Infection dynamics of the tick-borne pathogen "Candidatus Neoehrlichia mikurensis" and coinfections with Borrelia afzelii in bank voles in southern Sweden

Applied and Environmental Microbiology

Volumn 80, Issue 5, 2014, Pages 1645-1649

  Andersson, Martin ^a   Scherman, Kristin ^a   Råberg, Lars ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPLASMATACEAE; ANAPLASMATACEAE INFECTION; ANIMAL; ANIMAL DISEASE; ARTICLE; ARVICOLINAE; BORRELIA BURGDORFERI; GENETICS; ISOLATION AND PURIFICATION; LYME DISEASE; MICROBIOLOGY; MIXED INFECTION; PREVALENCE; REAL TIME POLYMERASE CHAIN REACTION; RODENT DISEASE; SWEDEN;

ANAPLASMATACEAE; ANAPLASMATACEAE INFECTIONS; ANIMALS; ARVICOLINAE; BORRELIA BURGDORFERI GROUP; COINFECTION; LYME DISEASE; PREVALENCE; REAL-TIME POLYMERASE CHAIN REACTION; RODENT DISEASES; SWEDEN;

EID: 84894088670     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.03469-13     Document Type: Article

References (28)

1. Welinder-Olsson C, Kjellin E, Vaht K, Jacobsson S, Wennerås C. 2010. First case of human "Candidatus Neoehrlichia mikurensis" infection in a febrile patient with chronic lymphocytic leukemia. J. Clin. Microbiol. 48: 1956-1959. http://dx.doi.org/10.1128/JCM.02423-09.
2. Fehr JS, Bloemberg GV, Ritter C, Hombach M, Lüscher TF, Weber R, Keller PM. 2010. Septicemia caused by tick-borne bacterial pathogen Candidatus Neoehrlichia mikurensis. Emerg. Infect. Dis. 16:1127-1129. http://dx.doi.org/10.3201/eid1607.091907.
3. Von Loewenich FD, Geissdörfer W, Disqué C, Matten J, Schett G, Sakka SG, Bogdan C. 2010. Detection of "Candidatus Neoehrlichia mikurensis" in two patients with severe febrile illnesses: evidence for a European sequence variant. J. Clin. Microbiol. 48:2630-2635. http://dx.doi.org/10.1128/JCM.00588-10.
4. Pekova S, Vydra J, Kabickova H, Frankova S, Haugvicova R, Mazal O, Cmejla R, Hardekopf DW, Jancuskova T, Kozak T. 2011. Candidatus Neoehrlichia mikurensis infection identified in two hemato-oncologic patients: benefit of molecular techniques for rare pathogen detection. Diagn. Microbiol. Infect. Dis. 69:266-270. http://dx.doi.org/10.1016/j.diagmicrobio.2010.10.004.
5. Richter D, Matuschka F-R. 2012. "Candidatus Neoehrlichia mikurensis," Anaplasma phagocytophilum, and Lyme disease spirochetes in questing European vector ticks and in feeding ticks removed from people. J. Clin. Microbiol. 50:943-947. http://dx.doi.org/10.1128/JCM.05802-11.
6. Lommano E, Bertaiola L, Dupasquier C, Gern L. 2012. Infections and coinfections of questing Ixodes ricinus ticks by emerging zoonotic pathogens in western Switzerland. Appl. Environ. Microbiol. 78:4606-4612. http://dx.doi.org/10.1128/AEM.07961-11.
7. Jahfari S, Fonville M, Hengeveld P, Reusken C, Scholte E-J, Takken W, Heyman P, Medlock J, Heylen D, Kleve J, Sprong H. 2012. Prevalence of Neoehrlichia mikurensis in ticks and rodents from northwest Europe. Parasit. Vectors 5:74. http://dx.doi.org/10.1186/1756-3305-5-74.
8. Andersson M, Råberg L. 2011. Wild rodents and novel human pathogen Candidatus Neoehrlichia mikurensis, Southern Sweden. Emerg. Infect. Dis. 17:1716-1718. http://dx.doi.org/10.3201/eid1709.101058.
9. Ginsberg HS. 2008. Potential effects of mixed infections in ticks on transmission dynamics of pathogens: comparative analysis of published records. Exp. Appl. Acarol. 46:29-41. http://dx.doi.org/10.1007/s10493-008-9175-5.
10. Herrmann C, Gern L, Voordouw MJ. 2013. Species co-occurrence patterns among Lyme borreliosis pathogens in the tick vector Ixodes ricinus. Appl. Environ. Microbiol. 79:7273-7280. http://dx.doi.org/10.1128/AEM.02158-13.
