Antigen-presenting cells are stratified within normal human corneas and are rapidly mobilized during ex vivo viral infection

Investigative Ophthalmology and Visual Science

Volumn 55, Issue 2, 2014, Pages 1118-1123

  Knickelbein, Jared E ^a   Buela, Kristine Ann ^a   Hendricks, Robert L ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen presenting cells; Cornea; Dendritic cells; Human; Langerhans cells

Indexed keywords

CD45 ANTIGEN; CD68 ANTIGEN; GLYCOPROTEIN P 15095; HLA DR ANTIGEN; LANGERIN;

ADULT; AGED; ANTIGEN PRESENTING CELL; ARTICLE; CELL MIGRATION; CELL MOTILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORNEA; CORNEA EPITHELIUM; DENDRITIC CELL; EX VIVO STUDY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LANGERHANS CELL; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; PHENOTYPE; PRIORITY JOURNAL; STRATIFICATION;

ANTIGEN-PRESENTING CELLS; CORNEA; DENDRITIC CELLS; HUMAN; LANGERHANS CELLS;

ADULT; AGED; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, CD11C; CORNEA; FLOW CYTOMETRY; HERPESVIRUS 1, HUMAN; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; KERATITIS, HERPETIC; LECTINS, C-TYPE; MANNOSE-BINDING LECTINS; MICROSCOPY, CONFOCAL; MIDDLE AGED; PHENOTYPE; TISSUE DONORS; YOUNG ADULT;

EID: 84894439855     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-13523     Document Type: Article

References (22)

1. Steinman RM. Dendritic cells: understanding immunogenicity. Eur J Immunol. 2007;37(suppl 1):S53-S60.
2. Knickelbein JE, Watkins SC, McMenamin PG, Hendricks RL. Stratification of antigen-presenting cells within the normal cornea. Ophthalmol Eye Dis. 2009;1:45-54.
3. Hamrah P, Zhang Q, Liu Y, Dana MR. Novel characterization of MHC class II-negative population of resident corneal Langerhans cell-type dendritic cells. Invest Ophthalmol Vis Sci. 2002; 43:639-646.
4. Lee EJ, Rosenbaum JT, Planck SR. Epifluorescence intravital microscopy of murine corneal dendritic cells. Invest Ophthalmol Vis Sci. 2010;51:2101-2108.
5. Hattori T, Chauhan SK, Lee H, et al. Characterization of Langerin-expressing dendritic cell subsets in the normal cornea. Invest Ophthalmol Vis Sci. 2011;52:4598-4604.
6. Hamrah P, Liu Y, Zhang Q, Dana MR. The corneal stroma is endowed with a significant number of resident dendritic cells. Invest Ophthalmol Vis Sci. 2003;44:581-589.
7. Nakamura T, Ishikawa F, Sonoda KH, et al. Characterization and distribution of bone marrow-derived cells in mouse cornea. Invest Ophthalmol Vis Sci. 2005;46:497-503.
8. Brissette-Storkus CS, Reynolds SM, Lepisto AJ, Hendricks RL. Identification of a novel macrophage population in the normal mouse corneal stroma. Invest Ophthalmol Vis Sci. 2002;43: 2264-2271.
9. Pels E, van der Gaag R. HLA-A, B, C, and HLA-DR antigens and dendritic cells in fresh and organ culture preserved corneas. Cornea. 1984;3:231-239.
10. Treseler PA, Foulks GN, Sanfilippo F. The expression of HLA antigens by cells in the human cornea. Am J Ophthalmol. 1984;98:763-772.
11. Whitsett CF, Stulting RD. The distribution of HLA antigens on human corneal tissue. Invest Ophthalmol Vis Sci. 1984;25: 519-524.
12. Yamagami S, Yokoo S, Usui T, Yamagami H, Amano S, Ebihara N. Distinct populations of dendritic cells in the normal human donor corneal epithelium. Invest Ophthalmol Vis Sci. 2005; 46:4489-4494.
13. Yamagami S, Ebihara N, Usui T, Yokoo S, Amano S. Bone marrow-derived cells in normal human corneal stroma. Arch Ophthalmol. 2006;124:62-69.
14. Mayer WJ, Mackert MJ, Kranebitter N, et al. Distribution of antigen presenting cells in the human cornea: correlation of in vivo confocal microscopy and immunohistochemistry in different pathologic entities. Curr Eye Res. 2012;37:1012-1018.
15. Frank GM, Buela KA, Maker DM, Harvey SA, Hendricks RL. Early responding dendritic cells direct the local NK response to control herpes simplex virus 1 infection within the cornea. J Immunol. 2012;188:1350-1359.
16. Decman V, Kinchington PR, Harvey SA, Hendricks RL. Gamma interferon can block herpes simplex virus type 1 reactivation from latency, even in the presence of late gene expression. J Virol. 2005;79:10339-10347.
17. Mayer WJ, Irschick UM, Moser P, et al. Characterization of antigen-presenting cells in fresh and cultured human corneas using novel dendritic cell markers. Invest Ophthalmol Vis Sci. 2007;48:4459-4467.
18. Cruzat A, Pavan-Langston D, Hamrah P. In vivo confocal microscopy of corneal nerves: analysis and clinical correlation. Semin Ophthalmol. 2010;25:171-177.
19. Kumar RL, Cruzat A, Hamrah P. Current state of in vivo confocal microscopy in management of microbial keratitis. Semin Ophthalmol. 2010;25:166-170.
20. Alhatem A, Cavalcanti B, Hamrah P. In vivo confocal microscopy in dry eye disease and related conditions. Semin Ophthalmol. 2012;27:138-148.
21. Shukla AN, Cruzat A, Hamrah P. Confocal microscopy of corneal dystrophies. Semin Ophthalmol. 2012;27:107-116.
22. Ardjomand N, Berghold A, Reich ME. Loss of corneal Langerhans cells during storage in organ culture medium, Optisol and McCarey-Kaufman medium. Eye (Lond). 1998;12: 134-138.