Preoperative chemo-radiation therapy for localised retroperitoneal sarcoma: A phase I-II study from the Italian Sarcoma Group

European Journal of Cancer

Volumn 50, Issue 4, 2014, Pages 784-792

  Gronchi, Alessandro ^a   De Paoli, Antonino ^b   Dani, Carla ^c   Merlo, Domenico Franco ^c   Quagliuolo, Vittorio ^d   Grignani, Giovanni ^e   Bertola, Giulio ^b   Navarria, Piera ^d   Sangalli, Claudia ^a   Buonadonna, Angela ^b   De Sanctis, Rita ^d   Sanfilippo, Roberta ^a   Dei Tos, Angelo Paolo ^f   Stacchiotti, Silvia ^a   Giorello, Laura ^c   Fiore, Marco ^a   Bruzzi, Paolo ^c   Casali, Paolo Giovanni ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^e CANDIOLO CANCER INSTITUTE   (Italy)

^f Treviso General Hospital   (Italy)

Author keywords

Chemotherapy; Radiation therapy; Retroperitoneal sarcoma; Soft tissue sarcoma

Indexed keywords

CHEMOTHERAPY; RADIATION THERAPY; RETROPERITONEAL SARCOMA; SOFT TISSUE SARCOMA;

AGED; CHEMORADIOTHERAPY, ADJUVANT; COMBINED MODALITY THERAPY; FEASIBILITY STUDIES; HUMANS; IFOSFAMIDE; ITALY; MIDDLE AGED; PREOPERATIVE CARE; RADIOTHERAPY DOSAGE; RETROPERITONEAL NEOPLASMS; SARCOMA; SURVIVAL ANALYSIS;

EID: 84894048263     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2013.11.021     Document Type: Article

References (32)

