AND OVER; ANALGESICS, OPIOID; BURNS; CONSTIPATION; FEMALE; HUMANS; INJECTIONS, SUBCUTANEOUS; LAXATIVES; MALE; MIDDLE AGED; NALTREXONE; NARCOTIC ANTAGONISTS; NECROSIS; QUATERNARY AMMONIUM COMPOUNDS; RETROSPECTIVE STUDIES; SOFT TISSUE INFECTIONS; TREATMENT OUTCOME;

EID: 84894471226     PISSN: 1559047X     EISSN: 15590488     Source Type: Journal    
DOI: 10.1097/BCR.0b013e31829b399d     Document Type: Article

References (30)

1. Ulmer JF. Burn pain management: a guideline-based approach. J Burn Care Rehabil 1998;19:151-9.
2. Sullivan SR, Friedrich JB, Engrav LH, et al. "Opioid creep" is real and may be the cause of "fluid creep". Burns 2004;30:583-90.
3. Woo M, O'Connor M, Yuan CS, Moss J. Reversal of opioidinduced gastric dysfunction in a critically ill burn patient after methylnaltrexone. Anesth Analg 2008;107:1965-7.
4. Mentec H, Dupont H, Bocchetti M, Cani P, Ponche F, Bleichner G. Upper digestive intolerance during enteral nutrition in critically ill patients: frequency, risk factors, and complications. Crit Care Med 2001;29:1955-61.
5. Jacobi J, Fraser GL, Coursin DB, et al.; Task Force of the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM), American Society of Health-System Pharmacists (ASHP), American College of Chest Physicians. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 2002;30:119-41.
6. Yuan CS, Foss JF, O'Connor M, et al. Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial. JAMA 2000;283:367-72.
7. Michna E, Blonsky ER, Schulman S, et al. Subcutaneous methylnaltrexone for treatment of opioid-induced constipation in patients with chronic, nonmalignant pain: a randomized controlled study. J Pain 2011;12:554-62.
8. Portenoy RK, Thomas J, Moehl Boatwright ML, et al. Subcutaneous methylnaltrexone for the treatment of opioid-induced constipation in patients with advanced illness: a double-blind, randomized, parallel group, dose-ranging study. J Pain Symptom Manage 2008;35:458-68.
9. Thomas J, Karver S, Cooney GA, et al. Methylnaltrexone for opioid-induced constipation in advanced illness. N Engl J Med 2008;358:2332-43.
10. Anissian L, Schwartz HW, Vincent K, et al. Subcutaneous methylnaltrexone for treatment of acute opioid-induced constipation: phase 2 study in rehabilitation after orthopedic surgery. J Hosp Med 2012;7:67-72.
11. Opioid analgesics. In: Lacy C, Armstrong L, Goldman M, Lance L, editors. Drug information handbook: a comprehensive resource for all clinicians and healthcare professionals. Hudson, OH: Lexicomp; 2011. p. 1807.
12. Vieweg WV, Lipps WF, Fernandez A. Opioids and methadone equivalents for clinicians. Prim Care Companion J Clin Psychiatry 2005;7:86-8.
13. Patanwala AE, Duby J, Waters D, Erstad BL. Opioid conversions in acute care. Ann Pharmacother 2007;41:255-66.
14. Marks RM, Sachar EJ. Undertreatment of medical inpatients with narcotic analgesics. Ann Intern Med 1973;78:173-81.
15. Choinière M, Melzack R, Girard N, Rondeau J, Paquin MJ. Comparisons between patients' and nurses' assessment of pain and medication efficacy in severe burn injuries. Pain 1990;40:143-52.
16. Ashburn MA. Burn pain: the management of procedurerelated pain. J Burn Care Rehabil 1995;16(3 Pt 2):365-71.
17. Pain Management Standards: Joint Commission on Accreditation of Healthcare Organizations; available from http://www.jcaho.org/ accredited+organizations/hospitals/standards/revisions/index.htm; accessed 3 March 2012.
18. American Society of Anesthesiologists Task Force on Pain Management. Practice guidelines for acute pain management in the perioperative setting. A report by the American Society of Anesthesiologists Task Force on Pain Management, Acute Pain Section. Anesthesiology 1995;82:1071-81.
19. Summer GJ, Puntillo KA, Miaskowski C, Green PG, Levine JD. Burn injury pain: the continuing challenge. J Pain 2007;8:533-48.
20. Lucas CE, Vlahos AL, Ledgerwood AM. Kindness kills: the negative impact of pain as the fifth vital sign. J Am Coll Surg 2007;205:101-7.
21. Kozol RA, Voytovich A. Misinterpretation of the fifth vital sign. Arch Surg 2007;142:417-9; discussion 419-20.
22. Modesto-Lowe V, Brooks D, Petry N. Methadone deaths: risk factors in pain and addicted populations. J Gen Intern Med 2010;25:305-9.
23. Markell KW, Renz EM, White CE, et al. Abdominal complications after severe burns. J Am Coll Surg 2009;208:940-7; discussion 947-9.
24. Scaife CL, Saffle JR, Morris SE. Intestinal obstruction secondary to enteral feedings in burn trauma patients. J Trauma 1999;47:859-63.
25. Kowal-Vern A, McGill V, Gamelli RL. Ischemic necrotic bowel disease in thermal injury. Arch Surg 1997;132:440-3.
26. Heyland DK, Cahill NE, Dhaliwal R, Sun X, Day AG, McClave SA. Impact of enteral feeding protocols on enteral nutrition delivery: results of a multicenter observational study. JPEN J Parenter Enteral Nutr 2010;34:675-84.
27. Viscusi ER, Gan TJ, Leslie JB, et al. Peripherally acting mu-opioid receptor antagonists and postoperative ileus: mechanisms of action and clinical applicability. Anesth Analg 2009;108:1811-22.
28. Candy B, Jones L, Goodman ML, Drake R, Tookman A. Laxatives or methylnaltrexone for the management of constipation in palliative care patients. Cochrane Database Syst Rev 2011:CD003448.
29. Yuan CS, Foss JF. Oral methylnaltrexone for opioid-induced constipation. JAMA 2000;284:1383-4.
30. Diego L, Atayee R, Helmons P, Hsiao G, von Gunten CF. Novel opioid antagonists for opioid-induced bowel dysfunction. Expert Opin Investig Drugs 2011;20:1047-56.