CD11c+dendritic cells rather than langerhans cells are reduced in normal skin of immunosuppressed renal transplant recipients

Acta Dermato-Venereologica

Volumn 94, Issue 2, 2014, Pages 173-178

  Sandvik, Lene F ^a,b   Skarstein, Kathrine ^a   Sviland, Lisbet ^a,b   Svarstad, Einar ^a,b   Nilsen, Arvid E ^a,b   Leivestad, Torbjørn ^c   Jonsson, Roland ^a   Appel, Silke ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Dendritic cells; Immunosuppression; Immunosurveillance; Macrophages; Renal transplant recipients; Squamous cell carcinoma

Indexed keywords

AGED; ANTIGENS, CD11C; CASE-CONTROL STUDIES; DENDRITIC CELLS; FEMALE; HUMANS; IMMUNOCOMPROMISED HOST; IMMUNOHISTOCHEMISTRY; KIDNEY TRANSPLANTATION; LANGERHANS CELLS; MACROPHAGES; MALE; MIDDLE AGED; REGISTRIES; SKIN;

EID: 84894044994     PISSN: 00015555     EISSN: 16512057     Source Type: Journal    
DOI: 10.2340/00015555-1679     Document Type: Article

References (39)

1. Wisgerhof HC, van der Geest LG, de Fijter JW, Haasnoot GW, Claas FH, le Cessie S, et al. Incidence of cancer in Acta Derm Venereol 94 kidney-transplant recipients: a long-term cohort study in a single center. Cancer Epidemiol 2011; 35: 105-111.
2. Wisgerhof HC, Edelbroek JR, de Fijter JW, Haasnoot GW, Claas FH, Willemze R, et al. Subsequent squamousand basal-cell carcinomas in kidney-transplant recipients after the first skin cancer: cumulative incidence and risk factors. Transplantation 2010; 89: 1231-1238.
3. Lindelof B, Jarnvik J, Ternesten-Bratel A, Granath F, Hedblad MA. Mortality and clinicopathological features of cutaneous squamous cell carcinoma in organ transplant recipients: a study of the Swedish cohort. Acta Derm Venereol 2006; 86: 219-222.
4. Jensen P, Hansen S, Moller B, Leivestad T, Pfeffer P, Geiran O, et al. Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens. J Am Acad Dermatol 1999; 40: 177-186.
5. Bouwes Bavinck JN, Hardie DR, Green A, Cutmore S, MacNaught A, O'Sullivan B, et al. The risk of skin cancer in renal transplant recipients in Queensland, Australia. A follow-up study. Transplantation 1996; 61: 715-721.
6. Ho WL, Murphy GM. Update on the pathogenesis of posttransplant skin cancer in renal transplant recipients. Br J Dermatol 2008; 158: 217-224.
7. Hofbauer GF, Bouwes Bavinck JN, Euvrard S. Organ transplantation and skin cancer: basic problems and new perspectives. Exp Dermatol 2010; 19: 473-482.
8. Demirkiran A, Hendrikx TK, Baan CC, van der Laan LJ. Impact of immunosuppressive drugs on CD4+CD25+FOXP3+ regulatory T cells: does in vitro evidence translate to the clinical setting? Transplantation 2008; 85: 783-789.
9. Hackstein H, Thomson AW. Dendritic cells: emerging pharmacological targets of immunosuppressive drugs. Nat Rev Immunol 2004; 4: 24-34.
10. Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature 2007; 449: 419-426.
11. Kupper TS, Fuhlbrigge RC. Immune surveillance in the skin: mechanisms and clinical consequences. Nat Rev Immunol 2004; 4: 211-222.
12. Helft J, Ginhoux F, Bogunovic M, Merad M. Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice. Immunol Rev 2010; 234: 55-75.
13. Romani N, Flacher V, Tripp CH, Sparber F, Ebner S, Stoitzner P. Targeting skin dendritic cells to improve intradermal vaccination. Curr Top Microbiol Immunol 2012; 351: 113-138.
14. Romani N, Clausen BE, Stoitzner P. Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev 2010; 234: 120-141.
15. Stoitzner P, Sparber F, Tripp CH. Langerhans cells as targets for immunotherapy against skin cancer. Immunol Cell Biol 2010; 88: 431-437.
16. Zaba LC, Krueger JG, Lowes MA. Resident and "inflammatory" dendritic cells in human skin. J Invest Dermatol 2009; 129: 302-308.
17. Ebner S, Ehammer Z, Holzmann S, Schwingshackl P, Forstner M, Stoitzner P, et al. Expression of C-type lectin receptors by subsets of dendritic cells in human skin. Int Immunol 2004; 16: 877-887.
