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Volumn 55, Issue 3, 2014, Pages 526-532

Treatment with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone is beneficial but toxic in very elderly patients with diffuse large B-cell lymphoma: A population-based cohort study on treatment, toxicity and outcome

Author keywords

DLBCL; Elderly; HemoBase; Population based

Indexed keywords

AGE FACTORS; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAUSE OF DEATH; COHORT STUDIES; CYCLOPHOSPHAMIDE; DOXORUBICIN; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPHOMA, LARGE B-CELL, DIFFUSE; MALE; NEOPLASM STAGING; PREDNISONE; REGISTRIES; TREATMENT OUTCOME; VINCRISTINE;

EID: 84894449156     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2013.810737     Document Type: Article
Times cited : (45)

References (39)
  • 1
    • 41549137352 scopus 로고    scopus 로고
    • Non-Hodgkin's lymphoma in very elderly patients over 80 years A descriptive analysis of clinical presentation and outcome
    • Thieblemont C, Grossoeuvre A, Houot R, et al. Non-Hodgkin's lymphoma in very elderly patients over 80 years. A descriptive analysis of clinical presentation and outcome. Ann Oncol 2008;19:774-779
    • (2008) Ann Oncol , vol.19 , pp. 774-779
    • Thieblemont, C.1    Grossoeuvre, A.2    Houot, R.3
  • 2
    • 0345257035 scopus 로고    scopus 로고
    • Non-Hodgkin's lymphoma in the elderly A review with emphasis on elderly patients, geriatric assessment, and future perspectives
    • Maartense E, Kluin-Nelemans HC, Noordijk EM. Non-Hodgkin's lymphoma in the elderly. A review with emphasis on elderly patients, geriatric assessment, and future perspectives. Ann Hematol 2003;82:661-670
    • (2003) Ann Hematol , vol.82 , pp. 661-670
    • Maartense, E.1    Kluin-Nelemans, H.C.2    Noordijk, E.M.3
  • 3
    • 0037165261 scopus 로고    scopus 로고
    • CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma
    • Coiffier B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 2002;346:235-242
    • (2002) N Engl J Med , vol.346 , pp. 235-242
    • Coiffier, B.1    Lepage, E.2    Briere, J.3
  • 4
    • 77957200763 scopus 로고    scopus 로고
    • Long-term outcome of patients in the LNH-98.5 trial the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: A study by the Groupe d'Etudes des Lymphomes de l 'Adulte
    • Coiffier B, Thieblemont C, Van Den Neste E, et al. Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l 'Adulte. Blood 2010 ; 116 : 2040-2045
    • (2010) Blood , vol.116 , pp. 2040-2045
    • Coiffier, B.1    Thieblemont, C.2    Van Den Neste, E.3
  • 5
    • 38549147027 scopus 로고    scopus 로고
    • Sixversus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20 + B-cell lymphomas: A randomised controlled trial (RICOVER-60)
    • Pfreundschuh M, Schubert J, Ziepert M, et al. Sixversus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20 + B-cell lymphomas: a randomised controlled trial (RICOVER-60). Lancet Oncol 2008;9:105-116
    • (2008) Lancet Oncol , vol.9 , pp. 105-116
    • Pfreundschuh, M.1    Schubert, J.2    Ziepert, M.3
  • 6
    • 84860425598 scopus 로고    scopus 로고
    • Two sides of the medallion: Poor treatment tolerance but better survival by standard chemotherapy in elderly patients with advanced-stage diffuse large B-cell lymphoma
    • van de Schans SA, Wymenga AN, van Spronsen DJ, et al. Two sides of the medallion: poor treatment tolerance but better survival by standard chemotherapy in elderly patients with advanced-stage diffuse large B-cell lymphoma. Ann Oncol 2012;23:1280-1286
    • (2012) Ann Oncol , vol.23 , pp. 1280-1286
    • Van De Schans, S.A.1    Wymenga, A.N.2    Van Spronsen, D.J.3
  • 7
