Synthesis and characterization of a novel controlled release zinc oxide/gentamicin-chitosan composite with potential applications in wounds care

International Journal of Pharmaceutics

Volumn 463, Issue 2, 2014, Pages 161-169

  Vasile, Bogdan Stefan ^a   Oprea, Ovidiu ^a   Voicu, Georgeta ^a   Ficai, Anton ^a   Andronescu, Ecaterina ^a   Teodorescu, Andrei ^a   Holban, Alina ^b  

^a UNIVERSITY POLITEHNICA OF BUCHAREST   (Romania)

^b UNIVERSITY OF BUCHAREST   (Romania)

Author keywords

Antimicrobial effect; Chitosan; Controlled release; Gentamicin; Improved wound dressing; Zinc oxide

Indexed keywords

CHITOSAN; GENTAMICIN; ZINC OXIDE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; DRUG ADSORPTION; DRUG DECOMPOSITION; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; DRY WEIGHT; FILM COATING; HYDROLYSIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OXIDATION; PARTICLE SIZE; PHOTOLUMINESCENCE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; THERMOSTABILITY; THICKNESS; TRANSMISSION ELECTRON MICROSCOPY; WATER LOSS; WOUND CARE; WOUND DRESSING; X RAY DIFFRACTION;

ANTIMICROBIAL EFFECT; CHITOSAN; CONTROLLED RELEASE; GENTAMICIN; IMPROVED WOUND DRESSING; ZINC OXIDE;

ANTI-BACTERIAL AGENTS; BANDAGES; CHITOSAN; DELAYED-ACTION PREPARATIONS; GENTAMICINS; LUMINESCENCE; METAL NANOPARTICLES; MICROBIAL SENSITIVITY TESTS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOCOMPOSITES; POWDER DIFFRACTION; PSEUDOMONAS AERUGINOSA; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STAPHYLOCOCCUS AUREUS; WOUND HEALING; X-RAY DIFFRACTION; ZINC OXIDE;

EID: 84894258161     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.11.035     Document Type: Article

References (43)

