Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from mycobacterium tuberculosis

Journal of the American Chemical Society

Volumn 136, Issue 7, 2014, Pages 2892-2896

  Chan, Hsiu Chien ^a   Feng, Xinxin ^b   Ko, Tzu Ping ^c   Huang, Chun Hsiang ^a   Hu, Yumei ^a   Zheng, Yingying ^a   Bogue, Shannon ^b   Nakano, Chiaki ^d   Hoshino, Tsutomu ^d   Zhang, Lilan ^a   Lv, Pin ^a   Liu, Wenting ^a   Crick, Dean C ^e   Liang, Po Huang ^c   Wang, Andrew H J ^c   Oldfield, Eric ^b   Guo, Rey Ting ^a  

^a Tianjin Airport Economic Area   (China)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^d NIIGATA UNIVERSITY   (Japan)

^e Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL AND ARYL TRANSFERASES; DIPHOSPHONATES; DITERPENES; ENZYME INHIBITORS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION;

EID: 84894434236     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja413127v     Document Type: Article

References (22)

1. Ernst, J. D. Nat. Rev. Immunol. 2012, 12, 581
2. Lienhardt, C.; Glaziou, P.; Uplekar, M.; Lonnroth, K.; Getahun, H.; Raviglione, M. Nat. Rev. Microbiol. 2012, 10, 407
3. Zumla, A.; Hafner, R.; Lienhardt, C.; Hoelscher, M.; Nunn, A. Nat. Rev. Drug. Discovery 2012, 11, 171
4. Koul, A.; Arnoult, E.; Lounis, N.; Guillemont, J.; Andries, K. Nature 2011, 469, 483
5. Liu, G. Y.; Essex, A.; Buchanan, J. T.; Datta, V.; Hoffman, H. M.; Bastian, J. F.; Fierer, J.; Nizet, V. J. Exp. Med. 2005, 202, 209
6. Liu, C. I.; Liu, G. Y.; Song, Y.; Yin, F.; Hensler, M. E.; Jeng, W. Y.; Nizet, V.; Wang, A. H.; Oldfield, E. Science 2008, 319, 1391
7. Nakano, C.; Hoshino, T. ChemBioChem 2009, 10, 2060
8. Hoshino, T.; Nakano, C.; Ootsuka, T.; Shinohara, Y.; Hara, T. Org. Biomol. Chem. 2011, 9, 2156
9. Nakano, C.; Ootsuka, T.; Takayama, K.; Mitsui, T.; Sato, T.; Hoshino, T. Biosci. Biotechnol. Biochem. 2011, 75, 75
10. Rudi, A.; Aknin, M.; Gaydou, E.; Kashman, Y. J. Nat. Prod. 2004, 67, 1932
11. Maugel, N.; Mann, F. M.; Hillwig, M. L.; Peters, R. J.; Snider, B. B. Org. Lett. 2010, 12, 2626
12. Spangler, J. E.; Carson, C. A.; Sorensen, E. J. Chem. Sci. 2010, 1, 202
13. Pethe, K.; Swenson, D. L.; Alonso, S.; Anderson, J.; Wang, C.; Russell, D. G. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 13642
14. Mann, F. M.; Xu, M.; Chen, X.; Fulton, D. B.; Russell, D. G.; Peters, R. J. J. Am. Chem. Soc. 2009, 131, 17526
15. Mann, F. M.; Prisic, S.; Hu, H.; Xu, M.; Coates, R. M.; Peters, R. J. J. Biol. Chem. 2009, 284, 23574
16. Hendlich, M.; Rippmann, F.; Barnickel, G. J. Mol. Graph. Modell. 1997, 15, 359
17. Friesner, R. A.; Murphy, R. B.; Repasky, M. P.; Frye, L. L.; Greenwood, J. R.; Halgren, T. A.; Sanschagrin, P. C.; Mainz, D. T. J. Med. Chem. 2006, 49, 6177
18. Valdar, W. S. Proteins 2002, 48, 227
19. Wang, W.; Dong, C.; McNeil, M.; Kaur, D.; Mahapatra, S.; Crick, D. C.; Naismith, J. H. J. Mol. Biol. 2008, 381, 129
20. Zhang, Y.; Cao, R.; Yin, F.; Hudock, M. P.; Guo, R. T.; Krysiak, K.; Mukherjee, S.; Gao, Y. G.; Robinson, H.; Song, Y.; No, J. H.; Bergan, K.; Leon, A.; Cass, L.; Goddard, A.; Chang, T. K.; Lin, F. Y.; Van Beek, E.; Papapoulos, S.; Wang, A. H.; Kubo, T.; Ochi, M.; Mukkamala, D.; Oldfield, E. J. Am. Chem. Soc. 2009, 131, 5153
21. Morphy, J. R.; Harris, C. J. Designing Multi-Target Drugs: Royal Society of Chemistry: London, 2012.
22. Lin, F. Y.; Zhang, Y.; Hensler, M.; Liu, Y. L.; Chow, O. A.; Zhu, W.; Wang, K.; Pang, R.; Thienphrapa, W.; Nizet, V.; Oldfield, E. ChemMedChem 2012, 7, 561