    • 84894445534 scopus 로고    scopus 로고
    • HemoBase:eenintelligent elektronisch patientendossier als coach voor de hemato-oncologische zorg
    • HoogendoornM,JoostenP, StormH, et al.HemoBase:eenintelligent elektronisch patientendossier als coach voor de hemato-oncologische zorg. Nederlands tijdschrift voor hematologie. 2009;6:104-110
    • (2009) Nederlands Tijdschrift voor Hematologie , vol.6 , pp. 104-110
    • Hoogendoorn, M.1    Joosten, P.2    Storm, H.3
  • 8
    • 69149089720 scopus 로고    scopus 로고
    • WHO classification oftumours of haematopoietic and lymphoid tissues
    • Swerdlow SH, Campoo E, Harris NL. WHO classification oftumours of haematopoietic and lymphoid tissues. Lyon: IARC; 2008
    • (2008) Lyon: IARC
    • Swerdlow, S.H.1    Campoo, E.2    Harris, N.L.3
  • 9
    • 12344312699 scopus 로고    scopus 로고
    • National Cancer Institute
    • National Cancer Institute. Common Terminology Criteria for Adverse Events. NIH. 2006. Available from: http://ctep.cancer.gov/protocolDevelopment/ electronic-Applications/docs/ctcaev3.pdf
    • (2006) Common Terminology Criteria for Adverse Events. NIH
  • 10
    • 33947496614 scopus 로고    scopus 로고
    • Revised response criteria for malignant lymphoma
    • Cheson BD, Pfistner B, Juweid ME, et al. Revised response criteria for malignant lymphoma. J Clin Oncol 2007 ; 25 : 579-586
    • (2007) J Clin Oncol , vol.25 , pp. 579-586
    • Cheson, B.D.1    Pfistner, B.2    Juweid, M.E.3
  • 11
    • 0031743935 scopus 로고    scopus 로고
    • Elderly patients with non-Hodgkin's lymphoma: Population-based results in the Netherlands
    • Maartense E Hermans J Kluin-Nelemans JC et al Elderly patients with non-Hodgkin's lymphoma: population-based results in The Netherlands Ann Oncol 1998 9 1219-1227
    • (1998) Ann Oncol , vol.9 , pp. 1219-1227
    • Maartense, E.1    Hermans, J.2    Kluin-Nelemans, J.C.3
  • 12
    • 0035060072 scopus 로고    scopus 로고
    • Treatment of elderly patients with intermediate- and high-grade non-Hodgkin's lymphoma: A retrospective population-based study
    • Peters FP, Lalisang RI, Fickers MM, et al. Treatment of elderly patients with intermediate- and high-grade non-Hodgkin's lymphoma: a retrospective population-based study . Ann Hematol 2001 ; 80 : 155-159
    • (2001) Ann Hematol , vol.80 , pp. 155-159
    • Peters, F.P.1    Lalisang, R.I.2    Fickers, M.M.3
  • 13
    • 0042914721 scopus 로고    scopus 로고
    • CHOP compared with CHOP plus granulocyte colony-stimulating factor in elderly patients with aggressive non-Hodgkin's lymphoma
    • Doorduijn JK, van der Holt B, van Imhoff GW, et al. CHOP compared with CHOP plus granulocyte colony-stimulating factor in elderly patients with aggressive non-Hodgkin's lymphoma. J Clin Oncol 2003 ; 21 : 3041-3050
    • (2003) J Clin Oncol , vol.21 , pp. 3041-3050
    • Doorduijn, J.K.1    Van Der Holt, B.2    Van Imhoff, G.W.3
  • 14
    • 24644500086 scopus 로고    scopus 로고
    • Introduction of combined CHOP plus rituximab therapy dramatically improved outcome of diffuse large B-cell lymphoma in British Columbia
    • Sehn LH , Donaldson J, Chhanabhai M , et al . Introduction of combined CHOP plus rituximab therapy dramatically improved outcome of diffuse large B-cell lymphoma in British Columbia. J Clin Oncol 2005 ; 23 : 5027-5033
    • (2005) J Clin Oncol , vol.23 , pp. 5027-5033
    • Sehn, L.H.1    Donaldson, J.2    Chhanabhai, M.3
  • 15
    • 79955473473 scopus 로고    scopus 로고
    • Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma: A multicentre, single-Arm, phase 2 trial
    • Peyrade F, Jardin F, Thieblemont C, et al. Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma: a multicentre, single-Arm, phase 2 trial. Lancet Oncol 2011;12:460-468
