Olfactory impairment and subjective olfactory complaints independently predict conversion to dementia: A longitudinal, population-based study

Journal of the International Neuropsychological Society

Volumn 20, Issue 2, 2014, Pages 209-217

  Stanciu, Ingrid ^a   Larsson, Maria ^a   Nordin, Steven ^b   Adolfsson, Rolf ^b   Nilsson, Lars Göran ^a   Olofsson, Jonas K ^a,c  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c Swedish Collegium for Advanced Study   (Sweden)

Author keywords

Alzheimer type dementia; Awareness; Memory; Olfaction; Smell disorder; Vascular dementia

Indexed keywords

AGED; DEMENTIA; DISEASE COURSE; FEMALE; HEALTH CARE PLANNING; HUMAN; LONGITUDINAL STUDY; MALE; MENTAL HEALTH; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; ODOR; PATHOPHYSIOLOGY; PHYSIOLOGY; PREDICTIVE VALUE; SMELLING DISORDER; STATISTICAL MODEL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; COMMUNITY HEALTH PLANNING; DEMENTIA; DISEASE PROGRESSION; FEMALE; HUMANS; LOGISTIC MODELS; LONGITUDINAL STUDIES; MALE; MENTAL STATUS SCHEDULE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; OLFACTION DISORDERS; PREDICTIVE VALUE OF TESTS; SMELL;

EID: 84894111138     PISSN: 13556177     EISSN: 14697661     Source Type: Journal    
DOI: 10.1017/S1355617713001409     Document Type: Article

References (56)

