Body fat partitioning does not explain the interethnic variation in insulin sensitivity among asian ethnicity: the singapore adults metabolism study

Diabetes

Volumn 63, Issue 3, 2014, Pages 1093-1102

  Khoo, Chin Meng ^a,b   Khee Shing Leow, Melvin ^b,c,d   Sadananthan, Suresh Anand ^d,e   Lim, Radiance ^d,f   Venkataraman, Kavita ^e,g   Khoo, Eric Yin Hao ^a   Velan, S Sendhil ^d,e,h   Ong, Yu Ting ^d   Kambadur, Ravi ^d,i   McFarlane, Craig ^d   Gluckman, Peter D ^d   Lee, Yun Seng ^d,g   Chong, Yap Seng ^e   Tai, E Shyong ^a,b,g  

^a Dept Medicine Endocrinol Diabet   (Singapore)

^b Singapore Graduate Medical School   (Singapore)

^c TAN TOCK SENG HOSPITAL   (Singapore)

^d AGENCY FOR SCIENCE   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^g NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^h AGENCY FOR SCIENCE   (Singapore)

ⁱ NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE; ADIPOSITY; ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; HUMANS; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; MALE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SINGAPORE; SUBCUTANEOUS FAT;

EID: 84894460662     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1483     Document Type: Article

References (25)

1. Chandalia M, Lin P, Seenivasan T, et al. Insulin resistance and body fat distribution in South Asian men compared to Caucasian men. PLoS ONE 2007;2:e812
2. Liew CF, Seah ES, Yeo KP, Lee KO, Wise SD. Lean, nondiabetic Asian Indians have decreased insulin sensitivity and insulin clearance, and raised leptin compared to Caucasians and Chinese subjects. Int J Obes Relat Metab Disord 2003;27:784-789
3. Chandalia M, Abate N, Garg A, Stray-Gundersen J, Grundy SM. Relationship between generalized and upper body obesity to insulin resistance in Asian Indian men. J Clin Endocrinol Metab 1999;84:2329-2335
4. Khoo CM, Sairazi S, Taslim S, et al. Ethnicity modifies the relationships of insulin resistance, inflammation, and adiponectin with obesity in a multiethnic Asian population. Diabetes Care 2011;34:1120-1126
5. Tai ES, Lim SC, Chew SK, Tan BY, Tan CE. Homeostasis model assessment in a population with mixed ethnicity: the 1992 Singapore National Health Survey. Diabetes Res Clin Pract 2000;49:159-168
6. Lear SA, Humphries KH, Kohli S, Chockalingam A, Frohlich JJ, Birmingham CL. Visceral adipose tissue accumulation differs according to ethnic background: results of the Multicultural Community Health Assessment Trial (M-CHAT). Am J Clin Nutr 2007;86:353-359
7. Nazare JA, Smith JD, Borel AL, et al. Ethnic influences on the relations between abdominal subcutaneous and visceral adiposity, liver fat, and cardiometabolic risk profile: the International Study of Prediction of Intra-Abdominal Adiposity and Its Relationship With Cardiometabolic Risk/Intra-Abdominal Adiposity. Am J Clin Nutr 2012;96:714-726
8. Kumashiro N, Erion DM, Zhang D, et al. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 2011;108:16381-16385
9. Corcoran MP, Lamon-Fava S, Fielding RA. Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise. Am J Clin Nutr 2007;85:662-677
10. Ukropcova B, McNeil M, Sereda O, et al. Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor. J Clin Invest 2005;115:1934-1941
11. Bergman RN, Finegood DT, Ader M. Assessment of insulin sensitivity in vivo. Endocr Rev 1985;6:45-86
12. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672-679
13. Cowin GJ, Jonsson JR, Bauer JD, et al. Magnetic resonance imaging and spectroscopy for monitoring liver steatosis. J Magn Reson Imaging 2008; 28:937-945
14. Velan SS, Narasimhan K, Spencer RG, Raylman RR, Rajendran VM, Alway SE. Ankle orientation alters bulk susceptibility and residual dipolar couplings during plantar flexion and dorsiflexion of skeletal muscle. Poster presentation (Poster 2597) at the 18th Annual Meeting of the International Society of Magnetic Resonance in Medicine, 1-7 May 2010, Stockholm, Sweden
15. Pola A, Sadananthan SA, Yaligar J, et al. Skeletal muscle lipid metabolism studied by advanced magnetic resonance spectroscopy. Prog Nucl Magn Reson Spectrosc 2012;65:66-76
16. Sadananthan S, Zagorodnov V. Retrospective Techniques for Segmentation of Structural and Functional MR Brain Images. Singapore, Nanyang Technological University, 2010
17. Parimal S, Zagorodnov V. Segmentation of Magnetic Resonance Images of Brain and Abdomen. Singapore, Nanyang Technological University, 2010.
18. Sadananthan SA, Zheng W, Chee MWL, Zagorodnov V. Skull stripping using graph cuts. Neuroimage 2010;49:225-239
19. Li C, Xu C, Gui C, Fox MD. Distance regularized level set evolution and its application to image segmentation. IEEE Trans Image Process 2010;19: 3243-3254
20. Kelley DE, Thaete FL, Troost F, Huwe T, Goodpaster BH. Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am J Physiol Endocrinol Metab 2000;278:E941-E948
21. Lundbom J, Hakkarainen A, Lundbom N, Taskinen MR. Deep subcutaneous adipose tissue is more saturated than superficial subcutaneous adipose tissue. Int J Obes (Lond) 2013;37:620-622
22. Walker GE, Verti B, Marzullo P, et al. Deep subcutaneous adipose tissue: a distinct abdominal adipose depot. Obesity (Silver Spring) 2007;15:1933-1943
23. Dubé JJ, Amati F, Stefanovic-Racic M, Toledo FG, Sauers SE, Goodpaster BH. Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited. Am J Physiol Endocrinol Metab 2008;294:E882-E888
24. Neumann-Haefelin C, Kuhlmann J, Belz U, et al. Determinants of intramyocellular lipid concentrations in rat hindleg muscle. Magn Reson Med 2003;50:242-248
25. Abbasi F, Brown BW Jr, Lamendola C, McLaughlin T, Reaven GM. Relationship between obesity, insulin resistance, and coronary heart disease risk. J Am Coll Cardiol 2002;40:937-943