Laser speckle contrast imaging of cerebral blood flow in humans during neurosurgery: A pilot clinical study

Journal of Biomedical Optics

Volumn 15, Issue 6, 2010, Pages

  Parthasarathy, Ashwin B ^a   Weber, Erica L ^a   Richards, Lisa M ^a   Fox, Douglas J ^b   Dunn, Andrew K ^a  

^a The University of Texas at Austin   (United States)

^b St Davids Hospital   (United States)

Author keywords

cerebral blood flow; flow measurement; intraoperative imaging; laser speckle contrast imaging; scattering spectroscopy

Indexed keywords

ANIMAL MODEL; BASE-LINE CONDITIONS; BLOOD FLOW; CEREBRAL BLOOD FLOW; CLINICAL STUDY; ECG WAVEFORMS; FULL-FIELD; IMAGE MAPS; IN-VIVO; INDOCYANINE GREEN ANGIOGRAPHIES; INTRAOPERATIVE IMAGING; INTRAOPERATIVE MONITORING; LASER SPECKLE CONTRAST IMAGING; MOTION ARTIFACT; OPTICAL TECHNIQUE; QUANTITATIVE MEASURES; REAL TIME; SCATTERING SPECTROSCOPY; SPATIAL RESOLUTION; SURGICAL PROCEDURES; TISSUE VIABILITY;

BLOOD; FLOW MEASUREMENT; HEMODYNAMICS; MONITORING; NEUROSURGERY; RESONANCE; SPECKLE; SPECTROSCOPY; TISSUE;

MAGNETIC RESONANCE IMAGING;

ANIMALIA;

DIAGNOSTIC AGENT;

ARTICLE; BLOOD FLOW VELOCITY; BRAIN CIRCULATION; BRAIN TUMOR; CLINICAL TRIAL; EQUIPMENT; EQUIPMENT DESIGN; FLOW KINETICS; HUMAN; INSTRUMENTATION; LASER; NEUROSURGERY; PATHOLOGY; PATHOPHYSIOLOGY; PHOTOMETRY; PILOT STUDY;

BLOOD FLOW VELOCITY; BRAIN NEOPLASMS; CEREBROVASCULAR CIRCULATION; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; HUMANS; LASERS; NEUROSURGICAL PROCEDURES; PHOTOMETRY; PILOT PROJECTS; RHEOLOGY;

EID: 84894323642     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3526368     Document Type: Conference Paper

References (30)

