The soluble metal-binding domain of the copper transporter ATP7B binds and detoxifies cisplatin

Biochemical Journal

Volumn 419, Issue 1, 2009, Pages 51-56

  Dolgova, Nataliya V ^a   Olson, Doug ^b   Lutsenko, Svetlana ^c   Dmitriev, Oleg Y ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

ATPase; Chemotherapy; Cisplatin; Drug resistance; Wilson disease

Indexed keywords

ACTIVE DRUGS; ATPASE; BACTERIAL CULTURES; CANCER CELLS; CISPLATIN; CISPLATIN BINDING; COPPER BINDING; DRUG RESISTANCE; ENZYMATIC ACTIVITIES; IN-VIVO; METAL BINDING DOMAIN; N-TERMINAL; PROTEIN FRAGMENTS; SOLUBLE METALS; TOXIC EFFECT; WILSON DISEASE;

BINDING ENERGY; BINDING SITES; CELL CULTURE; CHEMOTHERAPY; METAL EXTRUSION;

PLATINUM COMPOUNDS;

CISPLATIN; METAL; WILSON DISEASE PROTEIN; ADENOSINE TRIPHOSPHATASE; CATION TRANSPORT PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL CELL; CELL PROTECTION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG BINDING SITE; DRUG DETERMINATION; DRUG DETOXIFICATION; DRUG PROTEIN BINDING; ESCHERICHIA COLI; METAL BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; BINDING SITE; CHEMISTRY; DRUG EFFECT; GENETICS; METABOLISM; PHASE CONTRAST MICROSCOPY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; WILSON DISEASE;

BACTERIA (MICROORGANISMS);

ADENOSINE TRIPHOSPHATASES; BINDING SITES; CATION TRANSPORT PROTEINS; CISPLATIN; ESCHERICHIA COLI; HEPATOLENTICULAR DEGENERATION; MICROSCOPY, INTERFERENCE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 62749183648     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20081359     Document Type: Article

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