Hypoxemia in sickle cell disease: Significance and management

Paediatric Respiratory Reviews

Volumn 15, Issue 1, 2014, Pages 17-23

  Caboot, Jason B ^a   Allen, Julian L ^b  

^a MADIGAN ARMY MEDICAL CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Hypoxemia; Pediatrics; Sickle cell anemia

Indexed keywords

ANEMIA, SICKLE CELL; ANOXIA; COMPLICATION; DISEASE MANAGEMENT; HUMAN;

ANEMIA, SICKLE CELL; ANOXIA; DISEASE MANAGEMENT; HUMANS;

EID: 84893951656     PISSN: 15260542     EISSN: 15260550     Source Type: Journal    
DOI: 10.1016/j.prrv.2013.12.004     Document Type: Review

References (65)

1. Quinn C.T., Ahmad N. Clinical correlates of steady-state oxyhaemoglobin desaturation in children who have sickle cell disease. Br J Haematol 2005, 131:129-134.
2. Hargrave D.R., Wade A., Evans J.P., et al. Nocturnal oxygen saturation and painful sickle cell crises in children. Blood 2003, 101:846-848.
3. Kirkham F.J., Hewes D.K., Prengler M., et al. Nocturnal hypoxaemia and central-nervous-system events in sickle-cell disease. Lancet 2001, 357:1656-1659.
4. Quinn C.T., Sargent J.W. Daytime steady-state haemoglobin desaturation is a risk factor for overt stroke in children with sickle cell anaemia. Br J Haematol 2008, 140:336-339.
5. Setty B.N., Stuart M.J., Dampier C., et al. Hypoxaemia in sickle cell disease: biomarker modulation and relevance to pathophysiology. Lancet 2003, 362:1450-1455.
6. Minniti C.P., Sable C., Campbell A., et al. Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen desaturation. Haematologica 2009, 94:340-347.
7. Stuart M.J., Nagel R.L. Sickle cell disease. Lancet 2004, 364:1343-1360.
8. Siddiqui A.K., Ahmed S. Pulmonary manifestations of sickle cell disease. Postgrad Med J 2003, 79:384-390.
9. Gladwin M.T., Vichinsky E. Pulmonary complications of sickle cell disease. N Engl J Med 2008, 359:2254-2265.
10. Minter K.R., Gladwin M.T. Pulmonary complications of sickle cell anemia. A need for increased recognition, treatment, and research. Am J Respir Crit Care Med 2001, 164:2016-2019.
11. Singh S.A., Koumbourlis A.C., Aygun B. Resolution of chronic hypoxemia in pediatric sickle cell patients after treatment with hydroxyurea. Pediatr Blood cancer 2008, 50:1258-1286.
12. Homi J., Levee L., Higgs D., et al. Pulse oximetry in a cohort study of sickle cell disease. Clin Lab Haematol 1997, 19:17-22.
13. Rackoff W.R., Kunkel N., Silber J.H., et al. Pulse oximetry and factors associated with hemoglobin oxygen desaturation in children with sickle cell disease. Blood 1993, 81:3422-3427.
14. Needleman J.P., Setty B.N., Varlotta L., et al. Measurement of hemoglobin saturation by oxygen in children and adolescents with sickle cell disease. Pediatr Pulmonol 1999, 28:423-428.
15. Caboot J.B., Jawad A.F., McDonough J.M., et al. Non-invasive measurements of carboxyhemoglobin and methemoglobin in children with sickle cell disease. Pediatr Pulmonol 2012, 47:808-815.
16. Niu X., Nouraie M., Campbell A., et al. Angiogenic and inflammatory markers of cardiopulmonary changes in children and adolescents with sickle cell disease. PLOS One 2009, 23:e7956.
17. Rucknagel D.L. The role of rib infarcts in the acute chest syndrome of sickle cell diseases. Pediatr Pathol Mol Med 2001, 20:137-154.
18. Sylvester K.P., Patey R.A., Milligan P., et al. Pulmonary function abnormalities in children with sickle cell disease. Thorax 2004, 59:67-70.
19. Sylvester K.P., Patey R.A., Milligan P., et al. Impact of acute chest syndrome on lung function of children with sickle cell disease. J Pediatr 2006, 149:17-22.
20. Kirkham F.J., Hewes D.K.M., Prengler M., et al. Nocturnal hypoxemia and central-nervous-system events in sickle-cell disease. Lancet 2001, 357:1656-1659.