18. Charles J, Chaperot L, Salameire D, Di Domizio J, Aspord C, Gressin R, et al. Plasmacytoid dendritic cells and dermatological disorders: focus on their role in autoimmunity and cancer. Eur J Dermatol 2010; 20: 16-23.
19. Fitzgerald-Bocarsly P, Dai J, Singh S. Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history. Cytokine Growth Factor Rev 2008; 19: 3-19.
20. Haniffa M, Shin A, Bigley V, McGovern N, Teo P, See P, et al. Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+nonlymphoid dendritic cells. Immunity 2012; 37: 60-73.
21. Jaiswal S, Chao MP, Majeti R, Weissman IL. Macrophages as mediators of tumor immunosurveillance. Trends Immunol 2010; 31: 212-219.
22. Zitvogel L, Tesniere A, Kroemer G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol 2006; 6: 715-727.
23. Zaba LC, Fuentes-Duculan J, Steinman RM, Krueger JG, Lowes MA. Normal human dermis contains distinct populationsof CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages. J Clin Invest 2007; 117: 2517-2525.
24. Glover MT, Deeks JJ, Raftery MJ, Cunningham J, Leigh IM. Immunosuppression and risk of non-melanoma skin cancer in renal transplant recipients. Lancet 1997; 349: 398.
25. Bergfelt L, Larko O, Blohme I. Skin disease in immunosuppressed patients in relation to epidermal Langerhans cells. Acta Derm Venereol 1993; 73: 330-334.
26. Sontheimer RD, Bergstresser PR, Gailiunas P, Jr., Helderman JH, Gilliam JN. Perturbation of epidermal Langerhans cells in immunosuppressed human renal allograft recipients. Transplantation 1984; 37: 168-174.
27. Gibson GE, O'Grady A, Kay EW, Leader M, Murphy GM. Langerhans cells in benign, premalignant and malignant skin lesions of renal transplant recipients and the effect of retinoid therapy. J Eur Acad Dermatol Venereol 1998; 10: 130-136.
28. Bhushan M, Cumberbatch M, Dearman RJ, Andrew SM, Kimber I, Griffiths CE. Tumour necrosis factor-alphainduced migration of human Langerhans cells: the influence of ageing. Br J Dermatol 2002; 146: 32-40.
29. Kanitakis J. Anatomy, histology and immunohistochemistry of normal human skin. Eur J Dermatol 2002; 12: 390-399; quiz 400-401.
30. Cerimele D, Celleno L, Serri F. Physiological changes in ageing skin. Br J Dermatol 1990; Suppl 35: 13-20.
31. Tan CY, Statham B, Marks R, Payne PA. Skin thickness measurement by pulsed ultrasound: its reproducibility, validation and variability. Br J Dermatol 1982; 106: 657-667.
32. Schacke H, Docke WD, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 2002; 96: 23-43.
33. Murphy GM, Norris PG, Young AR, Corbett MF, Hawk JL. Low-dose ultraviolet-B irradiation depletes human epidermal Langerhans cells. Br J Dermatol 1993; 129: 674-677.
34. Thiers BH, Maize JC, Spicer SS, Cantor AB. The effect of aging and chronic sun exposure on human Langerhans cell populations. J Invest Dermatol 1984; 82: 223-226.
35. Sandvik LF, Vogelsang P, Leivestad T, Jonsson R, Appel S. Quantification of plasmacytoid dendritic cells and type 1 myeloid dendritic cells in peripheral blood of renal transplant recipients with and without squamous cell carcinoma. Acta Derm Venereol 2012; 92: 623-624.
36. O'Donovan P, Perrett CM, Zhang X, Montaner B, Xu YZ, Harwood CA, et al. Azathioprine and UVA light generate mutagenic oxidative DNA damage. Science 2005; 309: 1871-1874.
37. Seite S, Zucchi H, Moyal D, Tison S, Compan D, Christiaens F, et al. Alterations in human epidermal Langerhans cells by ultraviolet radiation: quantitative and morphological study. Br J Dermatol 2003; 148: 291-299.
38. Heier I, Soyland E, Krogstad AL, Rodriguez-Gallego C, Nenseter MS, Jahnsen FL. Sun exposure rapidly reduces plasmacytoid dendritic cells and inflammatory dermal dendritic cells in psoriatic skin. Br J Dermatol 2011; 165: 792-801.
39. Ulrich C, Stockfleth E. Azathioprine, UV light, and skin cancer in organ transplant patients do we have an answer? Nephrol Dial Transplant 2007; 22: 1027-1029.