Preventive effects of Salacia reticulata on non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) in monosodium glutamate treated mice

Journal of Traditional Medicines

Volumn 28, Issue 2, 2011, Pages 73-82

  Watanabe, Michiru ^a,b   Shimada, Tsutomu ^b   Iiduka, Seiichi ^b   Iida, Nanae ^b   Kojima, Kazuko ^a,b   Ishizaki, Junko ^a   Sai, Yoshimichi ^a   Miyamoto, Ken ichi ^a   Aburada, Masaki ^b  

^a KANAZAWA UNIVERSITY   (Japan)

^b MUSASHINO UNIVERSITY   (Japan)

Author keywords

infiltration of inflammatory cells; liver hypertrophy; NAFLD; NASH; obesity; Salacia reticulata; vacuolar degeneration of hepatocyte by lipid accumulation

Indexed keywords

EID: 84894360414     PISSN: 18801447     EISSN: 18813747     Source Type: Journal    
DOI: 10.11339/jtm.28.73     Document Type: Article

References (23)

1. Lewis, JR., Mohanty, SR.: Nonalcoholic fatty liver disease: a review and update. Dig Dig Sci., 55, 560-578, 2010.
2. Adams, LA., Lymp, JF., St Sauver, J., Sanderson, SO., Lindor, KD., Feldstein, A., Angulo, P.: The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study. Gastroenterology., 129, 113-121, 2005.
3. Farrell, GC., Larter, CZ.: Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology., 43, 99-112, 2006.
4. Hashimoto, E., Yatsuji, S., Kaneda, H., Yoshioka, Y., Taniai, M., Tokushige, K., Shiratori, K.: The characteristics and natural history of Japanese patients with nonalcoholic fatty liver disease. Hepatol Res., 33, 72-76, 2005.
5. Sanyal, AJ., Banas, C., Sargeant, C., Luketic, VA., Sterling, RK., Stravitz, RT., Shiffman, ML., Heuman, D., Coterrell, A., Fisher, RA., Contos, MJ., Mills, AS.: Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. Hepatology., 43, 682-689, 2006.
6. Nagata, M., Suzuki, W., Iizuka, S., Tabuchi, M., Maruyama, H., Takeda, S., Aburada, M., Miyamoto, K.: Type 2 diabetes mellitus in obese mouse model induced by monosodium glutamate. Exp Anim. 55, 109-115, 2006.
7. Nakanishi, Y., Tsuneyama, K., Fujimoto, M., Salunga, TL., Nomoto, K., An, JL., Takano, Y., Iizuka, S., Nagata, M., Suzuki, W., Shimada, T., Aburada, M., Nakano, M., Selmi, C., Gershwin, ME.: Monosodium glutamate (MSG): a villain and promoter of liver inflammation and dysplasia. J Autoimmun., 30, 42-50, 2008.
8. Bergen, H.T., Mizuno, T.M., Taylor, J., Mobbs, C.V.: Hyperphagia and weight gain after gold-thioglucose: relation to hypothalamic neuropeptide Y and proopiomelanocortin. Endocrinology., 139, 4483-4488, 1998.
9. Tsukahara, F., Uchida, Y., Ohba, K., Ogawa, A., Yoshioka, T., Muraki, T.: The effect of acute cold exposure and norepinephrine on uncoupling protein gene expression in brown adipose tissue of monosodium glutamate-obese mice. Jpn. J. Pharmacol., 77, 247-249, 1998.
10. Yasuda, T., Masaki, T., Kakuma, T., Yoshimatsu, H.: Hypothalamic melanocortin system regulates sympathetic nerve activity in brown adipose tissue. Exp. Biol. Med., 229, 235-239, 2004.
11. Jayawardena, MHS., de Alwis, NMW., Hettigoda, V., Fernando, DJS.: Double blind randomised placebo controlled cross over study of a herbal preparation containing Salacia reticulata in the treatment of type 2 diabetes. J Ethnopharmacol., 97, 215-218, 2005.
12. Yoshikawa, M., Shimoda, H., Nishida, N., Takada, M., Matsuda, H.: Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats. J Nutr., 132, 1819-1824, 2002.
13. Yoshikawa, M., Ninomiya, K., Shimoda, H., Nishida, N., Matsuda, H.: Hepatoprotective and antioxidative properties of Salacia reticulata: Preventive effects of phenolic constituents on CCl4-induced liver injury in mice. Biol Pharm Bull, 25, 72-76, 2002.
14. Kishino, E., Ito, T., Fujita, K., Kiuchi, Y.: A mixture of the Salacia reticulata (Kotala himbutu) aqueous extract and cyclodextrin reduces the accumulation of visceral fat mass in mice and rats with high-fat diet-induced obesity. J Nutr., 136, 433-439, 2006.
15. Kishino, E., Ito, T., Fujita, K., Kiuchi, Y.: A mixture of Salacia reticulata (Kotala himbutu) aqueous extract and cyclodextrin reduces body weight gain, visceral fat accumulation, and total cholesterol and insulin increases in male Wistar fatty rats. Nutrition Research., 29, 55-63, 2009.
16. Im, R., Mano, H., Matsuura, T., Nakatani, S., Shimizu, J., Wada, M.: Mechanisms of blood glucose-lowering effect of aqueous extract from stems of Kothala himbutu (Salacia reticulata) in the mouse. J Ethnopharmacol., 121, 234-240, 2009.
17. Akase, T., Harasawa, Y., Akase, T., Ikeya, Y., Nagai, E., Iizuka, S., Nakagami, G.: Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in. TSOD mice. eCAM., doi:10.1093/ecam/nep052, 2009.
18. Shimada, T., Nagai, E., Harasawa, Y., Akase, T., Aburada, T., Iizuka, S., Miyamoto, K., Aburada, M.: Metabolic disease prevention and suppression of fat accumulation by Salacia reticulata. J Nat Med., 64, 2266-2274, 2010.
19. Freedman, B.D., Lee, E.J., Park, Y., Jameson, J.L.: A dominant negative peroxisome proliferator-activated receptor-gamma knock-in mouse exhibits features of the metabolic syndrome. J Biol Chem., 280, 17118-17125, 2005.
20. Paul, A.: Nonalcoholic Fatty Liver Disease. N Engl J Med., 346, 1221-1231, 2002.
21. Huang, THW., Peng, G., Li, GQ., Yamahara, J., Roufogalis, BD., Li, YH.: Salacia oblonga root improves postprandial hyperlipidemia and hepatic steatosis in Zucker diabetic fatty rats: Activation of PPAR-alpha. Toxicol Appl Pharmacol., 210, 225-235, 2006.
22. Gray, RH., de la Iglesia, FA.: Quantitative microscopy comparison of peroxisome proliferation by the lipid-regulating agent gemfibrozil in several species. Hepatology, 4, 520-530, 1984.
23. Nakajima, T., Tanaka, N., Kanbe, H., Hara, A., Kamijo, Y., Zhang, X., Gonzalez, FJ., Aoyama, T.: Bezafibrate at clinically relevant doses decreases serum/liver triglycerides via down-regulation of sterol regulatory element-binding protein-1c in mice: a novel peroxisome proliferator-activated receptor α-independent mechanism. Mol Pharmacol 75, 782-792, 2009.