Successful treatment of postneurosurgical multidrug-resistant Pseudomonas aeruginosa meningoencephalitis with combination therapy of colistin, rifampicin and doripenem

Journal of Antimicrobial Chemotherapy

Volumn 69, Issue 3, 2014, Pages 857-859

  Morelli, Paola ^a   Ferrario, Antonella ^a   Tordato, Federica ^a   Piazza, Aurora ^b   Casari, Erminia ^a  

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

Carbapenem; CSF; Infection

Indexed keywords

ANTIINFECTIVE AGENT; CARBAPENEM DERIVATIVE; COLISTIN; DORIPENEM; RIFAMPICIN;

ADULT; CASE REPORT; DRUG COMBINATION; DRUG EFFECTS; HUMAN; ISOLATION AND PURIFICATION; MALE; MENINGOENCEPHALITIS; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MULTIDRUG RESISTANCE; PROCEDURES; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; SURGICAL WOUND INFECTION; TREATMENT OUTCOME;

ADULT; ANTI-BACTERIAL AGENTS; CARBAPENEMS; COLISTIN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; DRUG THERAPY, COMBINATION; HUMANS; MALE; MENINGOENCEPHALITIS; MICROBIAL SENSITIVITY TESTS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RIFAMPIN; SURGICAL WOUND INFECTION; TREATMENT OUTCOME;

EID: 84894036525     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkt437     Document Type: Article

References (10)

1. Kiratisin P, Apisarnthanarak A, Kaewdaeng S. Synergistic activities between carbapenems and other antimicrobial agents against Acinetobacter baumannii including multidrug-resistant and extensively drug-resistant isolates. Int J Antimicrob Agents 2010; 36: 243-6.
2. Yigit H, Queenan AM, Anderson GJ et al. Novel carbapenemhydrolyzing-beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother 2001; 45: 1151-61.
3. Wen DY, Bottini AG, Hall WA et al. Infections in neurologic surgery. The intraventricular use of antibiotics. Neurosurg Clin N Am 1992; 3: 343-54.
4. Goyal K, Gautam V, Ray P. Doripenem vs meropenem against Pseudomonas and Acinetobacter. Indian J Med Microbiol 2012; 30: 350-1.
5. Markantonis SL, Markou N, Sakellaridis N et al. Penetration of colistin into cerebrospinal fluid. Antimicrob Agents Chemother 2009; 53: 4907-10.
6. Nalda-Molina R, Dokoumetzidis A, Charkoftaki G et al. Pharmacokinetics of doripenem in CSF of patients with non-inflamed meninges. J Antimicrob Chemother 2012; 67: 1722-9.
7. Stucki A, Cottagnoud M, Acosta F et al. Efficacy of doripenem against Escherichia coli and Klebsiella pneumoniae in experimental meningitis. J Antimicrob Chemother 2012; 67: 661-5.
8. Petrosillo N, Ioannidou E, Falagas ME. Colistin monotherapy vs. combination therapy: evidence from microbiological animal and clinical studies. Clin Microbiol Infect 2008; 14: 816-27.
9. Gelfand MS, Cleveland KO, Mazumder SA. Successful treatment with doripenem and tobramycin of ventriculitis due to imipenem-and meropenem-resistant Pseudomonas aeruginosa. J Antimicrob Chemother 2009; 63: 1297-9.
10. Livermore DM. Doripenem: antimicrobial profile and clinical potential. Diag Microbiol Infect Dis 2009; 63: 455-8.