Utilization of 15N-labelled yeast hydrolysate in Lactococcus lactis IL1403 culture indicates co-consumption of peptide-bound and free amino acids with simultaneous efflux of free amino acids

Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology

Volumn 105, Issue 3, 2014, Pages 511-522

  Kevvai, Kaspar ^a,b   Kütt, Mary Liis ^a,b   Nisamedtinov, Ildar ^a,b,c   Paalme, Toomas ^b  

^a Competence Centre of Food and Fermentation Technologies ^*  (Estonia)

^b TALLINN UNIVERSITY OF TECHNOLOGY   (Estonia)

^c LALLEMAND SAS   (France)

Author keywords

15N labelling; Amino acids; Lactococcus lactis; Peptides; Yeast hydrolysate

Indexed keywords

AMINO ACIDS; LACTOCOCCUS LACTIS; MODELS, BIOLOGICAL; PEPTIDES;

EID: 84894277584     PISSN: 00036072     EISSN: 15729699     Source Type: Journal    
DOI: 10.1007/s10482-013-0103-2     Document Type: Article

References (34)

1. Benthin S, Villadsen J (1996) Amino acid utilization by Lactococcus lactis subsp. cremoris FD1 during growth on yeast extract or casein peptone. J Appl Microbiol 80:65-72
2. Christensen JE, Steele JL (2003) Impaired growth rates in milk of Lactobacillus helveticus peptidase mutants can be overcome by use of amino acid supplements. J Bacteriol 185:3297-3306
3. Christensen JE, Dudley EG, Pederson JA, Steele JL (1999) Peptidases and amino acid catabolism in lactic acid bacteria. Antonie Van Leeuwenhoek 76:217-246
4. Cretenet M, Laroute V, Ulvé V, Jeanson S, Nouaille S, Even S, Piot M, Girbal L, Le Loir Y, Loubière P, Lortal S, Cocaign-Bousquet M (2011) Dynamic analysis of the Lactococcus lactis transcriptome in cheeses made from milk concentrated by ultrafiltration reveals multiple strategies of adaptation to stresses. Appl Environ Microbiol 77:247-257
5. den Hengst CD, Groeneveld M, Kuipers OP, Kok J (2006) Identification and functional characterization of the Lactococcus lactis CodY-regulated branched-chain amino acid permease BcaP (CtrA). J Bacteriol 188:3280-3289
6. Detmers FJ, Lanfermeijer FC, Abele R, Jack RW, Tampe R, Konings WN, Poolman B (2000) Combinatorial peptide libraries reveal the ligand-binding mechanism of the oligopeptide receptor OppA of Lactococcus lactis. Proc Natl Acad Sci USA 97:12487-12492
7. Doeven MK, Kok J, Poolman B (2005) Specificity and selectivity determinants of peptide transport in Lactococcus lactis and other microorganisms. Mol Microbiol 57:640-649
8. Driessen AJ, de Jong S, Konings WN (1987) Transport of branched-chain amino acids in membrane vesicles of Streptococcus cremoris. J Bacteriol 169:5193-5200
9. Foucaud C, Kunji ER, Hagting A, Richard J, Konings WN, Desmazeaud M, Poolman B (1995) Specificity of peptide transport systems in Lactococcus lactis: evidence for a third system which transports hydrophobic di- and tripeptides. J Bacteriol 177:4652-4657
10. Helinck S, Charbonnel P, Foucaud-Scheunemann C, Piard JC, Juillard V (2003) Charged casein-derived oligopeptides competitively inhibit the transport of a reporter oligopeptide by Lactococcus lactis. J Appl Microbiol 94:900-907
11. Jensen NBS, Christensen B, Nielsen J, Villadsen J (2002) The simultaneous biosynthesis and uptake of amino acids by Lactococcus lactis studied by (13)C-labeling experiments. Biotechnol Bioeng 78:11-16
12. Juillard V, Laan H, Kunji ER, Jeronimus-Stratingh CM, Bruins AP, Konings WN (1995a) The extracellular PI-type proteinase of Lactococcus lactis hydrolyzes beta-casein into more than one hundred different oligopeptides. J Bacteriol 177(12):3472-3478
13. Juillard V, Le Bars D, Kunji ER, Konings WN, Gripon JC, Richard J (1995b) Oligopeptides are the main source of nitrogen for Lactococcus lactis during growth in milk. Appl Environ Microbiol 61:3024-3030
14. Kok J, Buist G (2003) Genetics of Proteolysis in Lactococcus lactis. In: Wood B, Warner P (eds) Genetics of lactic acid Bacteria. Springer, New York, pp 189-223