1. G. Sutherland, T. Kaibara, C. Wallace, B. Tomanek, and M. Richter, Intraoperative assessment of aneurysm clipping using magnetic resonance angiography and diffusion-weighted imaging: technical case report., Neurosurgery 50, 893-898 (2002). 10.1097/00006123-200204000-00044 (Pubitemid 36322821)
2. N. Pouratian, S. Sheth, N. Martin, and A. Toga, Shedding light on brain mapping: advances in human optical imaging., Trends Neurosci. 26, 277-282 (2003). 10.1016/S0166-2236(03)00070-5 (Pubitemid 36556159)
3. A. Cannestra, S. Bookheimer, N. Pouratian, A. OFarrell, N. Sicotte, N. Martin, D. Becker, G. Rubino, and A. Toga, Temporal and topographical characterization of language cortices using intraoperative optical intrinsic signals., Neuroimage 12, 41-54 (2000). 10.1006/nimg.2000.0597 (Pubitemid 30602062)
4. T. Schwartz, Optical imaging of epileptiform events in visual cortex in response to patterned photic stimulation., Cereb. Cortex. 13, 1287-1298 (2003). 10.1093/cercor/bhg076 (Pubitemid 37466777)
5. E. Keller, A. Nadler, H. Alkadhi, S. Kollias, Y. Yonekawa, and P. Niederer, Noninvasive measurement of regional cerebral blood flow and regional cerebral blood volume by near-infrared spectroscopy and indocyanine green dilution., NeuroImage 20, 828-839 (2003). 10.1016/S1053-8119(03)00315-X (Pubitemid 37268107)
6. A. Raabe, P. Nakaji, J. Beck, L. Kim, F. Hsu, J. Kamerman, V. Seifert, and R. Spetzler, Prospective evaluation of surgical microscope-integrated intraoperative near-infrared indocyanine green videoangiography during aneurysm surgery., J. Neurosurg. 103, 982-989 (2005). (Pubitemid 43194546)
7. A. Raabe, D. Van De Ville, M. Leurenegger, A. Szelenyi, E. Hattingen, R. Gerlach, V. Seifert, C. Hauger, A. Lopez, R. Leitgeb, E. Martin-Williams, and T. Lasser, Laser doppler imaging for intraoperative human brain mapping., NeuroImage 44, 1284-1289 (2009). 10.1016/j.neuroimage.2008.10.049
8. J. Briers, Laser doppler, speckle and related techniques for blood perfusion mapping and imaging., Physiol. Meas. 22, R35-R66 (2001). 10.1088/0967-3334/22/4/201 (Pubitemid 33104651)
9. D. Boas and A. Dunn, Laser speckle contrast imaging in biomedical optics., J. Biomed. Opt. 15, 011109 (2010). 10.1117/1.3285504
10. A. Dunn, H. Bolay, M. Moskowitz, and D. Boas, Dynamic imaging of cerebral blood flow using laser speckle., J. Cereb. Blood Flow Metab. 21, 195-201 (2001). (Pubitemid 32207418)
11. A. Dunn, A. Devor, A. Dale, and D. Boas, Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex., NeuroImage 27, 279-290 (2005). 10.1016/j.neuroimage.2005. 04.024 (Pubitemid 41074831)
12. T. Durduran, C. Zhou, B. Edlow, G. Yu, R. Choe, M. Kim, B. Cucchiara, M. Putt, Q. Shah, S. Kasner, J. Greenberg, A. Yodh, and J. Detre, Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients., Opt. Express, 17, 3884-3902 (2009). 10.1364/OE.17.003884
13. C. Ayata, A. Dunn, Y. Gursoy-Ozdemir, Z. Huang, D. Boas, and M. Moskowitz, Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex., J. Cereb. Blood Flow Metab. 24, 744-755 (2004 a). (Pubitemid 38880219)
14. C. Ayata, H. Shin, S. Salomone, Y. Ozdemir-Gursoy, D. Boas, A. Dunn, and M. Moskowitz, Pronounced hypoperfusion during spreading depression in mouse cortex., J. Cereb. Blood Flow Metab. 24, 1172-1182 (2004 b). (Pubitemid 39332157)
15. H. Shin, A. Dunn, P. Jones, D. Boas, E. Lo, M. Moskowitz, and C. Ayata, Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia., Brain 130, 1631-1642 (2007 a). 10.1093/brain/awm071 (Pubitemid 47355921)
16. H. Shin, P. Jones, M. Garcia-Alloza, L. Borrelli, S. Greenberg, B. Bacskai, M. Frosch, B. Hyman, M. Moskowitz, and C. Ayata, Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy., Brain 130, 2310-2319 (2007 b). 10.1093/brain/awm156 (Pubitemid 47327629)
17. H. Shin, A. Dunn, P. Jones, D. Boas, M. Moskowitz, and C. Ayata, Vasoconstrictive neurovascular coupling during focal ischemic depolarizations., J. Cereb. Blood Flow Metab. 26, 1018-1030 (2006). 10.1038/sj.jcbfm.9600252 (Pubitemid 44134074)
18. Y. Huang, N. Tran, P. Shumaker, K. Kelly, E. Ross, J. Nelson, and B. Choi, Blood flow dynamics after laser therapy of port wine stain birthmarks., Lasers Surg. Med. 41, 563-571 (2009). 10.1002/lsm.20840
19. N. Hecht, J. Woitzik, J. Dreier, and P. Vajkoczy, Intraoperative monitoring of cerebral blood flow by laser speckle contrast analysis., Neurosurg. Focus 27 (4), E11 (2009). 10.3171/2009.8.FOCUS09148
20. W. Tom, A. Ponticorvo, and A. Dunn, Efficient processing of laser speckle contrast images., IEEE Trans. on Med. Imaging 27, 1728-1738 (2008). 10.1109/TMI.2008.925081
21. Safe Use of Lasers., ANSI Z136.1-2007 Laser Institute of America (2007).
22. A. Strong, E. Bezzina, P. Anderson, M. Boutelle, S. Hopwood, and A. Dunn, Evaluation of laser speckle flowmetry for imaging cortical perfusion in experimental stroke studies: quantitation of perfusion and detection of peri-infarct depolarisations., J. Cereb. Blood Flow Metab. 26, 645-653 (2006). 10.1038/sj.jcbfm.9600240
23. S. Yuan, A. Devor, D. Boas, and A. Dunn, Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging., Appl. Opt. 44, 1823-1830 (2005). (Pubitemid 40479532)
24. R. Bandyopadhyay, A. Gittings, S. Suh, P. Dixon, and D. Durian, Speckle-visibility spectroscopy: A tool to study time-varying dynamics., Rev. Sci. Instrum. 76, 093110 (2005). 10.1063/1.2037987 (Pubitemid 41395481)
25. P. Lemieux and D. Durian, Investigating non-Gaussian scattering processes by using n th-order intensity correlation functions., J. Opt. Soc. Am. A 16, 1651-1664 (1999). 10.1364/JOSAA.16.001651 (Pubitemid 129655451)
26. A. Parthasarathy, W. Tom, A. Gopal, X. Zhang, and A. Dunn, Robust flow measurement with multi-exposure speckle imaging., Opt. Express 16, 1975-1989 (2008). 10.1364/OE.16.001975 (Pubitemid 351240039)
27. R. H. Deckers, P. van Gelderen, M. Ries, O. Barret, J. H. Duyn, V. N. Ikonomidou, M. Fukunaga, G. H. Glover, and J. A. de Zwart, An adaptive filter for suppression of cardiac and respiratory noise in mri time series data., 10.1016/j.neuroimage.2006.08.006 NeuroImage 33, 1072-1081 (2006). 10.1016/j.neuroimage.2006.08.006 (Pubitemid 44780849)
28. W. Manafo, Treatment of Burns: Principles and Practice., WH Green, St. Louis, MO, (1971).
29. C. Stewart, R. Frank, K. Forrester, J. Tulip, R. Lindsay, and R. Bray, A comparison of two laser-based methods for determination of burn scar perfusion: laser Doppler versus laser speckle imaging., Burns 31, 744-752 (2005). 10.1016/j.burns.2005.04.004 (Pubitemid 41208229)
30. A. Sadhwani, K. Schomacker, G. Tearney, and N. Nishioka, Determination of Teflon thickness with laser speckle. I. potential for burn depth diagnosis., Appl. Opt 35, 5727-5735 (1996). 10.1364/AO.35.005727 (Pubitemid 126627826)