PANC-1 pancreatic cancer cell growth inhibited by cucurmosin alone and in combination with an epidermal growth factor receptor-targeted drug

Pancreas

Volumn 43, Issue 2, 2014, Pages 291-297

  Wang, Congfei ^a   Yang, Aiqin ^b   Zhang, Baoming ^a   Yin, Qiang ^a   Huang, Heguang ^a,b   Chen, Minghuang ^c   Xie, Jieming ^b  

^a Union Clinical School   (United States)

^b FUJIAN MEDICAL UNIVERSITY   (China)

^c FUJIAN INSTITUTE OF RESEARCH ON THE STRUCTURE OF MATTER   (China)

Author keywords

apoptosis; cooperation; Cucurmosin; epidermal growth factor receptor; growth inhibition; pancreatic cancer

Indexed keywords

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; PANCREATIC NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PLANT PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOME INACTIVATING PROTEINS, TYPE 1; SIGNAL TRANSDUCTION; TIME FACTORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84894462912     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0000000000000087     Document Type: Article

References (27)

1. Jemal A, Siegel R, Xu J, et al. Cancer statistics. CA Cancer J Clin. 2010:60:277-300.
2. El Maalouf G, Le Tourneau C, Batty GN, et al. Markers involved in resistance to cytotoxics and targeted therapeutics in pancreatic cancer. Cancer Treat Rev. 2008:35:167-174.
3. Van Damme EJM, Hao Q, Chen Y, et al. Ribosome-inactivating proteins: a family of plant proteins that do more than inactivate ribosomes. Crit Rev Plant Sci. 2001:20:395-465.
4. Nielsen K, Boston RS. Ribosome-inactivating proteins: a plant perspective. Annu Rev Plant Physiol Plant Mol Biol. 2001:52:785-816.
5. Girbés T, Ferreras JM, Arias FJ, et al. Description, distribution, activity and phylogenetic relationship of ribosome-inactivating proteins in plants, fungi and bacteria. Mini Rev Med Chem. 2004:4:461-476.
6. Stirpe F. Ribosome-inactivating proteins. Toxicon. 2004:44:371-383.
7. Barbieri L, Battelli MG, Stirpe F. Ribosome-inactivating proteins from plants. Biochim Biophys Acta. 1993:1154:237-282.
8. Stirpe F, Barbieri L. Ribosome-inactivating proteins up to date. FEBS Lett. 1986:195:1-8.
9. Lin JY, Tserng KY, Chen CC, et al. Abrin and ricin: new anti-tumour substances. Nature. 1970:227:292-293.
10. Chen M, Ye X, Cai J, et al. Crystallization and preliminary crystallographic study of cucurmosin, a ribosome-inactivating protein from the sarcocarp of Cucurbita moschata. Acta Crystallogr D Biol Crystallogr. 2000:56:665-666.
11. Shi XL, Zhou EX, Ye XM, et al. Molecular replacement studies of cucurmosin from Cucurbita moschata: structure homology with trichosanthin. Chinese J Struct Chem. 2003:22:165-168.
12. Chen MH, Ye XM. A ribosome-inactivating proteins: cucurmosin, application no. 99102290.4; Feb 11, 2000. Available at: http://211.157.104.87:8080/sipo/ zljs/hyjs-yx-new.jsp?recid=CN99102290.4. Accessed August 16, 2000.
13. Chen MH, Ye XM. A peptide: a polypeptide with N-terminal sequence of cucurmosin, application no. 03135045.3; September 29, 2005. Available at: http://211.157.104.87:8080/sipo/zljs/hyjs-yxnew.jsp?recid=CN03135045.3. Accessed April 6, 2005.
14. Chen MH, Xie JM, Xu Y, et al. Cucurmosin and its encoding gene, application no. 200710008402.6; January 4, 2008. Available at: http://211.157.104.87:8080/sipo/zljs/hyjs-yxnew.jsp?recid=CN200710008402.6. Accessed 9 July 9, 2008.
15. Hou X, Meehan EJ, Xie J, et al. Atomic resolution structure of cucurmosin, a novel type 1 ribosome-inactivating protein from the sarcocarp of Cucurbita moschata. J Struct Biol. 2008:164:81-87.
16. Storniolo AM, Enas NH, Brown CA, et al. An investigational new drug treatment program for patients with gemcitabine: results for over 3000 patients with pancreatic carcinoma. Cancer. 1999:85:1261-1268.
17. Starling N, Hawkes EA, Chau I, et al. A dose-escalation study of gemcitabine (Gem) plus oxaliplatin (Ox) in combination with imatinib in patients (pts) with gemcitabine-refractory advanced pancreatic adenocarcinoma (PC). J Clin Oncol. 2010:28:4155.
18. Endo Y, Mitsui K, Motizuki M, et al. The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28S ribosomal RNA caused by the toxins. J Biol Chem. 1987:262:5908-5912.
19. Xu C, Huang H, Chen M. Effects of cucurmosin on the cell proliferation and apoptosis in human pancreatic PANC-1 cells. Chinese Journal of Integrated Traditional and Western Medicine. 2012:32:234-238.
20. Thomberry NA, Lazebnik Y. Caspase: Enemies within. Science. 2005:281:1312-1316.
21. Reed JC. Bcl-2 family proteins and mitochondria. Biochim Biophys Acta. 2006:1366:127-137.
22. Normanno N, De Luca A, Bianco C, et al. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene. 2006:366:2-16.
23. Ueda S, Ogata S, Tsuda H, et al. The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas. 2004:29:e1-e8.
24. Frolov A, Liles JS, Kossenkov AV, et al. Epidermal growth factor receptor(EGFR) intron 1 polymorphism and clinical outcome in pancreatic adenocarcinoma. Am J Surg. 2010:200:398-405.
25. Cao C, Lu S, Sowa A, et al. Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs. Cancer Lett. 2008:266:249-262.
26. Bareschino MA, Schettino C, Troiani T, et al. Erlotinib in cancer treatment. Ann Oncol. 2007:18:35-41.
27. Zhang B, Huang H, Xie J, et al. Cucurmosin induces apoptosis of BxPC-3 human pancreatic cancer cells via inactivation of the EGFR signaling pathway. Oncol Rep. 2012:27:891-897.