-
1
-
-
77954227128
-
The role of the Hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment
-
Caro I, Low JA. The role of the Hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment. Clin Cancer Res 2010; 16:3335-3339
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3335-3339
-
-
Caro, I.1
Low, J.A.2
-
2
-
-
80955181031
-
The Hedgehog's tale: Developing strategies for targeting cancer
-
Ng JM, Curran T. The Hedgehog's tale: Developing strategies for targeting cancer. Nat Rev Cancer 2011; 11:493-501
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 493-501
-
-
Ng, J.M.1
Curran, T.2
-
3
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
Ingham PW, McMahon AP. Hedgehog signaling in animal development: Paradigms and principles. Genes Dev 2001; 15:3059-3087
-
(2001)
Genes Dev
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
4
-
-
15844381336
-
Human homolog of patched, a candidate gene for the basal cell nevus syndrome
-
Johnson RL, Rothman AL, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996; 272:1668-1671
-
(1996)
Science
, vol.272
, pp. 1668-1671
-
-
Johnson, R.L.1
Rothman, A.L.2
Xie, J.3
-
5
-
-
0023222358
-
Nevoid basal-cell carcinoma syndrome
-
Gorlin RJ. Nevoid basal-cell carcinoma syndrome. Medicine 1987; 66:98-113
-
(1987)
Medicine
, vol.66
, pp. 98-113
-
-
Gorlin, R.J.1
-
6
-
-
84861856844
-
Efficacy and safety of vismodegib in advanced basal-cell carcinoma
-
Sekulic A, Migden MR, Oro AE, et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med 2012; 366:2171-2179
-
(2012)
N Engl J Med
, vol.366
, pp. 2171-2179
-
-
Sekulic, A.1
Migden, M.R.2
Oro, A.E.3
-
7
-
-
84861876867
-
Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome
-
Tang JY, Mackay-Wiggan JM, Aszterbaum M, et al. Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome. N Engl J Med 2012; 366:2180-2188
-
(2012)
N Engl J Med
, vol.366
, pp. 2180-2188
-
-
Tang, J.Y.1
MacKay-Wiggan, J.M.2
Aszterbaum, M.3
-
8
-
-
84891274728
-
Long-Term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma (abcc): 18-month update of the pivotal erivance bcc study
-
(Suppl); abstr 9037
-
Sekulic A, Migden MR, Basset-Seguin N, et al. Long-Term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma (aBCC): 18-month update of the pivotal ERIVANCE BCC study. J Clin Oncol 2013; 31 (Suppl); abstr 9037
-
(2013)
J Clin Oncol
, vol.31
-
-
Sekulic, A.1
Migden, M.R.2
Basset-Seguin, N.3
-
9
-
-
84891277504
-
Vismodegib, a hedgehog pathway inhibitor (hpi), in advanced basal cell carcinoma (abcc): Stevie study interim analysis in 300 patients
-
Suppl); abstr 9036
-
Grob JJ, Kunstfeld R, Dreno B, et al. Vismodegib, a Hedgehog pathway inhibitor (HPI), in advanced basal cell carcinoma (aBCC): STEVIE study interim analysis in 300 patients. J Clin Oncol 2013; 31 (Suppl); abstr 9036
-
(2013)
J Clin Oncol
, pp. 31
-
-
Grob, J.J.1
Kunstfeld, R.2
Dreno, B.3
-
10
-
-
70349238733
-
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
-
Von Hoff DD, LoRusso PM, Rudin CM, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009; 361:1164-1172
-
(2009)
N Engl J Med
, vol.361
, pp. 1164-1172
-
-
Von Hoff, D.D.1
Lorusso, P.M.2
Rudin, C.M.3
-
11
-
-
84894106061
-
-
Hamburg, Germany. This is the first report of survival data of vismodegib in mBCC and distant metastasis
-
Sekulic A, Hauschild A, Migden MR, et al., editors. Survival of patients with metastatic basal cell carcinoma and distant metastasis: The effect of vismodegib, a Hedgehog pathway inhibitor. 8th World Congress of Melanoma; 2013; Hamburg, Germany. This is the first report of survival data of vismodegib in mBCC and distant metastasis
-
(2013)
Survival of Patients with Metastatic Basal Cell Carcinoma and Distant Metastasis: The Effect of Vismodegib, A Hedgehog Pathway Inhibitor 8th World Congress of Melanoma
-
-
Sekulic, A.1
