메뉴 건너뛰기




Volumn 15, Issue 3, 2014, Pages 375-384

Predictive biomarker candidates for the response of gastric cancer to targeted and cytotoxic agents

Author keywords

biomarker; chemotherapy; gastric cancer; predictive marker; targeted therapy

Indexed keywords

ANTINEOPLASTIC AGENTS; BIOLOGICAL MARKERS; CYTOTOXINS; HUMANS; MOLECULAR TARGETED THERAPY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; STOMACH NEOPLASMS; TOR SERINE-THREONINE KINASES;

EID: 84894442315     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.13.250     Document Type: Review
Times cited : (5)

References (75)
  • 1
    • 0037586420 scopus 로고    scopus 로고
    • Gastric cancer: Epidemiology, pathology, and treatment
    • Alberts S, Cervantes A, van de Velde C. Gastric cancer: epidemiology, pathology, and treatment. Ann. Oncol. 14(Suppl. 2), ii31-ii36 (2003).
    • (2003) Ann. Oncol. , vol.14 , Issue.SUPPL. 2
    • Alberts, S.1    Cervantes, A.2    Van De Velde, C.3
  • 2
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-esophageal junction cancer (ToGA): A Phase 3, open-label, randomised controlled trial
    • Bang YJ, van Cutsem E, Feyereislova A et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-esophageal junction cancer (ToGA): a Phase 3, open-label, randomised controlled trial. Lancet 376(9742), 687-697 (2010).
    • (2010) Lancet , vol.376 , Issue.9742 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3
  • 3
    • 84869091490 scopus 로고    scopus 로고
    • Molecular targeting therapy and biomarker for advanced gastric cancer
    • Shitara K, Doi T, Ohtsu A. Molecular targeting therapy and biomarker for advanced gastric cancer. J. Phys. Chem. Biophys. 2, 107-112 (2012).
    • (2012) J. Phys. Chem. Biophys. , vol.2 , pp. 107-112
    • Shitara, K.1    Doi, T.2    Ohtsu, A.3
  • 4
    • 84883746466 scopus 로고    scopus 로고
    • Assessment of HER2 gene amplification in adenocarcinomas of the stomach or gastroesophageal junction in the INT-0116/SWOG9008 clinical trial
    • Gordon MA, Gundacker HM, Benedetti J et al. Assessment of HER2 gene amplification in adenocarcinomas of the stomach or gastroesophageal junction in the INT-0116/SWOG9008 clinical trial. Ann. Oncol. 24(7), 1754-1761 (2013).
    • (2013) Ann. Oncol. , vol.24 , Issue.7 , pp. 1754-1761
    • Gordon, M.A.1    Gundacker, H.M.2    Benedetti, J.3
  • 5
    • 84555190809 scopus 로고    scopus 로고
    • MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib
    • Lennerz JK, Kwak EL, Ackerman A et al. MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. J. Clin. Oncol. 29(36), 4803-4810 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.36 , pp. 4803-4810
    • Lennerz, J.K.1    Kwak, E.L.2    Ackerman, A.3
  • 6
    • 77956895978 scopus 로고    scopus 로고
    • HER2 diagnostics in gastric cancer-guideline validation and development of standardized immunohistochemical testing
    • Rüschoff J, Dietel M, Baretton G et al. HER2 diagnostics in gastric cancer-guideline validation and development of standardized immunohistochemical testing. Virchows Arch. 457(3), 299-307 (2010).
    • (2010) Virchows Arch. , vol.457 , Issue.3 , pp. 299-307
    • Rüschoff, J.1    Dietel, M.2    Baretton, G.3
  • 7
    • 84877605189 scopus 로고    scopus 로고
    • A randomized, open-label, Phase III study of lapatinib in combination with weekly paclitaxel versus weekly paclitaxel alone in the second-line treatment of HER2 amplified advanced gastric cancer (AGC) in Asian population: Tytan study
    • Abstract 11
    • Bang Y. A randomized, open-label, Phase III study of lapatinib in combination with weekly paclitaxel versus weekly paclitaxel alone in the second-line treatment of HER2 amplified advanced gastric cancer (AGC) in Asian population: Tytan study. J. Clin. Oncol. 30(Suppl. 34) (2012) (Abstract 11).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.SUPPL. 34
    • Bang, Y.1
  • 8
    • 44249092320 scopus 로고    scopus 로고
    • Assessment of a HER2 scoring system for gastric cancer: Results from a validation study
    • Hofmann M, Stoss O, Shi D et al. Assessment of a HER2 scoring system for gastric cancer: results from a validation study. Histopathology 52(7), 797-805 (2008).
    • (2008) Histopathology , vol.52 , Issue.7 , pp. 797-805
    • Hofmann, M.1    Stoss, O.2    Shi, D.3
  • 9
    • 35148885729 scopus 로고    scopus 로고
    • A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
    • Berns K, Horlings HM, Hennessy BT et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 12(4), 395-402 (2007).