1. Albers, M. W., Tabert, M. H., & Devanand, D. P. (2006). Olfactory dysfunction as a predictor of neurodegenerative disease. Current Neurology and Neuroscience Reports, 6(5), 379-386. doi:10.1007/s11910-996-0018-7
2. American Psychiatric Association. (1994). Diagnostic and Statistical Manual of Mental Disorders (4th ed.). Washington, DC: American Psychiatric Association Press.
3. Bacon, A. W., Bondi, M. W., Salmon, D. P., & Murphy, CM. (1998). Very early changes in olfactory functioning due to Alzheimer's disease and the role of apolipoprotein E in olfaction. Annuals of the New York Acadamey of Sciences, 855, 723-731. doi:10.1111/j.1749-6632.1998.tb10651.x
4. Bahar-Fuchs, A., Moss, S., Rowe, C, & Savage, G. (2011). Awareness of olfactory deficits in healthy aging, amnestic mild cognitive impairment and Alzheimer's disease. International Psychogeriatrics, 23(7), 1097-1106. doi:10.1017/S10416102100 02371
5. Bende, M., & Nordin, S. (1997). Perceptual learning in olfaction: Professional wine tasters versus controls. Physiology & Behavior, 62(5), 1065-1070. doi:10.1016/S0031-9384 (97) 00251-5
6. Cooney, T. M., Schaie, W., & Willis, S. L. (1988). The relationship between prior functioning on cognitive and personality dimensions and subject attrition in longitudinal research. Journal of Geronology, 43, 1217.
7. Da Silva, J., Gonçalves-Pereira, M., Xavier, M., & Mukaetova-Ladinska, E. B. (2013). Affective disorders and risk of developing dementia: Systematic review. The British Journal of Ppsychiatry: The journal of Mental Science, 202, 177-186. doi:10.1192/bjp. bp. 111.101931
8. Davies, D. C., Brooks, J. W., & Lewis, D. A. (1993). Axonal loss from the olfactory tracts in Alzheimer's disease. Neurobiology of Aging, 14, 353-357. doi:10.1016/0197-4580 (93) 90121-Q
9. Devanand, D., Michaels-Marston, K. S., Xinhua, L., Pelton, G. H., Padilla, M., Marder, K., & Mayeux, R. (2000). Olfactory deficits in patients with mild cognitive impairment predict Alzheimer's disease at follow-up. American Journal of Psychiatry, 157, 1399-1405. doi:10.1176/appi.ajp. 157.9.1399
10. Djordjevic, J., Jones-Gotman, M., De Sousa, K., & Chertkow, H. (2008). Olfaction in patients with mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging, 29(5), 693-706. doi:10.1016/j.neurobiolaging. 2006.11.014
11. Dureman, I., Kebbon, L., & Österberg, E. (1971). A manual to the DS-battery. Psykologiförbundet AB, Stockholm.
12. Erk, S., Spottke, A., Meisen, A., Wagner, M., Walter, H., & Jessen, F. (2011). Evidence of neuronal compensation during episodic memory in subjective memory impairment. Archives of General Psychiatry, 68(8), 845-852. doi:10.1001/archgenpsychiatry. 2011.80
13. Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). Mini-mental state: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189-198.
14. Geerlings, M. I., Jonker, C., Bouter, L. M., Adèr, H. J., & Schmand, B. (1999). Association between memory complaints and incident Alzheimer's disease in elderly people with normal baseline cognition. The American Journal of Psychiatry, 156(4), 531-537.
15. Gorelick, P. B., Scuteri, A., Black, S. E., De Carli, C., Greenberg, S. M., Iadecola, C., Seshadri, S. (2011). Vascular contributions to cognitive impairment and dementia: A statement for healthcare professionals from the American heart association/American stroke association. Stroke, 42(9), 2672-2713. doi:10.1161/STR.0b013e3182299496
16. Graves, A. B., Bowen, J. D., Rajaram, L., McCormick, W. C., McCurry, S. M., Schellenberg, G. D., & Larson, E. B. (1999). Impaired olfaction as a marker for cognitive decline: Interaction with apolipoprotein E e4 status. Neurology, 53(7), 1480-1487. doi:10.1212/WNL.53.7.1480
17. Gray, A. J., Staples, V., Murren, K., Dhariwal, A., & Bentham, P. (2001). Olfactory identification is impaired in clinic-based patients with vascular dementia and senile dementia of Alzheimer type. International Journal of Geriatric Psychiatry, 16(5), 513-517. doi:10.1002/gps.383
18. Hedner, M., Larsson, M., Arnold, N., Zucco, G. M., & Hummel, T. (2010). Cognitive factors in odor detection, odor discrimination, and odor identification tasks. Journal of Clinical and Experimental Neuropsychology, 32(10), 1062-1067. doi:10.1080/138033910036 83070