Hauschild, A.2
Migden, M.R.3
-
12
-
-
79954577056
-
A phase i dose-escalation study of lde225, a smoothened (smo) antagonist, in patients with advanced solid tumors
-
Suppl); abstr 2500
-
Rodon Ahnert J, Baselga J, Tawbi HA, et al. A phase I dose-escalation study of LDE225, a smoothened (Smo) antagonist, in patients with advanced solid tumors. J Clin Oncol 2010; 28 (Suppl); abstr 2500
-
(2010)
J Clin Oncol
, vol.28
-
-
Rodon Ahnert, J.1
Baselga, J.2
Tawbi, H.A.3
-
13
-
-
84859942285
-
Phase i study of LDE225 in advanced solid tumors: Updated analysis of safety, preliminary efficacy, and pharmacokinetic-pharmacodynamic correlation
-
Suppl); abstr 3062
-
Tawbi HA, Rodon Ahnert J, Dummer R, et al. Phase I study of LDE225 in advanced solid tumors: Updated analysis of safety, preliminary efficacy, and pharmacokinetic-pharmacodynamic correlation. J Clin Oncol 2011; 29 (Suppl); abstr 3062
-
(2011)
J Clin Oncol
, vol.29
-
-
Tawbi, H.A.1
Rodon Ahnert, J.2
Dummer, R.3
-
14
-
-
79960340656
-
Topical treatment of basal cell carcinomas in nevoid basal cell carcinoma syndrome with a smoothened inhibitor
-
Skvara H, Kalthoff F, Meingassner JG, et al. Topical treatment of basal cell carcinomas in nevoid basal cell carcinoma syndrome with a smoothened inhibitor. J Investig Dermatol 2011; 131:1735-1744
-
(2011)
J Investig Dermatol
, vol.131
, pp. 1735-1744
-
-
Skvara, H.1
Kalthoff, F.2
Meingassner, J.G.3
-
15
-
-
84894088314
-
-
Novartis. [Accessed September 9 2013
-
Novartis. Key developments in the fourth quarter of 2011 2011. http://www. novartis.com/downloads/investors/financial-results/q4-2011- innovation-Tables. pdf. [Accessed September 9 2013
-
(2011)
Key Developments in the Fourth Quarter of 2011
-
-
-
16
-
-
79954620413
-
A first-in-human, phase i study of an oral hedgehog (HH) pathway antagonist, BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors
-
Suppl); abstr 2501
-
Siu LL, Papadopoulos K, Alberts SR, et al. A first-in-human, phase I study of an oral hedgehog (HH) pathway antagonist, BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors. J Clin Oncol 2010; 28 (Suppl); abstr 2501
-
(2010)
J Clin Oncol
, vol.28
-
-
Siu, L.L.1
Papadopoulos, K.2
Alberts, S.R.3
-
17
-
-
84894092439
-
A phase i dose-escalation, pharmacokinetic (PK) and pharmacodynamic (PD) evaluation of LY2940680, an Oral Smo Inhibitor
-
Suppl 1); abstr 594
-
Bendell J, Weiss G, Infante J, et al. A phase I dose-escalation, pharmacokinetic (PK) and pharmacodynamic (PD) evaluation of LY2940680, an Oral Smo Inhibitor. Eur J Cancer 2012; 47 (Suppl 1); abstr 594
-
(2012)
Eur J Cancer
, vol.47
-
-
Bendell, J.1
Weiss, G.2
Infante, J.3
-
18
-
-
84887617215
-
Phase 1 dose-escalation trial of the investigational hedgehog (hh) pathway inhibitor tak-441 in patients with advanced solid tumors
-
abstr 2739
-
Goldman JW, Eckhardt SG, Borad M, et al. Phase 1 dose-escalation trial of the investigational Hedgehog (HH) pathway inhibitor TAK-441 in patients with advanced solid tumors. Ann Oncol 2012; 23 (Suppl 9); abstr 2739
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL.9
-
-
Goldman, J.W.1
Eckhardt, S.G.2
Borad, M.3
-
21
-
-
79960245151
-
A phase i study of ipi-926, a novel hedgehog pathway inhibitor, in patients (pts) with advanced or metastatic solid tumors
-
Suppl); abstr 3014
-
Rudin CM, Jimeno A, Miller WH, et al. A phase I study of IPI-926, a novel hedgehog pathway inhibitor, in patients (pts) with advanced or metastatic solid tumors. J Clin Oncol 2011; 29 (Suppl); abstr 3014
-
(2011)
J Clin Oncol
, vol.29
-
-
Rudin, C.M.1
Jimeno, A.2
Miller, W.H.3
-
22
-
-
84894054546
-
-
Accessed September 9
-
Infinity. Annual Report 2012. http://phx.corporate-ir.net/External.File? item=UGFyZW50SUQ9NTAzMDc5fENoaWxkSUQ9NTQzODAxfFR5cGU 9MQ==&t=1. [Accessed September 9 2013
-
(2013)
