The senescence-associated secretory phenotype promotes benign prostatic hyperplasia

American Journal of Pathology

Volumn 184, Issue 3, 2014, Pages 721-731

  Vital, Paz ^a   Castro, Patricia ^a   Tsang, Susan ^a   Ittmann, Michael ^a  

^a MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CATHEPSIN D; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; INTERLEUKIN 8;

ANIMAL; CELL AGING; COMPLICATION; EPITHELIUM CELL; HUMAN; MALE; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; PHENOTYPE; PROSTATE; PROSTATE HYPERTROPHY; STROMA CELL; TRANSGENIC MOUSE; URINARY BLADDER NECK OBSTRUCTION;

ANIMALS; BIOMARKERS; CATHEPSIN D; CELL AGING; CYTOKINES; EPITHELIAL CELLS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-4; INTERLEUKIN-8; MALE; MICE; MICE, NUDE; MICE, TRANSGENIC; PHENOTYPE; PROSTATE; PROSTATIC HYPERPLASIA; STROMAL CELLS; URINARY BLADDER NECK OBSTRUCTION;

EID: 84894212929     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.11.015     Document Type: Article

References (44)

1. R.J. Glynn, E.W. Campion, G.R. Bouchard, and J.E. Silbert The development of benign prostatic hyperplasia among volunteers in the Normative Aging Study Am J Epidemiol 121 1985 78 90 (Pubitemid 15150691)
2. J.T. Wei, E. Calhoun, and S.J. Jacobsen Urologic Diseases in America project: benign prostatic hyperplasia J Urol 179 2008 S75 S80 (Pubitemid 351483917)
3. E. Shapiro, V. Hartanto, E.J. Perlman, R. Tang, B. Wang, and H. Lepor Morphometric analysis of pediatric and nonhyperplastic prostate glands: evidence that BPH is not a unique stromal process Prostate 33 1997 177 182 (Pubitemid 27509417)
4. J. Campisi Replicative senescence: an old lives' tale? Cell 84 1996 497 500 (Pubitemid 26071729)
5. I. Ben-Porath, and R.A. Weinberg The signals and pathways activating cellular senescence Int J Biochem Cell Biol 37 2005 961 976 (Pubitemid 40311739)
6. C. López-Otín, M.A. Blasco, L. Partridge, M. Serrano, and G. Kroemer The hallmarks of aging Cell 153 2013 1194 1217
7. G.P. Dimri, X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E.E. Medrano, M. Linskens, I. Rubelj, O. Pereira-Smith, M. Peacock, and J. Campisi A biomarker that identifies senescent human cells in culture and in aging skin in vivo Proc Natl Acad Sci USA 92 1995 9363 9367
8. J. Choi, I. Shendrik, M. Peacocke, D. Peehl, R. Buttyan, E.F. Ikeguchi, A.E. Katz, and M.C. Benson Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia Urology 56 2000 160 166 (Pubitemid 30408685)
9. P. Castro, D. Giri, D. Lamb, and M. Ittmann Cellular senescence in the pathogenesis of benign prostatic hyperplasia Prostate 55 2003 30 38 (Pubitemid 36397742)
10. J.P. Coppé, C.K. Patil, F. Rodier, Y. Sun, D.P. Muñoz, J. Goldstein, P.S. Nelson, P.Y. Desprez, and J. Campisi Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor PLoS Biol 6 2008 2853 2868
11. A. Freund, A.V. Orjalo, P.Y. Desprez, and J. Campisi Inflammatory networks during cellular senescence: causes and consequences Trends Mol Med 16 2010 238 246
12. D. Giri, and M. Ittmann Interleukin-1alpha is a paracrine inducer of FGF7, a key epithelial growth factor in benign prostatic hyperplasia Am J Pathol 157 2000 249 255 (Pubitemid 30641741)
13. D. Giri, and M. Ittmann Interleukin-8 is a paracrine inducer of fibroblast growth factor 2, a stromal and epithelial growth factor in benign prostatic hyperplasia Am J Pathol 159 2001 139 147 (Pubitemid 33704200)
14. P. Castro, C. Xia, L. Gomez, D.J. Lamb, and M. Ittmann Interleukin-8 expression is increased in senescent prostatic epithelial cells and promotes the development of benign prostatic hyperplasia Prostate 60 2004 153 159 (Pubitemid 38758580)
15. T.M. Wheeler, and R.M. Lebovitz Fresh tissue harvest for research from prostatectomy specimens Prostate 25 1994 274 279 (Pubitemid 24364132)
16. I.G. Schauer, S.J. Ressler, J.A. Tuxhorn, T.D. Dang, and D.R. Rowley Elevated epithelial expression of interleukin-8 correlates with myofibroblast reactive stroma in benign prostatic hyperplasia Urology 72 2008 205 213
17. J.A. Tuxhorn, S.J. McAlhany, T.D. Dang, G.E. Ayala, and D.R. Rowley Stromal cells promote angiogenesis and growth of human prostate tumors in a differential reactive stroma (DRS) xenograft model Cancer Res 62 2002 3298 3307 (Pubitemid 34602428)
18. S. Feng, O. Dakhova, C.J. Creighton, and M. Ittmann Endocrine fibroblast growth factor FGF19 promotes prostate cancer progression Cancer Res 73 2013 2551 2562
19. M.R. Seethammagari, X. Xie, N.M. Greenberg, and D.M. Spencer EZC-prostate models offer high sensitivity and specificity for noninvasive imaging of prostate cancer progression and androgen receptor action Cancer Res 66 2006 6199 6209
20. J. Wang, W. Yu, Y. Cai, C. Ren, and M.M. Ittmann Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression Neoplasia 10 2008 847 856