1. C.D.M. Fletcher, J.A. Bridge, P.C.W. Hogendoorn, and F. Mertens WHO classification of tumours of soft tissue and bone 2013 IARC Lyon
2. ESMO/European Sarcoma Network Working Group Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up Ann Oncol 23 Suppl. 7 2012 vii92 vii99
3. A. Gronchi, S. Lo Vullo, and M. Fiore et al. Aggressive surgical policies in a retrospectively reviewed single-institution case series of retroperitoneal soft tissue sarcoma patients J Clin Oncol 27 2009 24 30
4. S. Bonvalot, M. Rivoire, and M. Castaing et al. Primary retroperitoneal sarcomas: a multivariate analysis of surgical factors associated with local control J Clin Oncol 27 2009 31 37
5. S. Bonvalot, C.P. Raut, and R.E. Pollock et al. Technical considerations in surgery for retroperitoneal sarcomas: position paper from E-Surge, a master class in sarcoma surgery, and EORTC-STBSG Ann Surg Oncol 19 2012 2981 2991
6. A. Gronchi, R. Miceli, and C. Colombo et al. Frontline extended surgery is associated with improved survival in retroperitoneal low-intermediate grade soft tissue sarcomas Ann Oncol 23 4 2012 1067 1073
7. A. Gronchi, P.G. Casali, and L. Mariani et al. Status of surgical margins and prognosis in adult soft tissue sarcomas of the extremities: a series of patients treated at a single institution J Clin Oncol 23 2005 96 104
8. A. Stojadinovic, D.H.Y. Leung, and A. Hoos et al. Analysis of the prognostic significance of microscopic margins in 2084 localized primary adult soft tissue sarcomas Ann Surg 235 2002 424 434
9. A. Gronchi, S. Lo Vullo, and C. Colombo et al. Extremity soft tissue sarcoma in a series of patients treated at a single institution: the local control directly impacts survival Ann Surg 251 2010 512 517
10. P.W.T. Pisters, L.B. Harrison, and D.H.Y. Leung et al. Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma J Clin Oncol 14 1996 859 868
11. J.C. Yang, A.E. Chang, and W.F. Sindelar et al. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity J Clin Oncol 16 1998 197 203
12. J.F. Tierney Adjuvant chemotherapy for localized respectable soft-tissue sarcoma of adults: meta-analysis of individual data-sarcoma meta-analysis collaboration Lancet 350 1997 1647 1654
13. S. Frustaci, F. Gherlinzoni, and A. De Paoli et al. Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: results of the Italian randomized cooperative trial J Clin Oncol 19 2001 1238 1247
14. P.J. Woll, P. Reichardt, and A. Le Cesne et al. EORTC Soft Tissue and Bone Sarcoma Group and the NCIC Clinical Trials Group Sarcoma Disease Site Committee. Adjuvant chemotherapy with doxorubicin, ifosfamide, and lenograstim for resected soft-tissue sarcoma (EORTC 62931): a multicentre randomised controlled trial Lancet Oncol 13 2012 1045 1054
15. N. Pervaiz, N. Colterjohn, and F. Farrokhyar et al. A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma Cancer 113 2008 573 581
16. C. Meazza, M. Casanova, and R. Luksch et al. Prolonged 14-day continuous infusion of high-dose ifosfamide with an external portable pump: feasibility and efficacy in refractory pediatric sarcoma Pediatr Blood Cancer 55 4 2010 617 620
17. E.A. Eisenhauer, P. Therasse, and J. Bogaerts et al. New response evaluation criteria in solid tumors: revised RECIST guideline (version 1.1) Eur J Cancer 45 2009 228 247
18. W.E. Kaplan, and P. Meier Nonparametric estimation from incomplete observations J Am Stat Assoc 53 1958 457 481
19. D.R. Cox Regression models and life tables (with discussion) J Roy Stat Soc B 34 1972 187 220
20. T.M. Pawlik, P.W. Pisters, and L. Mikula et al. Long-term results of two prospective trials of preoperative external beam radiotherapy for localized intermediate- or high-grade retroperitoneal soft tissue sarcoma Ann Surg Oncol 13 4 2006 508 517
21. P.W. Pisters, M.T. Ballo, and M.J. Fenstermacher et al. Phase I trial of preoperative concurrent doxorubicin and radiation therapy, surgical resection, and intraoperative electron-beam radiation therapy for patients with localized retroperitoneal sarcoma J Clin Oncol 21 16 2003 3092 3097
22. S. Bonvalot, R. Miceli, and M. Berselli Aggressive surgery in retroperitoneal soft tissue sarcoma carried out at high-volume centers is safe and is associated with improved local control Ann Surg Oncol 17 2010 1507 1514
23. K.M. Alektiar, K. Hu, and L. Anderson et al. High-dose-rate intraoperative radiation therapy (HDR-IORT) for retroperitoneal sarcomas Int J Radiat Oncol Biol Phys 47 1 2000 157 163
24. S.S. Yoon, Y.L. Chen, and D.G. Kirsch et al. Proton-beam, intensity-modulated, and/or intraoperative electron radiation therapy combined with aggressive anterior surgical resection for retroperitoneal sarcomas Ann Surg Oncol 17 6 2010 1515 1529
25. M. Feng, J. Murphy, and K.A. Griffith et al. Long-term outcomes after radiotherapy for retroperitoneal and deep truncal sarcoma Int J Radiat Oncol Biol Phys 69 1 2007 103 110
26. N.N. Paryani, R.A. Zlotecki, and E.L. Swanson et al. Multimodality local therapy for retroperitoneal sarcoma Int J Radiat Oncol Biol Phys 82 3 2012 1128 1134
27. D. Latz, T. Schulze, and C. Manegold et al. Combined effects of ionizing radiation and 4-hydroperoxyifosfamide in vitro Radiat Oncol 46 1998 279 283
28. J.N. Cormier, S.R. Patel, and C.E. Herzog et al. Concurrent ifosfamide-based chemotherapy and irradiation. Analysis of treatment related toxicity in 43 patients with sarcoma Cancer 92 6 2001 1550 1555
29. R. Sanfilippo, A. Constantinidou, and R. Bertulli et al. Sensitivity of well-differentiated/dedifferentiated liposarcoma (WD/DD) and myxoid round cell/liposarcoma (MRCL) to high-dose ifosfamide: Combined analysis from two European referral institutions J Clin Oncol 29 Suppl. 2011 abstr. 10023
30. S. Sleijfer, M. Ouali, and M. van Glabbeke et al. Prognostic and predictive factors for outcome to first-line ifosfamide-containing chemotherapy for adult patients with advanced soft tissue sarcomas: an exploratory, retrospective analysis on large series from the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG) Eur J Cancer 46 2010 72 83
31. P. Lorigan, J. Verweij, and Z. Papai et al. Phase III trial of two investigational schedules of ifosfamide compared with standard-dose doxorubicin in advanced or metastatic soft tissue sarcoma: a European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study J Clin Oncol 25 2007 3144 3150
32. A. Al Yami, A.M. Griffin, and P.C. Ferguson et al. Positive surgical margins in soft tissue sarcoma treated with preoperative radiation: is a postoperative boost necessary? Int J Radiat Oncol Biol Phys 77 4 2010 1191 1197