The proinflammatory effect of C-reactive protein on human endothelial cells depends on the FcγRIIa genotype

Thrombosis Research

Volumn 133, Issue 3, 2014, Pages 426-432

  Raaz Schrauder, Dorette ^a   Ekici, Arif B ^b   Klinghammer, Lutz ^a   Stumpf, Christian ^a   Achenbach, Stephan ^a   Herrmann, Martin ^a   Reis, André ^b   Garlichs, Christoph D ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

C reactive protein; Cell adhesion molecules; Coronary artery disease; Cytokines; Fc receptor IIa gene polymorphisms

Indexed keywords

C REACTIVE PROTEIN; FC RECEPTOR; FC RECEPTOR IIA; VASCULAR CELL ADHESION MOLECULE 1;

BLOOD; CORONARY ARTERY DISEASE; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; INFLAMMATION; METABOLISM; UMBILICAL VEIN ENDOTHELIAL CELL;

C-REACTIVE PROTEIN; CORONARY ARTERY DISEASE; GENOTYPE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; POLYMORPHISM, GENETIC; RECEPTORS, IGG; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84893937321     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2013.12.030     Document Type: Article

References (28)

1. P. Libby Inflammation in atherosclerosis Nature 420 2002 868 874
2. B.M. Scirica, and D.A. Morrow Is C-reactive protein an innocent bystander or proatherogenic culprit? The verdict is still out Circulation 113 2006 2128 2134 [discussion 51]
3. P.M. Ridker, C.H. Hennekens, J.E. Buring, and N. Rifai C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women N Engl J Med 342 2000 836 843
4. J. Danesh, J.G. Wheeler, G.M. Hirschfield, S. Eda, G. Eiriksdottir, and A. Rumley et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease N Engl J Med 350 2004 1387 1397
5. S. Fichtlscherer, G. Rosenberger, D.H. Walter, S. Breuer, S. Dimmeler, and A.M. Zeiher Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease Circulation 102 2000 1000 1006
6. M. Escribano-Burgos, A. Lopez-Farre, Gonzalez M. del Mar, C. Macaya, A. Garcia-Mendez, and P.J. Mateos-Caceres et al. Effect of C-reactive protein on Fcgamma receptor II in cultured bovine endothelial cells Clin Sci (Lond) 108 2005 85 91
7. T. Ishikawa, K. Hatakeyama, T. Imamura, H. Date, Y. Shibata, and Y. Hikichi et al. Involvement of C-reactive protein obtained by directional coronary atherectomy in plaque instability and developing restenosis in patients with stable or unstable angina pectoris Am J Cardiol 91 2003 287 292
8. D. Bharadwaj, M.P. Stein, M. Volzer, C. Mold, and T.W. Du Clos The major receptor for C-reactive protein on leukocytes is fcgamma receptor II J Exp Med 190 1999 585 590
9. S. Devaraj, T.W. Du Clos, and I. Jialal Binding and internalization of C-reactive protein by Fcgamma receptors on human aortic endothelial cells mediates biological effects Arterioscler Thromb Vasc Biol 25 2005 1359 1363
10. J. Ryu, C.W. Lee, J.A. Shin, C.S. Park, J.J. Kim, and S.J. Park et al. FcgammaRIIa mediates C-reactive protein-induced inflammatory responses of human vascular smooth muscle cells by activating NADPH oxidase 4 Cardiovasc Res 75 2007 555 565
11. M.P. Stein, J.C. Edberg, R.P. Kimberly, E.K. Mangan, D. Bharadwaj, and C. Mold et al. C-reactive protein binding to FcgammaRIIa on human monocytes and neutrophils is allele-specific J Clin Invest 105 2000 369 376
12. R. Zuniga, G.S. Markowitz, T. Arkachaisri, E.A. Imperatore, V.D. D'Agati, and J.E. Salmon Identification of IgG subclasses and C-reactive protein in lupus nephritis: the relationship between the composition of immune deposits and FCgamma receptor type IIA alleles Arthritis Rheum 48 2003 460 470
