Consequences of relaxin-3 null mutation in mice on food-entrainable arousal

Italian Journal of Anatomy and Embryology

Volumn 118, Issue 1 SUPPL., 2013, Pages 37-41

  Hosken, Ihaia T ^a   Smith, Craig M ^a,b   Chua, Berenice E ^a   Gundlach, Andrew L ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Arousal; Food anticipatory activity; Knockout mouse; Relaxin 3; Running wheel; RXFP3

Indexed keywords

RELAXIN; RELAXIN 3 PROTEIN, MOUSE; RELAXIN-3 PROTEIN, MOUSE;

ANIMAL; ANIMAL BEHAVIOR; AROUSAL; ARTICLE; C57BL MOUSE; FEEDING BEHAVIOR; FEMALE; GENETICS; KNOCKOUT MOUSE; MALE; MOUSE; PHYSIOLOGY;

ANIMALS; AROUSAL; BEHAVIOR, ANIMAL; FEEDING BEHAVIOR; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RELAXIN;

EID: 84893917952     PISSN: 11226714     EISSN: 20385129     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Ganella D.E., Ryan P.J., Bathgate R.A.D., Gundlach A.L. (2012) Increased feeding and body weight gain in rats after acute and chronic activation of RXFP3 by relaxin-3 and receptor-selective peptides: Functional and therapeutic implications. Behav. Pharmacol. 23, 516-525.
2. Ma S., Bonaventure P., Ferraro T., Shen P.J., Burazin T.C.D., Bathgate R.A.D., Liu C., Tregear, G.W., Sutton S.W., Gundlach A.L. (2007) Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat. Neuroscience 144, 165-190.
3. McGowan B.M., Stanley S.A., Smith K.L., White N.E., Connolly M.M., Thompson E.L., Gardiner J.V., Murphy K.G., Ghatei M.A., Bloom S.R. (2005) Central relaxin-3 administration causes hyperphagia in male Wistar rats. Endocrinology 146, 3295-3300.
4. Mistlberger R.E. (1994) Circadian food-anticipatory activity: formal models and physiological mechanisms. Neurosci. Biobehav. Rev. 18, 171-195.
5. Shabanpoor F., Hossain M.A., Ryan P.J., Belgi A., Layfield S., Kocan M., Zhang S., Samuel C.S., Gundlach A.L., Bathgate R.A.D., Separovic F., Wade, J.D. (2012) Minimization of relaxin-3 leading to high affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1. J. Med. Chem. 55, 1671-1681.
6. Smith C.M., Hosken I.T., Sutton S.W., Lawrence A.J., Gundlach, A.L. (2012) Relaxin- 3 null mutation mice display a circadian hypoactivity phenotype. Genes Brain Behav. 11, 94-104.
7. Smith C.M., Ryan P.J., Hosken I.T., Ma S., Gundlach A.L. (2011) Relaxin-3 systems in the brain - The first 10 years. J. Chem. Neuroanat. 42, 262-275.
8. Smith C.M., Shen P.J., Banerjee A., Bonaventure P., Ma S., Bathgate R.A.D., Sutton S.W., Gundlach, A.L. (2010) Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain. J. Comp. Neurol. 518, 4016-4045.
9. Stephan, F.K. (2002). The "other" circadian system: food as a Zeitgeber. J. Biol. Rhythms 17, 284-292.
10. Wakamatsu H., Yoshinobu Y., Aida R., Moriya T., Akiyama M., Shibata S. (2001) Restricted feeding induced anticipatory activity rhythm is associated with a phase shift of the expression of mPer1 and mPer2 mRNA in the cerebral cortex and hippocampus but not in the suprachiasmatic nucleus of mice. Eur. J. Neurosci. 13: 1190-1196.
11. Watanabe Y., Tsujimura A., Takao K., Nishi K., Ito Y., Yasuhara Y., Nakatomi Y., Yokoyama C., Fukui K., Miyakawa T., Tanaka, M. (2011) Relaxin-3-deficient mice showed slight alteration in anxiety-related behavior. Front. Behav. Neurosci. 5, 50.
12. Welsh D.K., Takahashi J.S., Kay S.A. (2010) Suprachiasmatic nucleus: cell autonomy and network properties. Ann. Rev. Physiol.72, 551-577.