11. Telfer S, Lambin X, Birtles R, Beldomenico P, Burthe S, Paterson S, Begon M. 2010. Species interactions in a parasite community drive infection risk in a wildlife population. Science 330:243-246. http://dx.doi.org/10.1126/science.1190333.
12. Dumler J, Choi K. 2005. Human granulocytic anaplasmosis and Anaplasma phagocytophilum. Emerg. Infect. Dis. 11:1828-1833. http://dx.doi.org/10.3201/eid1112.050898.
13. Nieto NC, Foley JE. 2009. Meta-analysis of coinfection and coexposure with Borrelia burgdorferi and Anaplasma phagocytophilum in humans, domestic animals, wildlife, and Ixodes ricinus complex ticks. Vector-Borne Zoonotic Dis. 9:93-102. http://dx.doi.org/10.1089/vbz.2008.0072.
14. Thomas V, Anguita J, Barthold SW. 2001. Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis alters murine immune responses, pathogen burden, and severity of Lyme arthritis. Infect. Immun. 69:3359-3371. http://dx.doi.org/10.1128/IAI.69.5.3359-3371.2001.
15. Holden K, Hodzic E, Feng S, Freet KJ, Lefebvre RB, Barthold SW. 2005. Coinfection with Anaplasma phagocytophilum alters Borrelia burgdorferi population distribution in C3H/HeN mice. Infect. Immun. 73:3440-3444. http://dx.doi.org/10.1128/IAI.73.6.3440-3444.2005.
16. Piesman J. 1991. Experimental acquisition of the Lyme disease spirochete, Borrelia burgdorferi, by larval Ixodes dammini (Acari, Ixodidae) during partial blood meals. J. Med. Entomol. 28:259-262.
17. Dumler JS, Barbet AF, Bekker CP, Dasch GA, Palmer GH, Ray SC, Rikihisa Y, Rurangirwa FR. 2001. Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila. Int. J. Syst. Evol. Microbiol. 51:2145-2165. http://dx.doi.org/10.1099/00207713-51-6-2145.
18. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
19. Andersson M, Bartkova S, Lindestad O, Råberg L. 2013. Co-infection with "Candidatus Neoehrlichia mikurensis" and Borrelia afzelii in Ixodes ricinus ticks in Southern Sweden. Vector-Borne Zoonotic Dis. 13:438-442. http://dx.doi.org/10.1089/vbz.2012.1118.
20. Laird PW, Zijderveld A, Linders K, Rudnicki MA, Jaenisch R, Berns A. 1991. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19:4293. http://dx.doi.org/10.1093/nar/19.15.4293.
21. Råberg L. 2012. Infection intensity and infectivity of the tick-borne pathogen Borrelia afzelii. J. Evol. Biol. 25:1448-1453. http://dx.doi.org/10.1111/j.1420-9101.2012.02515.x.
22. Barbour AG, Maupin GO, Teltow GJ, Carter CJ, Piesman J. 1996. Identification of an uncultivable Borrelia species in the hard tick Amblyomma americanum: possible agent of a Lyme disease-like illness. J. Infect. Dis. 173:403-409. http://dx.doi.org/10.1093/infdis/173.2.403.
23. Gliwicz J. 1988. Seasonal dispersal in noncyclic populations of Clethrionomys glareolus and Apodemus flavicollis. Acta Theriol. 33:263-272.
24. Hellgren O, Andersson M, Råberg L. 2011. The genetic structure of Borrelia afzelii varies with geographic but not ecological sampling scale. J. Evol. Biol. 24:159-167. http://dx.doi.org/10.1111/j.1420-9101.2010.02148.x.
25. Belongia EA. 2002. Epidemiology and impact of coinfections acquired from Ixodes ticks. Vector-Borne Zoonotic Dis. 2:265-273. http://dx.doi.org/10.1089/153036602321653851.
26. Lord CC, Barnard B, Day K, Hargrove JW, McNamara JJ, Paul REL, Trenholme K, Woolhouse MEJ. 1999. Aggregation and distribution of strains in microparasites. Philos. Trans. R. Soc. Lond. B Biol. Sci. 354:799-807. http://dx.doi.org/10.1098/rstb.1999.0432.
27. Lello J, Boag B, Fenton A, Stevenson I, Hudson P. 2004. Competition and mutualism among the gut helminths of a mammalian host. Nature 428:20-24. http://dx.doi.org/10.1038/428020a.
28. Levin ML, Fish D. 2000. Acquisition of coinfection and simultaneous transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis ticks. Infect. Immun. 68:2183-2186. http://dx.doi.org/10.1128/IAI.68.4.2183-2186.2000.