N-glycosylation mutations within hepatitis B virus surface major hydrophilic region contribute mostly to immune escape

Journal of Hepatology

Volumn 60, Issue 3, 2014, Pages 515-522

  Yu, De Min ^a   Li, Xin Hua ^a,f   Mom, Vannary ^b   Lu, Zhong Hua ^d   Liao, Xiang Wei ^a   Han, Yue ^a   Pichoud, Christian ^b   Gong, Qi Ming ^a   Zhang, Dong Hua ^a   Zhang, Yan ^e   Deny, Paul ^b,g   Zoulim, Fabien ^b,c   Zhang, Xin Xin ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b INSERM   (France)

^c HOSPICES CIVILS DE LYON   (France)

^d Wu Xi Hospital of Infectious Diseases   (China)

^e Shanghai Jiao Tong University   (China)

^f SUN YAT SEN UNIVERSITY   (China)

^g UNIVERSITÉ PARIS 13   (France)

Author keywords

HBsAg; Immune escape; Major hydrophilic region; Mutation; N glycosylation

Indexed keywords

HEPATITIS B SURFACE ANTIGEN;

ADOLESCENT; ADULT; AGED; CHEMICAL PHENOMENA; FEMALE; GENETICS; GLYCOSYLATION; HUMAN; IMMUNE EVASION; IMMUNOLOGY; MALE; MIDDLE AGED; MUTATION;

ADOLESCENT; ADULT; AGED; FEMALE; GLYCOSYLATION; HEPATITIS B SURFACE ANTIGENS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNE EVASION; MALE; MIDDLE AGED; MUTATION;

EID: 84894041288     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.11.004     Document Type: Article

References (41)