    • (2007) Cancer Cell , vol.12 , Issue.4 , pp. 395-402
    • Berns, K.1    Horlings, H.M.2    Hennessy, B.T.3
  • 10
    • 84859377144 scopus 로고    scopus 로고
    • MET activation mediates resistance to lapatinib inhibition of HER2-amplified gastric cancer cells
    • Chen CT, Kim H, Liska D et al. MET activation mediates resistance to lapatinib inhibition of HER2-amplified gastric cancer cells. Mol. Cancer Ther. 11(3), 660-669 (2012).
    • (2012) Mol. Cancer Ther. , vol.11 , Issue.3 , pp. 660-669
    • Chen, C.T.1    Kim, H.2    Liska, D.3
  • 11
    • 84875035582 scopus 로고    scopus 로고
    • Phase II study evaluating 2 dosing schedules of oral foretinib (GSK1363089), cMET/VEGFR2 inhibitor, in patients with metastatic gastric cancer
    • Shah MA, Wainberg ZA, Catenacci DV et al. Phase II study evaluating 2 dosing schedules of oral foretinib (GSK1363089), cMET/VEGFR2 inhibitor, in patients with metastatic gastric cancer. PLoS ONE 8(3), e54014-e54022 (2013).
    • (2013) PLoS ONE , vol.8 , Issue.3
    • Shah, M.A.1    Wainberg, Z.A.2    Catenacci, D.V.3
  • 12
    • 84875249205 scopus 로고    scopus 로고
    • A Phase II study of tivantinib monotherapy in patients with previously treated advanced or recurrent gastric cancer
    • Abstract 4082
    • Muro K, Ryu M, Yasui H et al. A Phase II study of tivantinib monotherapy in patients with previously treated advanced or recurrent gastric cancer. J. Clin. Oncol. 30(Suppl.) (2012) (Abstract 4082).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.SUPPL.
    • Muro, K.1    Ryu, M.2    Yasui, H.3
  • 13
    • 84863719409 scopus 로고    scopus 로고
    • MET in gastric carcinomas: Comparison between protein expression and gene copy number and impact on clinical outcome
    • Lee HE, Kim MA, Lee HS et al. MET in gastric carcinomas: comparison between protein expression and gene copy number and impact on clinical outcome. Br. J. Cancer 107(2), 325-333 (2012).
    • (2012) Br. J. Cancer , vol.107 , Issue.2 , pp. 325-333
    • Lee, H.E.1    Kim, M.A.2    Lee, H.S.3
  • 14
    • 80052511675 scopus 로고    scopus 로고
    • Final efficacy results from OAM4558g, a randomized Phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC
    • Abstract 7505
    • Spigel DR, Ervin TJ, Ramlau R et al. Final efficacy results from OAM4558g, a randomized Phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC. J. Clin. Oncol. 29(Suppl.) (2011) (Abstract 7505).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.SUPPL.
    • Spigel, D.R.1    Ervin, T.J.2    Ramlau, R.3
  • 15
    • 84870511276 scopus 로고    scopus 로고
    • Evaluation of MET pathway biomarkers in a Phase II study of rilotumumab or placebo in combination with epirubicin, cisplatin, and capecitabine in patients with locally advanced or metastatic gastric or esophagogastric junction cancer
    • Abstract 4005
    • Oliner KS, Rui Tang R, Anderson A et al. Evaluation of MET pathway biomarkers in a Phase II study of rilotumumab or placebo in combination with epirubicin, cisplatin, and capecitabine in patients with locally advanced or metastatic gastric or esophagogastric junction cancer. J. Clin. Oncol. 30(Suppl.) (2012) (Abstract 4005).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.SUPPL.
    • Oliner, K.S.1    Rui Tang, R.2    Anderson, A.3
  • 16
    • 84902084207 scopus 로고    scopus 로고
    • MetGastric: A randomized Phase III study of onartuzumab in combination with mFOLFOX6 in patients with metastatic HER2-negative and MET-positive adenocarcinoma of the stomach or gastroesophageal junction
    • Abstract TPS4155
    • Cunningham D, Bang Y, Tabernero J et al. MetGastric: a randomized Phase III study of onartuzumab in combination with mFOLFOX6 in patients with metastatic HER2-negative and MET-positive adenocarcinoma of the stomach or gastroesophageal junction. J. Clin. Oncol. 31(Suppl.) (2013) (Abstract TPS4155).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.SUPPL.
    • Cunningham, D.1    Bang, Y.2    Tabernero, J.3
  • 17
    • 79957834501 scopus 로고    scopus 로고
    • A multicenter Phase II trial of single-agent cetuximab in advanced esophageal and gastric adenocarcinoma
    • Chan JA, Blaszkowsky LS, Enzinger PC et al. A multicenter Phase II trial of single-agent cetuximab in advanced esophageal and gastric adenocarcinoma. Ann. Oncol. 22(6), 1367-1373 (2011).
