Mesenchymal stromal cells: Inhibiting PDGF receptors or depleting fibronectin induces mesodermal progenitors with endothelial potential

Stem Cells

Volumn 32, Issue 3, 2014, Pages 694-705

  Ball, S G ^a,b   Worthington, J J ^b   Canfield, A E ^a,b   Merry, C L R ^b   Kielty, C M ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Endothelial; Fibronectin; Mesenchymal stromal cells; Neovascularization; Platelet derived growth factor receptor; Spheroids

Indexed keywords

ENDOTHELIAL; FIBRONECTIN; MESENCHYMAL STROMAL CELLS; NEOVASCULARIZATION; PLATELET-DERIVED GROWTH FACTOR RECEPTOR; SPHEROIDS;

ADULT; ANGIOGENESIS INDUCING AGENTS; ANIMALS; COLLAGEN; DRUG COMBINATIONS; ENDOTHELIAL CELLS; FEMALE; FIBRONECTINS; GENE EXPRESSION PROFILING; HOMEODOMAIN PROTEINS; HUMANS; LAMININ; MALE; MESENCHYMAL STROMAL CELLS; MESODERM; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PHYSIOLOGIC; OCTAMER TRANSCRIPTION FACTOR-3; PROTEOGLYCANS; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; UP-REGULATION; YOUNG ADULT;

EID: 84894230823     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1538     Document Type: Article

References (36)

1. Pittenger MF, Mackay AM, Jaiswal RK, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143-147.
2. Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8: 315-317.
3. Slukvin II, Vodyanik M,. Endothelial origin of mesenchymal stem cells. Cell Cycle 2011; 10: 1370-1373.
4. Vodyanik MA, Yu J, Zhang X, et al. A mesoderm-derived precursor for mesenchymal stem and endothelial cells. Cell Stem Cell 2010; 7: 718-729.
5. Crisan M, Yap S, Casteilla L, et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008; 3: 301-313.
6. Méndez-Ferrer S, Michurina TV, Ferraro F, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010; 466: 829-834.
7. Bianco P, Cao X, Frenette PS, et al. The meaning, the sense and the significance: Translating the science of Mesenchymal stem cells into medicine. Nat Med 2013; 19: 35-42.
8. Oswald J, Boxberger S, Jørgensen B, et al. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 2004; 22: 377-384.
9. Whyte JL, Ball SG, Shuttleworth CA, et al. Density of human bone marrow stromal cells regulate commitment to vascular lineages. Stem Cell Res 2011; 6: 238-250.
10. Dennis JE, Charbord P,. Origin and differentiation of human and murine stroma. Stem Cells 2002; 20: 205-214.
11. Morikawa S, Mabuchi Y, Niibe K, et al. Development of mesenchymal stem cells partially originate from the neural crest. Biochem Biophys Res Commun 2009; 379: 1114-1119.
12. Lee G, Kim H, Elkabetz Y, et al. Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells. Nat Biotechnol 2007; 25: 1468-1475.
13. Minasi MG, Riminucci M, De Angelis L, et al. The meso-angioblast: A multipotent self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues. Development 2002; 129: 2773-2783.
14. Betsholtz C, Karlsson L, Lindahl P,. Developmental roles of platelet-derived growth factors. Bioessays 2001; 23: 494-507.
15. Andrae J, Gallini R, Betsholtz C,. Role of platelet-derived growth factors in physiology and medicine. Genes Dev 2008; 22: 1276-1312.
16. Tallquist M, Kazlauskas A,. PDGF signalling in cells and mice. Cytokine Growth Factor Rev 2004; 15: 205-213.
17. Soriano P,. The PDGF alpha receptor is required for neural crest cell survival and for normal patterning of the somites. Development 1009; 124: 2691-2700.
18. Hellström M, Kalén M, Lindahl P, et al. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 1999; 126: 3047-3055.
19. Boström H, Willetts K, Pekny M, et al. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 1996; 85: 863-873.
20. Yang X, Chrisman H, Weijer CJ,. PDGF signalling controls the migration of mesoderm cells during chick gastrulation by regulating N-cadherin expression. Development 2008; 135: 3521-3530.
21. Ball SG, Shuttleworth A, Kielty CM,. Platelet-derived growth factor receptor alpha is a key determinant of smooth muscle alpha actin filaments in bone marrow-derived mesenchymal stem cells. Int J Biochem Cell Biol 2007; 39: 379-391.
22. Veevers-Lowe J, Ball SG, Shuttleworth A, et al. Mesenchymal stem cell migration is regulated by fibronectin through α5β1-integrin-mediated activation of PDGFR-β and potentiation of growth factor signals. J Cell Sci 2011; 124: 1288-1300.
23. Ball SG, Bayley C, Shuttleworth CA, et al. Neuropilin-1 regulates platelet-derived growth factor receptor signalling in Mesenchymal stem cells. Biochem J 2010; 427: 29-40.
24. White ES, Baralle FE, Muro AF,. New insights into form and function of fibronectin splice variants. J Pathol 2008; 216: 1-14.
25. White ES, Muro AF,. Fibronectin splice variants: Understanding their multiple roles in health and disease using engineered mouse models. IUBMB Life 2011; 63: 538-546.
26. Astrof S, Crowley D, Hynes RO,. Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Dev Biol 2007; 311: 11-24.
27. Hewitt KJ, Shamis Y, Knight E, et al. PDGFRβ expression and function in fibroblasts derived from pluripotent cells is linked to DNA demethylation. J Cell Sci 2012; 125: 2276-2287.
28. Ball SG, Shuttleworth A, Kielty CM,. Inhibition of platelet-derived growth factor receptor signaling regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency. Stem Cells 2012; 30: 548-560.
29. Weiswald LB, Guinebretiére JM, Richon S, et al. In situ protein expression in tumour spheres: Development of an immunostaining protocol for confocal microscopy. BMC Cancer 2010; 10: 106.
30. Owens GK,. Regulation of differentiation of vascular smooth muscle cells. Physiol Rev 1995; 75: 487-517.
31. Tada S, Era T, Furusawa C, et al. Characterization of mesendoderm: A diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture. Development 2005; 132: 4363-4374.
32. Larue L, Antos C, Butz S, et al. A role for cadherins in tissue formation. Development 1996; 122: 3185-3194.
33. Redmer T, Diecke S, Grigoryan T, et al. E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming. EMBO Rep 2011; 12: 720-726.
34. Chen T, Yuan D, Wei B, et al. E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation. Stem Cells 2010; 28: 1315-1325.
35. Yamashita J, Itoh H, Hirashima M, et al. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 2000; 408: 92-96.
36. Ponce ML,. Tube formation: An in vitro matrigel angiogenesis assay. Methods Mol Biol 2009; 467: 183-188.