Sodium balance is not just a renal affair

Current Opinion in Nephrology and Hypertension

Volumn 23, Issue 2, 2014, Pages 101-105

  Titze, Jens ^a,b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hypertonicity; Magnetic resonance imaging; Na homeostasis; Sodium balance; Sodium storage

Indexed keywords

ANIMALS; BODY WATER; HUMANS; IMMUNE SYSTEM; KIDNEY; MAGNETIC RESONANCE IMAGING; MUSCLE, SKELETAL; OSMOTIC PRESSURE; SKIN; SODIUM; SODIUM, DIETARY; TIME FACTORS; WATER-ELECTROLYTE BALANCE;

EID: 84894049764     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/01.mnh.0000441151.55320.c3     Document Type: Review

References (27)

1. Bernard C. Leçons sur les proprietes physiologiques et les alterations pathologiques des liquides de l'organisme. Paris: Bailliere; 1859.
2. Ludwig C. Veränderlichkeit der Chloridausscheidung mit der Zufuhr. In: Ludwig C, editor. Lehrbuch der Physiologie des Menschen, 2nd ed. Leipzig & Heidelberg: Wintersche Verlagshandlung; 1861. pp. 398-400.
3. Cannon WB. The constancy of the salt content of the blood. The wisdom of the body. New York: WW Norton; 1932; pp. 91-97.
4. Smith HW. From fish to philosopher. The story of our internal environment. Boston: Little Brown; 1953.
5. Kahle KT, Ring AM, Lifton RP. Molecular physiology of the WNK kinases. Ann Rev Physiol 2008; 70:329-355.
6. Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 2001; 104:545-556.
7. Ehret GB, Munroe PB, Rice KM, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011; 478:103-109.
8. Coffman TM. Under pressure: the search for the essential mechanisms of hypertension. Nat Med 2011; 17:1402-1409.
9. Walser M. Phenomenological analysis of renal regulation of sodium and potassium balance. Kidney Int 1985; 27:837-841.
10. Rose BD. Regulation of water and electrolyte balance. In: Rose BD, editor. Clinical physiology of acid-base and electrolyte disorders, 4th ed. New York: McGraw-Hill, Inc; 1994. pp. 235-260.
11. Rakova N, Juttner K, Dahlmann A, et al. Long-term space flight simulation reveals infradian rhythmicity in human Na() balance. Cell metabolism 2013; 17:125-131.
12. Titze J, Dahlmann A, Lerchl K, et al. Spooky sodium balance. Kidney Int 2013. doi: 10.1038/ki.2013.367. [Epub ahead of print]
13. Inglese M, Madelin G, Oesingmann N, et al. Brain tissue sodium concentration inmultiple sclerosis: a sodium imaging study at 3 tesla. Brain 2010; 133 (Pt 3):847-857.
14. Kopp C, Linz P, Hammon M, et al. Seeing the sodium in a patient with hypernatremia. Kidney Int 2012; 82:1343-1344.
15. Kopp C, Linz P, Wachsmuth L, et al. (23)Na magnetic resonance imaging of tissue sodium. Hypertension 2012; 59:167-172.
16. Kopp C, Linz P, Dahlmann A, et al. 23Na magnetic resonance imagingdetermined tissue sodium in healthy subjects and hypertensive patients. Hypertension 2013; 61:635-640.
17. Kleinewietfeld M, Manzel A, Titze J, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature 2013; 496:518-522.
18. Wu C, Yosef N, Thalhamer T, et al. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature 2013; 496:513-517.
19. Go WY, Liu X, Roti MA, et al. NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment. Proc Natl Acad Sci U S A 2004; 101:10673-10678.
20. Titze J, Shakibaei M, Schafflhuber M, et al. Glycosaminoglycan polymerization may enable osmotically inactive Na storage in the skin. Am J Physiol Heart Circ Physiol 2004; 287:H203-H208.
21. Schafflhuber M, Volpi N, Dahlmann A, et al. Mobilization of osmotically inactive Na by growth and by dietary salt restriction in rats. Am J Physiol Renal Physiol 2007; 292:F1490-F1500.
22. Muller S, Quast T, Schroder A, et al. Salt-dependent chemotaxis of macrophages. PloS One 2013; 8:e73439.
23. Machnik A, Neuhofer W, Jantsch J, et al. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-Cdependent buffering mechanism. Nat Med 2009; 15:545-552.
24. Machnik A, Dahlmann A, Kopp C, et al. Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/ vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats. Hypertension 2010; 55:755-761.
25. Wiig H, Schroder A, Neuhofer W, et al. Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. J Clin Invest 2013; 123:2803-2815.
26. Martel C, Li W, Fulp B, et al. Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice. J Clin Invest 2013; 123:1571-1579.
27. Helle F, Karlsen TV, Tenstad O, et al. High-salt diet increases hormonal sensitivity in skin precapillary resistance vessels. Acta physiologica 2013; 207:577-581.