    • (2011) Lancet Oncol , vol.12 , pp. 460-468
    • Peyrade, F.1    Jardin, F.2    Thieblemont, C.3
  • 16
    • 34648816088 scopus 로고    scopus 로고
    • Non-Hodgkin's lymphoma in the elderly Part 2: Treatment of diffuse aggressive lymphomas
    • discussion 1198-1208 1210
    • Morrison VA. Non-Hodgkin's lymphoma in the elderly. Part 2: treatment of diffuse aggressive lymphomas. Oncology (Williston Park) 2007;21:1191- 1198;discussion 1198-1208, 1210
    • (2007) Oncology (Williston Park) , vol.21 , pp. 1191-1198
    • Morrison, V.A.1
  • 17
    • 78650515906 scopus 로고    scopus 로고
    • 2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours
    • Aapro MS, Bohlius J, Cameron DA, et al. 2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours. Eur J Cancer 2011 ; 47 : 8-32
    • (2011) Eur J Cancer , vol.47 , pp. 8-32
    • Aapro, M.S.1    Bohlius, J.2    Cameron, D.A.3
  • 18
    • 33745989223 scopus 로고    scopus 로고
    • 2006 Update of recommendations for the use of white blood cell growth factors: An evidence-based clinical practice guideline
    • Smith TJ, Khatcheressian J, Lyman GH, et al. 2006 Update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. J Clin Oncol 2006;24: 3187-3205
    • (2006) J Clin Oncol , vol.24 , pp. 3187-3205
    • Smith, T.J.1    Khatcheressian, J.2    Lyman, G.H.3
  • 19
    • 0036080490 scopus 로고    scopus 로고
    • Impact of age and colony-stimulating factor use on hospital length of stay for febrile neutropenia in CHOP-treated non-Hodgkin's lymphoma
    • Chrischilles E, Delgado DJ, Stolshek BS, et al. Impact of age and colony-stimulating factor use on hospital length of stay for febrile neutropenia in CHOP-treated non-Hodgkin's lymphoma. Cancer Control 2002 ; 9 : 203-211
    • (2002) Cancer Control , vol.9 , pp. 203-211
    • Chrischilles, E.1    Delgado, D.J.2    Stolshek, B.S.3
  • 20
    • 0038603184 scopus 로고    scopus 로고
    • CHOP is superior to CNOP in elderly patients with aggressive lymphoma while outcome is unaffected by filgrastim treatment: Results of a Nordic Lymphoma Group randomized trial
    • Osby E, Hagberg H, Kvaloy S, et al. CHOP is superior to CNOP in elderly patients with aggressive lymphoma while outcome is unaffected by filgrastim treatment: results of a Nordic Lymphoma Group randomized trial . Blood 2003 ; 101 : 3840-3848
    • (2003) Blood , vol.101 , pp. 3840-3848
    • Osby, E.1    Hagberg, H.2    Kvaloy, S.3
  • 21
    • 0042914721 scopus 로고    scopus 로고
    • CHOP compared with CHOP plus granulocyte colony-stimulating factor in elderly patients with aggressive non-Hodgkin' s lymphoma
    • Doorduijn JK, van der Holt B, van Imhoff GW, et al. CHOP compared with CHOP plus granulocyte colony-stimulating factor in elderly patients with aggressive non-Hodgkin' s lymphoma. J Clin Oncol 2003 ; 21 : 3041-3050
    • (2003) J Clin Oncol , vol.21 , pp. 3041-3050
    • Doorduijn, J.K.1    Van Der Holt, B.2    Van Imhoff, G.W.3
  • 22
    • 24344445873 scopus 로고    scopus 로고
    • Antibacterial prophylaxis after chemotherapy for solid tumors and lymphomas
    • Cullen M , Steven N, Billingham L , et al . Antibacterial prophylaxis after chemotherapy for solid tumors and lymphomas. N Engl J Med 2005 ; 353 : 988-998
    • (2005) N Engl J Med , vol.353 , pp. 988-998
    • Cullen, M.1    Steven, N.2    Billingham, L.3
  • 23
    • 24344471724 scopus 로고    scopus 로고
    • Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia
    • Bucaneve G, MicozziA, MenichettiF, et al.Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia. N Engl J Med 2005 ; 353 : 977-987
    • (2005) N Engl J Med , vol.353 , pp. 977-987
    • Bucaneve, G.1    Micozzi, A.2    Menichetti, F.3
