Small renal cell carcinomas - How dangerous are they really? Results of a large multicenter study

European Journal of Cancer

Volumn 50, Issue 4, 2014, Pages 739-745

  Steffens, Sandra ^a   Junker, Kerstin ^b,c   Roos, Frederik C ^d   Janssen, Martin ^b   Becker, Frank ^b   Henn, Daniela ^e   Wegener, Gerd ^a   Siemer, Stefan ^b   Hofmann, Rainer ^f   Schrader, Mark ^e   Stöckle, Michael ^b   Thüroff, Joachim W ^d   Hartmann, Arndt ^g   Kuczyk, Markus A ^a   Schrader, Andres J ^e,f  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c JENA UNIVERSITY HOSPITAL   (Germany)

^d UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^e UNIVERSITY HOSPITAL ULM   (Germany)

^f PHILIPPS UNIVERSITY MARBURG   (Germany)

^g UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Follow up; Kidney cancer; Metastasis; Prognosis; Risk factor; Small renal tumours; Survival

Indexed keywords

FOLLOW-UP; KIDNEY CANCER; METASTASIS; PROGNOSIS; RISK FACTOR; SMALL RENAL TUMOURS; SURVIVAL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, RENAL CELL; FEMALE; FOLLOW-UP STUDIES; HUMANS; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; NEPHRECTOMY; SURVIVAL ANALYSIS; TUMOR BURDEN; YOUNG ADULT;

EID: 84894068539     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2013.11.020     Document Type: Article

References (18)

1. C.J. Kane, K. Mallin, J. Ritchey, M.R. Cooperberg, and P.R. Carroll Renal cell cancer stage migration: analysis of the National Cancer Data Base Cancer 113 1 2008 78 83
2. A.J. Pantuck, A. Zisman, and A.S. Belldegrun The changing natural history of renal cell carcinoma J Urol 166 5 2001 1611 1623
3. H. Van Poppel, F. Becker, J.A. Cadeddu, I.S. Gill, G. Janetschek, and M.A. Jewett et al. Treatment of localised renal cell carcinoma Eur Urol 60 4 2011 662 672
4. I. Frank, M.L. Blute, J.C. Cheville, C.M. Lohse, A.L. Weaver, and H. Zincke Solid renal tumors: an analysis of pathological features related to tumor size J Urol 170 6 Pt 1 2003 2217 2220
5. M.M. Nguyen, and I.S. Gill Effect of renal cancer size on the prevalence of metastasis at diagnosis and mortality J Urol 181 3 2009 1020 1027 [discussion 1027]
6. E. Guethmundsson, H. Hellborg, S. Lundstam, S. Erikson, and B. Ljungberg Metastatic potential in renal cell carcinomas ≤7 cm: Swedish Kidney Cancer Quality Register data Eur Urol 60 5 2011 975 982
7. R.H. Thompson, J.R. Hill, Y. Babayev, A. Cronin, M. Kaag, and S. Kundu et al. Metastatic renal cell carcinoma risk according to tumor size J Urol 182 1 2009 41 45
8. E.C. Umbreit, M.S. Shimko, M.A. Childs, C.M. Lohse, J.C. Cheville, and B.C. Leibovich et al. Metastatic potential of a renal mass according to original tumour size at presentation BJU Int 109 2 2012 190 194 [discussion 194]
9. B. Ljungberg, N.C. Cowan, D.C. Hanbury, M. Hora, M.A. Kuczyk, and A.S. Merseburger et al. EAU guidelines on renal cell carcinoma: the 2010 update Eur Urol 58 3 2010 398 406
10. T. Klatte, J.J. Patard, M. de Martino, K. Bensalah, G. Verhoest, and A. de la Taille et al. Tumor size does not predict risk of metastatic disease or prognosis of small renal cell carcinomas J Urol 179 5 2008 1719 1726
11. S. Steffens, M. Janssen, F.C. Roos, F. Becker, S. Schumacher, and C. Seidel et al. Incidence and long-term prognosis of papillary compared to clear cell renal cell carcinoma - a multicentre study Eur J Cancer 48 15 2012 2347 2352
12. T. Oda, A. Takahashi, N. Miyao, M. Yanase, N. Masumori, and N. Itoh et al. Cell proliferation, apoptosis, angiogenesis and growth rate of incidentally found renal cell carcinoma Int J Urol 10 1 2003 13 18
13. D.A. Kunkle, P.L. Crispen, T. Li, and R.G. Uzzo Tumor size predicts synchronous metastatic renal cell carcinoma: implications for surveillance of small renal masses J Urol 177 5 2007 1692 1696 [discussion 1697]
14. J.C. Cheville, C.M. Lohse, H. Zincke, A.L. Weaver, and M.L. Blute Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma Am J Surg Pathol 27 5 2003 612 624
15. J.J. Patard, E. Leray, N. Rioux-Leclercq, L. Cindolo, V. Ficarra, and A. Zisman et al. Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience J Clin Oncol 23 12 2005 2763 2771
16. H. Wunderlich, A. Schlichter, D. Zermann, O. Reichelt, H. Kosmehl, and J. Schubert Multifocality in renal cell carcinoma: a bilateral event? Urol Int 63 3 1999 160 163
17. W.W. Roberts, S.B. Bhayani, M.E. Allaf, T.Y. Chan, L.R. Kavoussi, and T.W. Jarrett Pathological stage does not alter the prognosis for renal lesions determined to be stage T1 by computerized tomography J Urol 173 3 2005 713 715
18. K. Junker, V. Ficarra, E.D. Kwon, B.C. Leibovich, R.H. Thompson, and E. Oosterwijk Potential role of genetic markers in the management of kidney cancer Eur Urol 63 2 2013 333 340