    • (2011) Ann. Oncol. , vol.22 , Issue.6 , pp. 1367-1373
    • Chan, J.A.1    Blaszkowsky, L.S.2    Enzinger, P.C.3
  • 18
    • 84876951761 scopus 로고    scopus 로고
    • Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): A randomised, open-label phase 3 trial
    • Lordick F, Kang YK, Chung HC et al. Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial. Lancet Oncol. 14(6), 490-499 (2013).
    • (2013) Lancet Oncol. , vol.14 , Issue.6 , pp. 490-499
    • Lordick, F.1    Kang, Y.K.2    Chung, H.C.3
  • 19
    • 76349109904 scopus 로고    scopus 로고
    • Cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric cancer: A Phase II study of the arbeitsgemeinschaft internistische onkologie (AIO)
    • Lordick F, Luber B, Lorenzen S et al. Cetuximab plus oxaliplatin/ leucovorin/5-fluorouracil in first-line metastatic gastric cancer: a Phase II study of the arbeitsgemeinschaft internistische onkologie (AIO). Br. J. Cancer 102(3), 500-505 (2010).
    • (2010) Br. J. Cancer , vol.102 , Issue.3 , pp. 500-505
    • Lordick, F.1    Luber, B.2    Lorenzen, S.3
  • 20
    • 33847663871 scopus 로고    scopus 로고
    • Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study)
    • Pinto C, Di Fabio F, Siena S et al. Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study). Ann. Oncol. 18(3), 510-517 (2007).
    • (2007) Ann. Oncol. , vol.18 , Issue.3 , pp. 510-517
    • Pinto, C.1    Di Fabio, F.2    Siena, S.3
  • 21
    • 33750618860 scopus 로고    scopus 로고
    • Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127
    • Dragovich T, McCoy S, Fenoglio-Preiser CM et al. Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127. J. Clin. Oncol. 24(30), 4922-4927 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.30 , pp. 4922-4927
    • Dragovich, T.1    McCoy, S.2    Fenoglio-Preiser, C.M.3
  • 22
    • 0037604501 scopus 로고    scopus 로고
    • C-Jun regulates eyelid closure and skin tumor development through EGFR signaling
    • Zenz R, Scheuch H, Martin P et al. c-Jun regulates eyelid closure and skin tumor development through EGFR signaling. Dev. Cell 4(6), 879-889 (2003).
    • (2003) Dev. Cell , vol.4 , Issue.6 , pp. 879-889
    • Zenz, R.1    Scheuch, H.2    Martin, P.3
  • 23
    • 0023874489 scopus 로고
    • Expression of epidermal growth factor receptor in human gastric and colonic carcinomas
    • Yasui W, Sumiyoshi H, Hata J et al. Expression of epidermal growth factor receptor in human gastric and colonic carcinomas. Cancer Res. 48(1), 137-141 (1988).
    • (1988) Cancer Res. , vol.48 , Issue.1 , pp. 137-141
    • Yasui, W.1    Sumiyoshi, H.2    Hata, J.3
  • 24
    • 34548404210 scopus 로고    scopus 로고
    • Mechanisms for oncogenic activation of the epidermal growth factor receptor
    • Zandi R, Larsen AB, Andersen P, Stockhausen MT, Poulsen HS. Mechanisms for oncogenic activation of the epidermal growth factor receptor. Cell. Signal. 19(10), 2013-2023 (2007).
    • (2007) Cell. Signal. , vol.19 , Issue.10 , pp. 2013-2023
    • Zandi, R.1    Larsen, A.B.2    Andersen, P.3    Stockhausen, M.T.4    Poulsen, H.S.5
  • 25
    • 44849091213 scopus 로고    scopus 로고
    • EGFR regulation by microRNA in lung cancer: Correlation with clinical response and survival to gefitinib and EGFR expression in cell lines
    • Weiss GJ, Bemis LT, Nakajima E et al. EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines. Ann. Oncol. 19(6), 1053-1059 (2008).