21. Klings E.S., Wyszynski D.F., Nolan V.G., et al. Abnormal pulmonary function in adults with sickle cell anemia. Am J Respir Crit Care Med 2006, 173:1264-1269.
22. Koumbourlis A.C., Lee D.J., Lee A. Longitudinal changes in lung function and somatic growth in children with sickle cell disease. Pediatr Pulmonol 2007, 42:483-488.
23. Santoli F., Zerah F., Vasile N., et al. Pulmonary function in sickle cell disease with or without acute chest syndrome. Eur Respir J 1998, 12:1124-1129.
24. Leong M.A., Dampier C., Varlotta L., et al. Airway hyperreactivity in children with sickle cell disease. J Pediatr 1997, 131:278-283.
25. Ozbek O.Y., Malbora B., Sen N., et al. Airway hyperreactivity detected by methacholine challenge in children with sickle cell disease. Pediatr Pulmonol 2007, 42:1187-1192.
26. Koumbourlis A.C., Zar H.J., Hurlet-Jensen A., et al. Prevalence and reversibility of lower airway obstruction in children with sickle cell disease. J Pediatr 2001, 138:188-192.
27. Boyd J.H., Macklin E.A., Strunk R.C., et al. Asthma is associated with acute chest syndrome and pain in children with sickle cell anemia. Blood 2006, 108:2923-2927.
28. Knight-Madden J.M., Forrester T.S., Lewis N.A., et al. Asthma in children with sickle cell disease and its association with acute chest syndrome. Thorax 2005, 60:206-210.
29. Boyd J.H., Moinuddin A., Strunk R.C., et al. Asthma and acute chest in sickle-cell disease. Pediatr Pulmonol 2004, 38:229-232.
30. Boyd J.H., Macklin E.A., Strunk R.C., et al. Asthma is associated with increased mortality in individuals with sickle cell anemia. Haematologica 2007, 92:1115-1118.
31. Sylvester K.P., Patey R.A., Rafferty G.F., et al. Airway hyperresponsiveness and acute chest syndrome in children with sickle cell anemia. Pediatr Pulmonol 2007, 42:272-276.
32. Gladwin M.T., Sachdev V., Jison M.L., et al. Pulmonary hypertension as a risk for death in patients with sickle cell disease. N Engl J Med 2004, 350:886-895.
33. Sidman J.D., Fry T.L. Exacerbations of sickle cell disease by obstructive sleep apnea. Arch Otolaryngol Head Neck Surg 1988, 114:916-917.
34. Franco M., Leong M., Varlotta L., et al. Sleep hypoxemia in children with sickle cell disease. Am J Respir Crit Care Med 1996, 153:A494.
35. Hargrave D.R., Wade A., Evans J.P.M., et al. Nocturnal oxygen saturation and painful sickle cell crises in children. Blood 2003, 101:846-848.
36. Kaleyias J., Mostofi N., Grant M., et al. Severity of obstructive sleep apnea in children with sickle cell disease. J Pediatr Hematol Oncol 2008, 30:659-665.
37. Rogers V.E., Lewin D.S., Winnie G.B., et al. Polysomnographic characteristics of a referred sample of children with sickle cell disease. J Clin Sleep Med 2010, 6:374-381.
38. Spivey F.J., Uong E.C., Strunk R., et al. Low daytime pulse oximetry reading is associated with nocturnal desaturation and obstructive sleep apnea in children with sickle cell anemia. Pediatr Blood Cancer 2006, 50:359-362.
39. Needleman J.P., Franco M.E., Varlotta L., et al. Mechanisms of nocturnal oxyhemoglobin desaturation in children and adolescents with sickle cell disease. Pediatr Pulmonol 1999, 28:418-422.
40. Strauss T., Sin S., Marcus C.L., et al. Upper airway lymphoid tissue size in children with sickle cell disease. Chest 2012, 142:94-100.
41. Samuels M.P., Stebbens V.A., Davies S.C., et al. Sleep related upper airway obstruction and hypoxaemia in sickle cell disease. Arch Dis Child 1992, 67:925-929.
42. Salles C., Ramos R.T., Daltro C., et al. Prevalence of obstructive sleep apnea in children and adolescents with sickle cell anemia. J Bras Pneumol 2009, 35:1075-1083.
43. Maddern B.R., Ohene-Frempong K., Reed H.T., et al. Obstructive sleep apnea syndrome in sickle cell disease. Ann Otol Rhinol Laryngol 1989, 98:174-178.
