Effect of the cytochrome P450 2D6*10 genotype on the pharmacokinetics of tramadol in post-operative patients

Pharmazie

Volumn 69, Issue 2, 2014, Pages 138-141

  Xu, Jing ^a   Zhang, Xiang Cai ^a   Lv, Xiao Qin ^a   Xu, Ying Ying ^a   Wang, Guo Xiang ^a   Jiang, Bo ^a   Cai, Long ^a   Cai, Xiu Jun ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANALGESICS, OPIOID; AREA UNDER CURVE; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2D6; FEMALE; GASTROINTESTINAL TRACT; GENOTYPE; HALF-LIFE; HUMANS; MALE; MASS SPECTROMETRY; MIDDLE AGED; PAIN, POSTOPERATIVE; POLYMORPHISM, GENETIC; TRAMADOL;

EID: 84894257525     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2014.3749     Document Type: Article

References (18)

1. Allegaert K, Anderson BJ, Verbesselt R, Debeer A, De Hoon J, Devlieger H, Van Den Anker JN, Tibboel D (2005) Tramadol disposition in the very young: an attempt to assess in vivo cytochrome P-450 2D6 activity. Brit J Anaesth 95: 231-239. (Pubitemid 41487151)
2. Frank D, Jaehde U, Fuhr U (2007) Evaluation of probe drugs and pharmacokinetic metrics for CYP2D6 phenotyping. Eur J Clin Pharmacol 63: 321-333. (Pubitemid 46399125)
3. Gan SH, Ismail R, Wan Adnan WA, Wan Z (2002) Correlation of tramadol pharmacokinetics and CYP2D6*10 genotype in Malaysian subjects. J Pharm Biomed Anal 30: 189-195. (Pubitemid 35013483)
4. Garcia-Barceló M, Chow LY, Chiu HF, Wing YK, Lee DT, Lam KL, Waye MM (2000) Genetic analysis of the CYP2D6 locus in a Hong Kong Chinese population. Clin Chem 46: 18-23. (Pubitemid 30090955)
5. García-Quetglas E, Azanza JR, Sádaba B, Muñoz MJ, Gil I, Campanero MA (2007) Pharmacokinetics of tramadol enantiomers and their respective phase I metabolites in relation to CYP2D6 phenotype. Pharmacol Res 55: 122-130. (Pubitemid 46186038)
6. Ji L (2008) Rapid detection of point mutation at C2938T, G1846T, G1846A, C188T in Chinese population. Int J Lab Med 29: 577-580.
7. Ji L, Pan SX, Wu JM, Marti-Jaun J, Hersberger M (2002) Genetic polymorphisms of CYP2D6 in Chinese mainland. Chin Med J: 115: 1780-1784. (Pubitemid 36105051)
8. Kirchheiner J, Keulen JT, Bauer S, Roots I, Brockmöller J (2008) Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol. J. Clin Psychopharmacol 28: 78-83.
9. Li Q, Wang R, Guo Y, Pei F (2009) Influence of CYP2D6 genetic polymorphism on pharmacokinetics of tramadol in Chinese population. Chin J Clin Pharmacol 25, 302-307.
10. Neafsey P, Ginsberg G, Hattis D, Sonawane B (2009) Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): population distribution of CYP2D6 activity. J Toxicol Environ Health B Crit Rev 12: 334-361.
11. Pedersen RS, Damkier P, Brøsen K (2006) Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers. Eur J Clin Pharmacol 62: 513-521.
12. Sheng H, XiaoH(2008) Gene polymorphisms of P450 and drug metabolism. Int J Genet 31: 206-212.
13. Slanar O, Nobilis M, Kvétina J, Matousková O, Idle JR, Perlík F (2007) Pharmacokinetics of tramadol is affected by MDR1 polymorphism C3435T. Eur J Clin Pharmacol 63: 419-421. (Pubitemid 46399127)
14. Stamer UM, Musshoff F, Kobilay M, Madea B, Hoeft A, Stuber F (2007) Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes. Clin Pharmacol Ther 82: 41-47. (Pubitemid 46944194)
15. Wang G, Zhang H, He F, Fang X (2006) Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population. Eur J Clin Pharmacol 62: 927-931. (Pubitemid 44657626)
16. Wang SL, Huang JD, Lai MD, Liu BH, Lai ML (1993) Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: polymorphism in RFLP and DNA sequence of CYP2D6. Clin Pharmacol Ther 53: 410-418.
17. Yu J, Wang J, Li P, Sun X, Wang Q (2008) The effects of cytochrome P450 2D6*10 gene polymorphisms on the pharmacokinetics of tramadol Chin J Anesthesiol 28: 677-679.
18. Zhou SF (2009) Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. Clin Pharmacokinet 48: 761-804.