21. H.O. Byun, N.K. Han, H.J. Lee, K.B. Kim, Y.G. Ko, G. Yoon, Y.S. Lee, S.I. Hong, and J.S. Lee Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence Cancer Res 69 2009 4638 4647
22. O. Cussenot, P. Berthon, R. Berger, I. Mowszowicz, A. Faille, F. Hojman, P. Teillac, A. Le Duc, and F. Calvo Immortalization of human adult normal prostatic epithelial cells by liposomes containing large T-SV40 gene J Urol 146 1991 881 886
23. Y. Matsuo, H. Sawai, N. Ochi, A. Yasuda, H. Takahashi, H. Funahashi, H. Takeyama, and S. Guha Interleukin-1alpha secreted by pancreatic cancer cells promotes angiogenesis and its therapeutic implications J Surg Res 153 2009 274 281
24. I.D. McLaren, T.J. Jerde, and W. Bushman Role of interleukins, IGF and stem cells in BPH Differentiation 82 2011 237 243
25. K.L. Lee, and D.M. Peehl Molecular and cellular pathogenesis of benign prostatic hyperplasia J Urol 172 2004 1784 1791 (Pubitemid 39363056)
26. T.J. Jerde, and W. Bushman IL-1 induces IGF-dependent epithelial proliferation in prostate development and reactive hyperplasia Sci Signal 2 2009 ra49
27. F. Ropiquet, D. Giri, D.J. Lamb, and M. Ittmann FGF7 and FGF2 are increased in benign prostatic hyperplasia and are associated with increased proliferation J Urol 162 1999 595 599 (Pubitemid 29434402)
28. N. Kyprianou, H. Tu, and S.C. Jacobs Apoptotic versus proliferative activities in human benign prostatic hyperplasia Hum Pathol 27 1996 668 675 (Pubitemid 26240318)
29. R. Olinski, T.H. Zastawny, M. Foksinski, A. Barecki, and M. Dizdaroglu DNA base modifications and antioxidant enzyme activities in human benign prostatic hyperplasia Free Radic Biol Med 18 1995 807 813
30. D.C. Malins, N.L. Polissar, and S.J. Gunselman Models of DNA structure achieve almost perfect discrimination between normal prostate, benign prostatic hyperplasia (BPH), and adenocarcinoma and have a high potential for predicting BPH and prostate cancer Proc Natl Acad Sci USA 94 1997 259 264
31. I. Reyes, N. Reyes, M. Iatropoulos, A. Mittelman, and J. Geliebter Aging-associated changes in gene expression in the ACI rat prostate: implications for carcinogenesis Prostate 63 2005 169 186 (Pubitemid 40525366)
32. D.A. Barron, and D.R. Rowley The reactive stroma microenvironment and prostate cancer progression Endocr Relat Cancer 19 2012 R187 R204
33. I.G. Schauer, and D.R. Rowley The functional role of reactive stroma in benign prostatic hyperplasia Differentiation 82 2011 200 210
34. C. Bavik, I. Coleman, J.P. Dean, B. Knudsen, S. Plymate, and P.S. Nelson The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms Cancer Res 66 2006 794 802 (Pubitemid 43165944)
35. F.L. Pruitt, Y. He, O.E. Franco, M. Jiang, J.M. Cates, and S.W. Hayward Cathepsin D acts as an essential mediator to promote malignancy of benign prostatic epithelium Prostate 73 2013 476 488
36. J.P. Cherry, J.A. Mordente, J.R. Chapman, M.S. Choudhury, H. Tazaki, C. Mallouh, and S. Konno Analysis of cathepsin D forms and their clinical implications in human prostate cancer J Urol 160 1998 2223 2228 (Pubitemid 128703659)
37. G. Kramer, G.E. Steiner, A. Handisurya, U. Stix, A. Haitel, B. Knerer, A. Gessl, C. Lee, and M. Marberger Increased expression of lymphocyte-derived cytokines in benign hyperplastic prostate tissue, identification of the producing cell types, and effect of differentially expressed cytokines on stromal cell proliferation Prostate 52 2002 43 58 (Pubitemid 34553191)
38. G.E. Steiner, M.E. Newman, D. Paikl, U. Stix, N. Memaran-Dagda, C. Lee, and M.J. Marberger Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate Prostate 56 2003 171 182 (Pubitemid 36918167)
39. A. Handisurya, G.E. Steiner, U. Stix, R.C. Ecker, S. Pfaffeneder-Mantai, D. Langer, G. Kramer, N. Memaran-Dadgar, and M. Marberger Differential expression of interleukin-15, a pro-inflammatory cytokine and T-cell growth factor, and its receptor in human prostate Prostate 49 2001 251 262 (Pubitemid 33117000)
40. Y. Sugimoto, T. Koji, and S. Miyoshi Modification of expression of stem cell factor by various cytokines J Cell Physiol 181 1999 285 294 (Pubitemid 29463643)
41. G. Imokawa, Y. Yada, N. Morisaki, and M. Kimura Biological characterization of human fibroblast-derived mitogenic factors for human melanocytes Biochem J 330 1998 1235 1239 (Pubitemid 28162000)
42. J.A. Rodriguez-Nieves, and J.A. Macoska Prostatic fibrosis, lower urinary tract symptoms, and BPH Nat Rev Urol 10 2013 546 550
43. M. Gharaee-Kermani, S. Kasina, B.B. Moore, D. Thomas, R. Mehra, and J.A. Macoska CXC-type chemokines promote myofibroblast phenoconversion and prostatic fibrosis PLoS One 7 2012 e49278
44. J. Ma, M. Gharaee-Kermani, L. Kunju, J.M. Hollingsworth, J. Adler, E.M. Arruda, and J.A. Macoska Prostatic fibrosis is associated with lower urinary tract symptoms J Urol 188 2012 1375 1381