    • (2008) Ann. Oncol. , vol.19 , Issue.6 , pp. 1053-1059
    • Weiss, G.J.1    Bemis, L.T.2    Nakajima, E.3
  • 26
    • 34548258303 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab
    • Sartore-Bianchi A, Moroni M, Veronese S et al. Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab. J. Clin. Oncol. 25(22), 3238-3245 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.22 , pp. 3238-3245
    • Sartore-Bianchi, A.1    Moroni, M.2    Veronese, S.3
  • 27
    • 73349094741 scopus 로고    scopus 로고
    • Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
    • Laurent-Puig P, Cayre A, Manceau G et al. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J. Clin. Oncol. 27(35), 5924-5930 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.35 , pp. 5924-5930
    • Laurent-Puig, P.1    Cayre, A.2    Manceau, G.3
  • 28
    • 52049090365 scopus 로고    scopus 로고
    • Role of KRAS and EGFR as biomarkers of response to erlotinib in National cancer institute of canada clinical trials group study BR.21
    • Zhu CQ, da Cunha Santos G, Ding K et al. Role of KRAS and EGFR as biomarkers of response to erlotinib in National cancer institute of canada clinical trials group study BR.21. J. Clin. Oncol. 26(26), 4268-4275 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.26 , pp. 4268-4275
    • Zhu, C.Q.1    Da Cunha Santos, G.2    Ding, K.3
  • 29
    • 84862777035 scopus 로고    scopus 로고
    • A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets
    • Deng N, Goh LK, Wang H et al. A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets. Gut 61(5), 673-684 (2012).
    • (2012) Gut , vol.61 , Issue.5 , pp. 673-684
    • Deng, N.1    Goh, L.K.2    Wang, H.3
  • 30
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of OS according to tumour KRAS and BRAF mutation status
    • van Cutsem E, Kohne CH, Lang I et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of OS according to tumour KRAS and BRAF mutation status. J. Clin. Oncol. 29(15), 2011-2019 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.15 , pp. 2011-2019
    • Van Cutsem, E.1    Kohne, C.H.2    Lang, I.3
  • 31
    • 0242574321 scopus 로고    scopus 로고
    • BRAF and KRAS mutations in stomach cancer
    • Lee SH, Lee JW, Soung YH et al. BRAF and KRAS mutations in stomach cancer. Oncogene 22(44), 6942-6945 (2003).
    • (2003) Oncogene , vol.22 , Issue.44 , pp. 6942-6945
    • Lee, S.H.1    Lee, J.W.2    Soung, Y.H.3
  • 32
    • 0842263902 scopus 로고    scopus 로고
    • Mutational analysis of BRAF and K-ras in gastric cancers: Absence of BRAF mutations in gastric cancers
    • Kim IJ, Park JH, Kang HC et al. Mutational analysis of BRAF and K-ras in gastric cancers: absence of BRAF mutations in gastric cancers. Hum. Genet. 114(1), 118-120 (2003).
    • (2003) Hum. Genet. , vol.114 , Issue.1 , pp. 118-120
    • Kim, I.J.1    Park, J.H.2    Kang, H.C.3
  • 33
    • 77955288855 scopus 로고    scopus 로고
    • Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determine their response to everolimus
    • Di Nicolantonio F, Arena S, Tabernero J et al. Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determine their response to everolimus. J. Clin. Invest. 120(8), 2858-2866 (2010).
    • (2010) J. Clin. Invest. , vol.120 , Issue.8 , pp. 2858-2866
    • Di Nicolantonio, F.1    Arena, S.2    Tabernero, J.3
  • 34
    • 77957328515 scopus 로고    scopus 로고
    • MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors
    • Cepero V, Sierra JR, Corso S et al. MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors. Cancer Res. 70(19), 7580-7590 (2010).
    • (2010) Cancer Res. , vol.70 , Issue.19 , pp. 7580-7590
    • Cepero, V.1    Sierra, J.R.2    Corso, S.3
  • 35
    • 84863101033 scopus 로고    scopus 로고
    • Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines
    • doi:10.1007/s00432-011-1128-4 Epub ahead of print
    • Heindl S, Eggenstein E, Keller S et al. Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines. J. Cancer Res. Clin. Oncol. doi:10.1007/s00432-011-1128-4 (2012) (Epub ahead of print).
    • (2012) J. Cancer Res. Clin. Oncol.
    • Heindl, S.1    Eggenstein, E.2    Keller, S.3
  • 36
    • 84861392332 scopus 로고    scopus 로고
    • Phase III trial of everolimus in previously treated patients with advanced gastric cancer: GRANITE-1
    • Abstracts LBA3
    • van Cutsem E, Yeh K, Bang Y et al. Phase III trial of everolimus in previously treated patients with advanced gastric cancer: GRANITE-1. J. Clin. Oncol. 30(Suppl. 4) (2012) (Abstracts LBA3).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.SUPPL. 4
    • Van Cutsem, E.1    Yeh, K.2    Bang, Y.3
  • 37
    • 84862824218 scopus 로고    scopus 로고
    • Phase II study of everolimus with biomarker exploration in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidine and platinum
    • Yoon DH, Ryu MH, Park YS et al. Phase II study of everolimus with biomarker exploration in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidine and platinum. Br. J. Cancer 106(6), 1039-1044 (2012).
    • (2012) Br. J. Cancer , vol.106 , Issue.6 , pp. 1039-1044
    • Yoon, D.H.1    Ryu, M.H.2    Park, Y.S.3
  • 38
    • 35348858663 scopus 로고    scopus 로고
    • Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma
    • Cho D, Signoretti S, Dabora S et al. Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma. Clin. Genitourin. Cancer 5(6), 379-385 (2007).