1. E. Andronescu, A.M. Grumezescu, A. Ficai, I. Gheorghe, M. Chifiriuc, D.E. Mihaiescu, and V. Lazar In vitro efficacy of antibiotic magnetic dextran microspheres complexes against Staphylococcus aureus and Pseudomonas aeruginosa strains Biointerface Res. Appl. Chem. 2 2012 332 338
2. D. Archana, J. Dutta, and P.K. Dutta Evaluation of chitosan nano dressing for wound healing: Characterization, in vitro and in vivo studies Int. J. Biol. Macromol. 57 2013 193 203
3. P.F. Builders, B. Kabele-Toge, M. Builders, B.A. Chindo, P.A. Anwunobi, and Y.C. Isimi Wound healing potential of formulated extract from Hibiscus sabdariffa calyx Indian J. Pharm. Sci. 75 2013 45 52
4. L. Casettari, D. Vllasaliu, J.K.W. Lam, M. Soliman, and L. Illum Biomedical applications of amino acid-modified chitosans: a review Biomaterials 33 2012 7565 7583
5. D. Doutt, H.L. Mosbacker, G. Cantwell, J. Zhang, J.J. Song, and L.J. Brillson Impact of near-surface defects and morphology on ZnO luminescence Appl. Phys. Lett. 94 2009 Art. no. 042111
6. H. Eidi, O. Joubert, C. Nemos, S. Grandemange, B. Mograbi, B. Foliguet, J. Tournebize, P. Maincent, A. Le Faou, I. Aboukhamis, and B.H. Rihn Drug delivery by polymeric nanoparticles induces autophagy in macrophages Int. J. Pharm. 422 2012 495 503
7. A. El Shafei, and A. Abou-Okeil ZnO/carboxymethyl chitosan bionano-composite to impart antibacterial and UV protection for cotton fabric Carbohydr. Polym. 83 2011 920 925
8. D. Gingasu, O. Oprea, I. Mindru, D.C. Culita, and L. Patron Alkali earth metal indates synthesized by precursor method Digest J. Nanomater. Biostruct. 6 2011 1215 1226
9. A.M. Grumezescu, E. Andronescu, A. Ficai, C. Bleotu, and M.C. Chifiriuc Chitin based biomaterial for antimicrobial therapy: fabrication, characterization and in vitro profile based interaction with eukaryotic and prokaryotic cells Biointerface Res. Appl. Chem. 2 2012 438 445
10. A.M. Grumezescu, E. Andronescu, A. Ficai, C. Bleotu, D.E. Mihaiescu, and M.C. Chifiriuc Synthesis, characterization and in vitro assessment of the magnetic chitosan-carboxymethylcellulose biocomposite interactions with the prokaryotic and eukaryotic cells Int. J. Pharm. 436 2012 771 777
11. 12 core/shell nanosystem Lett. Appl. NanoBioSci. 1 2012 31 35
12. A.M. Grumezescu, A.M. Holban, E. Andronescu, A. Ficai, C. Bleotu, and M.C. Chifiriuc Water dispersible metal oxide nanobiocomposite as a potentiator of the antimicrobial activity of kanamycin Lett. Appl. NanoBioSci. 1 2012 77 82
13. A.M. Grumezescu, D.E. Mihaiescu, and D. Tamas Hybrid materials for drug delivery of rifampicin: evaluation of release profile Biointerface Res. Appl. Chem. 1 2012 229 235
14. D.X. Jiang, L.X. Cao, G. Su, H. Qu, and D. Sun Luminescence enhancement of Mn doped ZnS nanocrystals passivated with zinc hydroxide Appl. Surf. Sci. 253 2007 9330 9335 (Pubitemid 47374858)
15. P.T.S. Kumar, V.K. Lakshmanan, T.V. Anilkumar, C. Ramya, P. Reshmi, A.G. Unnikrishnan, S.V. Nair, and R. Jayakumar Flexible and microporous chitosan hydrogel/nano ZnO composite bandages for wound dressing: in vitro and in vivo evaluation ACS Appl. Mater. Interfaces 4 2012 2618 2629
16. P.T.S. Kumar, V.K. Lakshmanan, R. Biswas, S.V. Nair, and R. Jayakumar Synthesis and biological evaluation of chitin hydrogel/nano ZnO composite bandage as antibacterial wound dressing J. Biomed. Nanotechnol. 8 2012 891 900
17. Q. Liu, W.T. Ren, Y. Zhang, and Y.X. Zhang Hydrogenated carboxylated nitrite rubber/modified zinc carbonate basic composites with photoluminescence properties Eur. Polym. J. 47 2011 1135 1141
18. Y. Liu, and H.I. Kim Characterization and antibacterial properties of genipin-crosslinked chitosan/poly(ethylene glycol)/ZnO/Ag nanocomposites Carbohydr. Polym. 89 2012 111 116
19. N. Manjunatha, S. Vasanti, N. Rajesh, and N. Uma Formulation and evaluation of biopolymer based microspheres for nasal drug delivery Int. J. PharmTech Res. 2 2010 856 862
20. D.E. Mihaiescu, A.M. Grumezescu, P.C. Balaure, D.E. Mogosanu, and V. Traistaru Magnetic scaffold for drug targeting: evaluation of cephalosporins controlled release profile Biointerface Res. Appl. Chem. 1 2011 191 195
21. D.E. Mihaiescu, M. Horja, I. Gheorghe, A. Ficai, A.M. Grumezescu, C. Bleotu, and C.M. Chifiriuc Water soluble magnetite nanoparticles for antimicrobial drugs delivery Lett. Appl. NanoBioSci. 1 2012 45 49