15. Konings WN (2002) The cell membrane and the struggle for life of lactic acid bacteria. Antonie Van Leeuwenhoek 82:3-27
16. Konings WN, Poolman B, Driessen AJ (1989) Bioenergetics and solute transport in lactococci. Crit Rev Microbiol 16:419-476
17. Lahtvee PJ, Adamberg K, Arike L, Nahku R, Aller K, Vilu R (2011) Multi-omics approach to study the growth efficiency and amino acid metabolism in Lactococcus lactis at various specific growth rates. Microb Cell Fact 10:1-12
18. Lamarque M, Charbonnel P, Aubel D, Piard JC, Atlan D, Juillard V (2004) A multifunction ABC transporter (Opt) contributes to diversity of peptide uptake specificity within the genus Lactococcus. J Bacteriol 186:6492-6500
19. Lamarque M, Aubel D, Piard JC, Gilbert C, Juillard V, Atlan D (2011) The peptide transport system Opt is involved in both nutrition and environmental sensing during growth of Lactococcus lactis in milk. Microbiology 157:1612-1619
20. Lobo-Alfonso J, Price P, Jayme D (2010) Benefits and limitations of protein extracts. In: Pasupuleti VK, Demain AL (eds) Protein hydrolysates in biotechnology. Springer, New York, pp 55-78
21. Nisamedtinov I, Kevvai K, Orumets K, Rautio JJ, Paalme T (2010) Glutathione accumulation in ethanol-stat fed-batch culture of Saccharomyces cerevisiae with a switch to cysteine feeding. Appl Microbiol Biotechnol 87:175-183
22. Nissen-Meyer J, Lillehaug D, Nes IF (1992) The plasmid-encoded lactococcal envelope-associated proteinase is encoded by a chromosomal gene in Lactococcus lactis subsp. cremoris BC101. Appl Environ Microbiol 58:750-753
23. Poolman B, Smid EJ, Konings WN (1987a) Kinetic properties of a phosphate-bond-driven glutamate-glutamine transport system in Streptococcus lactis and Streptococcus cremoris. J Bacteriol 169:2755-2761
24. Poolman B, Driessen AJ, Konings WN (1987b) Regulation of solute transport in streptococci by external and internal pH values. Microbiol Rev 51:498-508
25. Poquet I, Saint V, Seznec E, Simoes N, Bolotin A, Gruss A (2000) HtrA is the unique surface housekeeping protease in Lactococcus lactis and is required for natural protein processing. Mol Microbiol 35:1042-1051
26. Rockwood AL, Van Orden SL (1996) Ultrahigh-speed calculation of isotope distributions. Anal Chem 68:2027-2030
27. Savijoki K, Ingmer H, Varmanen P (2006) Proteolytic systems of lactic acid bacteria. Appl Microbiol Biotechnol 71:394-406
28. Schuurman-Wolters GK, Poolman B (2005) Substrate specificity and ionic regulation of GlnPQ from Lactococcus lactis. An ATP-binding cassette transporter with four extracytoplasmic substrate-binding domains. J Biol Chem 280:23785-23790
29. Smid EJ, Konings WN (1990) Relationship between utilization of proline and proline-containing peptides and growth of Lactococcus lactis. J Bacteriol 172:5286-5292
30. Trip H, Mulder NL, Lolkema JS (2012) Cloning, expression, and functional characterization of secondary amino acid transporters of Lactococcus lactis. J Bacteriol 195:340-350
31. Tynkkynen S, Buist G, Kunji E (1993) Genetic and biochemical characterization of the oligopeptide transport system of Lactococcus lactis. J Bacteriol 175:7523-7532
32. Ummadi M, Curic-Bawden M (2010) Use of protein hydrolysates in industrial starter culture fermentations. In: Pasupuleti VK, Demain AL (eds) Protein hydrolysates in biotechnology. Springer, New York, pp 91-114
33. Xie Y, Chou L, Cutler A, Weimer B (2004) DNA macroarray profiling of Lactococcus lactis subsp. lactis IL1403 gene expression during environmental stresses. Appl Environ Microbiol 70:6738-6747
34. Zhang G, Mills DA, Block DE (2009) Development of chemically defined media supporting high-cell-density growth of lactococci, enterococci, and streptococci. Appl Environ Microbiol 75:1080-1087