    • (2007) Clin. Genitourin. Cancer , vol.5 , Issue.6 , pp. 379-385
    • Cho, D.1    Signoretti, S.2    Dabora, S.3
  • 39
    • 39749126103 scopus 로고    scopus 로고
    • Phospho-S6 ribosomal protein: A potential new predictive sarcoma marker for targeted mTOR therapy
    • Iwenofu OH, Lackman RD, Staddon AP, Goodwin DG, Haupt HM, Brooks JS. Phospho-S6 ribosomal protein: a potential new predictive sarcoma marker for targeted mTOR therapy. Mod. Pathol. 21(3), 231-237 (2008).
    • (2008) Mod. Pathol. , vol.21 , Issue.3 , pp. 231-237
    • Iwenofu, O.H.1    Lackman, R.D.2    Staddon, A.P.3    Goodwin, D.G.4    Haupt, H.M.5    Brooks, J.S.6
  • 40
    • 84878889486 scopus 로고    scopus 로고
    • Phase 2 trial of single-agent everolimus in chemotherapy-naive patients with castration-resistant prostate cancer (SAKK 08/08)
    • Templeton AJ, Dutoit V, Cathomas R et al. Phase 2 trial of single-agent everolimus in chemotherapy-naive patients with castration-resistant prostate cancer (SAKK 08/08). Eur. Urol. 64(1), 150-158 (2013).
    • (2013) Eur. Urol. , vol.64 , Issue.1 , pp. 150-158
    • Templeton, A.J.1    Dutoit, V.2    Cathomas, R.3
  • 41
    • 84866516574 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2 gene amplification status and its clinicopathologic significance in gastric carcinoma
    • Jung EJ, Jung EJ, Min SY et al. Fibroblast growth factor receptor 2 gene amplification status and its clinicopathologic significance in gastric carcinoma. Hum. Pathol. 43(10), 1559-1566 (2012).
    • (2012) Hum. Pathol. , vol.43 , Issue.10 , pp. 1559-1566
    • Jung, E.J.1    Jung, E.J.2    Min, S.Y.3
  • 42
    • 84856829698 scopus 로고    scopus 로고
    • FGFR2 gene amplification and clinicopathological features in gastric cancer
    • Matsumoto K, Arao T, Hamaguchi T et al. FGFR2 gene amplification and clinicopathological features in gastric cancer. Br. J. Cancer 106(4), 727-732 (2012).
    • (2012) Br. J. Cancer , vol.106 , Issue.4 , pp. 727-732
    • Matsumoto, K.1    Arao, T.2    Hamaguchi, T.3
  • 43
    • 84879859652 scopus 로고    scopus 로고
    • Targeting FGFR with dovitinib (TKI258): Preclinical and clinical data in breast cancer
    • André F, Bachelot T, Campone M et al. Targeting FGFR with dovitinib (TKI258): preclinical and clinical data in breast cancer. Clin. Cancer Res. 19(13), 3693-3702 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , Issue.13 , pp. 3693-3702
    • André, F.1    Bachelot, T.2    Campone, M.3
  • 44
    • 84877100340 scopus 로고    scopus 로고
    • FGFR2 gene amplification in gastric cancer predicts sensitivity to the selective FGFR inhibitor AZD4547
    • Xie L, Su X, Zhang L et al. FGFR2 gene amplification in gastric cancer predicts sensitivity to the selective FGFR inhibitor AZD4547. Clin. Cancer Res. 19(9), 2572-2583 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , Issue.9 , pp. 2572-2583
    • Xie, L.1    Su, X.2    Zhang, L.3
  • 45
    • 80053573446 scopus 로고    scopus 로고
    • Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A randomized, double-blind, placebo-controlled Phase III study
    • Ohtsu A, Shah MA, van Cutsem E et al. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled Phase III study. J. Clin. Oncol. 29(30), 3968-3976 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.30 , pp. 3968-3976
    • Ohtsu, A.1    Shah, M.A.2    Van Cutsem, E.3
  • 46
    • 84863897798 scopus 로고    scopus 로고
    • Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A biomarker evaluation from the AVAGAST randomized Phase III trial
    • van Cutsem E, de Haas S, Kang YK et al. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a biomarker evaluation from the AVAGAST randomized Phase III trial. J. Clin. Oncol. 30(17), 2119-2127 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.17 , pp. 2119-2127
    • Van Cutsem, E.1    De Haas, S.2    Kang, Y.K.3
  • 47
    • 84863930279 scopus 로고    scopus 로고
    • Analysis of blood plasma factors in the AVITA Phase III randomized study of bevacizumab with gemcitabine-erlotinib in patients with metastatic pancreatic cancer
    • Abstract 803
    • van Cutsem E, Jayson G, Dive C et al. Analysis of blood plasma factors in the AVITA Phase III randomized study of bevacizumab with gemcitabine-erlotinib in patients with metastatic pancreatic cancer. Eur. J. Cancer 47(Suppl. 1), S95-S96 (2011) (Abstract 803).