22. O. Oprea, E. Andronescu, B.S. Vasile, G. Voicu, and C. Covaliu Synthesis and characterization of ZnO nanopowder by non-basic route Digest J. Nanomater. Biostruct. 6 2011 1393 1401
23. O. Oprea, O.R. Vasile, G. Voicu, and E. Andronescu The influence of the thermal treatment on luminescence properties of ZnO Digest J. Nanomater. Biostruct. 8 2013 747 756
24. L.L. Peng, and Y.H. Wang Effects of the template composition and coating on the photoluminescence properties of ZnS:Mn nanoparticles Nanoscale Res. Lett. 5 2010 839 845
25. I. Perelshtein, E. Ruderman, N. Perkas, T. Tzanov, J. Beddow, E. Joyce, T.J. Mason, M. Blanes, K. Molla, A. Patlolla, A.I. Frenkel, and A. Gedanken Chitosan and chitosan-ZnO-based complex nanoparticles: formation, characterization, and antibacterial activity J. Mater. Chem. B 1 2013 1968 1976
26. M.P. Ribeiro, P.I. Morgado, S.P. Miguel, P. Coutinho, and I.J. Correia Dextran-based hydrogel containing chitosan microparticles loaded with growth factors to be used in wound healing Mater. Sci. Eng. C: Mater. Biol. Appl. 33 2013 2958 2966
27. N.S. Sabri, A.K. Yahya, and M.K. Talari Emission properties of Mn doped ZnO nanoparticles prepared by mechanochemical processing J. Lumin. 132 2012 1735 1739
28. S.S. Sampath, and D.H. Robinson Comparison of new and existing spectrophotometric methods for the analysis of tobramycin and other aminoglycosides J. Pharm. Sci. 79 1990 428 431 (Pubitemid 20152176)
29. C. Saviuc, A.M. Grumezescu, A. Holban, C. Bleotu, C. Chifiriuc, P. Balaure, and V. Lazar Phenotypical studies of raw and nanosystem embedded Eugenia carryophyllata buds essential oil antibacterial activity on Pseudomonas aeruginosa and Staphylococcus aureus strains Biointerface Res. Appl. Chem. 1 2011 111 118
30. 2 and Ag nanoparticles coating Int. J. Pharm. 434 2012 366 374
31. K.T. Shalumon, K.H. Anulekha, S.V. Nair, S.V. Nair, K.P. Chennazhi, and R. Jayakumar Sodium alginate/poly(vinyl alcohol)/nano ZnO composite nanofibers for antibacterial wound dressings Int. J. Biol. Macromol. 49 2011 247 254
32. W. Simchua, N.A. Narkkong, and Y. Baimark Silk fibroin nanospheres for controlled gentamicin sulfate delivery Res. J. Nanosci. Nanotechnol. 1 2011 34 41
33. I.A. Sogias, A.C. Williams, and V.V. Khutoryanskiy Chitosan-based mucoadhesive tablets for oral delivery of ibuprofen Int. J. Pharm. 436 2012 602 610
34. Y. Song, X. Du, T.M. Li, Y.J. Zhu, and M. Li Phenotypic and molecular characterization of Staphylococcus aureus recovered from different clinical specimens of inpatients at a teaching hospital in Shanghai between 2005 and 2010 J. Med. Microbiol. 62 2013 274 282
35. R.S. Subhasree, D. Selvakumar, and N.S. Kumar Hydrothermal mediated synthesis of ZnO nanorods and their antibacterial properties Lett. Appl. NanoBioSci. 1 2012 2 7
36. F.J. Sun, X.B. Zhang, Y.D. Fang, J.H. Chen, H.Y. Xing, H.Q. Shi, W. Feng, and P.Y. Xia Spectrum and drug resistance of pathogens from patients with burns Burns 38 2012 1124 1130
37. F. Vaja, C. Comanescu, O. Oprea, D. Ficai, and C. Guran Effects of ZnO nanoparticles on the wet scrub resistance and photocatalytic properties of acrylic coatings Rev. Chim. 63 2012 722 726
38. F. Vaja, D. Ficai, A. Ficai, O. Oprea, and C. Guran Multifunctional advanced coatings based on ZnO/M obtained by nanocasting method J. Optoelectron. Adv. Mater. 15 2013 107 113
39. S. Vlad, C. Tanase, D. Macocinschi, C. Ciobanu, T. Balaes, D. Filip, I.N. Gostin, and L.M. Gradinaru Antifungal behaviour of polyurethane membranes with zinc oxide nanoparticles Digest J. Nanomater. Biostruct. 7 2012 51 58
40. G. Voicu, O. Oprea, B.S. Vasile, and E. Andronescu Antibacterial activity of zinc oxide-gentamicin hybrid material Digest J. Nanomater. Biostruct. 8 2013 1191 1203
41. A. Wijekoon, N. Fountas-Davis, and N.D. Leipzig Fluorinated methacrylamide chitosan hydrogel systems as adaptable oxygen carriers for wound healing Acta Biomater. 9 2013 5653 5664
42. M. Zabielinski, M.P. McLeod, C. Aber, J. Izakovic, and L.A. Schachner Trends and antibiotic susceptibility patterns of methicillin-resistant and methicillin-sensitive Staphylococcus aureus in an outpatient dermatology facility JAMA Dermatol. 149 2013 427 432
43. M.G. Zhao, J.Y. Huang, Y. Zhou, Q. Chen, X.H. Pan, H.P. He, and Z.Z. Ye A single mesoporous ZnO/Chitosan hybrid nanostructure for a novel free nanoprobe type biosensor Biosens. Bioelectron. 43 2013 226 230