Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres

Nature Materials

Volumn 13, Issue 3, 2014, Pages 308-316

  Jain, Anjana ^a,d   Betancur, Martha ^a   Patel, Gaurangkumar D ^a   Valmikinathan, Chandra M ^a   Mukhatyar, Vivek J ^a   Vakharia, Ajit ^a   Pai, S Balakrishna ^a   Brahma, Barunashish ^b   MacDonald, Tobey J ^c   Bellamkonda, Ravi V ^a  

^a Emory University   (United States)

^b Children's Health Care of Atlanta ^*  (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Worcester Polytechnic Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD VESSELS; BRAIN; CELL DEATH; CELL ENGINEERING; FISH; HYDROGELS; NANOFIBERS; POLYCAPROLACTONE;

BRAIN TUMOURS; CYTOTOXIC; GLIOBLASTOMA CELLS; GLIOBLASTOMA MULTIFORME; GLIOBLASTOMAS; SURVIVAL RATE; TUMOUR CELLS; WHITE MATTER TRACTS;

TUMORS;

NANOFIBER; POLYMER;

ARTICLE; BRAIN TUMOR; CHEMISTRY; GLIOBLASTOMA; HUMAN; HYDROGEL; PATHOLOGY; XENOGRAFT;

BRAIN NEOPLASMS; GLIOBLASTOMA; HETEROGRAFTS; HUMANS; HYDROGELS; NANOFIBERS; POLYMERS;

EID: 84894449285     PISSN: 14761122     EISSN: 14764660     Source Type: Journal    
DOI: 10.1038/nmat3878     Document Type: Article

References (20)

1. Davis, F. G., Freels, S., Grutsch, J., Barlas, S. & Brem, S. Survival rates in patients with primary malignant brain tumors stratified by patient age and tumor histological type: an analysis based on Surveillance, Epidemiology, and End Results (SEER) data, 1973-1991. J. Neurosurg. 88, 1-10 (1998).
2. Wiesner, S. M., Freese, A. & Ohlfest, J. R. Emerging concepts in glioma biology: implications for clinical protocols and rational treatment strategies. Neurosurg. Focus 19, E3 (2005).
3. Tuettenberg, J. et al. Recurrence pattern in glioblastoma multiforme patients treated with anti-angiogenic chemotherapy. J. Cancer Res. Clin. Oncol. 135, 1239-1244 (2009).
4. Rostomily, R. C. et al. Multimodality management of recurrent adult malignant gliomas: results of a phase II multiagent chemotherapy study and analysis of cytoreductive surgery. Neurosurgery 35, 378-388 (1994).
5. Bar, E. E. et al. Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells 25, 2524-2533 (2007).
6. Bellail, A. C., Hunter, S. B., Brat, D. J., Tan, C. & Van Meir, E. G. Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion. Int. J. Biochem. Cell Biol. 36, 1046-1069 (2004).
7. Bernstein, J. J. &Woodard, C. A. Glioblastoma cells do not intravasate into blood vessels. Neurosurgery 36, 124-132 (1995).
8. Weiner, H. L. et al. Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1. Cancer Res. 62, 6385-6389 (2002).
9. Becher, O. J. et al. Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas. Cancer Res. 68, 2241-2249 (2008).
10. Grossman, S. A. et al. The intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers. J. Neurosurg. 76, 640-647 (1992).
11. Kohn, K.W. Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1- nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas. Cancer Res. 37, 1450-1454 (1977).
12. Kee, N., Sivalingam, S., Boonstra, R. &Wojtowicz, J. M. The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis. J. Neurosci. Methods 115, 97-105 (2002).
13. Haghparast, S. M. A., Kihara, T., Shimizu, Y., Yuba, S. & Miyake, J. Actin-based biomechanical features of suspended normal and cancer cells. J. Biosci. Bioeng. 116, 380-385 (2013).
14. Biran, R., Noble, M. D. & Tresco, P. A. Directed nerve outgrowth is enhanced by engineered glial substrates. Exp. Neurol. 184, 141-152 (2003).
15. Kanda, S. et al. Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase. J. Biol. Chem. 278, 8244-8249 (2003).
16. Baluk, P., Morikawa, S., Haskell, A., Mancuso, M. & McDonald, D. M. Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors. Am. J. Pathol. 163, 1801-1815 (2003).
17. Hernandez, L., Smirnova, T.,Wycko-, J., Condeelis, J. & Segall, J. E. In vivo assay for tumor cell invasion. Methods Mol. Biol. 571, 227-238 (2009).
18. Wycko-, J., Gligoijevic, B., Entenberg, D., Segall, J. E. & Condeelis, J. The in vivo invasion assay: preparation and handling of collection needles. Cold Spring Harbor Protocols 10, 1232-1234 (2011).
19. Kim, Y. T., Haftel, V. K., Kumar, S. & Bellamkonda, R. V. The role of aligned polymer fiber-based constructs in the bridging of long peripheral nerve gaps. Biomaterials 29, 3117-3127 (2008).
20. Karumbaiah, L. et al. The upregulation of specific interleukin (IL) receptor antagonists and paradoxical enhancement of neuronal apoptosis due to electrode induced strain and brain micromotion. Biomaterials 33, 5983-5996 (2012).