The role of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in cerebrospinal fluids for screening of acute bacterial meningitis

Clinical Laboratory

Volumn 60, Issue 3, 2014, Pages 377-381

  Lippi, Giuseppe ^a   Avanzini, Paola ^a   Calzetti, Carlo ^b   Caleffi, Alberta ^a   Pipitone, Silvia ^a   Musa, Roberta ^a   Aloe, Rosalia ^a   Ferrari, Carlo ^b  

^a UO Diagnostica Ematochimica   (Italy)

^b Academic Hospital of Parma   (Italy)

Author keywords

Cerebrospinal fluids; Infectious diseases; Meningitis; Neutrophil gelatinase associated lipocalin; NGAL

Indexed keywords

ANTIBIOTIC AGENT; GLUCOSE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PROTEIN;

ACUTE BACTERIAL MENINGITIS; ANTIBIOTIC THERAPY; AREA UNDER THE CURVE; ARTICLE; BACTERIAL MENINGITIS; BIOCHEMICAL EQUIPMENT; CELL COUNT; CEREBROSPINAL FLUID CULTURE; CEREBROSPINAL FLUID LEVEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; ERYTHROCYTE; HUMAN; HUMAN CELL; LEUKOCYTE COUNT; LEUKOCYTE DIFFERENTIAL COUNT; LIMIT OF DETECTION; LUMBAR PUNCTURE; MEASUREMENT ACCURACY; MONONUCLEAR CELL; NEUTROPHIL; POLYMORPHONUCLEAR CELL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN FUNCTION; RECEIVER OPERATING CHARACTERISTIC; SCREENING; SENSITIVITY AND SPECIFICITY;

ACUTE DISEASE; ACUTE-PHASE PROTEINS; HUMANS; LIPOCALINS; MENINGITIS, BACTERIAL; PROTO-ONCOGENE PROTEINS; SENSITIVITY AND SPECIFICITY;

EID: 84893943929     PISSN: 14336510     EISSN: None     Source Type: Journal    
DOI: 10.7754/Clin.Lab.2013.121239     Document Type: Article

References (20)

1. Thigpen MC, Whitney CG, Messonnier NE, et al. Emerging Infections Programs Network. Bacterial meningitis in the United States, 1998-2007. N Engl J Med 2011;364:2016-25.
2. Scarborough M, Thwaites GE. The diagnosis and management of acute bacterial meningitis in resource-poor settings. Lancet Neurol 2008;7:637-48.
3. Bamberger DM. Diagnosis, initial management, and prevention of meningitis. Am Fam Physician 2010;82:1491-8.
4. Mace SE. Acute bacterial meningitis. Emerg Med Clin North Am 2008;26:281-317. (Pubitemid 351506493)
5. Segreti J, Harris AA. Acute bacterial meningitis. Infect Dis Clin North Am 1996;10:797-809. (Pubitemid 27011225)
6. Paradowski M, Lobos M, Kuydowicz J, Krakowiak M, Kubasiewicz-Ujma B. Acute phase proteins in serum and cerebrospinal fluid in the course of bacterial meningitis. Clin Biochem 1995;28:-459-66.
7. Jesse S, Steinacker P, Lehnert S, et al. A proteomic approach for the diagnosis of bacterial meningitis. PLoS One 2010;5:e10079.
8. Cervellin G, di Somma S. Neutrophil gelatinase-associated lipocalin (NGAL): the clinician's perspective. Clin Chem Lab Med 2012;50:1489-93.
9. Lippi G, Plebani M. Neutrophil gelatinase-associated lipocalin (NGAL): the laboratory perspective. Clin Chem Lab Med 2012;50:1483-7.
10. Axelsson L, Bergenfeldt M, Ohlsson K. Studies of the release and turnover of a human neutrophil lipocalin. Scand J Clin Lab Invest 1995;55:577-88.
11. Leung JC, Lam MF, Tang SC, et al. Roles of neutrophil gelatinase-associated lipocalin in continuous ambulatory peritoneal dialysis-related peritonitis. J Clin Immunol 2009;29:365-78.
12. Martino FK, Filippi I, Giavarina D, et al. Neutrophil gelatinase-associated lipocalin in the early diagnosis of peritonitis: the case of neutrophil gelatinase-associated lipocalin. Contrib Nephrol 2012;178:258-63.
13. Lippi G, Caleffi A, Pipitone S, et al. Assessment of neutrophil gelatinase-associated lipocalin and lactate dehydrogenase in peritoneal fluids for the screening of bacterial peritonitis. Clin Chim Acta, in press.
14. Lippi G, Cervellin G. Neutrophil gelatinase-associated lipocalin: a more specific assay is needed for diagnosing renal injury. Clin Chim Acta 2012;413:1160-1.
15. Lippi G, Aloe R, Storelli A, Cervellin G, Trenti T. Evaluation of NGAL Test™, a fully-automated neutrophil gelatinase-associated lipocalin (NGAL) immunoassay on Beckman Coulter AU 5822. Clin Chem Lab Med 2011;50:1581-4.
16. Close RM, Ejidokun OO, Verlander NQ, et al. Early diagnosis model for meningitis supports public health decision making. J Infect 2011;63:32-8.
17. Lippi G, Salvagno GL, Banfi G. Serum but not urine concentration of neutrophil gelatinase-associated lipocalin is influenced by acute leukocyte variations. Leuk Lymphoma 2012;53:1643-5.
18. Barresi V, Tuccari G, Barresi G. NGAL immunohistochemical expression in brain primary and metastatic tumors. Clin Neuropathol 2010;29:317-22.
19. Flo TH, Smith KD, Sato S, et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 2004;432:917-21. (Pubitemid 40037155)
20. Shameem S, Vinod Kumar CS, Neelagund YF. Bacterial meningitis: rapid diagnosis and microbial profile: a multicentered study. J Commun Dis 2008;40:111-20.