  • 24
    • 78650066026 scopus 로고    scopus 로고
    • How i treat elderly patients with diffuse large B-cell lymphoma
    • Pfreundschuh M. How I treat elderly patients with diffuse large B-cell lymphoma. Blood 2010;116:5103-5110
    • (2010) Blood , vol.116 , pp. 5103-5110
    • Pfreundschuh, M.1
  • 25
    • 27844612519 scopus 로고    scopus 로고
    • Fluoroquinolone resistance in hematopoietic stem cell transplant recipients with infectious complications
    • Bonadio M, Morelli G, Mori S, et al. Fluoroquinolone resistance in hematopoietic stem cell transplant recipients with infectious complications. Biomed Pharmacother 2005 ; 59 : 511-516
    • (2005) Biomed Pharmacother , vol.59 , pp. 511-516
    • Bonadio, M.1    Morelli, G.2    Mori, S.3
  • 26
    • 33847414083 scopus 로고    scopus 로고
    • Management of elderly patients with hematological neoplasms
    • Mora O, Zucca E . Management of elderly patients with hematological neoplasms. Ann Oncol 2007 ; 18(Suppl. 1): i49-i53
    • (2007) Ann Oncol , vol.18 , Issue.SUPPL. 1
    • Mora, O.1    Zucca, E.2
  • 27
    • 79956353648 scopus 로고    scopus 로고
    • Diffuse large B-cell lymphoma in the elderly: Diffusion of treatment with rituximab and survival advances with and without anthracyclines
    • Link BK, Brooks J, Wright K, et al. Diffuse large B-cell lymphoma in the elderly: diffusion of treatment with rituximab and survival advances with and without anthracyclines. Leuk Lymphoma 2011; 52 : 994-1002
    • (2011) Leuk Lymphoma , vol.52 , pp. 994-1002
    • Link, B.K.1    Brooks, J.2    Wright, K.3
  • 28
    • 79952032395 scopus 로고    scopus 로고
    • Activity and safety of dose-Adjusted infusional cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy with rituximab in very elderly patients with poor-prognostic untreated diffuse large B-cell non-Hodgkin lymphoma
    • Musolino A, Boggiani D, Panebianco M, et al. Activity and safety of dose-Adjusted infusional cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy with rituximab in very elderly patients with poor-prognostic untreated diffuse large B-cell non-Hodgkin lymphoma. Cancer 2011 ; 117 : 964-973
    • (2011) Cancer , vol.117 , pp. 964-973
    • Musolino, A.1    Boggiani, D.2    Panebianco, M.3
  • 29
    • 77954051890 scopus 로고    scopus 로고
    • Brief-durationrituximab/ chemotherapy followed by maintenance rituximab in patients with diffuse large B-cell lymphoma who are poor candidates for R-CHOP chemotherapy: A phase II trial of the Sarah Cannon Oncology Research Consortium
    • HainsworthJD,FlinnIW, SpigelDR, et al.Brief-durationrituximab/ chemotherapy followed by maintenance rituximab in patients with diffuse large B-cell lymphoma who are poor candidates for R-CHOP chemotherapy: a phase II trial of the Sarah Cannon Oncology Research Consortium. Clin Lymphoma Myeloma Leuk 2010;10:44-50
    • (2010) Clin Lymphoma Myeloma Leuk , vol.10 , pp. 44-50
    • Hainsworth, J.D.1    Flinn, I.W.2    Spigel, D.R.3
  • 30
    • 84867174986 scopus 로고    scopus 로고
    • Rituximab and bendamustine in patients with CD20 + diffuse large B-cell lymphoma not eligible for cyclophosphamide, doxorubicin, vincristine and prednisone-like chemotherapy
    • Walter E, Schmitt T, Dietrich S, et al. Rituximab and bendamustine in patients with CD20 + diffuse large B-cell lymphoma not eligible for cyclophosphamide, doxorubicin, vincristine and prednisone-like chemotherapy. Leuk Lymphoma 2012;53:2290-2292
    • (2012) Leuk Lymphoma , vol.53 , pp. 2290-2292
    • Walter, E.1    Schmitt, T.2    Dietrich, S.3
  • 31
    • 70349275955 scopus 로고    scopus 로고
    • A comprehensive geriatric assessment is more effective than clinical judgment to identify elderly diffuse large cell lymphoma patients who benefit from aggressive therapy