19. Hummel, T., Sekinger, B., Wolf, S. R., Pauli, E., & Kobal, G. (1997). 'Sniffin' sticks': Olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chemical Senses, 22, 39-52. doi:10.1586/ern. 09.115
20. Jorm, A. F., Christensen, H., Henderson, A. S., Korten, A. E., Mackinnon, A. J., & Scott, R. (1994). Complaints of cognitive decline in the elderly: A comparison of reports by subjects and informants in a community survey. Psychological Medicine, 24, 365-374. doi:10.1017/S0033291700027343
21. Jorm, A. F., Christensen, H., Korten, A. E., Jacomb, P. A., & Henderson, A. S. (2001). Memory complaints as a precursor of memory impairment in older people: A longitudinal analysis over 7-8 years. Psychological Medicine, 31, 441-449.
22. Larsson, M., Nilsson, L. G., Olofsson, J. K., & Nordin, S. (2004). Demographic and cognitive predictors of cued odor identification: Evidence from a population-based study. Chemical Senses, 29(6), 547-554. doi:10.1093/chemse/ bjh059
23. Larsson, M., Semb, H., Winblad, B., Amberla, K., Wahlund, L.-O., & Bäckman, L. (1999). Odor identification in normal aging and early Alzheimer's disease: Effects of retrieval support. Neuropsychology, 13, 1-7. doi:10.1037/0894-4105.13.1.47
24. McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Phelps, C. H. (2011). The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers and Dementia, 7(3), 263-269. doi:10.1016/j.jalz. 2011.03.005
25. Mesholam, R. I., Moberg, P. J., Mahr, R. N., & Doty, R. L. (1998). Olfaction in neurodegenerative disease: A meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases. Archives of Neurology, 55(1), 84-90. doi:10.1001/archneur. 55.1.84
26. Morgan, C. D., Nordin, S., & Murphy, C. (1995). Odor identification as an early marker for Alzheimer's disease: Impact of lexical functioning and detection sensitivity. Journal of Clinical and Experimental Neuropsychology, 17(5), 793-803. doi:10.1080/01688639508405168
27. Murphy, C., Schubert, C. R., Cruickshanks, K. J., Klein, B. E., Klein, R., & Nondahl, D. M. (2002). Prevalence of olfactory impairment in older adults. The Journal of the American Medical Association, 288(18), 2307-2312. doi:10.1001/jama.288.18. 2307
28. Nilsson, L. G., Adolfsson, R., Backman, L., De Frias, C. M., Molander, B., & Nyberg, L. (2004). Betula: A prospective cohort study on memory, health and aging. Aging Neuropsychology and Cognition, 11, 134-148. doi:10.1080/13825580490511026
29. Nilsson, L. G., Backman, L., Erngrud, K., Nyberg, L., Adolfsson, R., Bucht, G., & Winblad, B. (1997). The Betula prospective cohort study: Memory, health and aging. Aging Neuropsychology and Cognition, 4, 1-32. doi:10.1080/13825589708256633
30. Nordin, S., & Brämerson, A. (2008). Complaints of olfactory disorders: Epidemiology, assessment and clinical implications. Current Opinion in Allergy and Clinical Immunology, 8, 10-15. doi:10.1097/ACI.0b013e3282f3f473
31. Nordin, S., Brämerson, A., Lidén, E., & Bende, M. (1998). The Scandinavian odor-identification test: Development, reliability, validity and normative data. Acta Oto-Laryngologica, 118, 226-234. doi:10.1080/ 00016489850154946
32. Nordin, S., Monsch, A., & Murphy, C. (1995). Unawareness of smell loss in normal aging and Alzheimer's disease: Discrepancy between self-reported and diagnosed smell sensitivity. Journal of Gerontology, 50(B), 187-192. doi:10.1093/geronb/50B.4. P187
33. O'Connor, D. W., Pollitt, P. A., Roth, M., Brook, P. B., & Reiss, B. B. (1990). Memory complaints and impairment in normal, depressed, and demented elderly persons identified in a community survey. Archives of General Psychiatry, 47, 224-227. doi:10.1001/archpsyc.1990.01810150024005
34. O'Hara, M. W., Hinrichs, J. V., Kohout, F. J., Wallace, R. B., & Lemke, J. H. (1986). Memory complaint and memory performance in the depressed elderly. Psychology and Aging, 1, 208-214. doi:10.1037/0882-7974.1.3.208
35. Ohm, T. G., & Braak, H. (1987). Olfactory bulb changes in Alzheimer's disease. Acta Neuropathologica (Berlin), 73, 365-369. doi:10.1007%2FBF00688261
36. Olofsson, J. K., Nordin, S., Wiens, S., Hedner, M., Nilsson, L.-G., & Larsson, M. (2010). Odor identification impairment in elderly ApoE-e4 carriers is independent of dementia. Neurobiology of Aging, 31, 567-577. doi:10.1016/j.neurobiolaging.2008.05.019
37. Olofsson, J. K., Rogalski, E., Harrison, T., Mesulam, M.-M., & Gottfried, J. (2013). A cortical pathway to odor naming: Evidence from primary progressive aphasia. Brain, 136, 1245-1259. doi:10.1093/brain/awt019
