Continued declining incidence and improved survival of progressive multifocal leukoencephalopathy in HIV/AIDS patients in the current era

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 33, Issue 2, 2014, Pages 179-187

  Casado, J L ^a   Corral, I ^a   Garcia J ^a   Martinez San Millan J ^a   Navas, E ^a   Moreno, A ^a   Moreno, S ^a  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTI-RETROVIRAL AGENTS; CD4 LYMPHOCYTE COUNT; COHORT STUDIES; FEMALE; HUMANS; INCIDENCE; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; MALE; MIDDLE AGED; SURVIVAL ANALYSIS;

EID: 84893922401     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-013-1941-6     Document Type: Article

References (38)

1. Richardson EP Jr (1961) Progressive multifocal leukoencephalopathy. N Eng J Med 265:815-823
2. Gillespie SM, Chang Y, Lemp G et al (1991) Progressive multifocal leukoencephalopathy in persons infected with human immunodeficiency virus, San Francisco, 1981-1989. Ann Neurol 30:597-604
3. Berger JR, Kaszovitz B, Post MJ, Dickinson G (1987) Progressive multifocal leukoencephalopathy associated with human immunodeficiency virus infection. A review of the literature with a report of sixteen cases. Ann Intern Med 107:78-87
4. Wyen C, Hoffmann C, Schmeisser N et al (2004) Progressive multifocal leukencephalopathy in patients on highly active antiretroviral therapy: survival and risk factors of death. J Acquir Immune Defic Syndr 37:1263-1268
5. Tan CS, Koralnik IJ (2010) Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. Lancet Neurol 9:425-437
6. De Luca A, Giancola ML, Ammassari A et al (2000) The effect of potent antiretroviral therapy and JC virus load in cerebrospinal fluid on clinical outcome of patients with AIDS-associated progressive multifocal leukoencephalopathy. J Infect Dis 182:1077-1083
7. Clifford DB, Yiannoutsos C, Glicksman M et al (1999) HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy. Neurology 52:623-625
8. Taoufik Y, Gasnault J, Karaterki A et al (1998) Prognostic value of JC virus load in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy. J Infect Dis 178:1816-1820
9. Bossolasco S, Calori G, Moretti F et al (2005) Prognostic significance of JC virus DNA levels in cerebrospinal fluid of patients with HIV-associated progressive multifocal leukoencephalopathy. Clin Infect Dis 40:738-744
10. Engsig FN, Hansen AB, Omland LH et al (2009) Incidence, clinical presentation, and outcome of progressive multifocal leukoencephalopathy in HIV-infected patients during the highly active antiretroviral therapy era: a nationwide cohort study. J Infect Dis 199:77-83
11. Berenguer J, Miralles P, Arrizabalaga J et al (2003) Clinical course and prognostic factors of progressive multifocal leukoencephalopathy in patients treated with highly active antiretroviral therapy. Clin Infect Dis 36:1047-1052
12. Grabar S, Lanoy E, Allavena C et al (2008) Causes of the first AIDS-defining illness and subsequent survival before and after the advent of combined antiretroviral therapy. HIV Med 9:246-256
13. Cinque P, Koralnik IJ, Clifford DB (2003) The evolving face of human immunodeficiency virus-related progressive multifocal leukoencephalopathy: defining a consensus terminology. J Neurovirol 9(Suppl 1):88-92
14. Rockstroh JK, Gatell J, Landman R, Antinori A (2010) Management of late-presenting patients with HIV infection. Antivir Ther 15(Suppl 1):25-30
15. Fedele CG, Ciardi M, Delia S, Echevarria JM, Tenorio A (1999) Multiplex polymerase chain reaction for the simultaneous detection and typing of polyomavirus JC, BK and SV40 DNA in clinical samples. J Virol Method 82:137-144
16. Letendre SL, Ellis RJ, Ances BM, McCutchan JA (2010) Neurologic complications of HIV disease and their treatment. Top HIV Med 18:45-55
17. Cinque P, Bossolasco S, Brambilla AM et al (2003) The effect of highly active antiretroviral therapy-induced immune reconstitution on development and outcome of progressive multifocal leukoencephalopathy: study of 43 cases with review of the literature. J Neurovirol 9(Suppl 1):73-80
18. Couzigou C, Semaille C, Le Strat Y et al (2007) Differential improvement in survival among patients with AIDS after the introduction of HAART. AIDS Care 19:523-531
