Pharmacodynamically optimized erythropoietin treatment combined with phlebotomy reduction predicted to eliminate blood transfusions in selected preterm infants

Pediatric Research

Volumn 75, Issue 2, 2014, Pages 336-342

  Rosebraugh, Matthew R ^a   Widness, John A ^b   Nalbant, Demet ^b   Cress, Gretchen ^b   Veng Pedersen, Peter ^c  

^a ABBVIE INC   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANEMIA; BIRTH WEIGHT; BLOOD TRANSFUSION; BLOOD VOLUME; COMPUTER SIMULATION; ERYTHROCYTE TRANSFUSION; ERYTHROPOIETIN; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, VERY LOW BIRTH WEIGHT; PHLEBOTOMY; TIME FACTORS;

HEMOGLOBIN; RECOMBINANT ERYTHROPOIETIN;

ARTICLE; BLEEDING; BLOOD ANALYSIS; BLOOD SAMPLING; BLOOD VOLUME; CLINICAL ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG ELIMINATION; DRUG HALF LIFE; EC50; ELECTROLYTE DISTURBANCE; ERYTHROCYTE LIFESPAN; ERYTHROCYTE TRANSFUSION; ERYTHROPOIESIS; EVIDENCE BASED PRACTICE; EXTREMELY LOW BIRTH WEIGHT; FEMALE; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERVOLEMIA; MATHEMATICAL MODEL; NECROTIZING ENTEROCOLITIS; NEWBORN; NEWBORN ANEMIA; PHLEBOTOMY; PREMATURITY; VERY LOW BIRTH WEIGHT;

EID: 84894139013     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2013.213     Document Type: Article

References (33)