38. Olofsson, J. K., Rönnlund, M., Nordin, S., Nyberg, L., Nilsson, L.-G., & Larsson, M. (2009). Odor identification deficit as a predictor of five-year global cognitive change: Interactive effects with age and ApoE-epsilon4. Behavior Genetics, 39, 496-503. doi:10.1007/s10519-009-9289-5
39. Pause, B. M., Miranda, A., Göder, R., Aldenhoff, J. B., & Ferstl, R. (2001). Reduced olfactory performance in patients with major depression. Journal of Psychiatric Research, 35, 271-277. doi:10.1016/S0022-3956 (01) 00029-2
40. Ponsen, M. M., Stoffers, D., Booij, J., Van Eck-Smit, B. L. F., Wolters, E. Ch., & Berendse, H. W. (2004). Idiopathic hyposmia as a preclinical sign of Parkinson's disease. Annuals of Neurology, 56, 173-181. doi:10.1002/ana.20160
41. Radloff, L. S. (1977). The CES-D Scale: A self-report depression scale of research in the general population. Applied Psychological Measurement, 1, 385-401. doi:10.1177/014662167700100306
42. Schab, F. R. (1991). Odor memory: Taking stock. Psychological Bulletin, 2, 242-251. doi:10.1037%2F%2F0033-2909.109.2.242
43. Schmand, B., Jonker, C., Geerlings, M. I., & Lindeboom, J. (1997). Subjective memory complaints in the elderly: Depressive symptoms and future dementia. British Journal of Psychiatry, 171, 373-376. doi:10.1212/WNL.46.1.121
44. Schmand, B., Jonker, C., Hooijer, C., & Lindeboom, J. (1996). Subjective memory complaints may announce dementia. Neurology, 46, 121-125. doi:10.1212/WNL.46.1.121
45. Schubert, C. R., Carmichael, L. L., Murphy, C., Klein, B. E. K., Klein, R., & Cruickshanks, K. J. (2008). Olfaction and the 5-year incidence of cognitive impairment in an epidemiological study of older adults. Journal of the American Geriatrics Society, 56, 1517-1521. doi:10.1111/j.1532-5415.2008.01826. x
46. Sevush, S., & Leve, N. (1993). Denial of memory deficit in Alzheimer's disease. American Journal of Psychiatry, 150, 748-751.
47. Shu, C.-H., Hummel, T., Lee, P.-L., Chiu, C.-H., Lin, S.-H., & Yuan, B.-C. (2009). The proportion of self-rated olfactory dysfunction does not change across the life span. American Journal of Rhinology & Allergy, 23(4), 413-416. doi:10.2500/ajra.2009.23.3343
48. Stevens, J., Cain, W., & Burke, R. (1988). Variability of olfactory thresholds. Chemical Senses, 13(4), 643-653. doi:10.1093/chemse/13.4.643
49. Sunderland, A., Watts, K., Baddeley, A. D., & Harris, J. E. (1986). Subjective memory assessment and test performance in elderly adults. Journal of Gerontology, 41, 376-384. doi:10.1093% 2Fgeronj%2F41.3.376
50. Swan, G. E., & Carmelli, D. (2002). Impaired olfaction predicts cognitive decline in nondemented older adults. Neuroepidemiology, 21, 58-67. doi:10.1159/000048618
51. Tobiansky, R., Blizard, R., Livingston, G., & Mann, A. (1995). The Gospel Oak Study stage IV: The clinical relevance of subjective memory impairment in older people. Psychological Medicine, 25, 779-786. doi:10.1017%2FS00332917000 35029
52. Vogel, A., Stokholm, J., Gade, A., Andersen, B. B., Hejl, A.-M., & Waldemar, G. (2004). Awareness of deficits in mild cognitive impairment and Alzheimer's disease: Do MCI patients have impaired insight? Dementia and Geriatric Cognitive Disorders, 17(3), 181-187. doi:10.1159%2F000076354
53. Waldorff, F. B., Siersma, V., Vogel, A., & Waldemar, G. (2012). Subjective memory complaints in general practice predicts future dementia: A 4-year follow-up study. International Journal of Geriatric Psychiatry, 27(11), 1180-1188. doi:10.1002%2Fgps.3765
54. Wang, L., Van Belle, G., Crane, P. K., Kukull, W. A., Bowen, J. D., McCormick, W. C., & Larson, E. B. (2004). Subjective memory deterioration and future dementia in people aged 65 and older. Journal of the American Geriatrics Society, 52(12), 2045-2051. doi:10.1111/j.1532-5415.2004.52568.x
55. Wehling, E., Nordin, S., Espeseth, T., Reinvang, I., & Lundervold, A. (2011). Unawareness of olfactory dysfunction and its association with cognitive functioning in middle aged and old adults. Archives of Clinical Neuropsychology, 26, 260-269. doi:10.1093%2Farclin%2Facr019
56. Wilson, R. S., Arnold, S. E., Tang, X., & Bennett, D. A. (2006). Odor identification and decline in different cognitive domains in old age. Neuroepidemiology, 26, 61-67. doi:10.1159%2F0000 90250