1. H. Fujii, K. Moriyama, N. Sakamoto, T. Kondo, K. Yasuda, and Y. Hiraizumi et al. Gly145 to Arg substitution in HBs antigen of immune escape mutant of hepatitis B virus Biochem Biophys Res Commun 184 1992 1152 1157
2. H.E. Blum, and B. Hepatitis Virus: significance of naturally occurring mutants Intervirology 35 1993 40 50
3. S. Gunther, S. Miska, H. Meisel, and H. Will Structure and selection of hepatitis B virus variants during the natural course of infection and interferon therapy Princess Takamatsu Symp 25 1995 211 220
4. H. Kohno, T. Inoue, F. Tsuda, H. Okamoto, and Y. Akahane Mutations in the envelope gene of hepatitis B virus variants co-occurring with antibody to surface antigen in sera from patients with chronic hepatitis B J Gen Virol 77 1996 1825 1831
5. S. Locarnini, and F. Zoulim Molecular genetics of HBV infection Antivir Ther 15 2010 3 14
6. M. El Chaar, D. Candotti, R.A. Crowther, and J.P. Allain Impact of hepatitis B virus surface protein mutations on the diagnosis of occult hepatitis B virus infection Hepatology 52 2010 1600 1610
7. R. Chakravarty, M. Neogi, S. Roychowdhury, and C.K. Panda Presence of hepatitis B surface antigen mutant G145R DNA in the peripheral blood leukocytes of the family members of an asymptomatic carrier and evidence of its horizontal transmission Virus Res 90 2002 133 141
8. Z. Moraczewska, K. Madalinski, and P.V. Holland Simultaneous presence in serum of HBsAg and anti-HBs of different specificities Intervirology 9 1978 189 192
9. A. Theamboonlers, V. Chongsrisawat, P. Jantaradsamee, and Y. Poovorawan Variants within the "a" determinant of HBs gene in children and adolescents with and without hepatitis B vaccination as part of Thailand's Expanded Program on Immunization (EPI) Tohoku J Exp Med 193 2001 197 205
10. P. Colson, P. Borentain, A. Motte, M. Henry, V. Moal, and D. Botta-Fridlund et al. Clinical and virological significance of the co-existence of HBsAg and anti-HBs antibodies in hepatitis B chronic carriers Virology 367 2007 30 40
11. O. Lada, Y. Benhamou, T. Poynard, and V. Thibault Coexistence of hepatitis B surface antigen (HBs Ag) and anti-HBs antibodies in chronic hepatitis B virus carriers: influence of "a" determinant variants J Virol 80 2006 2968 2975
12. S.N. Kazim, S.K. Sarin, B.C. Sharma, L.A. Khan, and S.E. Hasnain Characterization of naturally occurring and Lamivudine-induced surface gene mutants of hepatitis B virus in patients with chronic hepatitis B in India Intervirology 49 2006 152 160
13. T. Koyanagi, M. Nakamuta, H. Sakai, R. Sugimoto, M. Enjoji, and K. Koto et al. Analysis of HBs antigen negative variant of hepatitis B virus: unique substitutions, Glu129 to Asp and Gly145 to Ala in the surface antigen gene Med Sci Monit 6 2000 1165 1169
14. S.A. Locarnini, and L. Yuen Molecular genesis of drug-resistant and vaccine-escape HBV mutants Antivir Ther 15 2010 451 461
15. J. Hou Prevalence of naturally occurring surface gene variants of hepatitis B virus in nonimmunized surface antigen-negative Chinese carriers Hepatology 34 2001 1027 1034
16. J. Hou, P. Karayiannis, J. Waters, K. Luo, C. Liang, and H.C. Thomas A unique insertion in the S gene of surface antigen - negative hepatitis B virus Chinese carriers Hepatology 21 1995 273 278
17. W.F. Carman The clinical significance of surface antigen variants of hepatitis B virus J Viral Hepat 4 1997 11 20
18. M.P. Cooreman, G. Leroux-Roels, and W.P. Paulij Vaccine- and hepatitis B immune globulin-induced escape mutations of hepatitis B virus surface antigen J Biomed Sci 8 2001 237 247
19. K. Yamamoto, M. Horikita, F. Tsuda, K. Itoh, Y. Akahane, and S. Yotsumoto et al. Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen J Virol 68 1994 2671 2676
20. T. Bauer, K. Weinberger, and W. Jilg Variants of two major T cell epitopes within the hepatitis B surface antigen are not recognized by specific T helper cells of vaccinated individuals Hepatology 35 2002 455 465
21. Y. Chen, F. Qian, Q. Yuan, X. Li, W. Wu, and X. Guo et al. Mutations in hepatitis B virus DNA from patients with coexisting HBsAg and anti-HBs J Clin Virol 52 2011 198 203
22. C. Wu, X. Zhang, Y. Tian, J. Song, D. Yang, and M. Roggendorf et al. Biological significance of aa substitutions in hepatitis B surface antigen (HBsAg) for glycosylation, secretion, antigenicity and immunogenicity of HBsAg and hepatitis B virus replication J Gen Virol 91 2010 483 492
23. K. Ito, Y. Qin, M. Guarnieri, T. Garcia, K. Kwei, and M. Mizokami et al. Impairment of hepatitis B virus virion secretion by single-amino-acid substitutions in the small envelope protein and rescue by a novel glycosylation site J Virol 84 2010 12850 12861
24. D.J. Vigerust, and V.L. Shepherd Virus glycosylation: role in virulence and immune interactions Trends Microbiol 15 2007 211 218
25. J. Roth, C. Zuber, S. Park, I. Jang, Y. Lee, and K.G. Kysela et al. Protein N-glycosylation, protein folding, and protein quality control Mol Cells 30 2010 497 506
26. F.M. Lu, T. Li, S. Liu, and H. Zhuang Epidemiology and prevention of hepatitis B virus infection in China J Viral Hepat 17 2010 4 9
27. X. Huang, Y. Qin, P. Zhang, G. Tang, Q. Shi, and J. Xu et al. PreS deletion mutations of hepatitis B virus in chronically infected patients with simultaneous seropositivity for hepatitis-B surface antigen and anti-HBs antibodies J Med Virol 82 2010 23 31
28. J.M. Zhang, Y. Xu, X.Y. Wang, Y.K. Yin, X.H. Wu, and X.H. Weng et al. Coexistence of hepatitis B surface antigen (HBsAg) and heterologous subtype-specific antibodies to HBsAg among patients with chronic hepatitis B virus infection Clin Infect Dis 44 2007 1161 1169
29. A.S. Lok, and B.J. McMahon Chronic hepatitis B: update 2009 Hepatology 50 2009 661 662
30. S. Margeridon, A. Lachaux, C. Trepo, F. Zoulim, and A. Kay A quasi-monoclonal anti-HBs response can lead to immune escape of 'wild-type' hepatitis B virus J Gen Virol 86 2005 1687 1693
31. S. Villet, C. Pichoud, J.P. Villeneuve, C. Trepo, and F. Zoulim Selection of a multiple drug-resistant hepatitis B virus strain in a liver-transplanted patient Gastroenterology 131 2006 1253 1261
32. S. Villet, G. Billioud, C. Pichoud, J. Lucifora, O. Hantz, and C. Sureau et al. In vitro characterization of viral fitness of therapy-resistant hepatitis B variants Gastroenterology 136 2009 168 176 e162
33. C. He, F. Nomura, S. Itoga, K. Isobe, and T. Nakai Prevalence of vaccine-induced escape mutants of hepatitis B virus in the adult population in China: a prospective study in 176 restaurant employees J Gastroenterol Hepatol 16 2001 1373 1377
34. Y. Dong, S.L. Liu, X.J. Zhai, F.C. Zhu, H. Pan, and J.X. Yu et al. A serological and molecular survey of hepatitis B in children 15 years after inception of the national hepatitis B vaccination program in eastern China J Med Virol 81 2009 1517 1524
35. V. Thakur, S.N. Kazim, R.C. Guptan, S.E. Hasnain, A. Bartholomeusz, and V. Malhotra et al. Transmission of G145R mutant of HBV to an unrelated contact J Med Virol 76 2005 40 46
36. S. Amini-Bavil-Olyaee, M. Vucur, T. Luedde, C. Trautwein, and F. Tacke Differential impact of immune escape mutations G145R and P120T on the replication of lamivudine-resistant hepatitis B virus e antigen-positive and -negative strains J Virol 84 2010 1026 1033
37. B. Weber Genetic variability of the S gene of hepatitis B virus: clinical and diagnostic impact J Clin Virol 32 2005 102 112
38. T. Kalinina, A. Riu, L. Fischer, H. Will, and M. Sterneck A dominant hepatitis B virus population defective in virus secretion because of several S-gene mutations from a patient with fulminant hepatitis Hepatology 34 2001 385 394
39. R. Patient, C. Hourioux, P.Y. Sizaret, S. Trassard, C. Sureau, and P. Roingeard Hepatitis B virus subviral envelope particle morphogenesis and intracellular trafficking J Virol 81 2007 3842 3851
40. M. Mhamdi, A. Funk, H. Hohenberg, H. Will, and H. Sirma Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles Hepatology 46 2007 95 106
41. European Association for The Study Of The Liver EASL Clinical Practice Guidelines: management of chronic hepatitis B J Hepatol 50 2009 227 242