19. Khanna N, Elzi L, Mueller NJ et al (2009) Incidence and outcome of progressive multifocal leukoencephalopathy over 20 years of the Swiss HIV Cohort Study. Clin Infect Dis 48:1459-1466
20. Colubi MM, Pérez-Elías MJ, Elías L et al (2012) Missing scheduled visits in the outpatient clinic as a marker of short-term admissions and death. HIV Clin Trials 13:289-295
21. Falcó V, Olmo M, del Saz SV et al (2008) Influence of HAART on the clinical course of HIV-1-infected patients with progressive multifocal leukoencephalopathy: results of an observational multicenter study. J Acquir Immune Defic Syndr 49:26-31
22. Giudici B, Vaz B, Bossolasco S et al (2000) Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy: effects on cerebrospinal fluid markers of JC virus replication and immune response. Clin Infect Dis 30:95-99
23. Berger JR, Levy RM, Flomenhoft D, Dobbs M (1998) Predictive factors for prolonged survival in acquired immunodeficiency syndrome-associated progressive multifocal leukoencephalopathy. Ann Neurol 44:341-349
24. Cinque P, Pierotti C, Viganò MG et al (2001) The good and evil of HAART in HIV-related progressive multifocal leukoencephalopathy. J Neurovirol 7:358-363
25. Gasnault J, Kahraman M, de Goër de Herve MG, Durali D, Delfraissy JF, Taoufik Y (2003) Critical role of JC virus-specific CD4 T-cell responses in preventing progressive multifocal leukoencephalopathy. AIDS 17:1443-1449
26. Marzocchetti A, Sanguinetti M, Giambenedetto SD et al (2007) Characterization of JC virus in cerebrospinal fluid from HIV-1 infected patients with progressive multifocal leukoencephalopathy: insights into viral pathogenesis and disease prognosis. J Neurovirol 13:338-346
27. Du Pasquier RA, Autissier P, Zheng Y, Jean-Jacques J, Koralnik IJ (2005) Presence of JC virus-specific CTL in the cerebrospinal fluid of PML patients: rationale for immune-based therapeutic strategies. AIDS 19:2069-2076
28. Drake AK, Loy CT, Brew BJ et al (2007) Human immunodeficiency virus-associated progressive multifocal leucoencephalopathy: epidemiology and predictive factors for prolonged survival. Eur J Neurol 14:418-423
29. Lanoy E, Guiguet M, Bentata M et al (2011) Survival after neuroAIDS: association with antiretroviral CNS Penetration-Effectiveness score. Neurology 76:644-651
30. Gasnault J, Lanoy E, Bentata M, Gulgust M, Costagliola D (2008) Intracerebral penetrating ART are more efficient on survival of HIV+ patients with progressive multifocal leucoencephalopathy (ANRS CO4-FHDH). In: Proceedings of the 15th Conference on Retroviruses and Opportunistic Infections (CROI), Boston, Massachusetts, USA, February 2008
31. Tada H, Rappaport J, Lashgari M, Amini S, Wong-Staal F, Khalili K (1990) Trans-activation of the JC virus late promoter by the tat protein of type 1 human immunodeficiency virus in glial cells. Proc Natl Acad Sci USA 87:3479-3483
32. Berger JR, Chauhan A, Galey D, Nath A (2001) Epidemiological evidence and molecular basis of interactions between HIV and JC virus. J Neurovirol 7:329-338
33. Gasnault J, Costagliola D, Hendel-Chavez H et al (2011) Improved survival of HIV-1-infected patients with progressive multifocal leukoencephalopathy receiving early 5-drug combination antiretroviral therapy. PLoS One 6:e20967
34. Khanna N, Wolbers M, Mueller NJ et al (2009) JC virus-specific immune responses in human immunodeficiency virus type 1 patients with progressive multifocal leukoencephalopathy. J Virol 83:4404-4411
35. Cinque P, Scarpellini P, Vago L, Linde A, Lazzarin A (1997) Diagnosis of central nervous system complications in HIV-infected patients: cerebrospinal fluid analysis by the polymerase chain reaction. AIDS 11:1-17
36. Marzocchetti A, Di Giambenedetto S, Cingolani A, Ammassari A, Cauda R, De Luca A (2005) Reduced rate of diagnostic positive detection of JC virus DNA in cerebrospinal fluid in cases of suspected progressive multifocal leukoencephalopathy in the era of potent antiretroviral therapy. J Clin Microbiol 43:4175-4177
37. Cinque P, Vago L, Dahl H et al (1996) Polymerase chain reaction on cerebrospinal fluid for diagnosis of virus-associated opportunistic diseases of the central nervous system in HIV-infected patients. AIDS 10:951-958
38. Koralnik IJ, Boden D, Mai VX, Lord CI, Letvin NL (1999) JC virus DNA load in patients with and without progressive multifocal leukoencephalopathy. Neurology 52:253-260