Efficacy and safety of oral porcine relaxin (pRLX) in adjunct to physical exercise in the treatment of peripheral arterial disease (PAD)

Italian Journal of Anatomy and Embryology

Volumn 118, Issue 1 SUPPL., 2013, Pages 84-91

  Sonaglia, Francesco ^a   Milia, Paolo ^a   Caserio, Marco ^a   Bigazzi, Bernardo ^a   Bigazzi, Benedetta ^a   Ricotta, Serena ^a   Bani, Daniele ^a   Bigazzi, Mario ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

RELAXIN;

ADOLESCENT; ADULT; AGED; ANIMAL; ARTICLE; CHRONIC DISEASE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXERCISE; FEMALE; HUMAN; MALE; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SWINE; TREATMENT OUTCOME; VERY ELDERLY; YOUNG ADULT;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CHRONIC DISEASE; EXERCISE; FEMALE; HUMANS; MALE; MIDDLE AGED; PERIPHERAL ARTERIAL DISEASE; RELAXIN; SWINE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84893919894     PISSN: 11226714     EISSN: 20385129     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Schroll M, Munck O. Estimation of peripheral arteriosclerotic disease by ankle blood pressure measurements in a population of 60 year old men and women. J Chron Dis 1981; 34: 261-9.
2. Aronow WS Peripheral arterial disease of the lower extremities. Arch Med Sci. 2012 May 9;8(2):375-88
3. Gardner AW, Katzel LI, Sorkin JD, et al. Improved functional outcomes following exercise rehabilitation in patients with intermittent claudication. J Gerontol Med Sci 2000; 55A: M570-7.
4. Hamburg NM, Balady GJ. Exercise rehabilitation in peripheral arterial disease. Functional impact and mechanisms of benefits. Circulation 2011; 123: 87-97.
5. Gardner AW, Poehlman ET. Exercise rehabilitation programs for the treatment of claudication pain. A metaanalysis. JAMA 1995; 274: 975-80.
6. Criqui MH, Fronek A, Barrett-Connor E, et al. The prevalence of peripheral arterial disease in a defined population. Circulation 1985; 71: 510-5.
7. Newman A, Siscovick DS, Manolio TA, et al. Ankle-arm index as a marker of atherosclerosis in the Cardiovascular Health Study. Circulation 1993; 88: 837-45.
8. Coelho PA, Bellmunt S, McGorrian C et al. Antithrombotic therapy in peripheral artery disease: antithrombotic therapy and prevention of thrombosis, 9th edition: American College of Chest Physicians Evidence Based Clinical Practice Guidelines Chest February 2012; 141 (2 suppl):e669S-e690s
9. Hisaw, F.L. (1926) Proc. Soc. Exp. Biol. Med., 23, 661-663.
10. Hall, K. (1947) J. Endocrinol., 5, 174-185.
11. Baccari M.C. 1,and Bani D Relaxin and Nitric Oxide Signalling Current Protein and Peptide Science, 2008, 9, 638-645
12. Bani D, Bigazzi M. Relaxin as a cardiovascular drug: a promise kept. Current Drug Safety 2011, 6: 324-8.
13. Casten GG, Gilmore HR, Houghton FE, Samuels SS. A new approach to the management of obliterative peripheral arterial disease. Angiology 1960; 11: 408-14.
14. Min, G. and Sherwood, O.D. (1996) Biol. Reprod., 55, 1243-1252.
15. Hsu, S.Y., Nakabayashi, K., Nishi, S., Kumagai, J., Kudo, M., Sherwood, O.D. and Hsueh, A.J. (2002) Science, 295, 671-673.
16. Kohsaka, T., Min, G., Lukas, G. Trupin, S., Campbell, E.T. and Sherwood, O.D. (1998) Biol. Reprod., 59, 991-999.
17. Vasilenko, P., Mead, J.P. and Weidmann, J.E. (1986) Biol. Reprod.,35, 987-995.
18. Bani, G, Maurizi, M., Bigazzi, M. and Bani Sacchi, T. (1995) Biol. Reprod., 53, 253-262
19. Bani, G., Bani Sacchi, T., Bigazzi, M. and Bianchi, S. (1988) Histol. Histopathol., 3, 337-343.
20. Bigazzi, M., Del Mese, A., Petrucci, F., Casali, R. and Novelli, G.P. (1986) Acta Endocrinol., 112, 296-299.
21. Danielson, L.A., Sherwood, O.D. and Conrad, K.P. (1999) J. Clin.Invest., 103, 525-533
22. Bani, D., Nistri, S., Quattrone, S., Bigazzi, M. and Bani Sacchi, T.(2001) J. Endocrinol., 171, 541-549.
23. Bani, D., Ballati, L., Masini, E., Bigazzi, M. and Bani Sacchi, T.(1997) Endocrinology, 138, 1909-1915.
24. Bani Sacchi, T., Bigazzi, M., Bani, D., Mannaioni, P.F. and Masini, E. (1995) Brit. J. Pharmacol., 116, 1589-1594.
25. Masini, E., Bani, D., Bello, M.G., Bigazzi, M., Mannaioni, P.F. and Bani Sacchi, T. (1997) Endocrinology, 138, 4713-4720.