44. Sears D.A., Udden M.M., Thomas L.J. Carboxyhemoglobin levels in patients with sickle-cell anemia: relationship to hemolytic and vasoocclusive severity. Am J Med Sci 2001, 322:345-348.
45. Schechter A.N., Gladwin M.T. Hemoglobin and the paracrine and endocrine functions of nitric oxide. N Engl J Med 2003, 348:1483-1485.
46. Dweik R.A., Laskowski D., Abu-Soud H.M., et al. Nitric oxide synthesis in the lung: Regulation by oxygen through a kinetic mechanism. J Clin Invest 1998, 101:660-666.
47. Liu C.Y., Udden M.M., Hellums J.D. Oxygen transport in thin layers of packed sickle erythrocytes. Microvasc Res 1995, 49:78-96.
48. Blaisdell C.J., Goodman S., Clark K., et al. Pulse oximetry is a poor predictor of hypoxemia in stable children with sickle cell disease. Arch Pediatr Adolesc Med 2000, 154:900-903.
49. Craft J.A., Alessandrini E., Kenney L.B., et al. Comparison of oxygenation measurements in pediatric patients during sickle cell crises. J Pediatr 1994, 124:93-95.
50. Miller S.T., How I. treat acute chest syndrome in children with sickle cell disease. Blood 2011, 117:5297-5305.
51. Zipursky A., Robieux I.C., Brown E.J., et al. Oxygen therapy in sickle cell disease. Am J Pediatr Hematol Oncol 1992, 14:222-228.
52. Robieux I.C., Kellner J.D., Coppes M.J., et al. Analgesia in children with sickle cell crisis: comparison of intermittent opioids vs. continuous intravenous infusion of morphine and placebo-controlled study of oxygen inhalation. Pediatr Hematol Oncol 1992, 9:317-326.
53. Embury S.H., Garcia J.F., Mohandas N., et al. Effects of oxygen inhalation on endogenous erythropoietin kinetics, erythropoiesis, and properties of blood cells in sickle-cell anemia. N Engl J Med 1984, 311:291-295.
54. Laszlo J., Obenour W., Saltzman H.A. Effects of hyperbaric oxygenation on sickle syndromes. South Med J 1969, 62:453-456.
55. Mychaskiw I.I.G., Woodyard S.A., Brunson C.D., et al. In vitro effects of hyperbaric oxygen on sickle cell morphology. J Clin Anesth 2001, 13:255-258.
56. Balfour-Lynn I.M., Field D.J., Gringras P., et al. BTS guidelines for home oxygen in children. Thorax 2009, 64(Suppl 2):ii1-ii26. Paediatric Section of the Home Oxygen Guideline Development Group of the BTS Standards of Care Committee.
57. Emre U., Miller S.T., Gutierez M., et al. Effect of transfusion in acute chest syndrome of sickle cell disease. J Pediatr 1995, 127:901-904.
58. Miller S.T., Wright E., Abbound M., et al. Impact of chronic transfusions on incidence of pain and acute chest syndrome during the Stroke Prevention Trial (STOP) in sickle-cell anemia. J Pediatr 2001, 139:785-789.
59. Charache S., Terrin M.L., Moore R.D., et al. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. N Engl J Med 1995, 332:1317-1322.
60. Friedman M., Wilson M., Lin H.C., et al. Updated systematic review of tonsillectomy and adenoidectomy for treatment of pediatric obstructive sleep apnea/hypopnea syndrome. Otolaryngol Head Neck Surg 2009, 140:800-808.
61. Marshall M.J., Bucks R.S., Hogan A.M., et al. Auto-adjusting positive airway pressure in children with sickle cell anemia: results of a phase I randomized controlled trial. Haematologica 2009, 94:1006-1010.
62. Bellet P.S., Kalinyak K.A., Shukla R., et al. Incentive spirometry to prevent acute pulmonary complications in sickle cell diseases. N Engl J Med 1995, 333:699-703.
63. Hsu L.L., Batts B.K., Rau J.L. Positive expiratory pressure device acceptance by hospitalized children with sickle cell disease is comparable to incentive spirometry. Respir Care 2005, 50:624-627.
64. Head C.A., Swerdlow P., McDade W.A., et al. Beneficial effects of nitric oxide breathing in adult patients with sickle cell crisis. Am J Hematol 2010, 85:800-802.
65. Gladwin M.T., Kato G.J., Weiner D., et al. Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial. JAMA 2011, 305:893-902. DeNOVO Investigators.