13. S. Gavasso, O. Nygard, E.R. Pedersen, J.H. Aarseth, O. Bleie, and K.M. Myhr et al. Fcgamma receptor IIIA polymorphism as a risk-factor for coronary artery disease Atherosclerosis 180 2005 277 282
14. D. Raaz, M. Herrmann, A.B. Ekici, L. Klinghammer, B. Lausen, and R.E. Voll et al. FcgammaRIIa genotype is associated with acute coronary syndromes as first manifestation of coronary artery disease Atherosclerosis 205 2009 512 516
15. M.P. Schneider, J.H. Leusen, M. Herrmann, C.D. Garlichs, K. Amann, and S. John et al. The Fcgamma receptor IIA R131H gene polymorphism is associated with endothelial function in patients with hypercholesterolaemia Atherosclerosis 218 2011 411 415
16. E.A. Jaffe, R.L. Nachman, C.G. Becker, and C.R. Minick Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria J Clin Invest 52 1973 2745 2756
17. L.E. Carlsson, S. Santoso, G. Baurichter, H. Kroll, S. Papenberg, and P. Eichler et al. Heparin-induced thrombocytopenia: new insights into the impact of the FcgammaRIIa-R-H131 polymorphism Blood 92 1998 1526 1531
18. S. Devaraj, B. Davis, S.I. Simon, and I. Jialal CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human aortic endothelial cells under static and shear flow conditions Am J Physiol Heart Circ Physiol 291 2006 H1170 H1176
19. L. Fotis, G. Agrogiannis, I.S. Vlachos, A. Pantopoulou, A. Margoni, and M. Kostaki et al. Intercellular Adhesion Molecule (ICAM)-1 and Vascular Cell Adhesion Molecule (VCAM)-1 at the Early Stages of Atherosclerosis in a Rat Model In Vivo 26 2012 243 250
20. D. Raaz-Schrauder, L. Klinghammer, C. Baum, T. Frank, P. Lewczuk, and S. Achenbach et al. Association of systemic inflammation markers with the presence and extent of coronary artery calcification Cytokine 57 2012 251 257
21. M. Cheng, Y. Li, J. Wu, Y. Nie, L. Li, and X. Liu et al. IL-8 induces imbalances between nitric oxide and endothelin-1, and also between plasminogen activator inhibitor-1 and tissue-type plasminogen activator in cultured endothelial cells Cytokine 41 2008 9 15
22. S. Devaraj, D.Y. Xu, and I. Jialal C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: implications for the metabolic syndrome and atherothrombosis Circulation 107 2003 398 404
23. U. Singh, S. Devaraj, and I. Jialal C-reactive protein decreases tissue plasminogen activator activity in human aortic endothelial cells: evidence that C-reactive protein is a procoagulant Arterioscler Thromb Vasc Biol 25 2005 2216 2221
24. S. Suemitsu, M. Watanabe, E. Yokobayashi, S. Usui, T. Ishikawa, and Y. Matsumoto et al. Fcgamma receptors contribute to pyramidal cell death in the mouse hippocampus following local kainic acid injection Neuroscience 166 2010 819 831
25. H.H. Shih, S. Zhang, W. Cao, A. Hahn, J. Wang, and J.E. Paulsen et al. CRP is a novel ligand for the oxidized LDL receptor LOX-1 Am J Physiol Heart Circ Physiol 296 2009 H1643 H1650
26. C.J. Hoffmann, M. Hohberg, S. Chlench, J. Maroski, M. Drab, and G. Siegel et al. Suppression of zinc finger protein 580 by high oxLDL/LDL-ratios is followed by enhanced expression of endothelial IL-8 Atherosclerosis 216 2011 103 108
27. P.M. Ridker, C.P. Cannon, D. Morrow, N. Rifai, L.M. Rose, and C.H. McCabe et al. C-reactive protein levels and outcomes after statin therapy N Engl J Med 352 2005 20 28
28. L.A. Lange, C.S. Carlson, L.A. Hindorff, E.M. Lange, J. Walston, and J.P. Durda et al. Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events JAMA 296 2006 2703 2711