Infinity Annual Report 2012
-
-
-
23
-
-
84894026207
-
Phase 1 dose-escalation study of PF-0449913, an oral hedgehog inhibitor in patients with select solid tumors
-
abstr 587
-
Wagner A, Messersmith W, Shaik N, et al. Phase 1 dose-escalation study of PF-0449913, an oral hedgehog inhibitor in patients with select solid tumors. Eur J Cancer 2012; 48 (Suppl 6); abstr 587
-
(2012)
Eur J Cancer
, vol.48
, Issue.SUPPL.6
-
-
Wagner, A.1
Messersmith, W.2
Shaik, N.3
-
24
-
-
84894087636
-
-
Accessed September 9
-
Pfizer. Product Pipeline 2013. http://www.pfizer.com/sites/default/files/ product-pipeline/pipeline-2013-0509.pdf. [Accessed September 9 2013
-
(2013)
Pfizer. Product Pipeline 2013
-
-
-
25
-
-
84894065833
-
-
Strategic alliances, a promise of success for Siena Biotech 2011]. Accessed September 9
-
Siena Biotech. Le alleanze strategiche, premessa di successo per Siena Biotech 2011 [Strategic alliances, a promise of success for Siena Biotech 2011]. http://euroinfocentre.it/regioni/docs/reg7-Siena Biotech-Russell Thomas-Milan 21-06-11.pdf. [Accessed September 9 2013
-
(2013)
Siena Biotech le Alleanze Strategiche, Premessa di Successo per Siena Biotech 2011
-
-
-
26
-
-
79960349060
-
Identification of mk-5710 ((8as)-8a-methyl-1,3-dioxo-2-[(1s,2r)-2- phenylcyclo-propyl]-n-(1-phenyl-1h-pyrazol-5-yl)hexahydro-imidazo[1,5-A] pyrazine-7(1h)-carbox amide), a potent smoothened antagonist for use in hedgehog pathway dependent malignancies, part 2
-
Kinzel O, Alfieri A, Altamura S, et al. Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo-propyl]-N-(1-phenyl-1H- pyrazol-5-yl)hexahydro-imidazo[1,5-A]pyrazine-7(1H)-carbox amide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 2. Bioorg Med Chem Lett 2011; 21:4429-4435
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 4429-4435
-
-
Kinzel, O.1
Alfieri, A.2
Altamura, S.3
-
27
-
-
77950492233
-
Itraconazole, a commonly used antifungal that inhibits hedgehog pathway activity and cancer growth
-
Kim J, Tang JY, Gong R, et al. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell 2010; 17:388-399
-
(2010)
Cancer Cell
, vol.17
, pp. 388-399
-
-
Kim, J.1
Tang, J.Y.2
Gong, R.3
-
28
-
-
84894077742
-
An open-label, exploratory phase II study of oral itraconazole for the treatment of basal cell carcinoma
-
abstr LB-223
-
Kim D, Kim J, Spaunhurst K, et al. An open-label, exploratory phase II study of oral itraconazole for the treatment of basal cell carcinoma. Cancer research 2012; 72 (8 Suppl 1); abstr LB-223
-
(2012)
Cancer Research
, vol.72
, Issue.8 SUPPL.1
-
-
Kim, D.1
Kim, J.2
Spaunhurst, K.3
-
29
-
-
33747332214
-
Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion
-
Bijlsma MF, Spek CA, Zivkovic D, et al. Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion. PLoS Biol 2006; 4: E232
-
(2006)
PLoS Biol
, vol.4
-
-
Bijlsma, M.F.1
Spek, C.A.2
Zivkovic, D.3
-
30
-
-
84863432213
-
Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway
-
DeBerardinis AM, Banerjee U, Miller M, et al. Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway. Bioorg Med Chem Lett 2012; 22:4859-4863
-
(2012)
Bioorg Med Chem Lett
, vol.22
, pp. 4859-4863
-
-
Deberardinis, A.M.1
Banerjee, U.2
Miller, M.3
-
31
-
-
84894076393
-
-
The Independent Institute [Accessed September 16
-
The Independent Institute. The Drug Development and Approval Process. http://www.fdareview.org/approval-process.shtml. [Accessed September 16 2013
-
(2013)
The Drug Development and Approval Process
-
-
-
32
-
-
79551600015
-
Targeting cancer stem cells by inhibiting wnt, notch, and hedgehog pathways
-
Takebe N, Harris PJ, Warren RQ, Ivy SP. Targeting cancer stem cells by inhibiting Wnt, notch, and Hedgehog pathways. Nat Rev Clin Oncol 2011; 8:97-106
-
(2011)
Nat Rev Clin Oncol
, vol.8
, pp. 97-106
-
-
Takebe, N.1
Harris, P.J.2
Warren, R.Q.3
Ivy, S.P.4
|