    • (2011) Eur. J. Cancer , vol.47 , Issue.SUPPL. 1
    • Van Cutsem, E.1    Jayson, G.2    Dive, C.3
  • 48
    • 84875412193 scopus 로고    scopus 로고
    • Biomarker results from the AVADO Phase 3 trial of first-line bevacizumab plus docetaxel for HER2-negative metastatic breast cancer
    • Miles DW, de Haas SL, Dirix LY et al. Biomarker results from the AVADO Phase 3 trial of first-line bevacizumab plus docetaxel for HER2-negative metastatic breast cancer. Br. J. Cancer 108(5), 1052-1060 (2013).
    • (2013) Br. J. Cancer , vol.108 , Issue.5 , pp. 1052-1060
    • Miles, D.W.1    De Haas, S.L.2    Dirix, L.Y.3
  • 49
    • 84874095390 scopus 로고    scopus 로고
    • Predictive impact of circulating vascular endothelial growth factor in four Phase III trials evaluating bevacizumab
    • Hegde PS, Jubb AM, Chen D et al. Predictive impact of circulating vascular endothelial growth factor in four Phase III trials evaluating bevacizumab. Clin. Cancer Res. 19(4), 929-937 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , Issue.4 , pp. 929-937
    • Hegde, P.S.1    Jubb, A.M.2    Chen, D.3
  • 50
    • 79251473728 scopus 로고    scopus 로고
    • Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer
    • Jubb AM, Miller KD, Rugo HS et al. Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer. Clin. Cancer Res. 17(2), 372-381 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.2 , pp. 372-381
    • Jubb, A.M.1    Miller, K.D.2    Rugo, H.S.3
  • 51
    • 84878979173 scopus 로고    scopus 로고
    • Predictive biomarkers for bevacizumab: Are we there yet? Clin
    • Maru D, Venook AP, Ellis LM. Predictive biomarkers for bevacizumab: are we there yet? Clin. Cancer Res. 19(11), 2824-2827 (2013).
    • (2013) Cancer Res. , vol.19 , Issue.11 , pp. 2824-2827
    • Maru, D.1    Venook, A.P.2    Ellis, L.M.3
  • 52
    • 84892852372 scopus 로고    scopus 로고
    • Ramucirumab monotherapy for previously treated advanced gastric or gastro-esophageal junction adenocarcinoma (REGARD): An international, randomised, multicentre, placebo-controlled, Phase 3 trial
    • Fuchs CS, Tomasek J, Yong CJ et al. Ramucirumab monotherapy for previously treated advanced gastric or gastro-esophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, Phase 3 trial. Lancet 383(9911), 31-39 (2013).
    • (2013) Lancet , vol.383 , Issue.9911 , pp. 31-39
    • Fuchs, C.S.1    Tomasek, J.2    Yong, C.J.3
  • 53
    • 84859000031 scopus 로고    scopus 로고
    • Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy
    • Kim HK, Choi IJ, Kim CG et al. Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy. Pharmacogenomics J. 12(2), 119-127 (2012).
    • (2012) Pharmacogenomics J. , vol.12 , Issue.2 , pp. 119-127
    • Kim, H.K.1    Choi, I.J.2    Kim, C.G.3
  • 54
    • 55649090161 scopus 로고    scopus 로고
    • Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples
    • Yamada Y, Arao T, Gotoda T et al. Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples. Cancer Sci. 99(11), 2193-2199 (2008).
    • (2008) Cancer Sci. , vol.99 , Issue.11 , pp. 2193-2199
    • Yamada, Y.1    Arao, T.2    Gotoda, T.3
  • 55
    • 33645105045 scopus 로고    scopus 로고
    • Identification by functional cloning from a retroviral cDNA library of cDNAs for ribosomal protein L36 and the 10-kDa heat shock protein that confer cisplatin resistance
    • Shen DW, Liang XJ, Suzuki T, Gottesman MM. Identification by functional cloning from a retroviral cDNA library of cDNAs for ribosomal protein L36 and the 10-kDa heat shock protein that confer cisplatin resistance. Mol. Pharmacol. 69(4), 1383-1388 (2006).
    • (2006) Mol. Pharmacol. , vol.69 , Issue.4 , pp. 1383-1388
    • Shen, D.W.1    Liang, X.J.2    Suzuki, T.3    Gottesman, M.M.4
  • 56
    • 39449115649 scopus 로고    scopus 로고
    • Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer
    • Matsubara J, Nishina T, Yamada Y et al. Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer. Br. J. Cancer 98(4), 832-839 (2008).