    • Tucci A , Ferrari S, Bottelli C, et al . A comprehensive geriatric assessment is more effective than clinical judgment to identify elderly diffuse large cell lymphoma patients who benefit from aggressive therapy. Cancer 2009;115:4547-4553
    • (2009) Cancer , vol.115 , pp. 4547-4553
    • Tucci, A.1    Ferrari, S.2    Bottelli, C.3
  • 32
    • 79954428066 scopus 로고    scopus 로고
    • Results of comprehensive geriatric assessment effect survival in patients with malignant lymphoma
    • Winkelmann N, Petersen I , Kiehntopf M , et al . Results of comprehensive geriatric assessment effect survival in patients with malignant lymphoma. J Cancer Res Clin Oncol 2011;137:733-738
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 733-738
    • Winkelmann, N.1    Petersen, I.2    Kiehntopf, M.3
  • 33
    • 79960185849 scopus 로고    scopus 로고
    • Predictive value of geriatric assessment for patients older than 70 years, treated with chemotherapy
    • Aaldriks AA, Maartense E, le Cessie S, et al. Predictive value of geriatric assessment for patients older than 70 years, treated with chemotherapy. Crit Rev Oncol Hematol 2011;79:205-212
    • (2011) Crit Rev Oncol Hematol , vol.79 , pp. 205-212
    • Aaldriks, A.A.1    Maartense, E.2    Le Cessie, S.3
  • 34
    • 80053056355 scopus 로고    scopus 로고
    • Comprehensive geriatric assessment in the decision-making process in elderly patients with cancer: ELCAPA study
    • Caillet P, Canoui-Poitrine F, Vouriot J, et al . Comprehensive geriatric assessment in the decision-making process in elderly patients with cancer: ELCAPA study. J Clin Oncol 2011;29:3636-3642
    • (2011) J Clin Oncol , vol.29 , pp. 3636-3642
    • Caillet, P.1    Canoui-Poitrine, F.2    Vouriot, J.3
  • 35
    • 84864952316 scopus 로고    scopus 로고
    • The impact of age Charlson comorbidity index, and performance status on treatment of elderly patients with diffuse large B cell lymphoma
    • Lin TL, Kuo MC, Shih LY, et al. The impact of age, Charlson comorbidity index, and performance status on treatment of elderly patients with diffuse large B cell lymphoma . Ann Hematol 2012; 91 : 1383-1391
    • (2012) Ann Hematol , vol.91 , pp. 1383-1391
    • Lin, T.L.1    Kuo, M.C.2    Shih, L.Y.3
  • 36
    • 79959750248 scopus 로고    scopus 로고
    • Charlson Comorbidity Index is an independent prognostic factor among elderly patients with diffuse large B-cell lymphoma
    • Kobayashi Y, Miura K, Hojo A, et al. Charlson Comorbidity Index is an independent prognostic factor among elderly patients with diffuse large B-cell lymphoma. J Cancer Res Clin Oncol 2011;137: 1079-1084
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 1079-1084
    • Kobayashi, Y.1    Miura, K.2    Hojo, A.3
  • 37
    • 0035661510 scopus 로고    scopus 로고
    • The Vulnerable Elders Survey: A tool for identifying vulnerable older people in the community
    • Saliba D, Elliott M, Rubenstein LZ, et al. The Vulnerable Elders Survey: a tool for identifying vulnerable older people in the community. J Am Geriatr Soc 2001;49:1691-1699
    • (2001) J Am Geriatr Soc , vol.49 , pp. 1691-1699
    • Saliba, D.1    Elliott, M.2    Rubenstein, L.Z.3
  • 39
    • 84863889174 scopus 로고    scopus 로고
    • Under-representation of older adults in cancer registration trials: Known problem, little progress
    • Scher KS, Hurria A . Under-representation of older adults in cancer registration trials: known problem, little progress. J Clin Oncol 2012 ; 30 : 2036-2038 .
    • (2012) J Clin Oncol , vol.30 , pp. 2036-2038
    • Scher, K.S.1    Hurria, A.2


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