1. Levy GJ, Strauss RG, Hume H, et al. National survey of neonatal transfusion practices: I. Red blood cell therapy. Pediatrics 1993;91:523-9.
2. Widness JA. Pathophysiology of Anemia During the Neonatal Period, Including Anemia of Prematurity. Neoreviews 2008;9:e520.
3. dos Santos AM, Guinsburg R, de Almeida MF, et al.; Brazilian Network on Neonatal Research. Red blood cell transfusions are independently associated with intra-hospital mortality in very low birth weight preterm infants. J Pediatr 2011;159:371-376.e1-3.
4. Galel SA, Fontaine MJ. Hazards of neonatal blood transfusion. Neoreviews 2006;7:e69-e74.
5. Ohlsson A, Aher SM. Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev 2012;9:CD004863.
6. McCoy TE, Conrad AL, Richman LC, Lindgren SD, Nopoulos PC, Bell EF. Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion. Child Neuropsychol 2011:1-21.
7. Carroll PD, Widness JA. Nonpharmacological, blood conservation techniques for preventing neonatal anemia-effective and promising strategies for reducing transfusion. Semin Perinatol 2012;36:232-43.
8. Rosebraugh MR, Widness JA, Nalbant D, Veng-Pedersen P. A mathematical modeling approach to quantify the role of phlebotomy losses and need for transfusions in neonatal anemia. Transfusion 2013;53:1353-60.
9. Rabe H, Alvarez JR, Lawn C, Seddon P, Amess PN. A management guideline to reduce the frequency of blood transfusion in very-low-birth-weight infants. Am J Perinatol 2009;26:179-83.
10. Juul S. Erythropoietin in anemia of prematurity. J Matern Fetal Neonatal Med 2012;25:Suppl 5:80-4.
11. Freise KJ, Schmidt RL, Gingerich EL, Veng-Pedersen P, Widness JA. The effect of anticoagulant, storage temperature and dilution on cord blood hematology parameters over time. Int J Lab Hematol 2009;31:496-504.
12. Carroll PD, Nankervis CA, Iams J, Kelleher K. Umbilical cord blood as a replacement source for admission complete blood count in premature infants. J Perinatol 2012;32:97-102.
13. Rabe H, Jewison A, Alvarez RF, et al.; Brighton Perinatal Study Group. Milking compared with delayed cord clamping to increase placental transfusion in preterm neonates: a randomized controlled trial. Obstet Gynecol 2011;117(2 Pt 1):205-11.
14. Madan A, Kumar R, Adams MM, Benitz WE, Geaghan SM, Widness JA. Reduction in red blood cell transfusions using a bedside analyzer in extremely low birth weight infants. J Perinatol 2005;25:21-5.
15. Widness JA, Madan A, Grindeanu LA, Zimmerman MB, Wong DK, Stevenson DK. Reduction in red blood cell transfusions among preterm infants: results of a randomized trial with an in-line blood gas and chemistry monitor. Pediatrics 2005;115:1299-306.
16. Bell EF, Strauss RG, Widness JA, et al. Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants. Pediatrics 2005;115:1685-91.
17. Kirpalani H, Whyte RK, Andersen C, et al. The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr 2006;149:301-7.
18. Bell EF. When to transfuse preterm babies. Arch Dis Child Fetal Neonatal Ed 2008;93:F469-73.
19. Shander A, Hofmann A, Ozawa S, Theusinger OM, Gombotz H, Spahn DR. Activity-based costs of blood transfusions in surgical patients at four hospitals. Transfusion 2010;50:753-65.
20. La Gamma EF, Blau J. Transfusion-related acute gut injury: feeding, flora, flow, and barrier defense. Semin Perinatol 2012;36:294-305.
21. Rawlings JS, Pettett G, Wiswell TE, Clapper J. Estimated blood volumes in polycythemic neonates as a function of birth weight. J Pediatr 1982;101:594-9.
22. Strauss RG, Mock DM, Widness JA, Johnson K, Cress G, Schmidt RL. Posttransfusion 24-hour recovery and subsequent survival of allogeneic red blood cells in the bloodstream of newborn infants. Transfusion 2004;44:871-6.
23. Schulman I, Smith CH, Stern GS. Studies on the anemia of prematurity. AMA Am J Dis Child 1954;88:567-95.
24. Usher R, Lind J. Blood volume of the newborn premature infant. Acta Paediatr Scand 1965;54:419-31.
25. Steinberg MH, Benz EJ, Jr., Adewoye HA, Ebert B. Pathobiology of the human erythrocyte and its hemoglobins. In: Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, McGlave P, eds. Hematology: Basic Principles and Applications. New York, NY: Elsevier, 2005: 442-54.
26. Landaw SA. Factors that accelerate or retard red blood cell senescence. Blood Cells 1988;14:47-67.
27. Woo S, Krzyzanski W, Jusko WJ. Target-mediated pharmacokinetic and pharmacodynamic model of recombinant human erythropoietin (rHuEPO). J Pharmacokinet Pharmacodyn 2007;34:849-68.
28. Rosebraugh M, Widness JA, Veng-Pedersen P. Receptor-based dosing optimization of erythropoietin in juvenile sheep after phlebotomy. Drug Metab Dispos 2011;39:1214-20.
29. Freise KJ, Widness JA, Veng-Pedersen P. Erythropoietic response to endogenous erythropoietin in premature very low birth weight infants. J Pharmacol Exp Ther 2010;332:229-37.
30. Rosebraugh MR, Widness JA, Veng-Pedersen P. Multidose optimization simulation of erythropoietin treatment in preterm infants. Pediatr Res 2012;71(4 Pt 1):332-7.
31. Sawyer ST, Krantz SB, Goldwasser E. Binding and receptor-mediated endocytosis of erythropoietin in Friend virus-infected erythroid cells. J Biol Chem 1987;262:5554-62.
32. Juul SE, McPherson RJ, Bauer LA, Ledbetter KJ, Gleason CA, Mayock DE. A phase I/II trial of high-dose erythropoietin in extremely low birth weight infants: pharmacokinetics and safety. Pediatrics 2008;122: 383-91.
33. Veng-Pedersen P. Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT. J Pharmacokinet Biopharm 1977;5:513-31.