    • (2008) Br. J. Cancer , vol.98 , Issue.4 , pp. 832-839
    • Matsubara, J.1    Nishina, T.2    Yamada, Y.3
  • 57
    • 56549110980 scopus 로고    scopus 로고
    • Epidermal growth factor receptor as a predictor of tumour response to preoperative chemoradiation in locally advanced gastric carcinoma
    • Sirak I, Petera J, Hatlova J et al. Epidermal growth factor receptor as a predictor of tumour response to preoperative chemoradiation in locally advanced gastric carcinoma. Strahlenther. Onkol. 184(11), 592-597 (2008).
    • (2008) Strahlenther. Onkol. , vol.184 , Issue.11 , pp. 592-597
    • Sirak, I.1    Petera, J.2    Hatlova, J.3
  • 58
    • 84863936531 scopus 로고    scopus 로고
    • Gene modules and response to neoadjuvant chemotherapy in breast cancer subtypes: A pooled analysis
    • Ignatiadis M, Singhal SK, Desmedt C et al. Gene modules and response to neoadjuvant chemotherapy in breast cancer subtypes: a pooled analysis. J. Clin. Oncol. 30(16), 1996-2004 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.16 , pp. 1996-2004
    • Ignatiadis, M.1    Singhal, S.K.2    Desmedt, C.3
  • 59
    • 34948820602 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
    • Apetoh L, Ghiringhelli F, Tesniere A et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat. Med. 13(9), 1050-1059 (2007).
    • (2007) Nat. Med. , vol.13 , Issue.9 , pp. 1050-1059
    • Apetoh, L.1    Ghiringhelli, F.2    Tesniere, A.3
  • 60
    • 0031982522 scopus 로고    scopus 로고
    • ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy
    • Metzger R, Leichman CG, Danenberg KD et al. ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy. J. Clin. Oncol. 16(1), 309-316 (1998).
    • (1998) J. Clin. Oncol. , vol.16 , Issue.1 , pp. 309-316
    • Metzger, R.1    Leichman, C.G.2    Danenberg, K.D.3
  • 61
    • 42149100439 scopus 로고    scopus 로고
    • ERCC1 mRNA levels and survival of advanced gastric cancer patients treated with a modified FOLFOX regimen
    • Wei J, Zou Z, Qian X et al. ERCC1 mRNA levels and survival of advanced gastric cancer patients treated with a modified FOLFOX regimen. Br. J. Cancer 98(8), 1398-1402 (2008).
    • (2008) Br. J. Cancer , vol.98 , Issue.8 , pp. 1398-1402
    • Wei, J.1    Zou, Z.2    Qian, X.3
  • 62
    • 20244379716 scopus 로고    scopus 로고
    • Combined GADD45A and thymidine phosphorylase expression levels predict response and survival of neoadjuvant-treated gastric cancer patients
    • Napieralski R, Ott K, Kremer M et al. Combined GADD45A and thymidine phosphorylase expression levels predict response and survival of neoadjuvant-treated gastric cancer patients. Clin. Cancer Res. 11(8), 3025-3031 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , Issue.8 , pp. 3025-3031
    • Napieralski, R.1    Ott, K.2    Kremer, M.3
  • 63
    • 84875340813 scopus 로고    scopus 로고
    • Evidence for predictive role of BRCA1 and bTUBIII in gastric cancer
    • Moiseyenko VM, Volkov NM, Suspistin EN et al. Evidence for predictive role of BRCA1 and bTUBIII in gastric cancer. Med. Oncol. 30(2), 545-553 (2013).
    • (2013) Med. Oncol. , vol.30 , Issue.2 , pp. 545-553
    • Moiseyenko, V.M.1    Volkov, N.M.2    Suspistin, E.N.3
  • 64
    • 84878892701 scopus 로고    scopus 로고
    • Correlation between expressions of ERCC1/TS mRNA and effects of gastric cancer to chemotherapy in the short term
    • Chen L, Li G, Li J et al. Correlation between expressions of ERCC1/TS mRNA and effects of gastric cancer to chemotherapy in the short term. Cancer Chemother. Pharmacol. 71(4), 921-928 (2013).
    • (2013) Cancer Chemother. Pharmacol. , vol.71 , Issue.4 , pp. 921-928
    • Chen, L.1    Li, G.2    Li, J.3
  • 65
    • 80051546264 scopus 로고    scopus 로고
    • Predictive values of 5-fluorouracil pathway genes for S-1 treatment in patients with advanced gastric cancer
    • Jeung HC, Rha SY, Shin SJ et al. Predictive values of 5-fluorouracil pathway genes for S-1 treatment in patients with advanced gastric cancer. Anticancer Drugs 22(8), 801-810 (2011).
    • (2011) Anticancer Drugs , vol.22 , Issue.8 , pp. 801-810
    • Jeung, H.C.1    Rha, S.Y.2    Shin, S.J.3
  • 66
    • 6944226476 scopus 로고    scopus 로고
    • Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric cancer
    • Ichikawa W, Takahashi T, Suto K et al. Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric cancer. Br. J. Cancer 91(7), 1245-1250 (2004).
    • (2004) Br. J. Cancer , vol.91 , Issue.7 , pp. 1245-1250
    • Ichikawa, W.1    Takahashi, T.2    Suto, K.3
  • 67
    • 0037837441 scopus 로고    scopus 로고
    • Chromosomal instability rather than p53 mutation is associated with response to neoadjuvant cisplatin-based chemotherapy in gastric carcinoma
    • Ott K, Vogelsang H, Mueller J et al. Chromosomal instability rather than p53 mutation is associated with response to neoadjuvant cisplatin-based chemotherapy in gastric carcinoma. Clin. Cancer Res. 9(6), 2307-2315 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.6 , pp. 2307-2315
    • Ott, K.1    Vogelsang, H.2    Mueller, J.3
  • 68
    • 68949205565 scopus 로고    scopus 로고
    • Chemosensitivity and survival in gastric cancer patients with microsatellite instability
    • Oki E, Kakeji Y, Zhao Y et al. Chemosensitivity and survival in gastric cancer patients with microsatellite instability. Ann. Surg. Oncol. 16(9), 2510-2515 (2009).
    • (2009) Ann. Surg. Oncol. , vol.16 , Issue.9 , pp. 2510-2515
    • Oki, E.1    Kakeji, Y.2    Zhao, Y.3
  • 69
    • 84877721344 scopus 로고    scopus 로고
    • Biomarker analysis in oesophagogastric cancer: Results from the REAL3 and Trans MAGIC trials
    • pii: S0959-8049(13)00115-9
    • Okines AF, Gonzalez de Castro D, Cunningham D et al. Biomarker analysis in oesophagogastric cancer: results from the REAL3 and Trans MAGIC trials. Eur. J. Cancer pii: S0959-8049(13)00115-9 (2013).
    • (2013) Eur. J. Cancer
    • Okines, A.F.1    Gonzalez De Castro, D.2    Cunningham, D.3
  • 70
    • 84877839648 scopus 로고    scopus 로고
    • Oncogenic ERBB3 mutations in human cancers
    • Jaiswal BS, Kljavin NM, Stawiski EW et al. Oncogenic ERBB3 mutations in human cancers. Cancer Cell 23(5), 603-617 (2013).
    • (2013) Cancer Cell , vol.23 , Issue.5 , pp. 603-617
    • Jaiswal, B.S.1    Kljavin, N.M.2    Stawiski, E.W.3
  • 71
    • 79951986443 scopus 로고    scopus 로고
    • A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients
    • Kim HK, Choi IJ, Kim CG et al. A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. PLoS ONE 6(2), e16694-e16705 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.2
    • Kim, H.K.1    Choi, I.J.2    Kim, C.G.3
  • 72
    • 77956513752 scopus 로고    scopus 로고
    • Deciphering signaling pathways in clinical tissues for personalized medicine using protein microarrays
    • Malinowsky K, Wolff C, Ergin B, Berg D, Becker KF. Deciphering signaling pathways in clinical tissues for personalized medicine using protein microarrays. J. Cell. Physiol. 225(2), 364-370 (2010).
    • (2010) J. Cell. Physiol. , vol.225 , Issue.2 , pp. 364-370
    • Malinowsky, K.1    Wolff, C.2    Ergin, B.3    Berg, D.4    Becker, K.F.5
  • 73
    • 84882977045 scopus 로고    scopus 로고
    • Genetics and biomarkers in personalisation of lung cancer treatment
    • Rosell R, Bivona TG, Karachaliou N. Genetics and biomarkers in personalisation of lung cancer treatment. Lancet 382(9893), 720-731 (2013).
    • (2013) Lancet , vol.382 , Issue.9893 , pp. 720-731
    • Rosell, R.1    Bivona, T.G.2    Karachaliou, N.3
  • 74
    • 84861814883 scopus 로고    scopus 로고
    • Precision of multiple reaction monitoring mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue
    • doi:10.1021/pr300130t Epub ahead of print
    • Sprung RW, Martinez MA, Carpenter KL et al. Precision of multiple reaction monitoring mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue. J. Proteome Res. doi:10.1021/pr300130t (2012) (Epub ahead of print).
    • (2012) J. Proteome Res.
    • Sprung, R.W.1    Martinez, M.A.2    Carpenter, K.L.3
  • 75
    • 84895071790 scopus 로고    scopus 로고
    • Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins
    • Epub ahead of print
    • Kennedy JJ, Abbatiello SE, Kim K et al. Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins. Nat. Methods (2013) (Epub ahead of print).
    • (2013) Nat. Methods
    • Kennedy, J.J.1    Abbatiello, S.E.2    Kim, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.